Analytical method development and its application to extractive spectrophotometric determination of Co (II) using 1, 2-Propanedione, 1-phenyl-1-(2-hydroxybenzylideneazine) -2- oxime (PDPHBAO).
Analytical method development and its application to extractive spectrophotometric determination of Co (II) using 1, 2-Propanedione, 1-phenyl-1-(2-hydroxybenzylideneazine) -2- oxime (PDPHBAO).
chitosan nanoparticles synthesis and application in various fields i.e. biocompatible fruit preservatives, water treatment with non toxic substrate, cotton functionalization, etc.
Curcumin extract nanoparticles: preparation, characterization and antimicrobi...Innspub Net
In recent years, synthesized zinc oxide nanoparticles have been increasingly investigated for different medicinal uses. In the present study, we aimed at the biosynthesis of zinc oxide using a curcumin extract. Although, toxic effects of curcumin derivative and zinc oxide nanoparticles in different concentration have been studied specifically on animal models besides the antibacterial activity of synthesized curcumin extract and zinc oxide nanoparticles. The aim of the study was to synthesize extract combined zinc oxide nanoparticles. Methods: The synthesized nanoparticles and extract were characterized for the particle size distribution, morphology, optical properties and surface charge by using UVvisible spectroscopy, dynamic light scattering (DLS), (TEM) and (SEM). Elemental composition and structural properties were studied by energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction spectroscopy (XRD). Results: The synthesized nanoparticles and curcumin were irregular shape and had a size distribution in the range of 50–100 nm. The in vitro toxicity effects of zinc oxide and extract showed no toxic effect with different concentration with antibacterial effect.
Synthesis and study of structural and magnetic properties of superparamagneti...Nanomedicine Journal (NMJ)
Objective(s):
This paper describes coating of magnetite nanoparticles (MNPs) with amorphous silica shells.
Materials and Methods:
First, magnetite (Fe3O4) NPs were synthesized by co-precipitation method and then treated with stabilizer molecule of trisodium citrate to enhance their dispersibility. Afterwards, coating with silica was carried out via a sol-gel approach in which the electrostatically stabilized MNPs were used as seeds. The samples were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy and vibrating sample magnetometer (VSM).
Results:
The results of XRD analysis implied that the prepared nanocomposite consists of two compounds of crystalline magnetite and amorphous silica that formation of their core/shell structure with the shell thickness of about 5 nm was confirmed by TEM images. The magnetic studies also indicated that produced Fe3O4@SiO2 core/shell nanocomposite exhibits superparamagnetic properties at room temperature.
Conclusion:
These core/shell structure due to having superparamagnetic property of Fe3O4 and unique properties of SiO2, offers a high potential for many biomedical applications.
Keywords
Magnetite; Silica; Core-shell structure; Superparamagnetism; Biomedical applications
Synthesis and Spectral Characterization of UO2(VI), Th(IV) and ZrO(IV) Complexes with benzimidazolyl-2-hydrazones of diacetyl monoxime and benzil monoxime
Ranjan Kumar Mohapatra1, Pradeep Kumar Das2
chitosan nanoparticles synthesis and application in various fields i.e. biocompatible fruit preservatives, water treatment with non toxic substrate, cotton functionalization, etc.
Curcumin extract nanoparticles: preparation, characterization and antimicrobi...Innspub Net
In recent years, synthesized zinc oxide nanoparticles have been increasingly investigated for different medicinal uses. In the present study, we aimed at the biosynthesis of zinc oxide using a curcumin extract. Although, toxic effects of curcumin derivative and zinc oxide nanoparticles in different concentration have been studied specifically on animal models besides the antibacterial activity of synthesized curcumin extract and zinc oxide nanoparticles. The aim of the study was to synthesize extract combined zinc oxide nanoparticles. Methods: The synthesized nanoparticles and extract were characterized for the particle size distribution, morphology, optical properties and surface charge by using UVvisible spectroscopy, dynamic light scattering (DLS), (TEM) and (SEM). Elemental composition and structural properties were studied by energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction spectroscopy (XRD). Results: The synthesized nanoparticles and curcumin were irregular shape and had a size distribution in the range of 50–100 nm. The in vitro toxicity effects of zinc oxide and extract showed no toxic effect with different concentration with antibacterial effect.
Synthesis and study of structural and magnetic properties of superparamagneti...Nanomedicine Journal (NMJ)
Objective(s):
This paper describes coating of magnetite nanoparticles (MNPs) with amorphous silica shells.
Materials and Methods:
First, magnetite (Fe3O4) NPs were synthesized by co-precipitation method and then treated with stabilizer molecule of trisodium citrate to enhance their dispersibility. Afterwards, coating with silica was carried out via a sol-gel approach in which the electrostatically stabilized MNPs were used as seeds. The samples were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy and vibrating sample magnetometer (VSM).
Results:
The results of XRD analysis implied that the prepared nanocomposite consists of two compounds of crystalline magnetite and amorphous silica that formation of their core/shell structure with the shell thickness of about 5 nm was confirmed by TEM images. The magnetic studies also indicated that produced Fe3O4@SiO2 core/shell nanocomposite exhibits superparamagnetic properties at room temperature.
Conclusion:
These core/shell structure due to having superparamagnetic property of Fe3O4 and unique properties of SiO2, offers a high potential for many biomedical applications.
Keywords
Magnetite; Silica; Core-shell structure; Superparamagnetism; Biomedical applications
Synthesis and Spectral Characterization of UO2(VI), Th(IV) and ZrO(IV) Complexes with benzimidazolyl-2-hydrazones of diacetyl monoxime and benzil monoxime
Ranjan Kumar Mohapatra1, Pradeep Kumar Das2
Biosorption Activity of Nymphaea lotus (Water Lily)theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
ACETYLATION OF BENZYLIC ALCOHOLS OVER BiFeO3 (BFO), Bi0.86Sm0.07Eu0.07FeO3 (B...EDITOR IJCRCPS
BiFeO3 (BFO), Bi0.86Sm0.07Eu0.07FeO3 (BSEFO), and Bi0.86Sm0.07Cd0.07FeO3 (BSCFO) nanopowders were prepared by the sol-gel
combustion method and the catalytic performances were evaluated in acetylation reaction of benzyl alcohol. The physical chemical
properties of catalysts were characterized by using XRD, FT-IR, scanning electron microscope (SEM), EDX and BET surface.
Efficient acetylation of benzyl alcohol was carried out over all the nano powders using acetyl chloride/ acetonitrile at room
temperature. Among the nanopowders, BSCFO showed the highest catalytic performance and the yield of benzyl acetate was 89,
45, and 69 percent over BSCFO, BFO, and BSEFO, respectively. Partial substitution of Sm-Eu and Sm-Cd in bismuth ferrite
improved the catalytic performance and increased the specific surface area of the catalysts. A direct relationship was resulted
between catalytic performance and surface of catalysts, where BSCFO with the highest surface area (111m2/g) exhibited the
superior catalytic performance. The quantitative yield for acetate product was also resulted for acetylation of p-methyl benzyl
alcohol, p-nitro benzyl alcohol and p-chloro benzyl alcohol on BSCFO. The catalysts showed good reusability in the process. The
study confirmed the catalysts could be promising catalyst for acetylation of alcohols.
Keywords: Europium, Samarium, Bismuth ferrites, nano perovskite, doping, Acetylation, benzylic alcohols.
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Green synthesis and characterization of silver nanoparticles using tinosopora...IJARIIT
User authentication is an important topic in the field of information security. To enforce security of information,
passwords were introduced. Text based password is a popular authentication method used from ancient times. However text
based passwords are prone to various attacks. Strong text-based password schemes could provide with certain degree of security.
However, the fact that strong passwords are difficult to memorize often leads their users to write them down on papers or even
save them in a computer file. Human actions such as choosing bad passwords and inputting passwords in an insecure way are
regarded as the weakest link in the authentication chain. Graphical password is one of the alternative solution to alphanumeric
password as it is very simple process to remember alphanumeric password. One of the major reasons behind this method
implementation is that, according to psychological studies human mind can easily remember images than alphabets or digits.
Graphical authentication has been proposed as a possible alternative solution to text-based authentication. A new technique of
captcha and OTP is being used for the verification purpose. Three times a person is given chance to try for login if the person
fails then he is blocked till the session expires.
Synthesis and Evaluation of the Cytotoxic and Anti-Proliferative Properties o...IJEAB
Doxorubicin (Dox) is a potent chemotherapeutic agent used in the treatment of cancer. In the present study, pH responsive chitosan polymer coated Dox nanoparticle (Composite) was developed to investigate targeted drug delivery against breast cancer. The anticancer drug DOX-ZnO QDs was loaded to the chitosan nanoparticles. The synthesized free and drug loaded nanoparticle were analyzed using Fourier transmission electron microscopy (FTIR) and UV-Visible spectroscopy(UV-Vis). The particle size was measured using Transmission Electron Microscopy (TEM). Further, the composite was evaluated for its anticancer effects. Drug release analysis showed significantly larger amount of drug released in acidic pH of 5.0 compared to pH 7.4. The composite was significantly more cytotoxic to the breast cancer cells MCF-7 and SKBR-3. The composite was however, less toxic to HEK-293 human embryonic kidney cells confirming minimum side effects on normal cells andcytotoxic to tumor cells. DAPI staining showed nuclear degradation in composite treated breast cancer cells. The cellular uptake of the composite was analyzed by confocal microscopy. The composite induced a G0/G1 phase arrest in breast cancer cells and the number of colonies formed by the composite treated breast cancer cells formed less number of colonies compared to free NP. Our results showed that our composite could serve as a promising therapeutic approach to improve clinical outcomes against various malignancies.
In this study, kinetics of demineralization of chitin extraction from snail shells was
investigated. Chitin was extracted from snail shells by demineralizing the
deproteinized shells in 1.2 M HCl solution. Prior to demineralization, the raw snail
shells were deproteinized using 1 M NaOH solution to remove proteins and organic
matter present in the shells. The product was dried before the demineralization
process was carried out. The results showed that based on the R2 values obtained for
each of the shrinking core models considered which include; fluid film diffusion
(FFD), ash layer diffusion (ALD), and chemical reaction control (CRC), it was noted
that the CRC model was prevalent for all the various range of particle sizes analyzed
(6.3 – 4.75 mm, 4.75 – 2 mm, 2 – 1 mm, and 600 – 300 μm). The surface morphologies
and the Fourier Transform Infra-Red (FTIR) bands of the extracted chitin were
similar to previous studies
Effect of Solvents on Size and Morphologies Of sno Nanoparticles via Chemical...Editor IJCATR
Stannous oxide (SnO) is an important functional material which contributes to a wide range of applications. In present
study, the SnO nanoparticles were synthesized using different solvents by chemical co-precipitation method. Different morphologies
of SnO nanoparticles have been obtained by different solvents. The size of SnO nanoparticles was estimated by powder X-ray
diffraction (PXRD) pattern and revealed that SnO crystallizes into tetragonal rutile phase. The chemical structural information of the
synthesized nanoparticles was studied by Fourier transform infrared (FTIR) spectroscopy. The prominent UV emission peak was
observed at 358 nm in the luminance spectra, studied by photoluminescence (PL) spectroscopy. The composition of the product SnO
nanoparticles could be determined by X-ray photoelectron spectroscopy (XPS) and the binding energies of O 1s and Sn 3d3/2 have been
found which are centered at 530 and 495 eV, respectively.
Preparation and characterization of hydroxyapatite reinforced with hardystoni...Nanomedicine Journal (NMJ)
Abstract
Objecttive(s):
Despite the poor mechanical properties of hydroxyapatite, its unique biological properties leads we think about study on improving its properties rather than completely replacing it with other biomaterials. Accordingly, in this study we introduced hydroxyapatite reinforced with hardystonite as a novel bio-nanocompositeand evaluate its in-vitro bioactivity with the aim of developing a mechanically strong and highly porous scaffold for bone tissue engineering applications.
Materials and Methods:
Natural Hydroxyapatite (NHA)-Hardystonite (HT) nanocomposite with different percentage of HT was synthesized by mechanical activation method and subsequent heating annealing process. This study showed that the addition of HT to HA not only increases the mechanical properties of HA but also improves its bioactivity. Dissolution curves presented in this study indicated that the pH value of SBF solution in the vicinity of HA-HT nanocomposite increases during the first week of experiment and decreases to blood pH at the second weekend. Hardystonite was composed of nano-crystalline structure with approximately diameter 40 nm. Specimens were composed of a blend of pure calcite (CaCO3) (98% purity, Merck), silica amorphous (SiO2) (98% purity, Merck) powder and pure zinc oxide (ZnO) with 50 % wt., 30 %wt and 20 %wt., respectively. These powders were milled by high energy ball mill using ball-to- powder ratio 10:1 and rotation speed of 600 rpm for 5 and 10 h. Then, the mixture mechanical activated has been pressed under 20 MPa. The samples pressed have been heated at 1100 ºC for 3 h in muffle furnace at air atmosphere. X-ray diffraction (XRD), scanning electron microscopy (SEM) and BET performed on the samples to characterize.
Results:
According to XRD results, the sample milled for 10 h just indicated the hardystonite phase, while the sample milled for 5 h illustrate hardystonite phase along with several phases.
Conclusion:
In fact, our study indicated that hardystonite powder was composed of nano-crystalline structure, about 40 nm, can be prepared by mechanical activation to use as a new biomaterials for orthopedic applications.
Biosorption Activity of Nymphaea lotus (Water Lily)theijes
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
ACETYLATION OF BENZYLIC ALCOHOLS OVER BiFeO3 (BFO), Bi0.86Sm0.07Eu0.07FeO3 (B...EDITOR IJCRCPS
BiFeO3 (BFO), Bi0.86Sm0.07Eu0.07FeO3 (BSEFO), and Bi0.86Sm0.07Cd0.07FeO3 (BSCFO) nanopowders were prepared by the sol-gel
combustion method and the catalytic performances were evaluated in acetylation reaction of benzyl alcohol. The physical chemical
properties of catalysts were characterized by using XRD, FT-IR, scanning electron microscope (SEM), EDX and BET surface.
Efficient acetylation of benzyl alcohol was carried out over all the nano powders using acetyl chloride/ acetonitrile at room
temperature. Among the nanopowders, BSCFO showed the highest catalytic performance and the yield of benzyl acetate was 89,
45, and 69 percent over BSCFO, BFO, and BSEFO, respectively. Partial substitution of Sm-Eu and Sm-Cd in bismuth ferrite
improved the catalytic performance and increased the specific surface area of the catalysts. A direct relationship was resulted
between catalytic performance and surface of catalysts, where BSCFO with the highest surface area (111m2/g) exhibited the
superior catalytic performance. The quantitative yield for acetate product was also resulted for acetylation of p-methyl benzyl
alcohol, p-nitro benzyl alcohol and p-chloro benzyl alcohol on BSCFO. The catalysts showed good reusability in the process. The
study confirmed the catalysts could be promising catalyst for acetylation of alcohols.
Keywords: Europium, Samarium, Bismuth ferrites, nano perovskite, doping, Acetylation, benzylic alcohols.
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Green synthesis and characterization of silver nanoparticles using tinosopora...IJARIIT
User authentication is an important topic in the field of information security. To enforce security of information,
passwords were introduced. Text based password is a popular authentication method used from ancient times. However text
based passwords are prone to various attacks. Strong text-based password schemes could provide with certain degree of security.
However, the fact that strong passwords are difficult to memorize often leads their users to write them down on papers or even
save them in a computer file. Human actions such as choosing bad passwords and inputting passwords in an insecure way are
regarded as the weakest link in the authentication chain. Graphical password is one of the alternative solution to alphanumeric
password as it is very simple process to remember alphanumeric password. One of the major reasons behind this method
implementation is that, according to psychological studies human mind can easily remember images than alphabets or digits.
Graphical authentication has been proposed as a possible alternative solution to text-based authentication. A new technique of
captcha and OTP is being used for the verification purpose. Three times a person is given chance to try for login if the person
fails then he is blocked till the session expires.
Synthesis and Evaluation of the Cytotoxic and Anti-Proliferative Properties o...IJEAB
Doxorubicin (Dox) is a potent chemotherapeutic agent used in the treatment of cancer. In the present study, pH responsive chitosan polymer coated Dox nanoparticle (Composite) was developed to investigate targeted drug delivery against breast cancer. The anticancer drug DOX-ZnO QDs was loaded to the chitosan nanoparticles. The synthesized free and drug loaded nanoparticle were analyzed using Fourier transmission electron microscopy (FTIR) and UV-Visible spectroscopy(UV-Vis). The particle size was measured using Transmission Electron Microscopy (TEM). Further, the composite was evaluated for its anticancer effects. Drug release analysis showed significantly larger amount of drug released in acidic pH of 5.0 compared to pH 7.4. The composite was significantly more cytotoxic to the breast cancer cells MCF-7 and SKBR-3. The composite was however, less toxic to HEK-293 human embryonic kidney cells confirming minimum side effects on normal cells andcytotoxic to tumor cells. DAPI staining showed nuclear degradation in composite treated breast cancer cells. The cellular uptake of the composite was analyzed by confocal microscopy. The composite induced a G0/G1 phase arrest in breast cancer cells and the number of colonies formed by the composite treated breast cancer cells formed less number of colonies compared to free NP. Our results showed that our composite could serve as a promising therapeutic approach to improve clinical outcomes against various malignancies.
In this study, kinetics of demineralization of chitin extraction from snail shells was
investigated. Chitin was extracted from snail shells by demineralizing the
deproteinized shells in 1.2 M HCl solution. Prior to demineralization, the raw snail
shells were deproteinized using 1 M NaOH solution to remove proteins and organic
matter present in the shells. The product was dried before the demineralization
process was carried out. The results showed that based on the R2 values obtained for
each of the shrinking core models considered which include; fluid film diffusion
(FFD), ash layer diffusion (ALD), and chemical reaction control (CRC), it was noted
that the CRC model was prevalent for all the various range of particle sizes analyzed
(6.3 – 4.75 mm, 4.75 – 2 mm, 2 – 1 mm, and 600 – 300 μm). The surface morphologies
and the Fourier Transform Infra-Red (FTIR) bands of the extracted chitin were
similar to previous studies
Effect of Solvents on Size and Morphologies Of sno Nanoparticles via Chemical...Editor IJCATR
Stannous oxide (SnO) is an important functional material which contributes to a wide range of applications. In present
study, the SnO nanoparticles were synthesized using different solvents by chemical co-precipitation method. Different morphologies
of SnO nanoparticles have been obtained by different solvents. The size of SnO nanoparticles was estimated by powder X-ray
diffraction (PXRD) pattern and revealed that SnO crystallizes into tetragonal rutile phase. The chemical structural information of the
synthesized nanoparticles was studied by Fourier transform infrared (FTIR) spectroscopy. The prominent UV emission peak was
observed at 358 nm in the luminance spectra, studied by photoluminescence (PL) spectroscopy. The composition of the product SnO
nanoparticles could be determined by X-ray photoelectron spectroscopy (XPS) and the binding energies of O 1s and Sn 3d3/2 have been
found which are centered at 530 and 495 eV, respectively.
Preparation and characterization of hydroxyapatite reinforced with hardystoni...Nanomedicine Journal (NMJ)
Abstract
Objecttive(s):
Despite the poor mechanical properties of hydroxyapatite, its unique biological properties leads we think about study on improving its properties rather than completely replacing it with other biomaterials. Accordingly, in this study we introduced hydroxyapatite reinforced with hardystonite as a novel bio-nanocompositeand evaluate its in-vitro bioactivity with the aim of developing a mechanically strong and highly porous scaffold for bone tissue engineering applications.
Materials and Methods:
Natural Hydroxyapatite (NHA)-Hardystonite (HT) nanocomposite with different percentage of HT was synthesized by mechanical activation method and subsequent heating annealing process. This study showed that the addition of HT to HA not only increases the mechanical properties of HA but also improves its bioactivity. Dissolution curves presented in this study indicated that the pH value of SBF solution in the vicinity of HA-HT nanocomposite increases during the first week of experiment and decreases to blood pH at the second weekend. Hardystonite was composed of nano-crystalline structure with approximately diameter 40 nm. Specimens were composed of a blend of pure calcite (CaCO3) (98% purity, Merck), silica amorphous (SiO2) (98% purity, Merck) powder and pure zinc oxide (ZnO) with 50 % wt., 30 %wt and 20 %wt., respectively. These powders were milled by high energy ball mill using ball-to- powder ratio 10:1 and rotation speed of 600 rpm for 5 and 10 h. Then, the mixture mechanical activated has been pressed under 20 MPa. The samples pressed have been heated at 1100 ºC for 3 h in muffle furnace at air atmosphere. X-ray diffraction (XRD), scanning electron microscopy (SEM) and BET performed on the samples to characterize.
Results:
According to XRD results, the sample milled for 10 h just indicated the hardystonite phase, while the sample milled for 5 h illustrate hardystonite phase along with several phases.
Conclusion:
In fact, our study indicated that hardystonite powder was composed of nano-crystalline structure, about 40 nm, can be prepared by mechanical activation to use as a new biomaterials for orthopedic applications.
Tide data warehousesolutionfort24_nayamsoft_flyerDileep Sankar
TIDE - T24 Intelli-Data Engine
TIDE is a native T24 ETL solution from Nayamsoft. It features the fastest ODBC driver in which can communicate to T24 natively. Comprehensive multi-value handling, meta data modification, efficient load handling are the key features of TIDE. An exclusive ODBC access to T24 via our unique ODBC driver is available for third party applications. T24 xml data can be extracted directly from T24 xml oracle database and exported as relational database. External systems can execute extraction packages remotely using TIDE Client API.
Eliminate Workers' Compensation Fraud Before it Eliminates Your BusinessEMPLOYERS
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Similar to Analytical method development and its application to extractive spectrophotometric determination of Co (II) using 1, 2-Propanedione, 1-phenyl-1-(2-hydroxybenzylideneazine) -2- oxime (PDPHBAO).
Synthesis, spectroscopic, electrochemical, magnetic properties and super oxid...IOSR Journals
Five new mixed-ligand nickel (II) complexes; viz; [Ni (BHM)(PMDT)]1; [Ni(BHM)(dien)] 2; [Ni(BHM)(L1)]3; [Ni(BHM)(L2)] 4, [Ni(BHM)(L3)] 5; where H2BHM= N’-(1E)-(5-bromo-2-hydroxyphenyl) methylidene] benzoylhydrazide, PMDT= N,N,N’,N,”N”-Pentamethyldiethylenetriamine; dien= diethylenetriamine; L1 = N,N- dimethyl-N’ (Pyrid-2-yl-methyl) ethylenediamine; L2= N-methyl-N’-(pyrid-2-ylmethyl)ethylenediamine; L3 = N,N-dimethyl-N’-(6-methyl)pyrid-2-ylmethyl) ethylenediamine, have been synthesized and characterized by using elemental analyses, FAB (fast atomic bombardment), magnetic measurements, electronic absorption , conductivity measurements, cyclic voltammetry (CV) and IR- spectroscopy . All the complexes yielded an irreversible couple that can be assigned to a NiII→ NiI redox process. Infrared spectra, ligand field spectra and magnetic susceptibility measurements agree with the observed octahedral environment. H2BHM is a diprotic tridentate Schiff base ligand (ONO donor atom) whereas L1-L3 possessing N3 coordination sites. The SOD activities have been measured using alkaline DMSO as a source of superoxide radical (O2–) and nitro blue tetrazolium (NBT) as O2– scavenger.
International Journal of Engineering and Science Invention (IJESI)inventionjournals
International Journal of Engineering and Science Invention (IJESI) is an international journal intended for professionals and researchers in all fields of computer science and electronics. IJESI publishes research articles and reviews within the whole field Engineering Science and Technology, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
METALLO - BIOACTIVE COMPOUNDS AS POTENTIAL NOVEL ANTICANCER THERAPYijac123
Mono and bi-organometallic complexes of Cu(II), Ni(II), Mn(II), Zn(II) and Ag(I) complexes with
oxaloamide ligand has much potential as therapeutic and diagnostic agents. The ligand allows the
thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for
functionalization. Specific examples involving the design of metal complexes as anticancer agents are
discussed. These complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS,
ESR) spectra, magnetic moments and conductance measurements, elemental and thermal analyses. Molar
conductances in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid
Cu(II) complexes (2-5) show an axial type indicating a d(X2-y2) ground state with a significant covalent
bond character. However, Mn(II) complex(9), shows an isotropic type indicating an octahedral geometry.
Cytotoxic evolution IC50 of the ligand and its complexes have been carried out. Cu(II) Complexes show
enhanced activity in comparison to the parent ligand or standard drug. Copper is enriched in various
human cancer tissues and is a co-factor essential for tumor angiogenesis processes. However, the use of
copper binding ligand to target tumor, copper could provide a novel strategy for cancer selective
treatment.
New One-Pot Synthetic Route and Spectroscopic Characterization of Hydroxo-Bri...AJASTJournal
A new convenient and efficient route for the synthesis of two very important hydroxo-bridged stepped-cubane copper complexes viz: [Cu4(bpy)4Cl2(OH)4]Cl2.6H2O (1) and [Cu4(phen)4Cl2(OH)4]Cl2.6H2O (2) have been obtained. This synthetic route from the mononuclear CubpyCl2 complex is easier, more reproducible and afforded the complex in a much higher yield than the other two previously reported procedures which were equally serendipitously discovered. The purity and formation of the complexes were confirmed with elemental (C,H,N) analysis and the details of the UV-Vis, Fourier transform infrared, electrospray ionization mass spectra of both complexes and the single crystal X-ray crystallography of 1 are presented and discussed. X-ray crystallography confirms the absolute structure of the complexes. The complexes were formed via the connection of four copper atoms to four hydroxide bridging ligands and four bipyridyl ligands with two chloride ligands. There are two coordinate environments around two pairs of copper atoms (CuN2ClO2 and CuN2O3) and each copper atom is pentacoordinate with square pyramidal geometry.
A new convenient and efficient route for the synthesis of two very important hydroxo-bridged stepped-cubane copper complexes viz: [Cu4(bpy)4Cl2(OH)4]Cl2.6H2O (1) and [Cu4(phen)4Cl2(OH)4]Cl2.6H2O (2) have been obtained. This synthetic route from the mononuclear CubpyCl2 complex is easier, more reproducible and afforded the complex in a much higher yield than the other two previously reported procedures which were equally serendipitously discovered. The purity and formation of the complexes were confirmed with elemental (C,H,N) analysis and the details of the UV-Vis, Fourier transform infrared, electrospray ionization mass spectra of both complexes and the single crystal X-ray crystallography of 1 are presented and discussed. X-ray crystallography confirms the absolute structure of the complexes. The complexes were formed via the connection of four copper atoms to four hydroxide bridging ligands and four bipyridyl ligands with two chloride ligands. There are two coordinate environments around two pairs of copper atoms (CuN2ClO2 and CuN2O3) and each copper atom is pentacoordinate with square pyramidal geometry.
SYNTHESIS AND CHARACTERIZATION OF SCHIFF BASE METAL COMPLEXES DERIVED FROM NA...chemsurya
New Schiff base metal complexes having general structural formulae ML2Cl2 where M= Co(II), Ni(II) and Cu(II), and MLCl2 where M=Zn(II), Cd(II) and Hg(II) were synthesized by the condensation of indoline-2,3-dione (Isatin) and naphtho[2,1-b]furan-2-carbohydrazide. Tentative structures for the synthesized compounds have been elucidated based on analytical, IR, 1HNMR, and Mass spectral studies. Further selected compounds were tested for their antimicrobial activity.
Synthesis and Crystal Structure of Anickel (II) and Zinc (II) Complex From 1,...IOSRJAC
:The title mononuclear nickel and zinc complexes, Ni(C11H9N4S3)2andZn(C11H9N4S3)2 .2(C3H7NO), were prepared by the reaction of Nickel(II) or Zinc(II)acetate with 1,5-bis[(2- thiophenyl)methylidene]thiocarbonohydrazide in a methanol solution. It features mono-deprotonated bisbidentate ligands, which coordinate to metal (II) ions by hydrazylN and thiocarbony lS atoms, yielding a tetracoordinated metal ions complexes. In Ni(II) complex the geometry around the metal ion is described as square planar. In the Zn(II) the metal atom shows severely tetrahedral distortion from anideal square-planar coordination geometry, as reflected by the dihedral angle between ZnN2and ZnS2 planes of 73.03(13)°. Two intramolecular hydrogen bonds are observed between the solvate dmf molecules and the coordinated ligands:N2—H2N…O1i and N6—H6N…O2 ii in this complex
In Vitro Antioxidant evaluation and DNA binding ability of Ni(II), Co(II), Cu...IOSRJAC
: In the present study, the antioxidant and DNA binding properties of Ni(II), Co(II), Cu(II) and Zn(II) metal complexes containing bidentate Schiff base for their possible free radicals scavenging properties associated with various diseases were considered. The different models such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferrous ion chelation(FIC),ferric reducing antioxidant power(FRAP),total antioxidant activities(phosphomolybdenum methods) and hydroxyl radical(•OH) radical scavenging activities at different concentrations for antioxidant and DNA absorption spectroscopic analysis were assayed for DNA binding studies. The metal complexes were found to be significant dose-dependent antioxidant activities comparable with that of the classical antioxidants, ascorbic acid, ethylene diaminetetraacetic acid(EDTA) and DNA binding potential withkb 4.990×10-5M -1 ,4.989×10-5M -1 ,4.994×10-5M -1 and 5.012×10-5M -1 respectively.The compounds exhibited are very reactive towards DPPH radicals, OH radicals and Fe(II) ions and they also actively reduces Fe(III) ion to Fe(II) and Mo(VI) ion to Mo(V) form. The obtained results indicate the importance of Schiff base metal complexes as a source of synthetic antioxidants and anticancer drugs.
An Efficient Synthetic Approach Towards 4-Cyano-3-(Methylthio)-5-Oxo-2H-Pyraz...inventionjournals
ABSTRACT: Synthesis of novel heterocyclic 4-cyano -3-(methylthio)-5-oxo-2H-pyrazole-1(5H)- carbothioamide (3) was prepared by condensing ethyl-2-cyano-3,3-bis (methylthio)acrylate (1) with thiosemicarbazide (2) in DMF and catalytic amount of potassium carbonate. Compound (3) has methylthio group at third position, which is replaced by different nucleophiles such as substituted anilines| phenols| hetryl amines| compounds containing active methylene group to afford 3-substituted derivatives of compound (3). All the newly synthesized compounds were screened for their antimicrobial activity.
Facial and Simple Synthesis of Some New (Pyrazole and Triazole) Coumarin Deri...IOSRJAC
2-oxo-2H-coumarin-3-carbohydrazide (2) which prepared from the reaction of ethyl-2-oxo-2Hcoumarin-3-carboxylate (1) with hydrazine hydrate in ethanol containing a catalytic amount of piperidine mixture consider a good and available starting intermediate for synthesis of series of functionalized coumarins. So, compound (2) was utilized as a key for the synthesis of some new (pyrazole, triazole)-2H- coumarin-2-one derivatives by the reaction with some selected reagents.
Synthesis, Characterization, Antibacterial and DNA Binding Studies of Mn (II)...IOSRJAC
Mn (II) complex of the Schiff base (L), 3-(2-(2-hydroxy-3-methoxybenzylidene) hydrazinyl) quinoxalin-2(1H)-one (VHQO) was prepared and characterized by IR, UV-VIS, Mass, Elemental analysis, TGDTA, magnetic susceptibility and conductivity measurements. VHQO behaved as monobasic, tridentate ligand and formed 1:2 complex (ML2) with the metal ion (M) coordinating through ring nitrogen, azomethine nitrogen and phenolic oxygen. Thermal analysis of the complex indicated the absence of lattice and coordinated water. Based on the spectral and analytical data, octahedral geometry was assigned to the complex. Antibacterial activity of the complex against gram positive bacteria, Bacillus subtillis, Staphylococcus aureus, and gram negative bacteria, Escherichia coli, Proteus vulgaris, Pseudomonas aeroginosa , and Klebsiella pneumonia was studied. The interaction of the complex with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy and the intrinsic binding constant was calculated.
Simple Synthesis of Some Novel Polyfunctionally Derivatives of 2H-Coumarin-2-...IOSRJAC
Compound (2) was prepared from the reaction of ethyl-2-oxo-2H-coumarin-3-carboxylate (1) with ethylcyanoacetate in ethanol containing a catalytic amount of piperidine as catalyst. Compound (2) is the key intermediate for the synthesis of several series of new compounds such as ((pyrimidine, tetrazine, piperidine, oxazepine)-2H-coumarin-2-one derivatives by reaction with selected reagents such as urea, cyanoacetamide, cyanoacetohydrazide, orthoaminophenol and 5-aminotriazole.
Synthesis, characterization and in vitro Antimicrobial activity of Cu (II) an...IOSR Journals
Abstract: Four Cu(II) and two Ni(II) complexes of azo carboxylate ligands were synthesized and characterized
by conductivity ,UV-visible and Infrared spectroscopy. The comparison of IR spectra of uncoordinated ligands
and their metal complexes indicated that ligands were coordinated to the metal through carboxylic oxygen atom
in bidented fashion. The electronic spectral data suggested square planner geometry of the complexes. The
conductivity study of the complexes indicated Cu(II) complexes are nonelectrolyte while Ni(II) complexes are
electrolyte in nature. All the complexes were tested for their in vitro antibacterial and antifungal activity against
different microbes and compared with standard drugs, Amphotericin-B and Ciprofloxacin. It was observed that
Ni(II)complexes are more effective than the corresponding Cu(II)complexes.Cu(II) complexes were found to be
inactive against the tested fungal species but they show moderate activity against the tested bacterial species.
One of the Ni(II) complex was found to be active in both fungal and bacterial species and also found to be more
effective than the other complexes.
Synthesis, spectroscopic, magnetic properties and superoxide dismutase (SOD) ...IOSR Journals
Three new ternary copper(II) complexes formulated as [Cu(HIda)(bipy)] 1; [Cu(HIda)(phen)] 2; [Cu(HIda)(dmp)] 3; where HIda =N-(2-hydroxyethyl)-2- iminodiacetic acid ; bipy = 2, 2’- bipyridine; phen = 1,10- phenanthroline; dmp = 2,9-dimethyl 1,10-phenanthroline, have been synthesized and characterized by partial elemental analysis, FAB-mass (m/z), EPR, UV-visible and CV measurements. The magnetic and spectroscopic data of all these complexes 1-3 indicate distorted octahedral geometry. The EPR spectra of these complexes in frozen DMSO solutions showed a single at g ca. 2. The trend in g-value (g||>g>2.0023) suggests that the unpaired electron on copper (II) has dx2–y2 character. The SOD activities of the complexes have been investigated. Antibacterial and antifungal activity of these complexes were also measured and discussed.
Similar to Analytical method development and its application to extractive spectrophotometric determination of Co (II) using 1, 2-Propanedione, 1-phenyl-1-(2-hydroxybenzylideneazine) -2- oxime (PDPHBAO). (20)
Patient compliance: Challenges in management of cardiac diseases in Kuala Lum...pharmaindexing
Background
The objective of this study was to investigate the degree of compliance among cardiac patients who attend the health facilities in Kuala Lumpur and Perak, Malaysia. The reasons for non-compliance and recommendations from healthcare professionals were also evaluated.
Method
A cross-sectional study of 400 patients and 100 healthcare professionals was carried out. This study utilizes variables on external factors and internal factors as the measurement tools. The questionnaire which consists of Morisky self-reported medication adherence questions was administered to patients and causes for non-compliance sought. Questionnaire for healthcare professionals was used to determine strategies that can improve compliance rate.
Results
The study revealed a 15.8% of high adherence rate, 54.3% of moderate adherence rate and 30% of poor adherence to cardiovascular disease medications. The chi-square tests showed the strong association between dependent and independent variables. The model chosen for testing the patient compliance through external and internal factors gives an R2 value of 85.0% with an adjusted R2 of 84.7%. The F value (317.187) was also significant (p=0.000) which means that the variables have better fit in the multivariate model. The major reasons determined for non-adherence were attitudes and beliefs, lifestyle, side effects and cost of medications. The study recommends that pharmacists and dispensing technicians should be adequately qualified to provide proper counselling to cardiac patients on their medicines and disease conditions.
Conclusion
The result of this study is of value to health care providers. Compliance to cardiovascular medications will avoid treatment failures encountered in therapy.
Overview on Recurrence Pregnancy Loss etiology and risk factorspharmaindexing
Recurrent pregnancy loss (RPL) can be defined as more than two to three consecutive miscarriages before 20 weeks’ gestation; it affects approximately 1% to 2% of women. RPL is a multifactorial disease. It is very important to study the etiology and risk factors of RPL to find the best diagnostic tests and suitable therapeutic intervention. This article will discuss the current understanding etiologies and risk factors of RPL.
Novel treatments for asthma: Corticosteroids and other anti-inflammatory agents.pharmaindexing
Asthma management is a challenge due to the prevalence of disease in the world. Based on the immunological and inflammatory mechanisms of asthma, corticosteroids and anti-inflammatory participate greatly in the treatment plan. Due to different reasons, there is still an unmet need to develop new agents in this field. A lot of compounds with anti-inflammatory effect are investigated in both pre-clinical and clinical studies.
A review on liver disorders and screening models of hepatoprotective agentspharmaindexing
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of bio chemicals necessary for digestion. The liver is necessary for survival; there is currently no way to compensate for the absence of liver function long term, although liver dialysis can be used short term.
Carbamazepine induced Steven Johnson syndrome: A case reportpharmaindexing
Drugs are the most common cause that induces Steven Johnson syndrome (SJS) and includes antiepileptic drugs, antiretroviral drugs, anti-tuberculosis drugs, Sulphonamides, fluoroquinolones, penicillins, non-Steroidal anti-inflammatory drugs, Multivitamins. The genetic markers are also the cause for carbamazepine induced Steven Johnson Syndrome. In our study, the antiepileptic drug (Carbamazepine) is the cause for Steven Johnson Syndrome. A female patient aged 25 years came to the hospital with the complaints of bubbling over the skin and all over the body with papillary vesicles associated with pain and irritation, fever, myalgia, and nausea. The patient is known case of Phenytoin induced Steven Johnson Syndrome. In this case the patient developed the Steven Johnson Syndrome approximately after one month after starting the carbamazepine.By the withdrawal of the drug, the condition of the patient was improved.
Monoherbal formulation development for laxative activitypharmaindexing
The Ayurvedic Pharmacopoeia specifically approves flaxseed as a poultice for boils externally and demulcent or laxative internally. In this study monoherbal formulation development for laxative activity of flaxseed was undertaken. The plantLinumusitatissimumhasshowed higher percentage of total ash as well as alcohol soluble extractive values. The aqueous extract of Linumusitatissimumwas prepared by using pilot scale extraction plant and spray drying unit. The qualitative phytochemical studies reveal the presence of amino acids, carbohydrates, vitamins and proteins. From the available literatures it was found that Linumusitatissimum contains more number of amino acids. The formulated tablets showed acceptable pharmacopoeial limits and complies with specifications for thickness, hardness, friability and weight variation. The formulation has showed better laxative activity indicating additive property of the combined phytoconstituents of the plant.
Monoherbal formulation development for laxative activitypharmaindexing
The Ayurvedic Pharmacopoeia specifically approves flaxseed as a poultice for boils externally and demulcent or laxative internally. In this study monoherbal formulation development for laxative activity of flaxseed was undertaken. The plantLinumusitatissimumhasshowed higher percentage of total ash as well as alcohol soluble extractive values. The aqueous extract of Linumusitatissimumwas prepared by using pilot scale extraction plant and spray drying unit. The qualitative phytochemical studies reveal the presence of amino acids, carbohydrates, vitamins and proteins. From the available literatures it was found that Linumusitatissimum contains more number of amino acids. The formulated tablets showed acceptable pharmacopoeial limits and complies with specifications for thickness, hardness, friability and weight variation. The formulation has showed better laxative activity indicating additive property of the combined phytoconstituents of the plant.
Pneumonia and respiratory failure from swine origin influenza H1n1pharmaindexing
Swine influenza (swine flu) became alarming health concern when World Health Organization declared as “public health emergency of international concern” on April 25, 2009. After documentation of human-to-human transmission of the virus in at least three countries of two WHO regions, the WHO raised the pandemic level to 6.1 During the 1918, flu pandemic infected one-third of the world's population (an estimated 500 million people) and caused approximately 50 million deaths.2 In 1976, an outbreak of swine influenza occurred in New Jersey, USA, which involved more than 200 cases, some of them severe, resulting in one death.3 In 1988, another fatality was reported as a complication of swine influenza.
A descriptive study on newborn care among postnatal mothers in selected mater...pharmaindexing
The newborn health challenge faced by India is more formidable than that experienced by any other country in the world. The newborn health is inevitably affected by the traditional care practices of the mothers causing high infant morbidity and mortality.The aim of the study were determine the knowledge, attitude and practice of postnatal mothers regarding new born care and find out the association between knowledge, attitude and practice of postnatal mothers regarding new born care and to determine the association between these as well as with the selected demographic variables. A descriptive study was conducted to assess the knowledge, attitude and practice of postnatal mothers regarding new born care in selected maternity centres in Madurai. Survey approach was employed to select sample and it consisted of 100 postnatal mothers. Data was collected using structured interview schedule. Findings of the study showed that 65% of postnatal mothers had moderate knowledge; 61% had favourable attitude and 57% of them had high practice of new born care. There was a significant association between knowledge and attitude (r=+0.567), knowledge and practice (r=+0.388), attitude and practice (r=+0.321) .There was a significant association between knowledge and education, monthly family income and obstetrical score at p<0.05. Findings of the study indicated the need to conduct frequent assessment of knowledge, attitude and practice of postnatal mothers regarding new born care. Awareness and attitude of the mothers towards new born care still has lots of lacunae especially in those who belong to the lower socio economic statusand poorly educated postnatal mothers. So it is imperative to provide comprehensive training in the field of new born care for mothers during pregnancy
Late 19th century was evident of intelligent biomaterial; which has changed researcher’s perspective towards science and technology. This intelligent biomaterial are envisioned to have huge impact on Healthcare from sequential signalling of biomedical molecule, mimicking natural gene, an effective drug carrier, to high resolution diagnostic tool.From drug discovery aspect many of NCE fail to reach therapeutic potential due to PK/ PD profile. Nanotechnology has changed the face of drug discovery form chemical evaluation to structure of proteins in signalling pathways and development of chemical antibody. Nanotechnology from lab to market approval is long process due to regulatory evaluation. Though it seems to be bright future market it has to go through a long process from being innovation to complete market product. This makes whole process expensive making investor reluctant to invest in big projects.Western world is aware of dramatic potential of nano-projects; which has its limitation in financial investments; with major challenge of transforming nano science to commercial pharmaceutical product.
The Flaws in health practice in post-operative management of a patient in ter...pharmaindexing
Introduction
Congenital urinary tract obstructions are common cause of kidney damage sometimes which sometimes presents itself without symptoms leading to abnormalities in blood filtration and consequently retarded kidney function. A cohort study was conducted in such patient to find out the short comings in treatment strategy.
Case presentation
A four years old child, weighing 14 kg was brought with severe constipation, fever, chest congestion and cough later developed left eye disorientation after admission to hospital, diagnosed with urinary tract obstruction, indicating acidosis and loss of electrolytes due to excessive loss of water. His therapy management included surgical treatment, dialysis and to improve his electrolyte levels within the normal with the treatment chest congestion and fever.
Conclusion
This case study reports the post operative treatment of congenital urinary tract obstructions in a tertiary care hospital and highlights the discrepancies observed. Antibiotic rationality and irrational prescribing was observed. The case study highlights the need of a clinical pharmacist in the health care team.
Corticosteroid induced disorders – An overviewpharmaindexing
Glucocorticoids are important in the treatment of many inflammatory, allergic, immunologic, and malignant disorders, and the toxicity of glucocorticoids is one of the commonest causes of iatrogenic illness associated with chronic inflammatory disease.Glucocorticoid-induced muscle atrophy is characterized by fast-twitch or type II muscle fiber atrophy. Corticosteroid (CS) therapy is widely used in the treatment of rheumatic diseases.Osteoporosis remains one of its major complications.Steroid induced glaucoma is a form of open angle glaucoma occurring as an adverse effect of corticosteroid therapy. Glucocorticoids induce hepatic and extrahepatic insulin resistance.Glucocorticoid treatment impairs both glucose transport in fat and muscle cells. Corticosteroid-induced psychosis represents a spectrum of psychological changes that can occur at any time during treatment. Cushing’s syndrome describes the signs and symptoms associated with prolonged exposure to inappropriately high levels of the hormone cortisol. Physicians must be aware of these adverse effects and be equipped to manage them.
Anti-inflammatory activity of pupalia lappacea L. Jusspharmaindexing
Pupalia lappacea (L) Juss is an erect shrub used in folklore medicine to treat bone fractures and in inflammatory conditions. Methanolic extract of aerial parts shown is claimed in traditional medicine that the leaves of the plant are used in the treatment of inflammation. In the present study, the methanolic extract of Pupalia lappacea was screened for its anti-inflammatory activity using carageenan induced rat paw edema egg white induced paw oedema models. The methanolic extract at the dose of 200 mg/kg p.o exhibited significant anti-inflammatory activity in carrageenan induced paw edema model (p<0.01). In egg white induced model, methanolic extract at the dose of 200 mg/kg inhibited paw oedema significantly (p<0.01) indicating that both test samples inhibit the increase in number of fibroblasts and synthesis of collagen and mucopolysaccharides during prostaglandin formation during the inflammation. These experimental results have established a pharmacological evidence for the folklore claim of the drug to be used as an anti inflammatory agent. HPTLC analysis of the extract shows the presence of gallic acid 1.24mg/ml, ferulic acid 2.00mg/ml, chlorogenic acid 46.25mg/ml and rutin 7.02mg/ml of the extract which were responsible for the claimed anti-inflammatory action in the animal models studied.
Lucinactant: A new solution in treating neonatal respiratory distress syndrom...pharmaindexing
Lucinactant is a novel synthetic surfactant, approved by the FDA on March 6th 2012, for use in treatment of RDS. It’s superiority as compared to the previously approved surfactants lie in containing sinapultide, a 21-amino acid peptide also known as KL4 peptide, which has been designed to mimic the activity of human surfactant protein. Lucinactant is completely devoid of any animal derived components. It is the fifth drug approved by the FDA for the treatment of RDS. It has shown immense efficacy in phase two clinical trials and animal model studies and exhibited better efficiency when compared to other surfactants in both 24 hour and two week mortality rates of infants in RDS. Lucinactant tends reduce the surface tension at the air-liquid interface of alveolar surfaces and allows lungs to function normally. It was observed that the side effects were lesser with Lucinactant when compared with other naturally derived surfactants.
Bioactivity screening of Soil bacteria against human pathogenspharmaindexing
Microorganisms have a profound effect on medical science as they not only infect & cause disease but also produce metabolic products that can cure infections. Soil happens to be a source for a variety of microorganisms. Most of the bacteria, particularly actinomycetes produce biologically active secondary metabolites. Though there are a number of antibiotics available, there is a pressing need for the discovery of new source for antimicrobials against the pathogens due to the development of drug resistance of the pathogenic microorganisms. In addition to, new pathogenic strains are also developing and causing infection to human beings. Bioactive compounds are compounds that are produced by any living organism and are known to exhibit various biological activities both in-vitro & in-vivo. Bioactivity may be antimicrobial, antineoplastic, anticancerous, immunomodulation, antifertility & others. Soil bacteria were isolated by standard technique and by making use of selective media. The isolates were identified and subjected for preliminary screening to look for their ability to produce bioactive materials. A total of 96 strains were isolated from three different soil samples. 14 of them were found to have antibacterial activity against the human pathogens like Staphylococcus aureus, Streptococcus faecalis, E.coli, Klebsiella aerogenes, Proteus vulgaris, Pseudomonas aureginosa and Salmonella typhi by preliminary screening. Further the selected (3) bacteria were grown in the suitable culture media for the production of bioactive metabolites by using rotary shake flask. The active metabolites was isolated by solvent extraction and concentrated by evaporation under reduced pressure. The antimicrobial screening of the active metabolites showed prominent effect against the clinical pathogens under the study.
A study on sigmoid Volvulus presentation and managementpharmaindexing
A study on sigmoid volvulus presentation and management was a 2yr retrospective study done at RMMCH.The diagnosis of sigmoid volvulus was made from a history of large bowel obstruction (constipation, abdominal distension, and abdominal pain), which were often recurrent and plain abdominal radiographs.The morbidity associated isSuperficial wound infection occurred in four patients. All the infected wounds eventually healed with conservative measures. Clinical anastomotic dehiscence was noted in 1 patient for which during relaparotomy proximal colostomy and mucous fistula was done. The mortality associated is shown is there were 9 deaths of which 7 were due to sepsis and 2 were due to comorbid illness. Two out of eight patients for whom a colopexy was done had a recurrent attack of sigmoid volvulus. The duration of hospital stay ranged between 10 and 21 days. Use of sigmoidoscopic detorsion for viable colon should be encouraged. Sigmoidopexy, which is associated with a recurrence rate of 20% in our series of patients, should be used selectively.Hartmann’s procedure is a safe option in sigmoid volvulus with gangrenous bowel. Primary anastomosis in emergency situation can be carried out with morbidity and mortality in patients with viable colon
Evaluation of Preliminary phytochemical on various some medicinal plantspharmaindexing
The present study was carried out to evaluate the physical status and percentage yield of methanolic extract and its fractions of whole plant of Leucas cephalotes, leaves of Hiptage benghalensis and leaves of Kydia calycina were recorded for future references and Preliminary phytochemical screening of MLC, MHB and MKC revealed the presence of carbohydrates, glycosides, saponins, flavonoids, steroidal and phenolic compounds. MLC revealed the presence of all the above mentioned phytoconstituents except saponins and also MKC steroidal compounds. The fractions of MLC, MHB and MKC revealed the presence of glycosides, phenolic compounds, steroids and flavonoids.
Comparision of in vitro antibacterial activity of cefoperazone and levofloxac...pharmaindexing
Cefoperazone (a third generation cephalosporin) has effective in vitro activity against majority of pathogens. Levofloxacin (a flouroquinolone) is one which prescribed more due to its increased antibacterial activity against Gram-positive, Gram-negative, and atypical bacteria. Microbial resistance to antibiotics is now prevalent and poses a serious clinical threat. An attempt has been made to evaluate sensitivity of Cefoperazone and Levofloxacin against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi. A total of 120 isolates were collected from different pathological laboratories and medical centers in Karachi, Pakistan. The above stated clinical isolates were extracted from urine/stool, skin, blood and sputum samples. Results show least resistance of Levofloxacin as compare to Cefoperazone against Escherichia coli (32.5% and 42.5%) and Pseudomonas aeruginosa (36% and 48%) while Staphylococcus aureus is still susceptible towards Cefoperazone and least sensitive to Levofloxacin by showing 26.6% and 50% resistance respectively. Study concluded that the prevalent pathogens are still susceptible towards Levofloxacin and Cefoperazone but the gradual increase in resistance is alarming to the general practice of prescribing antibiotic which require routine evaluation and surveillance to ensure the effectiveness of the antibacterial agents.
Concept of srotas from ayurvedic perspective with special reference to neurologypharmaindexing
Ayurveda is a life science. The researchers of ayurveda could rule out the presence of srotas (channels) spreading throughout the human body. These srotas (channels) are governed by vayu which is using all the srotas (channels) of the body to carry out the functional and physiological activities of the human body without which the human society will not exist. Several synonymous words have been described by the ayurvedicacharyas for srotas. Some are micro and some are macro in structures and they adopt the same colour of the particular dhatus of the body to which it belongs. The aim of the study is to justify that srotas are nothing but innurmerable channels or pathways of the nervous system governed by electric current without which no functional and physiological activities of the human body will develope.
Health promotion survey in overweight and obese students of universities in n...pharmaindexing
Introduction
Overweight and obesity is one of the major health problems in the UK and worldwide. Approximately two-thirds of the population in the UK is either overweight or obese. Overweight and obesity is an important issue that causes distress to most women. Health promotion is the best method to educate overweight and obese women. It is defined as the process enabling people to increase control over and to improve their health by Ottawa Charter for Health Promotion. It is aimed to enhance the well-being of the individuals and their positive attitudes towards prevention of various diseases. In order to make any improvement to the health promotion for overweight and obesity, the risk factors and the opinions from the public should first be identified and addressed.
Methods
Cross-sectional survey design was selected with a questionnaire that consisted of 20 open and close ended questions. A sample size of 196 was determined. The data thus gathered was analyzed using SPSS V20 (Statistical Package for Social Science version 20). Descriptive statistics (fx) and (SD) were used and Chi-square X2 test for association was employed.
Results
Out of the total 196 responses, only (40%) of the students had normal weight (SD 1.1), (25%) students had a good understanding of health promotion (SD 1.6), half (50%) appeared concerned about their weight (SD 0.5), (60%) had an obese family member (0.5). The BMI of students was associated with the presence of an obese member in their family and their weight as a concern for them. (P-value <0.05).
Conclusion
The health promotion service is beneficial as it was found to have raised concerns in the mind of the students regarding over weight and obesity. However it was observed that the understanding of health promotion service was different among students and this is the root of the problem.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
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Analytical method development and its application to extractive spectrophotometric determination of Co (II) using 1, 2-Propanedione, 1-phenyl-1-(2-hydroxybenzylideneazine) -2- oxime (PDPHBAO).
1. 98
* Corresponding author: Poonam.P.Shevde.
E-mail address: poonam_p_shevde@yahoo.in
IJPAR |Volume 2 | Issue 3 | July-Sep - 2013 ISSN: 2320-2831
Available Online at: www.ijpar.com
[Research article]
Analytical method development and its application to extractive
spectrophotometric determination of Co (II) using 1, 2-Propanedione, 1-
phenyl-1-(2-hydroxybenzylideneazine)-2-oxime (PDPHBAO).
Sushama. M. Lele , Poonam. P. Shevde, Rama. S. Lokhande.
Department of Chemistry, University of Mumbai, Vidyanagri, Santacruz (E),
Mumbai – 400 098, India.
ABSTRACT
The reagent was synthesized and characterization was carried out by FTIR, NMR, elemental analysis as well as
Mass spectrometry. The synthesized reagent was then applied for the development of the analytical method for
the extractive spectrophotometric determination of cobalt (II). Cobalt metal forms pale yellow coloured
complex, which can be extracted in chloroform at pH 9.4 having absorption maxima at 415 nm. Beer’s law is
obeyed in the concentration range 1-8.00 μg. The molar absorptivity and Sandell’s Sensitivity of the extracted
species are 7.1724 X 103
Lit mol-1
cm-2
and 8.2165 X 10-3
μg cm-2
respectively. The developed method is highly
sensitive, selective, simple, rapid, accurate, and has been satisfactorily applied for the determination of cobalt in
the synthetic mixtures, pharmaceutical samples, and alloys.
Keywords; Characterization; Cobalt; Extractive Spectrophotomertic determination; pharmaceutical samples.
INTRODUCTION
The significance of cobalt as a transition metal lies
in its wide spectrum of applications covering many
frontier areas of study, particularly in medicine.
Even though cobalt is not considered to be as toxic
as most of the heavy metals, it is an equally
harmful element. Hence owing to the significance
of cobalt, its determination from associated
elements by extractive spectrophotometry has been
of considerable importance.
Several isonitroso compounds [1,2], oximes [3-7],
semicarbazones and thiosemicarbazones [1,8,9]
have been used for the extraction and
spectrophotometric determination of metal ions.
They react with transition metal ions to give
coloured complexes [10, 11], which are extractable
in organic solvents.
A wide variety of Chelating agents like 2/
-
hydroxy -4/
- ethoxy -4 – methoxy chalcone oxime
[12], 2 -(6-methyl-2-benzothiazolylazo)-5-diethyl
amino phenol [13], 1-(1,3,4 – triazol-2- ylazo)-2-
naphthol [14], 2-(1,2,4 – triazol -5-ylazo)-5-
(dimethyl amino) benzoic acid [15], Pyridine -2-
acetaldehyde salicyloyl Hydrazone [16], N,N/
- bis
(2-amino Benzoyl) ethylene diamine [17], Meso –
tetrakis-(3-chloro-4-sulphophenyl) Porphyrin [18],
1-(5-nitro-2-pyridylazo)-2,7-dihydroxy
Naphthalene [19], 5-(O- carboxyphenylazo)-2,4-
dihydroxy benzoic acid [20], (2-arsonophenyl-azo)-
8- amino quinoline [21], α-benzyl monoxime [22],
2 H – Benzopyran -2- one-3- acetyl thiose
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Poonam.P.Shevde et al / Int. J. of Pharmacy and Analytical Research Vol-2(3) 2013 [98-102]
www.ijpar.com
micarbazone [23], 2-(2-quinolinylazo)-5-dimethyl
amino benzoic acid [24], 5-(4- chlorophenylazo) -
8- (benzenesulphonamido) quinoline [25], 2,4-
dihydroxy-5-nitropropiophenone [26], 2-(5-
carboxy- 1,3.4 – triazolylazo) -5- diethyl amino
aniline [27], Pyridoxal-4- phenyl-3-
thiosemicarbazone [28] and α-oximino-
Acetoacetanilide benzoyl hydrazone [29] etc have
been reported for the spectrophotometric
determination of cobalt.
However these methods suffer from limitations
such as critical pH [13,15,19,23], low stability of
complex [14], requirement of surfactants [20] or
other agents [24], requirement of heating [21], and
interference from some ions [21,27],inconvenient
extractant [30] etc. A method, far superior in
sensitivity and selectivity to these reported in the
literature [12, 16-18, 22, 25-30] is developed for
the extractive spectrophotometric determination of
cobalt with 1, 2-Propanedione, 1-phenyl-1-(2-
hydroxybenzylideneazine)-2-oxime (PDPHBAO).
A close literature survey indicates that PDPHBAO
has so far not been employed for either co-
ordination or analytical studies. The developed
method is highly sensitive, selective, simple, rapid,
accurate, and has been satisfactorily applied for the
determination of cobalt in the synthetic mixtures,
pharmaceutical samples, and alloys. The proposed
method is free from many limitations.
EXPERIMENTAL
The PDPHBAO was synthesized [ 31, 32, 33]
characterized [34] and used for extractive
spectrophotometric determination of Cu(II) A
stock solution (0.5 mg ml-1
) of PDPHBAO was
prepared by dissolving 0.05 g of the reagent in
100ml methanol to give 0.02% reagent solution of
PDPHBAO.
Cobalt (II) Solution
A weighed quantity of cobalt sulphate was
dissolved in double distilled water containing dilute
sulphuric acid and then diluted to the desired
volume using double distilled water. The cobalt
solution was then standardized by nitroso-R-salt
method[31].
Recommended procedure
Mix 1cm3
aqueous solution containing 1-100µg of
cobalt and 1 cm3
of 0.02 % methanolic solution of
PDPHBAO in 25 cm3
beaker. Adjust the pH of the
solution to required value with dilute solution of
H2SO4 and NaOH. Make the final aqueous volume
up to 10 cm3
. Transfer the solution into 125 cm3
separating funnel and equilibrate for 1min with 10
cm3
chloroform. Allow the two phases to separate
and measure the absorbance of the organic extract
containing the complex at 415 nm against reagent
blank.
Calibration Plot Slope ratio plot
0 1 2 3 4 5 6 7 8 9
0.0
0.2
0.4
0.6
0.8
1.0
Absorbance
Co (II) Concentration
In µg / ml
-3.6 -3.4 -3.2 -3.0 -2.8
-0.2
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
1.6
1.8
logD
log R
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Poonam.P.Shevde et al / Int. J. of Pharmacy and Analytical Research Vol-2(3) 2013 [98-102]
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RESULTS AND DISCUSSION
Condition Results
Absorption Maxima 415 nm
Solvent Chloroform
pH range 9.2-9.6
Equilibration time 30 seconds
Stability of Cobalt-PDPHBAO
48 h
Beer’s range
0.1 to 8.0 μg ml-1
Molar absorptivity
7.1724X 103
Lit mol-1
cm-1
Sandell’s sensitivity
8.2165 X 10-5
µg / cm2
Mole Ratio of Co : PDPHBAO
1 :2
Effect of foreign ions a
Masked with iodide
Ions Amt Ions Amt Ions Amount added
Cl -
30 mg Ti 10mg Mo(VI) 8 mg
Br -
30 mg Pt 10µg V(VI) 5 mg
I -
20 mg Ni 10µg Th(IV) 5 mg
F -
20 mg Cu 10µg U(VI) 2 mg
ClO3
-
10 mg Pd 10µg Zr(II) 2mg
BrO3
-
10 mg Fe(II) 5µg Tl(I) 2 mg
IO3
-
10 mg Fe(III) 10µg Ag(I)a
5 mg
SO3
-
10 mg Cr(II) 1mg Rh(II) 2 mg
SO4
-
20 mg Te(IV) 10mg Ba(II) 5 mg
S2O8
-
25mg Cd(II) 2 mg Na(I) 20 mg
Cr2O7
-2
10mg Mn(II) 5 mg K(I) 20mg
NO2
-
25mg Al(III) 10 mg
NO3
-
30 mg Ca(II) 10 mg
Urea 20 mg Zn(II) 10 mg
Thiourea 20 mg Ce(IV) 5 mg
CrO4
-2
15mg Mg(II) 10 mg
Acetate 30 mg Li(II) 5 mg
Tartarate 10 mg As(II) 10µg
Oxalate 10 mg Pb(II) 5µg
Phosphate 10 mg Cr(II) 5 mg
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Poonam.P.Shevde et al / Int. J. of Pharmacy and Analytical Research Vol-2(3) 2013 [98-102]
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APPLICATIONS
Analysis of synthetic mixtures Analysis of real samples
a
Values given are in microgram amount of the
metals.
b
Average of five determinations.
CONCLUSION
The proposed method is more highly sensitive and
selective than the reported methods for the
extractive spectrophotometric determination of
microgram amounts of cobalt. It offers advantages
like reliability and reproducibility in addition to its
simplicity, instant colour development and suffers
from less interference. It has been successfully
applied to the determination of cobalt at trace level
in synthetic mixtures, pharmaceutical samples,
vegetable oils and alloys.
REFERENCES
[1] B. J. Desai, V. M. Shinde, Microchim Acta 1 (1980) 93.
[2] U. B. Talwar, B. C. Haldar, Anal Chim. Acta 51 (1970) 53.
[3] U. Muralikrishna, A. Sivaramakrishna, Asian J. Chem. 13 (2001) 289.
[4] A. B. Bhatt, K. K. Desai, J. Inst. Chemists (India) 61 (1989) 5.
[5] D. Vijaykumar, R.C. Hussain, N. Appalaraja, J. Ind.Chem. Soc. 67 (1980) 786.
[6] K. K. Desai, H. B. Naik, Ind. J. Chem. 25A, (1980) 297.
[7] B. D. Desai, K. K. Desai, Asian J. Chem. 13 (2001) 366.
[8] M. V. Naik, N. V. Thakker, Ind. J. Chem. 34A (1995) 410.
[9] R. S. Lokhande, S. V. Poman, U. R. Kapadi, Asian J. Chem. 13 (2001) 1223.
[10] F. Feigl, Chemistry of specific selective and sensitive reaction, Academic press, New York, 1949.
[11] R. G. Desmukh, N. V. Thakkar, Ind. J. Chem. 24A (1985) 1066.
[12] J. J. Desai, P.G. Desai, A. G. Mehta,. Asian J. Chem.12 (2000) 1067.
[13] Y.Tang, Y. Q. Shu. L. Jianyan, Huaxue Fence 36 (2000) 370.
[14] Q. Y. Ye, H. J. Jiang, W. P. Zhou, Fenxi Shiyanshi 19 (2000) 40.
[15] Q. Y. Ye, H. H. Jianga, D. M. Han, Fenxi Shiyanshi 19 (2000) 52.
[16] S. S. Patil, A. D. Sawant, Ind. J. Chem. Technol. 8 (2001) 88.
[17] K. P. Girishkumar, K.R. Muthuselvi, Microchim. Acta 137 (2001) 25.
[18] J. Li, J.W. Zhang, H. S. Zhang, Fenxi Kexue Xuebao 17 (2001) 387.
[19] J. J. Sun, Y. W. Bai, B. Liu, X. L. Wang, Lihau Jianyan Huaxue Fence 37 (2001) 394.
[20] A. S. Amin, I. S. Ahmed, M. E. Moustafa, Anal. Lett. 34 (2001) 749.
[21] M. Ji, J. M. Xu, B. C. Wu, Huaxue Fence 37 (2001) 542.
[22] H. Eskandari, H. S. Ghaziaskar, A. A. Ensaf, Anal Sci. 17 (2001) 327.
[23] R. S. Lokhande, N. Shrinivasan, A. B. Chaudhari, J. Ind. Coun.Chem. 19 (2002) 12.
[24] L. Zhang, Y. Guanyu, W. Boxing, J. Ciquing, Y. Giayuang, Anal. Bioanal. Chem. 374 (2002) 1318.
[25] Y.X. Rong, C. Qiu-E, D.Z. Tao, Z. H. You, L. Zu-Bi, Guangpu Shiyanshi 19 (2002) 373.
[26] N. B. Patel, K. K. Desai, Asian J. Chem. 14 (2002) 1769.
Sr.
No.
Sample Amount of Co (II)
I Pharmaceutica
lSamples
Certified
Value
Found
1 Surbex –T
(Abott)
0.337mg 0.336mg
2 Vitamin B12 50mg 49.96mg
II Cobalt alloys
1 Cobalamine 68.9% 68.8%
2 Steel 9.67% 9.65%
III Vegetable Oil 0.0020% 0.0019%
No. Synthetic mixture
Compositiona
Amount
Foundb
1 Co(10)+Zn (10)+ Ca (10) 9.98
2 Co (10) + Mo (10)+Tl(10) 9.98
3 Co(10) +Mg(10)+Ba(10) 9.98
4 Co(10) + Pb (10)+Al(10) 9.97
5 Co (10) + U (10) +Te (10) 9.91
5. 102
Poonam.P.Shevde et al / Int. J. of Pharmacy and Analytical Research Vol-2(3) 2013 [98-102]
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[27] L. Huading, P.Fuyou, G. Changhua, L. Jianyan, Huaxue Fence. 38 (2002) 33.
[28] S. L. Subramanyan, K. J. Rajesh, A. Varada, Anal. Lett. 36 (2003) 605.
[29] P.V. Jagasia, D. P. Dave, J. Ind. Chem. Soc. 80 (2003) 145.
[30] A. I Vogel, Textbook of Quantitative Inorganic Analysis, 3rd
ed., London, (1975).
[31] J.Noyes. J.Am.Chem.Soc. 55, 388 (1933).
[32 ] W. Hartung and J. C. Munch. J. Am. Chem. Soc. 51,2264 (1929).
[33] R. G. Deshmukh. Ph. D. Thesis. University of Mumbai. (1992).
[34] S. M. Lele, Ph. D. Thesis. University of Mumbai. (2008).
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