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AMIODARONE
• Used for the prevention and treatment of serious atrial and
ventricular arrhythmias
AMIODARONE
Mechanism of action
• Increases the refractory period in all cardiac tissues
• Decreases automaticity of fibres in the Purkinje system
• Prolongs AV conduction
• Can block potassium, sodium and calcium channels and β
receptors
AMIODARONE
Drug interaction
• Amiodarone increases the plasma concentration of digoxin
• Amiodarone increases the plasma concentration of flecainide
by inhibiting its metabolism
• Amiodarone can result in increased plasma concentration of
Phenytoin
• Amiodarone increase anticoagulant effect by inhibiting
metabolism of Warfarin.
AMIODARONE
Adverse reaction
• Dizziness
• Bitter taste
• Headache
• Flushing
• Nausea and Vomiting
• Constipation
• Ataxia
• Weight loss
• Tremor
• Parasthesiae of fingers and toes
• Photosensitivity
• Blue-grey skin discolouration
• Pulmonary fibrosis and pneumonitis
• Cough, fever
• Allergic reaction
• Blurred vision
AMIODARONE
• Use with caution in patients with heart failure and liver or
thyroid function impairment
• Avoid in patients with second or third degree AV block and
bradycardia
Reference
• Knights, K & Kathleen, B 2011, Pharmacology for health
professionals, Chapter 12, Elsevier, Chatswood,
Australia.

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Amiodarone

  • 1.
  • 2. AMIODARONE • Used for the prevention and treatment of serious atrial and ventricular arrhythmias
  • 3. AMIODARONE Mechanism of action • Increases the refractory period in all cardiac tissues • Decreases automaticity of fibres in the Purkinje system • Prolongs AV conduction • Can block potassium, sodium and calcium channels and β receptors
  • 4. AMIODARONE Drug interaction • Amiodarone increases the plasma concentration of digoxin • Amiodarone increases the plasma concentration of flecainide by inhibiting its metabolism • Amiodarone can result in increased plasma concentration of Phenytoin • Amiodarone increase anticoagulant effect by inhibiting metabolism of Warfarin.
  • 5. AMIODARONE Adverse reaction • Dizziness • Bitter taste • Headache • Flushing • Nausea and Vomiting • Constipation • Ataxia • Weight loss • Tremor • Parasthesiae of fingers and toes • Photosensitivity • Blue-grey skin discolouration • Pulmonary fibrosis and pneumonitis • Cough, fever • Allergic reaction • Blurred vision
  • 6. AMIODARONE • Use with caution in patients with heart failure and liver or thyroid function impairment • Avoid in patients with second or third degree AV block and bradycardia
  • 7. Reference • Knights, K & Kathleen, B 2011, Pharmacology for health professionals, Chapter 12, Elsevier, Chatswood, Australia.