The document analyzes the antidiabetic effects of Stevia rebaudiana extract on diabetic patients. 15 diabetic patients aged 35-60 years were given Stevia leaf powder with tea 3 times per day for 15 days to replace sugar. Their fasting blood sugar (FBS) and post-prandial blood sugar (PPBS) levels were measured and compared to levels while taking medication and without medication. Results showed FBS decreased from 208.6 mg/dl without medication to 195.7 mg/dl with Stevia, and PPBS decreased from 283 mg/dl to 271.3 mg/dl. While Stevia consumption lowered blood sugar, the decreases were not statistically significant. The study suggests Stevia has potential
Obesity and hyperlipidemia is international /worldwide problem causing heart disease leading to major predisposing factor for morbidity and death. Conventional medicine used in allopathy include statins, fibrates, niacin and resins but are going to defame due to their adverse effects. Herbal medicine ginger has proved itself as one of the potent anti hyperlipidemic and anti obesity herb with least adverse effects. We did try to compare its hypolipidemic effects with placebo effects when used in mild to moderate hyperlipidemic patients. It was placebo-controlled single blind research study. Research was conducted at National hospital, Lahore, from July to November 2016. Consent was taken from sixty hyperlipidemic patients age range from 25 to 60 years. Both gender male and female patients were enrolled. Patients were randomly divided in two groups, 30 patients were on drug ginger pasted-powder advised to take 5 grams in divided doses with their normal diet for the period of three months. Thirty patients were on placebo pasted-wheat powder, with same color as of ginger powder, advised to take 5 grams in divided doses with their normal diet for the period of three months. Their base line lipid profile and body weight was recorded at start of treatment and were advised to come for check-up, fortnightly.
International Journal of Medical Science in Clinical Research and Review Vol 03, Issue 02,April – 2020 Page |
229
When duration of study was over, their lipid profile and body weight was measured and compared statistically with pre-treatment values. Three months treatment with 5 grams of ginger decreased total cholesterol from 233.11±1.53 mg/dl to 198.44±1.23 mg/dl, LDL cholesterol reduced from 202.21±1.88 mg/dl to 187.72± 1.98 mg/dl, reduced body weight from 76.01±2.66 kg to 72.80±1.87 kg. Both plasma total cholesterol and LDL cholesterol reduction was statistically significant, but body weight decrease was non-significant when analyzed biostatistically.
Evidence for a new category of diabetes care reversalJames McCarter
Virta Health doesn't just prevent or manage type 2 diabetes. We reverse the disease and restore metabolic health.
Virta Health delivers the first clinically-proven treatment to safely and sustainably reverse type 2 diabetes and other chronic metabolic disease without the risks, costs, or side effects of medications or surgery. Join us for this educational session as we review the impact of the Virta Treatment on metabolic and cardiovascular health in our clinical trial and nationwide commercial populations. We’ll discuss how nutritional ketosis combined with continuous remote care—technology-enabled and proactive, near real-time care from physicians and health coaches—is helping patients normalize blood sugar, remove diabetes medications, and lose clinically-significant body weight.
Continuous Care Intervention in Type 2 DiabetesJames McCarter
CME Talk at Washington University Kilo Diabetes Symposium, November 2nd, 2018. CME Objectives:
1. Describe the evidence for carbohydrate restriction in the management of type 2 diabetes.
2. Distinguish between nutritional ketosis, fasting ketosis and ketoacidosis.
3. Discuss the role of ketones as both energy sources and signaling molecules.
4. Discuss the rationale for reduction of glycemic-control prescriptions following implementation of nutritional ketosis in the treatment of type 2 diabetes.
5. Hypothesize factors that allow for sustained behavior change in diabetes reversal and remission.
Applying Nutritional Ketosis to the Treatment of Type 2 DiabetesJames McCarter
CME Objectives
1. Describe the evidence for carbohydrate restriction in the management of type 2 diabetes.
2. Distinguish between nutritional ketosis, fasting ketosis and ketoacidosis.
3. Discuss the role of ketones as both energy sources and signaling molecules.
4. Discuss the rationale for reduction of glycemic
control prescriptions following
implementation of nutritional ketosis in the treatment of type 2 diabetes.
5. Hypothesize factors that allow for sustained behavior change in diabetes reversal and
remission.
The Top Myths About Ketosis Debunked by Clinical TrialsJames McCarter
Present at CrossFit Health. October 13, 2019 by Dr. James McCarter. The one goal for this talk is arm medical providers to answer any objection to ketogenic and low carb nutrition approaches for the treatment of type 2 diabetes and other chronic metabolic diseases.
Effect of Patient Counseling in Improving Physical and Mental Health of Type-...Gangula Amareswara Reddy
The present study concluded that chronic diseases like diabetes affect the quality of life of patients.As the main goal of any medical care is the improvement of the patients’ overall quality of life, the clinical pharmacist imparted patient education through counseling has a major role in improving the physical as well as mental health outcomes.
What Spine Surgeons Need to Know About Dietary Strategies for Heart Disease a...James McCarter
Presentation to the North American Spine Society Annual Meeting. Interdisciplinary Spine Forum: Obesity and Diabetes: Impact on the Spine and Evidence-Based Management Strategies. Organized by Dr. Carrie Diulus
Diabetes and obesity have reached epidemic proportion. It is imperative that spine providers take these factors into consideration. We also have the opportunity to be powerful motivators to our patients with some straight forward evidence-based strategies.
Upon completion of this session, participants should gain strategies to:
Understand impact of metabolic syndrome on spine conditions/degeneration and treatment outcomes
Learn dietary strategies to have a positive impact on these conditions and the most current science behind these recommendations
Understanding the impact of strategies on heart disease and lipids
How to implement recommendations in a busy clinical setting
Effectiveness of Continuous Remote Care and Nutritional Ketosis for Type 2 Di...James McCarter
Society of Behavioral Medicine Annual Meeting, New Orleans,
April 14, 2018. eHealth Carbohydrate-Reduced Diet and Lifestyle
Programs for Adults with Type 2 Diabetes: Three Approaches
Obesity and hyperlipidemia is international /worldwide problem causing heart disease leading to major predisposing factor for morbidity and death. Conventional medicine used in allopathy include statins, fibrates, niacin and resins but are going to defame due to their adverse effects. Herbal medicine ginger has proved itself as one of the potent anti hyperlipidemic and anti obesity herb with least adverse effects. We did try to compare its hypolipidemic effects with placebo effects when used in mild to moderate hyperlipidemic patients. It was placebo-controlled single blind research study. Research was conducted at National hospital, Lahore, from July to November 2016. Consent was taken from sixty hyperlipidemic patients age range from 25 to 60 years. Both gender male and female patients were enrolled. Patients were randomly divided in two groups, 30 patients were on drug ginger pasted-powder advised to take 5 grams in divided doses with their normal diet for the period of three months. Thirty patients were on placebo pasted-wheat powder, with same color as of ginger powder, advised to take 5 grams in divided doses with their normal diet for the period of three months. Their base line lipid profile and body weight was recorded at start of treatment and were advised to come for check-up, fortnightly.
International Journal of Medical Science in Clinical Research and Review Vol 03, Issue 02,April – 2020 Page |
229
When duration of study was over, their lipid profile and body weight was measured and compared statistically with pre-treatment values. Three months treatment with 5 grams of ginger decreased total cholesterol from 233.11±1.53 mg/dl to 198.44±1.23 mg/dl, LDL cholesterol reduced from 202.21±1.88 mg/dl to 187.72± 1.98 mg/dl, reduced body weight from 76.01±2.66 kg to 72.80±1.87 kg. Both plasma total cholesterol and LDL cholesterol reduction was statistically significant, but body weight decrease was non-significant when analyzed biostatistically.
Evidence for a new category of diabetes care reversalJames McCarter
Virta Health doesn't just prevent or manage type 2 diabetes. We reverse the disease and restore metabolic health.
Virta Health delivers the first clinically-proven treatment to safely and sustainably reverse type 2 diabetes and other chronic metabolic disease without the risks, costs, or side effects of medications or surgery. Join us for this educational session as we review the impact of the Virta Treatment on metabolic and cardiovascular health in our clinical trial and nationwide commercial populations. We’ll discuss how nutritional ketosis combined with continuous remote care—technology-enabled and proactive, near real-time care from physicians and health coaches—is helping patients normalize blood sugar, remove diabetes medications, and lose clinically-significant body weight.
Continuous Care Intervention in Type 2 DiabetesJames McCarter
CME Talk at Washington University Kilo Diabetes Symposium, November 2nd, 2018. CME Objectives:
1. Describe the evidence for carbohydrate restriction in the management of type 2 diabetes.
2. Distinguish between nutritional ketosis, fasting ketosis and ketoacidosis.
3. Discuss the role of ketones as both energy sources and signaling molecules.
4. Discuss the rationale for reduction of glycemic-control prescriptions following implementation of nutritional ketosis in the treatment of type 2 diabetes.
5. Hypothesize factors that allow for sustained behavior change in diabetes reversal and remission.
Applying Nutritional Ketosis to the Treatment of Type 2 DiabetesJames McCarter
CME Objectives
1. Describe the evidence for carbohydrate restriction in the management of type 2 diabetes.
2. Distinguish between nutritional ketosis, fasting ketosis and ketoacidosis.
3. Discuss the role of ketones as both energy sources and signaling molecules.
4. Discuss the rationale for reduction of glycemic
control prescriptions following
implementation of nutritional ketosis in the treatment of type 2 diabetes.
5. Hypothesize factors that allow for sustained behavior change in diabetes reversal and
remission.
The Top Myths About Ketosis Debunked by Clinical TrialsJames McCarter
Present at CrossFit Health. October 13, 2019 by Dr. James McCarter. The one goal for this talk is arm medical providers to answer any objection to ketogenic and low carb nutrition approaches for the treatment of type 2 diabetes and other chronic metabolic diseases.
Effect of Patient Counseling in Improving Physical and Mental Health of Type-...Gangula Amareswara Reddy
The present study concluded that chronic diseases like diabetes affect the quality of life of patients.As the main goal of any medical care is the improvement of the patients’ overall quality of life, the clinical pharmacist imparted patient education through counseling has a major role in improving the physical as well as mental health outcomes.
What Spine Surgeons Need to Know About Dietary Strategies for Heart Disease a...James McCarter
Presentation to the North American Spine Society Annual Meeting. Interdisciplinary Spine Forum: Obesity and Diabetes: Impact on the Spine and Evidence-Based Management Strategies. Organized by Dr. Carrie Diulus
Diabetes and obesity have reached epidemic proportion. It is imperative that spine providers take these factors into consideration. We also have the opportunity to be powerful motivators to our patients with some straight forward evidence-based strategies.
Upon completion of this session, participants should gain strategies to:
Understand impact of metabolic syndrome on spine conditions/degeneration and treatment outcomes
Learn dietary strategies to have a positive impact on these conditions and the most current science behind these recommendations
Understanding the impact of strategies on heart disease and lipids
How to implement recommendations in a busy clinical setting
Effectiveness of Continuous Remote Care and Nutritional Ketosis for Type 2 Di...James McCarter
Society of Behavioral Medicine Annual Meeting, New Orleans,
April 14, 2018. eHealth Carbohydrate-Reduced Diet and Lifestyle
Programs for Adults with Type 2 Diabetes: Three Approaches
Data Driven is just the beginning, why the details of evidence matter by Dr. ...James McCarter
At Virta Health, our values include being evidence-based and prioritizing data and science over opinion in our decision-making. But how does this apply to the data we provide employers? Here are three questions we think employers should be asking healthcare providers and vendors offering health solutions to make smarter data-driven decisions (and some examples of vendor data that doesn’t stand up to scrutiny).
פירוט הרכיבים הטבעיים שנמצאים ב Cane תוסף תזונה טבעי המסייע לחולי סוכרת להגיע לאיזון ברמות הסוכר שלהם. Cane הוא תוסף תזונה מבית קיורהלייף, חברה הדואגת לאיכות חייהם של החולים במחלות כרוניות.
http://www.cane-curalife.com/
Now a days everybody wants evidence or proof for any purpose.so govt.of india introduces AYUSH research portal for the devalopment and taking awareness regarding ayurveda where it consists of clinical trial and pre-clinical trial data.
About the Ketogenic "Keto" Diet in One PageJames McCarter
Nutritional ketosis is a metabolic state where the body is predominantly fueled by dietary fat or body fat. It occurs when dietary carbohydrates are limited, dietary protein is moderate, and ketones are produced by the liver as part of fatty acid metabolism.
Fat as a Health Food: Benefits & Course Corrections During a Year of Tracking...James McCarter
Ketosis, where the body burns fats in preference to carbohydrates, is being promoted as an approach to weight loss and treatment for chronic diseases. I’ve taken a Quantified Self approach to tracking my experience with ketosis seeing a number of benefits and challenges along the way. One of the conclusions, which I’m testing further, is that the types of fats used to replace carbohydrates may be critical to optimal health in response to a ketogenic diet. These slides are from my March 17, 2015 presentation to the Quantified Self St. Louis Group (www.quantifiedstl.com) at the Cambridge Innovation Center.
Obesity context of type 2 diabetes and medication perspectivesApollo Hospitals
Drug therapy of obesity has harsh antecedent that many earlier introduced drugs are withdrawn from market. The drugs in present use lack sufficient long-term efficacy and safety data. The difficulty of reversing changing dietary habits and decline in physical activity, however, offers major scope for anti-obesity therapeutics, implied in managing the epidemic chronic inflammatory maladies and cardiovascular sequel. Metabolic syndrome, pre-diabetes and type 2 diabetes mellitus, commonly associate with obesity. Weight reduction is crucial to prevent and control type 2 diabetes. This emphasizes rational choice of therapeutic regimens that do not themselves cause weight gain, and better promote weight loss. Such an aspect is addressed briefly focusing upon the available newer anti-obesity drug options, in particular.
www.drdarmweightloss.com - Experience the life changing results of Dr. Darm's medically-supervised weight loss programs at Aesthetic Medicine in Portland, OR.
Approach to Support Diabetes through Data Visualization DivyaBastola
Used Tableau to created a Geo-map by zip codes, Bar chart by sex and race, and another Bar chart by age to display the dense of diabetes prevalence in 17 zip codes of North Texas.
Literature Review is conducted to demonstrate the reduction of hyperglycemia events after the implementation of an inpatient multidisciplinary glucose control management program.
Created Info-graphic to exhibit the ways to manage diabetes through education, counseling, meal/diet, and exercise and potential comorbidities in the diabetic patient that undergoes surgeries.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmacy.
Effect of Indian Spices to Manage the Diabetes and Associated Metabolic Disorderiosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
This is mainly made in the topic of Ashwagandha Antidiabetic effects....This is my final year project Power point slides presentation of 8th semester in bachelor of pharmaceutical technology....
I reffer this topic because there are various medicinal herbs which are showing hypoglycemic effect.. But withaferin is one of the most potent chemical constituent.. Not only hypoglycemic action it also having antimicrobial and antineoplastic/anticancer activity. So now a days withaferin is most choisable research interest in modern phytochemical study.
Name - Debraj Chakraborty (B.Pharm)
College - Eminent College of pharmaceutical technology
Semester - 8th
Session - 2018 - 2022
Data Driven is just the beginning, why the details of evidence matter by Dr. ...James McCarter
At Virta Health, our values include being evidence-based and prioritizing data and science over opinion in our decision-making. But how does this apply to the data we provide employers? Here are three questions we think employers should be asking healthcare providers and vendors offering health solutions to make smarter data-driven decisions (and some examples of vendor data that doesn’t stand up to scrutiny).
פירוט הרכיבים הטבעיים שנמצאים ב Cane תוסף תזונה טבעי המסייע לחולי סוכרת להגיע לאיזון ברמות הסוכר שלהם. Cane הוא תוסף תזונה מבית קיורהלייף, חברה הדואגת לאיכות חייהם של החולים במחלות כרוניות.
http://www.cane-curalife.com/
Now a days everybody wants evidence or proof for any purpose.so govt.of india introduces AYUSH research portal for the devalopment and taking awareness regarding ayurveda where it consists of clinical trial and pre-clinical trial data.
About the Ketogenic "Keto" Diet in One PageJames McCarter
Nutritional ketosis is a metabolic state where the body is predominantly fueled by dietary fat or body fat. It occurs when dietary carbohydrates are limited, dietary protein is moderate, and ketones are produced by the liver as part of fatty acid metabolism.
Fat as a Health Food: Benefits & Course Corrections During a Year of Tracking...James McCarter
Ketosis, where the body burns fats in preference to carbohydrates, is being promoted as an approach to weight loss and treatment for chronic diseases. I’ve taken a Quantified Self approach to tracking my experience with ketosis seeing a number of benefits and challenges along the way. One of the conclusions, which I’m testing further, is that the types of fats used to replace carbohydrates may be critical to optimal health in response to a ketogenic diet. These slides are from my March 17, 2015 presentation to the Quantified Self St. Louis Group (www.quantifiedstl.com) at the Cambridge Innovation Center.
Obesity context of type 2 diabetes and medication perspectivesApollo Hospitals
Drug therapy of obesity has harsh antecedent that many earlier introduced drugs are withdrawn from market. The drugs in present use lack sufficient long-term efficacy and safety data. The difficulty of reversing changing dietary habits and decline in physical activity, however, offers major scope for anti-obesity therapeutics, implied in managing the epidemic chronic inflammatory maladies and cardiovascular sequel. Metabolic syndrome, pre-diabetes and type 2 diabetes mellitus, commonly associate with obesity. Weight reduction is crucial to prevent and control type 2 diabetes. This emphasizes rational choice of therapeutic regimens that do not themselves cause weight gain, and better promote weight loss. Such an aspect is addressed briefly focusing upon the available newer anti-obesity drug options, in particular.
www.drdarmweightloss.com - Experience the life changing results of Dr. Darm's medically-supervised weight loss programs at Aesthetic Medicine in Portland, OR.
Approach to Support Diabetes through Data Visualization DivyaBastola
Used Tableau to created a Geo-map by zip codes, Bar chart by sex and race, and another Bar chart by age to display the dense of diabetes prevalence in 17 zip codes of North Texas.
Literature Review is conducted to demonstrate the reduction of hyperglycemia events after the implementation of an inpatient multidisciplinary glucose control management program.
Created Info-graphic to exhibit the ways to manage diabetes through education, counseling, meal/diet, and exercise and potential comorbidities in the diabetic patient that undergoes surgeries.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
This Journal publishes original research work that contributes significantly to further the scientific knowledge in pharmacy.
Effect of Indian Spices to Manage the Diabetes and Associated Metabolic Disorderiosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
This is mainly made in the topic of Ashwagandha Antidiabetic effects....This is my final year project Power point slides presentation of 8th semester in bachelor of pharmaceutical technology....
I reffer this topic because there are various medicinal herbs which are showing hypoglycemic effect.. But withaferin is one of the most potent chemical constituent.. Not only hypoglycemic action it also having antimicrobial and antineoplastic/anticancer activity. So now a days withaferin is most choisable research interest in modern phytochemical study.
Name - Debraj Chakraborty (B.Pharm)
College - Eminent College of pharmaceutical technology
Semester - 8th
Session - 2018 - 2022
Medicinal plants and diabetes A series of PresentationByMr. Allah Dad Kha...Mr.Allah Dad Khan
A series of PresentationByMr. Allah Dad Khan Former DG Agriculture Extension KP Province and Visiting Professor the University of Agriculture Peshawar Pakistan allahdad52@gmail.com
Management of Diabetes by Ayurveda & Yoga | Treatment and Medicine | BK ArogyamBK Arogyam
Controlling blood sugar through diet, oral medication or insulin is the main treatment. India is said to be the diabetes capital of the world. With nearly 50 million people in India suffering from diabetes, the country has a big challenge to face. First, let's know what is diabetes. Regular screening for complications is also required. Permanent Cure for Diabetes without Taking Insulin - New Research. Diabetes cure by islet transplantation (Edmonton Protocol )
In pancreatic islet transplantation, cells are taken from a donor pancreas and transferred into another person. Once implanted, the new islets begin to make and release insulin. Researchers hope that islet transplantation will help people with type 1 diabetes live without daily injections of insulin.
Diabetes is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Diabetes mellitus, or simply diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the pancreas does not produce enough insulin, or because cells do not respond to the insulin that is produced. The term diabetes is from the Greek word diabaineine refers a tubular organ that take-in or expels water-excessive urine discharges. In 1675, Thomas Willis added mellitus (means ―honey in Latin) to the word diabetes and called it as Diabetes Mellitus, which refers to too much of sweet taste urine. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger). Diabetes mellitus is a disorder of glucose regulation, characterized by an accumulating glucose concentration in the blood (Wilkins and Atanasov, 1996).
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Plant-based Eating: Enhancing Health Benefits, Minimizing Nutritional RisksRobin Allen
Learning Objectives
At the end of the session, the participants will be able to:
1. Know there is no single definition of a plant-based diet.
2. Discuss health aspects of vegetarian and vegan diets and quality of evidence supporting health claims.
3. Assess nutritional adequacy/status of vegetarians and/or vegans throughout the life cycle and provide strategies for meeting dietary recommendations for vitamin B12, DHA calcium, and zinc.
MY PRESENTATION @ CSIR NEIST SRTP ON - STRENGTHENING THE HEALTHY LIFESTYLE TH...Ram Kanth
This is my presentation at CSIR NEIST SRTP. Had a wonderful interaction with a good number of the audience around 325 +. It a great and memorable presentation of mine.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
An analysis of antidiabetic activity of stevia rebaudiana extract on diabetic patient
1. Journal of Natural Sciences Research www.iiste.org
ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.1, No.3, 2011
An Analysis of antidiabetic activity of Stevia rebaudiana
extract on diabetic patient
Neha Mishra*
Department of Food Science & Technology
Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad
*E-mail: nehadesire2011@gmail.com
Abstract:
The research paper tried to find out the effect of Stevia rebaudiana extract on diabetic patient of different
age group and gender. Stevia leaf powder was taken under normal diet and comparison has been made with
medicine, without medicine and with Stevia intake. Stevia powder has been replaced with sugar and instead
of sugar Stevia powder was consumed with tea three times a day, significant decrease in FBS and PPBS
was observed.
Key words: Stevia, FBS, PPBS, stevioside, Antidiabetic.
1. Introduction
Stevia is grown all across the world; it is known as stevia for its sweet leafs. It has been cultivated since
long time in china and Southeast Asia and India has been one of the major cultivators of the stevia in
international market. The leafs are the source of diterpene glycosides, stevioside and rebaudioside.
Stevioside is non-caloric and is reported to be 30 times sweeter than sugar (Kolb et.al. 2001). In India
diabetic patient are increasing day by day and according to world diabetic foundation it has the world's
largest diabetes population, followed by China with 43.2 million and it has major concern among health
experts and national and international healthcare. World health organization (WHO) has identified diabetes
as an epidemic condition (King and Rewwers, 1991) and one of the major killer of the decade. Estimation
by WHO, there will be about 250 million cases of diabetes mellitus throughout the world by
2025(Friedman, 2002).
Though various drugs are available in Indian market for diabetic control like oral hypoglycemic agents and
insulin for the treatment of diabetes mellitus, however the therapy with oral hypoglycemic agents is not
satisfactory. Several drugs such as biguanides and sulfonylureas are presently used to reduce
hyperglycemia in diabetes mellitus. Even these drugs have side effects and management of diabetes without
any side effect is big a challenge to the medical community.
There are various traditional herbs are available and consumed by the Indian t control and prevent
diabities.Few of them are Methi seeds (Fenugreek), Sweet neem (Kurri patta) and Sadabahar (Vinka rosia)
is good to reduce the blood sugar level. These traditional antidiabetics succeeded to provide control on
diabetic up to some extent but poor availability and high cost was constraint in developing countries like
India and rest of. The major reasons were the eating habits and taste of the Indian population. Methi were
used to one of the alternate to control diabetes but the bitter taste of Methi has been major constraint at
consumption level. Majority of Indian prefer vegetarian diets and prefer tea with sugar at least three times a
day. In India Sugar is considered one of the major contributory in increasing diabetes.
And these traditional alternatives cannot take place as an alternative of the sugar as well as have taste issues
while consumption, there is strong need to discover new kind of herb which can take place as a diet not as a
medicine and have control over the diabetes. As discussed above and many researches has been found that
Stevia has better antidiabetic properties as well as sweeter than sugar and which can be used as an alternate
to sugar and to control diabetes.
Stevia rebaudiana is known as “Calorie free Bio sweetener of High Quality” (Preethi et.al. 2011; N.Bharati
2003) .A recent scientific trail shows that this herb has many health benefiting. Stevia contains phyto-
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ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.1, No.3, 2011
chemical compound that helps to cure blood sugar, cholesterol and blood pressure. It is used as natural
sweetener and is having low calorie.
Following health benefits has been noticed about Stevia:
Stevia is having low calorie as compared to sugar.
Chlogenic acids reduce conversion of glycogen to glucose and reduces absorption of glucose and
reduce blood sugar level. It is used as a flavor enhancer, taste enhancer and anti bacterial effect. It
is heat stable at high temperature can be cooked with tea and food. Stevia can be used widely in
Jams, Sauces, Jelly, Confections, Beverages, Pharmaceuticals and in Alcoholic beverages and in
Dental products. It is used in tea, coffee and dairy products.
Leaf has stevioside of 10% to 12% on dry basis, even 50 gm of Stevia leaf can replace 1000g of can sugar.
The sweetness of stevioside is non-fermenting and it does not display browning while cooking.
2. Material and Methods
Stevia leaf powder was replaced with sugar in tea/Coffee and Milk intake. It has been checked and scored
by panel of trained judges for quality attributes such as aroma, texture, taste and appearance. Fifteen
patients were introduced who were vegetarian, Out of fifteen, nine patients were women and six patients
were men and the age group was 35-60 years (Table1). During the experimental period it was advised not
to use drugs. Patients were advised to take balanced diet as per directed by the physician and were advised
for regular check up in pathology (An ISO 9001 certified). Prior to experiment patients medical history
were examined and diabetic reports were analyzed for smooth conduct of the experiment.
Feeding trial was for 45 days. First 15 days patient was given medicine e and their fasting and post
prandial diabetic level were measured then for next 15 days they were not given any medicine under
normal diet and their prandial and fasting glucose level were measured and then for further 15 days they
were given Stevia leaf three times a day with tea and their glucose level were measured. Leafs were
collected from Bioved Research Institute, from Allahabad district and dried leafs were grinded in mixer.
About .5g and 1g of Stevia leaf powder was consumed with tea in place of sugar.
3. Result and Discussions
Initially patient were taking medicine to control their diabetic level, for 15 days patient were taking
medicine regularly as they were taking earlier under normal diet and their Fasting blood sugar (FBS) and
Post prandial (PPBS) blood sugar were taken FBS was 153.54 and PPBS was 189.56(Table 2).For next 15
days patient were asked to stop taking medicine under normal diet and in the supervision of physician and
their FBS and PPBS were checked which was 208.6 and 283 respectively. There is significant difference in
both FBS and PPBS which shows that while taking medicine their FBS and PPBS were under control
(Table3).
For further 15 days patient were given Stevia leaf powder with tea three times a about .1g to 5g And FBS
and PPBS were checked which was 195.7 and 271.3 .There was significant decrease in the FBS and PPBS
level while consuming Stevia leaf powder(Table4).
Now we tried to find out how statistically significant the consumption of Stevia leaf powder in diabetic
patient while considering both FBS & PPBS without medicine and with Stevia. There is significant
decrease in FBS with Stevia consumption but statistically not given desired result, this may be due to
sample size taken in consideration was not enough to show the significant result Table 5 and 6).
4. Conclusion
From the above discussions we can understand that Stevia leaf powder influenced blood sugar levels both
FBS and PPBS positively but not statistically significant. It can be concluded that Stevia possess a
potential anti diabetic effect and for more significant result large sample size should be taken in
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3. Journal of Natural Sciences Research www.iiste.org
ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.1, No.3, 2011
consideration under controlled condition and for extended period of time.
References:
A.D.Kinghorn, C.D.WU, D.D.Soejarto (2001).Stevioside. In: O’Brien Nabors, L. (Ed.), Alternative
Sweeteners, Dekker, New York, 167-183.
D. Preethi, T.M. Sridhar, C.V. Naidu (2011).Carbohydrate Concentration Influences on In Vitro Plant
Regeneration in Stevia rebaudiana ,Journal of Phytology, 3, 61-64.
Friedman EA. (2002) .Diabetic nephropathy: Improving prognosis, Saudi J Kidney Dis Trans, 13, 281-310.
J.P. Boyle, A.A. Honeeycutt, K.M. Narayan, T.J. Hoerger, L.S. Geiss, H. Chen, T.J.Thompson (2001)
.Projections of diabetes burden through 2050: impact of changing demography and disease prevalence in
the US, Diabetes Care, 24, 1936-1940.
Kolb N, Herrera JL, Ferreyra DJ, Uliana RF. (2001) .Analysis of sweet diterpene glycosides from Stevia
rebaudiana: Improved HPLC method, J Agric Food Chemical, 49, 38–41.
King H and Rewwers M. (1991). Diabetes in adult is now a third world problem,Bulletin: World Health
Organization, 69, 6430.
Melis, M.S (1995) .Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects, J.
Ethenopharmacol, 47, 129-134.
Melis, M.S. (1997). Effect of steviol on renal function and mean arterial pressure in rats, Phytomedicine, 3,
349-352.
National Diabetes Fact Sheet (NDFS), United States, (2005).
N.F. Komissarenko, A.I. Derkach, I.P. Kovalyov, N.P. Bublik (1994). Diterpene glycosides and
phenylpropanoids of Stevia rebaudiana Bertoni, Rastitel' nye Resursy, 1, 53-64.
N.Bharathi (2003). Stevia-The Calorie Free Natural Sweetener, Natural Product Rediance, 2,120-123.
P. Chan, B. Tomlinson, Y. Chen, J. Liu, M. Hsieh, J. Cheng (2000) .A double blind placebo-controlled
study of the effectiveness and tolerability of oral stevioside in human hypertension, Brit. J. Clin.
Pharmacol, 50, 215-220.
Pari, L. and Saravanan, R. (2004) .Antidiabetic effect of diasulin, a herbal drug, on blood glucose, plasma
insulin and hepatic enzymes of glucose metabolism in hyperglycaemic rats, Diabetes, Obesity and
Metabolism, 6, 286–292.
Ramachandran, A., Snehalatha, C. and Viswanathan, V. (2002) .Burden of type 2 diabetes and its
complications –The Indian scenario, Current Science, 83, 1471-1476.
S. Das, A.K. Das, R.A. Murphy, I.C. Punwani, M.P. Nasution, A.D. Kinghorn (1992) .Evaluation of the
cariogenic potential of the intense natural sweeteners stevioside and rebaudioside A,Caries Res,26,363-366.
Savita, S. M., Sheela, K., Sunanda, S., Shankar, A. G., Ramakrishna, P. and Sakey, S. (2004) .Health
implications of Stevia rebaudiana, Journal of Human Ecology, 15,191-194.
Shukla S., Mehta A., Mehta P., Bajpai V.K. (2011) .Evaluation of comparative antidiabetic effects of
ethanolic extracts of Caesalpinia bouncucella and Stevia rebaudiana in normal and alloxaninduced
experimental rats, Romanian Biotechnological Letters, 16, 6187-6199.
S.M. Savita,K.Sheela,Sharan Sunanda,A.G.Shankar,Parama R.,Srinivas S.(2004) .Health implications of
Stevia rebaudiana,Hum.Ecol.,15,191-194.
Uddin, M. S., Chowdhury, M. S. H., Khan, M. M .H. Uddin, M. B., Ahmed, R. and Baten, M. A. (2006) .In
vitro propagation of Stevia rebaudiana Bert in Bangladesh, African Journal of Biotechnology,5,1238-1240.
Vanek, T., Nepovim, A. and Valicek, P. (2001) .Determination of Stevioside in plant material and fruit
teas, Journal of food composition and analysis, 14,383-388.
www.who.int/mediacentre/events/annual/world_diabetes_day/en/,Retrived on 22nd November2011.
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4. Journal of Natural Sciences Research www.iiste.org
ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.1, No.3, 2011
Author 1: Neha Mishra is Research scholar in Department of Food Science & Technology at Sam
Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad.
Appendix:
Table: 1
Diet
Sr. No. Patient Gender Age
Vegetarian
1 A M 36
2 B M 39 √
3 C F 41 √
4 D F 52 √
5 E F 43 √
6 F F 56 √
7 G F 36 √
8 H F 47 √
9 I F 49 √
10 J F 54 √
11 K M 55 √
12 L M 51 √
13 M M 42 √
14 N F 48 √
15 O M 50 √
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ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.1, No.3, 2011
Table2: Fating blood sugar and pp under medicine for 15 days under normal diet
Fasting Blood Post Prandial Blood
Code Age Sex Sugar(mg/dl) Sugar (mg/dl)
After 15 days After 15 days
A 36 M 91.6 121.2
B 39 M 102.2 136
C 41 M 162.6 193
D 52 M 182.6 210
E 43 M 178 201
F 56 F 194.2 235.7
G 36 F 112.6 163
H 47 F 143.7 186.3
I 49 F 115.7 156.2
J 54 F 179.3 214
K 55 M 191.5 244
L 51 M 190 214
M 42 M 128.4 191
N 48 F 147.7 169
O 50 M 183 209
Mean ± SD 153.54 ± 35.7 189.56 ± 34.87
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6. Journal of Natural Sciences Research www.iiste.org
ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.1, No.3, 2011
Table3: Fating blood sugar and pp without medicine for 15 days under normal diet
Fasting Blood Post Prandial Blood
Code Age Sex
Sugar(mg/dl) Sugar (mg/dl)
After 15 days After 15 days
A 36 M 122.5 178.2
B 39 M 156 241
C 41 M 194 251
D 52 M 219 294
E 43 M 113 234
F 56 F 234 312
G 36 F 237 328
H 47 F 178 236
I 49 F 169 212
J 54 F 210 275
K 55 M 241 283
L 51 M 256 291
M 42 M 283 345
N 48 F 285.4 378
O 50 M 231 389
Mean ± SD 208.6 ± 52.7 283± 60.14
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7. Journal of Natural Sciences Research www.iiste.org
ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.1, No.3, 2011
Table4: Fasting blood sugar and pp with Stevia for 15 days under normal diet
Fasting Blood Post Prandial Blood
Code Age Sex
Sugar(mg/dl) Sugar (mg/dl)
After 15 days After 15 days
A 36 M 112 162
B 39 M 142 237
C 41 M 184 231
D 52 M 201 298
E 43 M 97 227
F 56 F 212 309
G 36 F 220 295.3
H 47 F 169 229
I 49 F 170 209
J 54 F 187 256
K 55 M 234 280
L 51 M 243 298
M 42 M 276 330
N 48 F 270.2 367
O 50 M 219 342
Mean ± SD 195.7± 52.33 271.3± 55.88
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8. Journal of Natural Sciences Research www.iiste.org
ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.1, No.3, 2011
Table 5: Fasting blood sugar without medicine and with Stevia
Fasting Blood Fasting Blood
Sugar(mg/dl) Sugar(mg/dl) With
Code Age Sex
Without Medicine Stevia intake
After 15 days After 15 days
A 36 M 122.5 112
B 39 M 156 142
C 41 M 194 184
D 52 M 219 201
E 43 M 113 97
F 56 F 234 212
G 36 F 237 220
H 47 F 178 169
I 49 F 169 170
J 54 F 210 187
K 55 M 241 234
L 51 M 256 243
M 42 M 283 276
N 48 F 285.4 270.2
O 50 M 231 219
Mean ± SD 208.6 ± 52.7 195.7 ± 52.34
t value 0.254134NS*
*NS: Non Significant
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ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.1, No.3, 2011
Table 6: pp blood sugar without medicine and with Stevia
Post Prandial Blood Post Prandial Blood
Code Age Sex
Sugar (mg/dl) Sugar (mg/dl)
After 15 days After 15 days
A 36 M 178.2 162
B 39 M 241 237
C 41 M 251 231
D 52 M 294 298
E 43 M 234 227
F 56 F 312 309
G 36 F 328 295.3
H 47 F 236 229
I 49 F 212 209
J 54 F 275 256
K 55 M 283 280
L 51 M 291 298
M 42 M 345 330
N 48 F 378 367
O 50 M 389 342
Mean ± SD 283.14 ± 60.14 271.35 ± 55.9
t value 0.2912NS
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