Upper airway anatomy includes the mouth, nasal cavity, nasopharynx, oropharynx, larynx, and lower airway including the trachea and bronchi. Factors predisposing to a difficult airway include congenital deformities, infections, tumors, arthritis, and injuries. A thorough airway assessment involves history, physical exam including focused tests like Mallampatti score, thyromental distance, jaw mobility, and neck range of motion to identify potential difficulties and plan management.