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1. Lagerstroemia speciosa [banaba] for Diabetes & Obesity

5. Ref: Diabetes Care 27:1047–1053, 2004

6. Always tired Blurred vision Crave extra liquids (more than 10 glass/day) Sexual dysfunction Unexplained weight loss Always hungry (especially after eating) Numbness and tingling of feet Frequent urination (especially during night) Some Symptoms of Diabetes

11. Family: Lythraceae English Name: Banaba Common Name: Crepe Myrtle Part Used: Leaves Lagerstroemia speciosa

12. Herbal Approach to Diabetes The unique combination of a glucose uptake stimulatory activity and absence of adipocyte differentiation activity suggest that banaba may be useful for management of hyperglycemia and obesity in type II diabetes * * Fang Liu et al., J Nutr, 2001; 131; pp 2242-2247.

14. Clinical Studies on Banaba Lagerstroemia speciosa

16. Effectiveness of banaba extract on mild Type II diabetes Yoshio Ikeda et al., Practice, 2001; 18 (4) Decreased blood glucose level Improved glucose tolerance Results 08 weeks Duration 50 mg of alcohol extract of banaba standardized to >1 % corosolic acid. Dose 26 [24 male & 2 female] with mild type II diabetes Patients Japan Place

17. Antidiabetic activity of standardized extract of banaba in Type 2 DM William VJ et al. J. of Ethanopharmacol, 2003; 87; pp 115-117 Banaba Dose Response Curve Daily dosage of 32 & 48 mg for 2 weeks showed a significant reduction in the blood glucose levels. Results 02 weeks Duration 16, 32 & 48 mg/day of aqueous ethanol extract of banaba [standardized to 1 % corosolic acid] orally Dose 56 Type 2 Diabetic patients Patients USA Place

18. Effect of corosolic acid on post challenge plasma glucose levels Fukushima M. et al., Diabetes Research and Clinical Practice ( 2006), [ Article in Press] * Corosolic acid treated subjects Showed lower glucose levels from 60 min until 120 min and reached statistical significance at 90 min. Results 07 days Duration 10 mg corosolic acid Dose 31 [16 men & 15 women] with fasting plasma glucose level btn. 110 & 140 mg/dl Patients Japan Place

19. Effectiveness of banaba extract in patient with mild type 2 diabetes Yoshio Ikeda Et al., Japan Pharmcology & Therapeutics, 1999, 27 (5). Decreased blood sugar level for mild type 2 diabetes Results 08 weeks Duration 375 mg of water extract of banaba, 3 times with meal. Dose 24 [18 males & 06 females] with mild type 2 diabetes Patients Japan Place

20. Pre-clinical Studies on Banaba Lagerstroemia speciosa

21. Hypoglycaemic activity of alcoholic extract of leaves of banaba Mishra Y et al. Indian Journal of Pharmacology , 1990; 22; pp 174-176 Significant hypoglycemic activity Results 2 weeks Duration 250 mg / 100 g b.w Alcoholic extract of banaba Dosage Albino rats of either sex Animal

22. Antidiabetic effects of corosolic acid in KK-Ay Diabetic Mice Toshihiro M et al. BIol.Pharm.Bull. 2006; 29(3); pp 585-587 Significant reduction in blood glucose levels after 1 week Results 02 weeks Duration Corosolic acid 2 mg/kg b.w Dosage KK-Ay strain male mice with a blood glucose level >300mg/dl Animal

23. Hypoglycaemic effect of decoction of banaba administered orally Faustino G, The Journal of the Philippine Medical Association, 1940; XX (7); pp 395-402 . Reduced blood sugar level Results 03 hrs. Duration 15 g/kg b.w Banaba decoction Dosage Male white rabbit Animal

24. Antiobesity activity of extract from banaba leaves on female KK-Ay mice Yuko Suzuki et al. J Nutr. Sci. Vitaminol, 1999; 45; pp 791-795. Significant decrease, to 65 % of the control level in total hepatic lipid contents. Due to reduction in the accumulation of triglyceride. Results 11 weeks Duration The diet (100 g) containing 5 % hot water extract of banaba Dosage Female obese KK-Ay mice Animal

26. Safety Studies on Banaba Lagerstroemia speciosa Banaba leaves have been historically drunk as tea

27. Safety in administering banaba extract Yoshio Ikeda et al., Practice, 2001; 18 (4) There was no harmful case and there were no abnormal changes in the values measure in the clinical Examinations Results 08 weeks Duration 50 mg of alcohol extract of banaba standardized to 1 % corosolic acid Dose 26 [24 male & 2 female] Patients Japan Place

28. Safety of banaba in patients with mild type 2 diabetes Yoshio Ikeda et al., Japan Pharmcology & Therapeutics, 1999, 27 (5). No adverse side effects and abnormal variations on the clinical diagnostic data during the study term were recognized in all 24 subjects. Results 08 weeks Duration 375 mg of water extract of banaba Dose 24 with mild type 2 diabetes Patients Japan Place

29. Safety of banaba decoction administered orally to rabbits Faustino G, The Journal of the Philippine Medical Association, 1940; XX (7); pp 395-402. Oral administration of large doses of the decoction of banaba have never been observed to produce convulsion or any toxic effects. Results 20 g / kg b.w banaba decoction Dosage Rabbits Animal

31. Standardization of Banaba extract S1 T1 S1 = Std. Corosolic acid T1 = Banaba extract Mobile phase : Buffer : Acetonitrile [65 : 35] Flow : 1.6ml/min Column: C-18 - 250 X4.6 mm Wavelength: 205nm TLC Mobile phase: Toluene : Ethyl acetate : Acetic acid [ 55: 45: 0.2] Detection: Lieberman reagent HPLC

32. Availability: Lagerstroemia speciosa extract standardized to corosolic acid (>1 % w/w). Standardized extract of banaba can be custom formulated as per specific requirements. The extract is recommended for incorporation in nutraceutical formulations intended for controlling blood sugar levels and for weight loss. Recommended dose and Availability Recommended dose: 50 mg/day/adult of standardized banaba extract. * * Yoshio Ikeda et al., Practice, 2001; 18 (4) * William VJ et al. J. of Ethanopharmacol, 2003; 87; pp 115-117

33. Thank you Disclaimer: The information provided herein has been collected from sources considered reliable, but has not been independently verified by Natural Remedies Pvt. Ltd.