Proton pump inhibitors work by irreversibly binding to and inhibiting the H+/K+ ATPase enzyme, also known as the proton pump, located on the parietal cells of the stomach. This proton pump is responsible for pumping hydrogen ions into the stomach to produce acid. By inhibiting this pump, proton pump inhibitors reduce acid production and are used to treat conditions caused by excess stomach acid such as ulcers, GERD, and indigestion. Common proton pump inhibitors include omeprazole, rabeprazole, lansoprazole, and pantoprazole.
2. What is Proton Pump Inhibitor……………………..?????
❖ Integral membrane protein on
parietal cells
❖ Pump proton into the stomach
❖ By using ATP, acidic hydrogen ion
replaces potassium ion
5. ● They are prodrugs activate in acidic environment
● Active metabolite is Sulphamide.
● Interact with -SH group of enzyme (H+/ K+ ATP-ase)
● Irreversibly binding inhibits the activity of enzyme.
MOA of PPIs
