Amyotrophic lateral sclerosis (ALS) causes motor neuron degeneration in the brain and spinal cord, resulting in progressive muscle weakness and paralysis. Frontotemporal lobar degeneration (FTLD) causes degeneration of neurons in the frontal and temporal lobes, leading to changes in behavior, personality, and language abilities. While ALS and FTLD present as distinct disorders, they share some common pathological features and genetic underpinnings. Mutations in genes involved in RNA processing and transport, like TARDBP, FUS, and C9ORF72, have been linked to both ALS and FTLD and may disrupt nucleocytoplasmic transport of RNA and proteins. Understanding the networks and interactions