This document provides an overview of muscles in the shoulder and upper extremity. It defines key muscle terminology like origin, insertion, and action. It then describes the major superficial and deep muscles of the shoulder, including the rotator cuff muscles. Next, it reviews the muscles of the arm responsible for flexion, extension, supination, and pronation. Finally, it briefly outlines the intrinsic hand muscles and flexor/extensor muscles to focus on for the lab exam.