1 Main minerals. Amino acids. Proteins folding 2021Mahiraamirova1
Presentation gives detailed description of proteins formation and explains some minerals role and their sources. Physico-chemical properties of amino acids and their role in bond formation are overviewed as well
Omega 3 fatty acid Best Source is Flaxseed Om Verma
Fatty acid is a carboxylic acid with a long unbranched aliphatic carbon chain, which is either saturated or unsaturated.
Most naturally occurring fatty acids have a chain of 4 to 28 carbons.
There are always even number of carbons.
First Carbon from carboxyl end is called α, second β, third γ, fourth δ ….. and last carbon is called ω or omega and the last end is called omega end.
This PPTX is a basic presentation of a short sight of 10 minutes, about what role, classification & properties of amino acids, Protein organization, functions of proteins
After the advent of "lipid hypothesis", which linked the consumption of dietary fat with increased risk of heart disease and other health problems, fats were so highly defamed by the medical establishment that many people started thinking that the best answer to the "fat problem" is to stay away from it as far as possible. Food processing companies quickly took advantage of this era of “fat phobia”, and soon flooded the market with "low fat" and "no free" products, promising to put an end to heart disease and obesity, but the incidence of these diseases is still skyrocketing.
The truth is that not all fats are equal. While the consumption of some ugly fats (trans-fats) are, really, a risk factor for many health problems, some other fats, including alpha-linolenic acid ALA (head of the omega-3 family) and linoleic acid LA (head of the omega-6 family), are so important for health that they have been termed "essential fatty acids" (EFAs). Our body need them to perform vitally important functions, but is unable to produce them. Therefore, we must get them from our food. That's why any attempt to indiscriminately reduce or eliminate all fats from our diet inevitably leads to an EFA deficiency, which may be very dangerous to health.
For all the good it does, fat is often blamed to cause obesity, because it contains 9 calories per gram, while carbohydrate and protein contain only 4 calories. Yet, it's a mistake to relate dietary fat with body fat. You can get fat eating carbs and protein, even if you eat little dietary fat.
In 1956, Hugh Sinclair, one of the world's greatest researchers in the field of nutrition, suggested that an upsurge in the so-called "diseases of civilization" e.g. coronary heart disease, strokes, type-2 diabetes, arthritis and cancer - was caused by modern diets being extremely poor in essential fatty acids (EFA) and full of processed foods rich in trans-fatty acids. Although Sinclair's opinions were not supported by his pears, and he was even criticized by some of them for his bold hypothesis, later research convincingly shown that he was, indeed, correct. In fact, he is now praised for insights that were far ahead of his time.
1 Main minerals. Amino acids. Proteins folding 2021Mahiraamirova1
Presentation gives detailed description of proteins formation and explains some minerals role and their sources. Physico-chemical properties of amino acids and their role in bond formation are overviewed as well
Omega 3 fatty acid Best Source is Flaxseed Om Verma
Fatty acid is a carboxylic acid with a long unbranched aliphatic carbon chain, which is either saturated or unsaturated.
Most naturally occurring fatty acids have a chain of 4 to 28 carbons.
There are always even number of carbons.
First Carbon from carboxyl end is called α, second β, third γ, fourth δ ….. and last carbon is called ω or omega and the last end is called omega end.
This PPTX is a basic presentation of a short sight of 10 minutes, about what role, classification & properties of amino acids, Protein organization, functions of proteins
After the advent of "lipid hypothesis", which linked the consumption of dietary fat with increased risk of heart disease and other health problems, fats were so highly defamed by the medical establishment that many people started thinking that the best answer to the "fat problem" is to stay away from it as far as possible. Food processing companies quickly took advantage of this era of “fat phobia”, and soon flooded the market with "low fat" and "no free" products, promising to put an end to heart disease and obesity, but the incidence of these diseases is still skyrocketing.
The truth is that not all fats are equal. While the consumption of some ugly fats (trans-fats) are, really, a risk factor for many health problems, some other fats, including alpha-linolenic acid ALA (head of the omega-3 family) and linoleic acid LA (head of the omega-6 family), are so important for health that they have been termed "essential fatty acids" (EFAs). Our body need them to perform vitally important functions, but is unable to produce them. Therefore, we must get them from our food. That's why any attempt to indiscriminately reduce or eliminate all fats from our diet inevitably leads to an EFA deficiency, which may be very dangerous to health.
For all the good it does, fat is often blamed to cause obesity, because it contains 9 calories per gram, while carbohydrate and protein contain only 4 calories. Yet, it's a mistake to relate dietary fat with body fat. You can get fat eating carbs and protein, even if you eat little dietary fat.
In 1956, Hugh Sinclair, one of the world's greatest researchers in the field of nutrition, suggested that an upsurge in the so-called "diseases of civilization" e.g. coronary heart disease, strokes, type-2 diabetes, arthritis and cancer - was caused by modern diets being extremely poor in essential fatty acids (EFA) and full of processed foods rich in trans-fatty acids. Although Sinclair's opinions were not supported by his pears, and he was even criticized by some of them for his bold hypothesis, later research convincingly shown that he was, indeed, correct. In fact, he is now praised for insights that were far ahead of his time.
Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. The key elements of an amino acid are carbon (C), hydrogen (H), oxygen (O), and nitrogen (N), although other elements are found in the side chains of certain amino acids. As many as 300 amino acids are found in nature but only 20 amino acids are standard as they are coded by genes (genetic codes) .A peptide bond is a special type of amide bond formed between two molecules where an α-carboxyl group of one molecule reacts with the α-amino group of another molecule releasing a water molecule . CLASSIFICATION OF AMINO ACIDS - On the basis of R-group On the basis of Polarity , On the basis of Nutritional requirement
On the basis of Catabolism
This Course is included in the syllabus of Bachelor in Science Agriculture level study in Tribhuvan University. The course belongs to 1h lecture.This slide include general introduction of amino acid. It describes about structure, function , type and role of amino acid.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. The key elements of an amino acid are carbon (C), hydrogen (H), oxygen (O), and nitrogen (N), although other elements are found in the side chains of certain amino acids. As many as 300 amino acids are found in nature but only 20 amino acids are standard as they are coded by genes (genetic codes) .A peptide bond is a special type of amide bond formed between two molecules where an α-carboxyl group of one molecule reacts with the α-amino group of another molecule releasing a water molecule . CLASSIFICATION OF AMINO ACIDS - On the basis of R-group On the basis of Polarity , On the basis of Nutritional requirement
On the basis of Catabolism
This Course is included in the syllabus of Bachelor in Science Agriculture level study in Tribhuvan University. The course belongs to 1h lecture.This slide include general introduction of amino acid. It describes about structure, function , type and role of amino acid.
Similar to Amino acids and its classification (20)
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This pdf is about the Schizophrenia.
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A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
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The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
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The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
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holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
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2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
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Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
1. Amino acids and its Classification
Dr. Vikas Kumar
School of Biotechnology
Shoolini University
Village Bajhol, Solan (H.P)
+91 9459527906
vikaskmr59@gmail.com
2. What are amino acids?
• Building Blocks of Proteins
• Organic compounds that contain amine (–NH2) and carboxyl (–
COOH) functional groups, along with a side chain (R group) specific
to each amino acid
•More than 300 amino acids are found in nature but only 22
amino acids are standard and present in protein because they are
coded by genes. Other amino acids are modified amino acids
and called non-protein amino acids.
11. Derived amino acids
Non-α-amino acids
Derived and
incorporated in tissue
protein
Derived and incorporated
in tissue protein
Derived amino
acids
Ornithine
12. Classification based on side chain
Amino acid
amino acids with non-polar
side chain
amino acids with polar, but
uncharged side chain
amino acids with charged
side chain
Alanine, valine, Leucine, Isoleucine, Phenyl
alanine, Tryptophan and Proline
Serine, Threonine, Tyrosine, Cysteine,
Asparagine, and Glutamine
Aspartic acid, and Glutamic acid
Lysine, Arginine and Histidine
13. Based Upon nutritional requirement
Non-Essential amino acids Essential amino acids
Amino acids
Semi-essential amino acid
Arginine and Histidine
14. Distribution in Proteins
Standard Protein amino
acids
Non-Standard protein amino
acids
Amino acids
Ornithine, Citrulline, beta-alanine
Histidine, Isoleucine, Lysine,
Leucine, Methionine etc.
15. Based upon metabolic fate
Ketogenic and
glucogenic amino
acids
Glucogenic amino acids
Amino acids
Ketogenic amino acids
A glucogenic amino acid is an amino acid that can be converted into glucose through gluconeogenesis.
Ketogenic amino acids, which are converted into ketone bodies.
leucine and lysinephenylalanine, isoleucine,
threonine, tryptophan
and tyrosine