Hepadnaviridae

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Hepadnaviridae

  1. 1. Hepadnaviridae & SyifaHepatitis Virus Syikin Ejat Acap Megat
  2. 2. Hepadnaviridae( Hepa = liver ; dna = deoxyribonucleicacid )It is a group of DNA viruses- The hepadna virus belongs to Class 7 under the Baltimore’s system for classification- Icosahedral nucleocapsid made of protein.- Enveloped and consist spike- Double-stranded DNA genome, mainly present in spherical versions and some pleomorphic ones, is enclosed by a lipid envelope.- Circle in shape- 42 nm in diameter
  3. 3. Hepatitis VirusContent Genome -Due to the partial DNA, it is a RNA intermediate. It is also an endogenous DNA which is dependent on DNA polymerase during DNA replication. -The genome of HBV is made of circular DNA, but it is unusual because the DNA is not fully double-stranded.The genome organization of HBV. The genes overlap. One end of the full length strand is linked to the
  4. 4. Modes ofTransmission
  5. 5. SIGN AND SYMPTOMSEXAMPLE :-• Loss of appetite• Nausea• Vomiting• Body aches• Mild fever• Dark urine• And then progresses to development of jaundice
  6. 6. TREATMENT• Alpha interferon- Very expensive treatment- Last round 12-15 weeks- Makes patient very sick- Reverse transciptase inhibitor- Drugs target virus replication strategy by inhibit reverse transcriptase• Recombinant HBsAg vaccine• Specific antiviral drugs such as lamivudine- Reverse transcriptase inhibitor
  7. 7. INFECTION TO HUMAN• Most of the people who come into contact with the virus are able to clear the infection alone.• There are some who cannot, and these patients progress to fulminant hepatitis.• This condition causes severe liver damage and, in very rare cases, may also lead to primary hepatocellular carcinoma.

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