This document describes the development of a visible residue limits (VRL) program to validate cleaning at a pharmaceutical manufacturing facility. Key parameters that influence visual inspections for cleaning validation like lighting, viewing distance and angle, and observer subjectivity were studied. Acceptable visible residue limits were determined for several active pharmaceutical ingredients (APIs) and excipients under different lighting conditions through visual inspections by multiple observers. The results provide a basis for using visible residue limits as part of a risk-based cleaning validation approach.
Online Monitoring of Wastewater in Common Effluent Treatment Plant using UV-V...Mudasir Gulzar
The document discusses online monitoring of wastewater parameters like COD and TSS in a Common Effluent Treatment Plant using UV/VIS spectroscopy. It describes how a local calibration procedure using samples from the specific plant can provide more accurate readings compared to a global calibration. Maintaining proper cleaning frequencies for the monitoring equipment is also important for avoiding measurement drift. The results showed that UV/VIS analyzers can reliably and accurately measure COD and TSS levels with a local calibration approach.
This document discusses non-destructive testing (NDT) methods, with a focus on visual inspection techniques. It defines NDT as examining materials and components without destroying them to find defects. Several NDT methods are described including visual inspection, liquid penetrant testing, magnetic particle testing, etc. Visual inspection can be unaided or aided using tools like magnifying mirrors, boroscopes, and robotic crawlers. Factors that influence visual testing like surface conditions, environment, and inspector fatigue are also covered. The document provides examples of visual inspection applications and lists advantages and limitations of various NDT methods.
TURBIDITY MEASUREMENT USING NIR DIGITAL CAMERAS AND GOOGLE EARTH ENGINE: A re...IRJET Journal
The document discusses several studies related to measuring water quality parameters like turbidity using digital imaging and image processing techniques. Specifically:
1. One study developed a method using two near-infrared cameras to capture scattered and transmitted light images when light passes through turbid solutions. Image processing was used to determine turbidity levels with high accuracy.
2. Another study proposed using a digital camera combined with a fuzzy neural network algorithm to measure turbidity accurately and efficiently based on color component analysis of images.
3. Additional studies explored using smartphone cameras and mobile apps to estimate turbidity and other water quality indicators by analyzing reflective light properties captured in images.
Turbidity poster presentation final editKala Drake
Turbidity is caused by particles suspended in water that scatter light, making the water appear cloudy. For a school project, students developed methods to measure turbidity without expensive laboratory equipment. They created a series of standard solutions by mixing specific ratios of barium chloride and sulfuric acid, known as McFarland standards, which produce consistent levels of turbidity. The students then calibrated a simple turbidity tube and a spectrophotometer using the McFarland standards and measured turbidity in pond water samples. Both methods produced similar results, with the tube suitable for field use but less precise and the spectrophotometer more accurate but requiring a lab setting.
This document discusses the verification process for contact lenses. It has two main stages - laboratory and clinical. In the laboratory, lenses are checked to ensure their parameters match what was ordered. Clinically, lenses should be verified upon receipt to ensure the correct lens was dispensed. Parameters like radius of curvature, diameters, thickness and power must be measured for both rigid and soft contact lenses using various techniques and instruments. On-eye verification is also important to assess fit and comfort. The goal of verification is to ensure patients receive high quality lenses that meet specifications and provide good vision.
qualification of instrument(UV & FTIR) BY Bhumi Suratiya, M.Pharm sem 2.pptxBhumiSuratiya
So, Here it's presentation on Qualification of instrument(UV & FTIR) BY Bhumi Suratiya, M.Pharm sem 2. Qualification of analytical instruments. it also includes design qualifications (DQ), Installation qualification(IQ)
Operational qualification(OQ)
Performance qualification(PQ).
Research Poster - ISPE Boston Area Student Competition WinnerConnor Williams
The integration of process analytical technologies (PAT) is paramount for bioprocess intensification. An NIR-based absorption photometer was developed to enable real-time monitoring of optical density in yeast fermentation cultures. Studies showed the photometer provided accurate measurements of optical density above 2.0 and could be used to automate nutrient feeds based on cell density measurements. Below an optical density of 2.0, readings were less accurate due to fluctuations from bubbles. Correlations between photometer readings and offline optical density measurements allowed modeling of culture growth in real-time.
Online Monitoring of Wastewater in Common Effluent Treatment Plant using UV-V...Mudasir Gulzar
The document discusses online monitoring of wastewater parameters like COD and TSS in a Common Effluent Treatment Plant using UV/VIS spectroscopy. It describes how a local calibration procedure using samples from the specific plant can provide more accurate readings compared to a global calibration. Maintaining proper cleaning frequencies for the monitoring equipment is also important for avoiding measurement drift. The results showed that UV/VIS analyzers can reliably and accurately measure COD and TSS levels with a local calibration approach.
This document discusses non-destructive testing (NDT) methods, with a focus on visual inspection techniques. It defines NDT as examining materials and components without destroying them to find defects. Several NDT methods are described including visual inspection, liquid penetrant testing, magnetic particle testing, etc. Visual inspection can be unaided or aided using tools like magnifying mirrors, boroscopes, and robotic crawlers. Factors that influence visual testing like surface conditions, environment, and inspector fatigue are also covered. The document provides examples of visual inspection applications and lists advantages and limitations of various NDT methods.
TURBIDITY MEASUREMENT USING NIR DIGITAL CAMERAS AND GOOGLE EARTH ENGINE: A re...IRJET Journal
The document discusses several studies related to measuring water quality parameters like turbidity using digital imaging and image processing techniques. Specifically:
1. One study developed a method using two near-infrared cameras to capture scattered and transmitted light images when light passes through turbid solutions. Image processing was used to determine turbidity levels with high accuracy.
2. Another study proposed using a digital camera combined with a fuzzy neural network algorithm to measure turbidity accurately and efficiently based on color component analysis of images.
3. Additional studies explored using smartphone cameras and mobile apps to estimate turbidity and other water quality indicators by analyzing reflective light properties captured in images.
Turbidity poster presentation final editKala Drake
Turbidity is caused by particles suspended in water that scatter light, making the water appear cloudy. For a school project, students developed methods to measure turbidity without expensive laboratory equipment. They created a series of standard solutions by mixing specific ratios of barium chloride and sulfuric acid, known as McFarland standards, which produce consistent levels of turbidity. The students then calibrated a simple turbidity tube and a spectrophotometer using the McFarland standards and measured turbidity in pond water samples. Both methods produced similar results, with the tube suitable for field use but less precise and the spectrophotometer more accurate but requiring a lab setting.
This document discusses the verification process for contact lenses. It has two main stages - laboratory and clinical. In the laboratory, lenses are checked to ensure their parameters match what was ordered. Clinically, lenses should be verified upon receipt to ensure the correct lens was dispensed. Parameters like radius of curvature, diameters, thickness and power must be measured for both rigid and soft contact lenses using various techniques and instruments. On-eye verification is also important to assess fit and comfort. The goal of verification is to ensure patients receive high quality lenses that meet specifications and provide good vision.
qualification of instrument(UV & FTIR) BY Bhumi Suratiya, M.Pharm sem 2.pptxBhumiSuratiya
So, Here it's presentation on Qualification of instrument(UV & FTIR) BY Bhumi Suratiya, M.Pharm sem 2. Qualification of analytical instruments. it also includes design qualifications (DQ), Installation qualification(IQ)
Operational qualification(OQ)
Performance qualification(PQ).
Research Poster - ISPE Boston Area Student Competition WinnerConnor Williams
The integration of process analytical technologies (PAT) is paramount for bioprocess intensification. An NIR-based absorption photometer was developed to enable real-time monitoring of optical density in yeast fermentation cultures. Studies showed the photometer provided accurate measurements of optical density above 2.0 and could be used to automate nutrient feeds based on cell density measurements. Below an optical density of 2.0, readings were less accurate due to fluctuations from bubbles. Correlations between photometer readings and offline optical density measurements allowed modeling of culture growth in real-time.
Near infrared spectroscopy-Food analysisFoodtech mbg
Near-infrared spectroscopy uses the near-infrared region of the electromagnetic spectrum to analyze the chemical composition of food and other solid materials. Measurements in the near-infrared region from 700-2500 nm are used for quantitative analysis of foods. A major advantage is its ability to directly measure the composition of solid foods using diffuse reflection techniques without needing to prepare samples. Near-infrared spectroscopy is used extensively in the food industry to rapidly and non-destructively measure attributes like moisture, fat, protein and sugar content.
This document evaluates quality assurance and radiation safety procedures for ruthenium-106 plaque brachytherapy treatment of eye tumors. Leakage tests found radiation levels from plaques to be below limits. Radiation surveys found levels around the facility to be slightly above background. During procedures, dose rates to surgeons were 3.5 mR/hr at the wrist and 55 μR/hr at eye level. The maximum leakage near autoclaves used to sterilize plaques was 400 μR/hr at 5 cm, dropping to 80 μR/hr at 1 meter. Proper shielding, monitoring, and safety protocols were followed to ensure protection of patients, staff and the public.
IRJET - A Smartphone ALS based Syringe System for Colorimetric Detection of C...IRJET Journal
This document describes a study that developed a smartphone-based system for detecting creatinine levels using a syringe and detection module attached to the smartphone's ambient light sensor. The syringe contained reagents to perform the Jaffe reaction for creatinine and was used to inject samples into the detection module. Standards were used to create a calibration curve relating creatinine concentration to changes in light intensity measured by the ambient light sensor. Results from the smartphone system agreed with those from a conventional spectrophotometer. The system provides a low-cost point-of-care method for measuring creatinine levels.
The document discusses analytical and sampling methods used for cleaning validation in the pharmaceutical industry. It describes specific and non-specific analytical methods, such as HPLC and TOC, and the validation criteria for such methods including specificity, range, accuracy, and precision. The document also outlines different sampling techniques used to collect residues from surfaces for analysis, including direct surface sampling, swab sampling, rinse sampling, and placebo sampling. It provides details on how to properly perform each sampling method and factors to consider.
Eye Tracking Accuracy Comparison Test
SMI RED 250 vs.GazeFlow WebCam EyeTracker
Download Demo!
GazeRecorder: WebCam Eye Tracking for usability testing :
https://gazerecorder.com
GazePointer:
Control mouse cursor position with your eyes via webcam.
http://www.sourceforge.net/projects/gazepointer
GazeInsight Cloud eye tracking online
https://app.gazerecorder.com
GazeCloud API
https://api.gazerecorder.com
Radiation monitoring involves measuring radiation levels in workplaces, areas, and the environment. There are several types of radiation monitoring:
Workplace monitoring measures radiation dose rates, surface contamination, and airborne radioactivity where radiation sources are used. Individual monitoring tracks radiation doses received by workers through personal dosimeters. Area monitoring measures radiation levels at predefined locations around facilities to ensure safety. Environmental monitoring routinely samples media like food, water and air near facilities to measure radiation levels and ensure public safety.
The document discusses the capabilities of new generation near-infrared (NIR) systems for analyzing grains and flours. It describes how newer NIR systems using photodiode arrays can more accurately measure additional quality parameters beyond just protein, moisture and ash contents, such as gluten content, water absorption, and starch damage. This allows millers to better optimize flour production processes in real-time without waiting for lab results.
6th Training Course on Radiation Protection for Radiation Workers and RCOs of BAEC, Medical Facilities & Industries
Training Institute, AERE, Savar, BAEC
24 - 29 October 2021
This document provides an overview of pharmaceutical inhalation technology. It discusses why inhalation is an effective drug delivery method, focusing on the lungs' ability to absorb molecules. Different dosage forms for inhalers are described, including metered dose inhalers, dry powder inhalers, and nebulizers. Key parameters for successful inhalers include reproducibility, purity, efficiency, and cost-effectiveness. Characterization techniques are outlined, such as measuring aerodynamic particle size distribution using cascade impactors to determine particle deposition in the lungs. Overall, the document covers the fundamentals of inhalation technology and characterization methods for developing effective inhaled pharmaceutical products.
1. The document discusses visual inspection as a non-destructive testing method for detecting discontinuities before they cause major problems.
2. It describes visual inspection using the naked eye as direct unaided visual testing, and using optical aids like magnifying glasses as direct aided visual testing.
3. Factors that can affect visual inspection are discussed, including surface condition, physical conditions, environmental factors, and mental fatigue.
Inspecting facilities with infrared imaging can improve productivity, safety, and employee morale in three key ways:
1) Infrared inspections can locate potential problems before new systems start up, helping with system testing and lowering equipment replacement costs.
2) Infrared inspections allow maintenance priorities to be set and the quality of repairs to be evaluated, extending equipment life.
3) By enabling predictive maintenance through early problem detection, infrared inspections create a more efficient maintenance program and a stable work environment, boosting employee morale.
This document discusses air pollution monitoring and different monitoring methods. It describes the need for well-planned monitoring to make rational decisions about environmental protection programs. Discrete sampling using manual methods are presented as a practical alternative for most monitoring objectives in India. High volume air samplers and respirable dust samplers are discussed as methods for ambient and workplace air quality monitoring. Continuous automatic instruments are better for surveillance but discrete sampling is more versatile and cost-effective for monitoring multiple locations and parameters.
Method Development and Validation : Laser diffraction particle size analyzer ...Md. Saddam Nawaz
The document provides guidance on method development and validation for laser scattering particle size distribution analysis. It discusses determining the appropriate measurement approach (dry vs. wet), locking down the refractive index, varying measurement settings to optimize results, and testing method reproducibility. The goals are to develop a reproducible method that tracks product performance using a structured approach and collecting data to support method choices. Available guidance documents on reproducibility criteria from ISO, USP, and EP are also reviewed. Steps discussed for method development include sampling techniques, choosing solvents, dispersion definitions, concentration considerations, and evaluating measurement duration, stability, pressure/ultrasound effects, and linearity.
Presentation ai hce 2017 bob chen updated-3.0Kartik Vora
This document summarizes the results of a study comparing airborne exposure monitoring for surrogates and actual APIs during pharmaceutical manufacturing processes. Personal and static air samples were taken for both a surrogate (mannitol) and an API during various unit operations. Exposures for the API were generally higher than the surrogate, likely due to differences in work practices. The study concluded that while surrogate monitoring can indicate particulate containment effectiveness, it may not accurately represent actual employee API exposures due to variability in properties and work practices. API exposure monitoring is needed to confirm particulate containment and exposure levels. Work practices were found to significantly impact personal exposures and differences between surrogate and API results.
The document discusses some critical issues with air pollution monitoring that can affect the reliability of the data generated. It summarizes that both the monitoring equipment and personnel play a role in data quality. Specifically, it notes that monitoring instruments often are not calibrated frequently enough and personnel are often not adequately trained. It also discusses challenges with calibrating equipment in the field and suggestions for improving the calibration process, including developing portable calibration devices. Overall, it argues that unreliable data can result if conditions of both the monitoring equipment and personnel are not properly addressed.
The document discusses in-process quality control (IPQC) for parenteral products. IPQC involves controlling manufacturing procedures from raw materials to finished product release. Key IPQC tests for parenterals include clarity testing to detect particulate matter using visual or automated methods, leakage testing of packaging, testing fill volume and pH, and sterility testing. The document outlines various physical, chemical, biological, and microbiological tests performed during IPQC to ensure product quality.
The document discusses in-process quality control (IPQC) for parenteral products. IPQC involves controlling manufacturing procedures from raw materials to finished product release. Key IPQC tests for parenterals include clarity testing to detect particulate matter using visual or automated methods, leakage testing of packaging, testing fill volume and pH, and sterility testing. The document outlines various physical, chemical, biological, and microbiological tests performed during IPQC to ensure product quality.
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptxMAGOTI ERNEST
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
Near infrared spectroscopy-Food analysisFoodtech mbg
Near-infrared spectroscopy uses the near-infrared region of the electromagnetic spectrum to analyze the chemical composition of food and other solid materials. Measurements in the near-infrared region from 700-2500 nm are used for quantitative analysis of foods. A major advantage is its ability to directly measure the composition of solid foods using diffuse reflection techniques without needing to prepare samples. Near-infrared spectroscopy is used extensively in the food industry to rapidly and non-destructively measure attributes like moisture, fat, protein and sugar content.
This document evaluates quality assurance and radiation safety procedures for ruthenium-106 plaque brachytherapy treatment of eye tumors. Leakage tests found radiation levels from plaques to be below limits. Radiation surveys found levels around the facility to be slightly above background. During procedures, dose rates to surgeons were 3.5 mR/hr at the wrist and 55 μR/hr at eye level. The maximum leakage near autoclaves used to sterilize plaques was 400 μR/hr at 5 cm, dropping to 80 μR/hr at 1 meter. Proper shielding, monitoring, and safety protocols were followed to ensure protection of patients, staff and the public.
IRJET - A Smartphone ALS based Syringe System for Colorimetric Detection of C...IRJET Journal
This document describes a study that developed a smartphone-based system for detecting creatinine levels using a syringe and detection module attached to the smartphone's ambient light sensor. The syringe contained reagents to perform the Jaffe reaction for creatinine and was used to inject samples into the detection module. Standards were used to create a calibration curve relating creatinine concentration to changes in light intensity measured by the ambient light sensor. Results from the smartphone system agreed with those from a conventional spectrophotometer. The system provides a low-cost point-of-care method for measuring creatinine levels.
The document discusses analytical and sampling methods used for cleaning validation in the pharmaceutical industry. It describes specific and non-specific analytical methods, such as HPLC and TOC, and the validation criteria for such methods including specificity, range, accuracy, and precision. The document also outlines different sampling techniques used to collect residues from surfaces for analysis, including direct surface sampling, swab sampling, rinse sampling, and placebo sampling. It provides details on how to properly perform each sampling method and factors to consider.
Eye Tracking Accuracy Comparison Test
SMI RED 250 vs.GazeFlow WebCam EyeTracker
Download Demo!
GazeRecorder: WebCam Eye Tracking for usability testing :
https://gazerecorder.com
GazePointer:
Control mouse cursor position with your eyes via webcam.
http://www.sourceforge.net/projects/gazepointer
GazeInsight Cloud eye tracking online
https://app.gazerecorder.com
GazeCloud API
https://api.gazerecorder.com
Radiation monitoring involves measuring radiation levels in workplaces, areas, and the environment. There are several types of radiation monitoring:
Workplace monitoring measures radiation dose rates, surface contamination, and airborne radioactivity where radiation sources are used. Individual monitoring tracks radiation doses received by workers through personal dosimeters. Area monitoring measures radiation levels at predefined locations around facilities to ensure safety. Environmental monitoring routinely samples media like food, water and air near facilities to measure radiation levels and ensure public safety.
The document discusses the capabilities of new generation near-infrared (NIR) systems for analyzing grains and flours. It describes how newer NIR systems using photodiode arrays can more accurately measure additional quality parameters beyond just protein, moisture and ash contents, such as gluten content, water absorption, and starch damage. This allows millers to better optimize flour production processes in real-time without waiting for lab results.
6th Training Course on Radiation Protection for Radiation Workers and RCOs of BAEC, Medical Facilities & Industries
Training Institute, AERE, Savar, BAEC
24 - 29 October 2021
This document provides an overview of pharmaceutical inhalation technology. It discusses why inhalation is an effective drug delivery method, focusing on the lungs' ability to absorb molecules. Different dosage forms for inhalers are described, including metered dose inhalers, dry powder inhalers, and nebulizers. Key parameters for successful inhalers include reproducibility, purity, efficiency, and cost-effectiveness. Characterization techniques are outlined, such as measuring aerodynamic particle size distribution using cascade impactors to determine particle deposition in the lungs. Overall, the document covers the fundamentals of inhalation technology and characterization methods for developing effective inhaled pharmaceutical products.
1. The document discusses visual inspection as a non-destructive testing method for detecting discontinuities before they cause major problems.
2. It describes visual inspection using the naked eye as direct unaided visual testing, and using optical aids like magnifying glasses as direct aided visual testing.
3. Factors that can affect visual inspection are discussed, including surface condition, physical conditions, environmental factors, and mental fatigue.
Inspecting facilities with infrared imaging can improve productivity, safety, and employee morale in three key ways:
1) Infrared inspections can locate potential problems before new systems start up, helping with system testing and lowering equipment replacement costs.
2) Infrared inspections allow maintenance priorities to be set and the quality of repairs to be evaluated, extending equipment life.
3) By enabling predictive maintenance through early problem detection, infrared inspections create a more efficient maintenance program and a stable work environment, boosting employee morale.
This document discusses air pollution monitoring and different monitoring methods. It describes the need for well-planned monitoring to make rational decisions about environmental protection programs. Discrete sampling using manual methods are presented as a practical alternative for most monitoring objectives in India. High volume air samplers and respirable dust samplers are discussed as methods for ambient and workplace air quality monitoring. Continuous automatic instruments are better for surveillance but discrete sampling is more versatile and cost-effective for monitoring multiple locations and parameters.
Method Development and Validation : Laser diffraction particle size analyzer ...Md. Saddam Nawaz
The document provides guidance on method development and validation for laser scattering particle size distribution analysis. It discusses determining the appropriate measurement approach (dry vs. wet), locking down the refractive index, varying measurement settings to optimize results, and testing method reproducibility. The goals are to develop a reproducible method that tracks product performance using a structured approach and collecting data to support method choices. Available guidance documents on reproducibility criteria from ISO, USP, and EP are also reviewed. Steps discussed for method development include sampling techniques, choosing solvents, dispersion definitions, concentration considerations, and evaluating measurement duration, stability, pressure/ultrasound effects, and linearity.
Presentation ai hce 2017 bob chen updated-3.0Kartik Vora
This document summarizes the results of a study comparing airborne exposure monitoring for surrogates and actual APIs during pharmaceutical manufacturing processes. Personal and static air samples were taken for both a surrogate (mannitol) and an API during various unit operations. Exposures for the API were generally higher than the surrogate, likely due to differences in work practices. The study concluded that while surrogate monitoring can indicate particulate containment effectiveness, it may not accurately represent actual employee API exposures due to variability in properties and work practices. API exposure monitoring is needed to confirm particulate containment and exposure levels. Work practices were found to significantly impact personal exposures and differences between surrogate and API results.
The document discusses some critical issues with air pollution monitoring that can affect the reliability of the data generated. It summarizes that both the monitoring equipment and personnel play a role in data quality. Specifically, it notes that monitoring instruments often are not calibrated frequently enough and personnel are often not adequately trained. It also discusses challenges with calibrating equipment in the field and suggestions for improving the calibration process, including developing portable calibration devices. Overall, it argues that unreliable data can result if conditions of both the monitoring equipment and personnel are not properly addressed.
The document discusses in-process quality control (IPQC) for parenteral products. IPQC involves controlling manufacturing procedures from raw materials to finished product release. Key IPQC tests for parenterals include clarity testing to detect particulate matter using visual or automated methods, leakage testing of packaging, testing fill volume and pH, and sterility testing. The document outlines various physical, chemical, biological, and microbiological tests performed during IPQC to ensure product quality.
The document discusses in-process quality control (IPQC) for parenteral products. IPQC involves controlling manufacturing procedures from raw materials to finished product release. Key IPQC tests for parenterals include clarity testing to detect particulate matter using visual or automated methods, leakage testing of packaging, testing fill volume and pH, and sterility testing. The document outlines various physical, chemical, biological, and microbiological tests performed during IPQC to ensure product quality.
Similar to A Risk-Based Approach to Cleaning.pdf (20)
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptxMAGOTI ERNEST
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...Leonel Morgado
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
Current Ms word generated power point presentation covers major details about the micronuclei test. It's significance and assays to conduct it. It is used to detect the micronuclei formation inside the cells of nearly every multicellular organism. It's formation takes place during chromosomal sepration at metaphase.
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...AbdullaAlAsif1
The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
The binding of cosmological structures by massless topological defectsSérgio Sacani
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
The ability to recreate computational results with minimal effort and actionable metrics provides a solid foundation for scientific research and software development. When people can replicate an analysis at the touch of a button using open-source software, open data, and methods to assess and compare proposals, it significantly eases verification of results, engagement with a diverse range of contributors, and progress. However, we have yet to fully achieve this; there are still many sociotechnical frictions.
Inspired by David Donoho's vision, this talk aims to revisit the three crucial pillars of frictionless reproducibility (data sharing, code sharing, and competitive challenges) with the perspective of deep software variability.
Our observation is that multiple layers — hardware, operating systems, third-party libraries, software versions, input data, compile-time options, and parameters — are subject to variability that exacerbates frictions but is also essential for achieving robust, generalizable results and fostering innovation. I will first review the literature, providing evidence of how the complex variability interactions across these layers affect qualitative and quantitative software properties, thereby complicating the reproduction and replication of scientific studies in various fields.
I will then present some software engineering and AI techniques that can support the strategic exploration of variability spaces. These include the use of abstractions and models (e.g., feature models), sampling strategies (e.g., uniform, random), cost-effective measurements (e.g., incremental build of software configurations), and dimensionality reduction methods (e.g., transfer learning, feature selection, software debloating).
I will finally argue that deep variability is both the problem and solution of frictionless reproducibility, calling the software science community to develop new methods and tools to manage variability and foster reproducibility in software systems.
Exposé invité Journées Nationales du GDR GPL 2024
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skills
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ESPP presentation to EU Waste Water Network, 4th June 2024 “EU policies driving nutrient removal and recycling
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