Sughandha, a 4 year 8 month old girl, presented with a 3 day history of cough and fever. She lives in a rural area in a large joint family with inadequate sanitation and hygiene. On examination, she had a pulse of 130/min and was diagnosed with upper respiratory tract infection. Her family lives in poor conditions with open defecation and untreated water. Recommendations included treatment for her infection and improving her family's living conditions, hygiene, diet, and access to healthcare.
Clinico-social case format for diarrhoea, demographic details, chief complaint, history of presenting illness, treatment history, past history, brief antenatal history, birth historym postnatal history, developmental history, nutrition history, immunisation history, personal history, family history, socio-economic / psycho-social history, environmental history, KAP about the disease, general examination, systemic examination, local examiantion, investigations, summary and case management.
Clinico-social case format for diarrhoea, demographic details, chief complaint, history of presenting illness, treatment history, past history, brief antenatal history, birth historym postnatal history, developmental history, nutrition history, immunisation history, personal history, family history, socio-economic / psycho-social history, environmental history, KAP about the disease, general examination, systemic examination, local examiantion, investigations, summary and case management.
RMNCH+A approach has been launched in 2013 and it essentially looks to address the major causes of mortality among women and children as well as the delays in accessing and utilizing health care and services. The RMNCH+A strategic approach has been developed to provide an understanding of ‘continuum of care’ to ensure equal focus on various life stages.
The RMNCH+A appropriately directs the States to focus their efforts on the most vulnerable population and disadvantaged groups in the country. It also emphasizes on the need to reinforce efforts in those poor performing districts that have already been identified as the high focus districts.
Important maternal and child health parameters to evaluate quality care for the special group. Includes MMR, IMR, SBR, PMR, NMR, PNMR, U5MR. Practical class for UG 4th sem
RMNCH+A approach has been launched in 2013 and it essentially looks to address the major causes of mortality among women and children as well as the delays in accessing and utilizing health care and services. The RMNCH+A strategic approach has been developed to provide an understanding of ‘continuum of care’ to ensure equal focus on various life stages.
The RMNCH+A appropriately directs the States to focus their efforts on the most vulnerable population and disadvantaged groups in the country. It also emphasizes on the need to reinforce efforts in those poor performing districts that have already been identified as the high focus districts.
Important maternal and child health parameters to evaluate quality care for the special group. Includes MMR, IMR, SBR, PMR, NMR, PNMR, U5MR. Practical class for UG 4th sem
Apnea (AP-nee-ah) is a pause in breathing that lasts 20 seconds or longer for full-term infants. If a pause in breathing lasts less than 20 seconds and makes your baby's heart beat more slowly (bradycardia) or if he turns pale or bluish (cyanotic), it can also be called apnea.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
3. DEMOGRAPHIC DATA
• Name- SUGHANDHA
• Age- 4 years 8 Month
• Sex- Female
• Religion- Hindu
• Father’s name & Age- Guddu Ram 28yrs
Mother’s name & Age- Prabhawati Devi 25yrs
• Address- Wabhanpura, Phulwarisharif,Patna
4. Family profile
• Type of family-
THREE
GENERATION family
• Total members- 9
• 4 children in family
• Habitation- Rural
PEDIGREE
5. Family profile
cont….
EDUCATION:
Father- 8th standard
Mother- 8th standard
OCCUPATION:
Father- Driver
Mother- ASHA worker
FAMILY INCOME:
Guddu Ram=2000/-
Prabhawati Devi=5000/-
Total 7000/-
6. Family profile
cont….
• SOCIOECONOMIC STATUS:
According to Kuppuswamy’s Socioeconomic Status
Scale (Modified)-
1.Education Score (middle school ) = 3
2.Occupation Score (semi-skilled) = 3
3.Income Score = 3
Total Score= 9
Socioeconomic Class- Upper Lower
7. Family profile
cont….
LIVING CONDITIONS:
-semi pukka house with 3 living room,
• NO bathroom; toilet; kitchen
• Food cooked in veranda on chullah .;area accessible to children
• Defaecation in open space.
• Natural ventilation- inadequate
• Natural lighting- inadequate
• Artificial lighting source- Electricity, kerosene lamp
• General cleanliness of rooms- inadequate
• Overcrowding –
• Room wise –present
• Social –absent
• Area wise-?
8. Family profile
cont….
• Source of water supply- hand pump(35feet)
• Storage utensils- uncovered
• Refuse disposal:
• -thrown near the house
• Water logging in nearby areas & open drains
• Personal hygiene:
• Bathing habits- daily
• Nails-unclean
• brushing teeth- daily (once)
• Hand washing practices: after defecation-ash/mud
• No handwashing before cooking or taking meal
•
9. Family profile
cont….
• Guddu Ram father of Sugandha is alcoholic and tobacoo
chewer.
• Amount of alcohol intake =150ml .
• Frequency= Daily .
• Amount of tobacco intake=3-4 pack /per day.
• No contraceptive measures taken
11. History of present illness -
COUGH
• Duration 3 days
• Gradual onset
• Brassy in character
• No whooping
• Productive in nature
• progressive increase in
frequency and severity
• Initially 5-6 times a day
throughout the day.
• No precipitating factor
• Aggravating factor- lying
down
• Relieving factor –sitting
,drinking water
• No diurnal variation
• Accompanied with
running nose.
• No associated pain
12. History of present illness -
COUGH
- Sputum
- yellow in colour
- Amount scanty
- No foul taste or odour
- No blood present
13. HISTORY OF PRESENT
ILLNESS cont.
FEVER-
- Duration 3 days
- Acute in onset
- Remittent in character
- Frequency 1-2 times a day
- Progressive increase in intensity
- Initially mild now moderate (101F)
- Accompanied with rigours
- No chills
- Relieved on medication
14. PAST HISTORY
• Similar episodes of fever and cough in past
• No history of – Pneumonia, Tuberculosis, Malaria, Kala-azar,
Jaundice, Asthma
• No past surgical history
15. PERINATAL
HISTORY
• Birth Date- 7 September 2010
Pregnancy was not booked
ANC
• No antenatal care was given.
• No IFA tablets taken
• TT vaccine administered
• Indiscriminate use of drugs for headache ,vomiting etc
• No USG
• no radiation exposure
16. PERINATAL
HISTORY
• First trimester- suffered from hyperemesis
gravidarum
• Rest trimesters uneventful
• Labour was uneventful
• Normal vaginal, term delivery at PHC, Phulwarisarif
ON 7TH SEPTEMBER 2010
17. PERINATAL HISTORY cont.
• Immediate postnatal & neonatal periods were uneventful
• Cried just after birth
• Birth weight- 3 kg
• Breast fed within 1 hr
19. GROSS MOTOR MILESTONES
• Started sitting at age of 6 months(6-8months )
• Climbed upstairs at age of 9months (10 months )
• Started walking at age of 13 month (12-15 month )
• started jumping and walking with both legs at age around
2year(2year)
• Started hopping and skipping step on coming downstairs at age of
4year
20. FINE MOTOR MILESTONE
• Started holding objects at age of 4month(3 month)
• Stated holding objects with thumb at age of 9 month (7-12 month
)
• Started eating by it self at age of 17 month (15 month )
• Started over writing at age of 2years(2year )
• Self dressing at age of 3year (3year)
• Button unbutton copy square cross at age of 4 year
21. Social and adaptive
milestones
• Started giving social and interactive smile at 2.5 months(2
months)
• Hand regard ; recognising mother at 3months(3 months)
• Spoke monosyllables at 7 months(6 months)
• Spoke disyllables at 8.5 months(9 months)
• Could make small sentences 2 years(normal)
• Normal speech ,asking questions at 3 years(normal)
• Could tell story ,recite poem at 4 years(normal)
22. Dietary history
• Child was exclusively breast fed till 6 months of age
• Complementary feeding started after 6 months
Daily calorie requirement for child= 1350 kcal
Daily protein requirement for child= 20.1 g
23. Dietary history cont….
• Calorie deficit= 1350-1132.5
=217.5 kcal
• Total protein intake= 29.15 gram
24. DIETARY PLAN
TIME FOOD ITEM AMOUNT CALORIES IN
KCal
PROTEIN IN
GRAMS
6 30 am Roti
Boiled egg
1
1/4
85
22.5
2.95
3.25
7 am Tea
bread
1 cup
1 slice
75
85
0.9
2.95
8 am Rice
dal
½ katori each 85
100
1.7
2.5
12 30 pm Rice
dal
½ katori each 85
100
1.7
2.5
2 00 pm Mango
sattu
1(medium)
1 tablespoon
160
90
2.0
5.0
3 30 pm rice ½ katori 85 1.7
5 ;30 pm Potato chips
Lays classic
1
five rs pack
160 2
TOTAL 1132.5 29.15
25. Immunization history
Well immunised for age
sughandha age-4 years 8 months, female
BCG
OPV-0
Hepatitis B-0
7/09/2010
DPT-1(6 weeks)
OPV-1
Hepatitis B
23/11/2010
DPT-2(10 weeks)
OPV 2
Hepatitis B-2
20/01/2011
DPT-3(14 weeks)
OPV 3
Hepatitis B-3
1/03/2011
Measles(9 months)
Vit A
19/6/2011
Dpt booster
Measles
Opv booster
12/1/2012
26. FAMILY HISTORY
• No history of any stillbirth, miscarriage or childhood death in
family
• No history of tuberculosis in family
grandfather, grandmother and father suffer from filariasis.
27. PERSONAL HISTORY
• Mixed Diet
• Normal sleep pattern (8-10 hr)
• Normal bladder & bowel habit
• No history of blood transfusion
• No known drug allergy
28. General Appearance(subjective)
• Appears to be acutely ill
• Able to speak a normal-length sentence without stopping to
take a breath
• Character of cry – hoarse
• Activity level - moderate
• Mental status -well oriented to time, place, and person
• Emotional reaction towards parent was positive and towards
examiner was negative
• Hygiene –inadequate
29. GENERAL
EXAMINATION
• Afebrile
• Pulse -130/ min ,regular , Adequate in volume ,synchronous
• Pallor- present
• Icterus- absent
• Cyanosis- absent
• No clubbing
• No pedal edema
• No thyroid enlargement.
30. REPIRATORY SYSTEM
• INSPECTION-
• shape of chest –circular
• Bilaterally symmetrical
• Trachea central in position
• Trail sign absent
• No drooping of shoulders
• No localised bulge/retraction
• Movement- abdominothoracic
• Symmetrical range of movements on both sides
• No suprasternal ,intercostal or subcostal recessions
31. Palpation
• No tenderness
• Tracheal position - midline
• Chest wall not tender
• Crepitus – absent
• Spinal abnormality- absent
• Nodes (axillary, supraclavicular, cervical)- not palpable
• No masses felt
• apical beat- in 4th inter costal space along midclavicular line
33. Auscultation
• Normal vesicular sound heard over chest
• Intensity of breath sounds normal
• Vocal resonance- symmetrical on both sides
• No pleural rub
• No added sound
34. Systemic examination
CIRCULATORY SYSTEM-
• S1 and S2 heard , no added sound , no murmur
ABDOMINAL-
• scaphoid in shape umbilicus was central in position ;everted ,
soft, non tender , no palpable mass ,no palpable organomegaly.
35. Anthropometric assessment
WEIGHT
• Weight of child=18.3 kg
• Weight for age= (Age in yrs x 2) + 8 kg
= (5 x 2) + 8
=18 kg
HEIGHT
• Height of child=102cm
• Height for age=(age in years x 6)+77
• = (5 x 6)+77
=107 cm
102/107 x100=95.32%
36. Anthropometric assessment
• Head circumference=49cm
(Normal for age- 48.5-51.5 cm)
• Mid upper arm circumference =17cm
(Normal for age- 17cm)
37. DIAGNOSIS
• A 5yr old girl Sugandha daughter of Guddu Ram and
Prabhawati Devi resident of Wabhanpura is suffering from
cough and fever since 3 days. This is probably a case of URTI.
39. LIVING CONDITIONS
• NO bathroom; toilet; kitchen
• Defaecation in open space
• Natural ventilation- inadequate
• Natural lighting- inadequate
• General cleanliness of rooms- inadequate
• Overcrowding –present
40. • source of water supply- hand pump(35feet)
• storage utensils- uncovered
REFUSE DISPOSAL:-
• Thrown near the house
• Water logging in nearby areas & open drains personal
PERSONEL HYGEINE
• Nails-unclean
• Hand washing practices: After defecation-ash/mud
• No handwashing Before cooking or taking meal
41. SOCIAL AND REPRODUCTIVE
• Lack of family planning.
• Alcohol and tobacco addiction of father .
• Domestic violence due to desire for a male child
• lack of awareness about antinatal care
42. CURE AND REMEDIES
Medical
treatment for the current medical conditions of
sughandha and other family members.
LIVING CONDITIONS
• toilet should be constructed.in house.
• Correction of ventilation and lighting.
• General cleanliness of rooms should be ensured.
• correction of overcrowding.
43. DISEASE
LOW INCOME
DESIRE FOR
MALE CHILD
LOWER
IMMUNITY
IMPROPER
SEWAGE SYSTEM
DIRTY
SURROUNDINGS
OVERCROWDIN
G
STRESS IN
FAMILY
MALNUTRITION
MORE NO Of
CHILDREN
LACK OF
AWARENESS
ALCOHOLISM
POOR CHILD
CARE
LACK OF
TOILET
IMPROPER
HYGEINE
LOW
EDUCATIO
N
44. • source of clean water should be ensured.
• storage utensils should be kept covered.
REFUSE DISPOSAL:-
• Should be disposed off properly.
• Correction of Water logging
PERSONEL HYGEINE
• Proper cutting of nails
• Hand washing practices: should be followed.
45. RECOMMENDED DIETARY
PLAN
TIME FOOD ITEM AMOUNT CALORIES IN
KCal
PROTEIN IN
GRAMS
6 30 am Roti
Boiled egg
1
1/4
85
22.5
2.95
3.25
7 am Tea
bread
1 cup
1 slice
75
85
0.9
2.95
8 am Rice
dal
½ katori each 85
100
1.7
2.5
12 30 pm Rice
dal
½ katori each 85
100
1.7
2.5
2 00 pm Mango
sattu
1
1 tablespoon
160
90
2.0
5.0
3 30 pm rice 2 85 1.7
5 ;30 pm Potato chips
Lays classic
1
five rs pack
160 2
TOTAL 1132.5 29.15
2 slice
6 pm Roti
sabji
1 pc
½ katori
85
85
2.95
1.5
5.9170
1387.5 36.55
46. SOCIAL AND REPRODUCTIVE
• family planning should be ensured,if not proper ANC should
be ensured in subsequent pregnancy.
• De addiction of father .
• Counselling about desire of a male child.
49. Types of families
• Nuclear-married couple and their children still regarded
as dependents
• joint/extended-
• Three generation family-people of three generations
living together.
50. • Mid arm cicumference- 9-11 at birth, 16 at 1yr then
negligible(0.25cm/yr) so at 5 years it equals
• 16+4*0.25
• =16+1
• = 17 cm
BACK TO MAIN
51. • VENTILATION
• FRESH AIR SUPPLY OF 3,000
C.FT/PERSON/HOUR(DE CHAUMONT)
• ADEQUATE CROSS VENTILATION SHOULD BE
MAINTAINED
• DOOR AREA +WINDOW AREA+VENTILATOR AREA
SHOULD BE ATLEAST 2/5TH OF TOTAL FLOOR AREA.
52. Types of fever
• Continuous-when body temperature never touches
normal and daily fluctuations are less then than 1 degree
celcius
• Remittent-daily fluctuations exceeding 2 degree celcius
• Intermittent-temperature may touch or remain normal
daily(quotidian),every alternate day (tertian) or after
every two days (quartan)
54. • Relation to posture
• Occurs in suppurative lung disease.
• lung abscess: on lying on the healthy side
• bronchiectasis: on leaning forwards.
• In bronchitis ,wheezing and congestive heart failure
cough is worse on lying down.
58. • Timing of cough
• At night: bronchial asthma & Left ventricular failure.
• Early morning cough: smokers.
• Episodic: Asthma
59. overcrowding
• Colds, asthma, influenza and diarrhoea
• Studies in New Zealand (Kearns et al 1992), Jakarta
(Clauson-Kaas et al 1997) and England (Martin
• 1976) gathered data through self-report and concluded
that coughs, colds, asthma, influenza and diarrhoea are
associated with household size and number of children
per household.
60. • Sex separation- owercrowding is considered to exist if 2
persons above 9 years of age not husband and wife,of
opposite sexes are obliged to sleep in the same room.
62. Trail sign
• In a child with marked tracheal displacement ,clavicular
head of the sternomastoid muscle is pushed forward as
a visible swelling on the displaced side.
63. • Marked suprasternal recessions are suggestive of
narrowing or obstruction of upper airways eg acute
laryngotracheobronchitis etc
64. CRY
It is the signal of discomfort ,boredom or hunger.
• High pitched cry-cerebral irritation and raised ICT
• In arthritis, osteomyelitis, abscess ,peritonitis-crying
become worse on picking up
• Hoarse crying is a feature of excessive crying-cretinism
,laryngitis ,laryngotracheobronchitis ,paralysis of left
recurrent laryngeal nerve
65. Hyperemesis gravidarum
• It is a severe type of vomiting of pregnancy which has
got deleterious effect on the health of the mother and/or
incapacities her in day to day activities.
66. roti
• 100 g of atta =350 kcal
• therefore
• 25 g atta = 350/4=85 kcal
• Likewise protien =2.95
kcal
• Total atta used per day by
the family=500 g
• Total numbers of rotis
made per day =20
• Atta /roti=500/20 =25g
67. VENTILATION
• FRESH AIR SUPPLY OF 3,000
C.FT/PERSON/HOUR(DE CHAUMONT)
• ADEQUATE CROSS VENTILATION SHOULD BE
MAINTAINED
• WINDOW AREA SHOULD BE 1/5TH OF FLOOR AREA
• DOOR AREA +WINDOW AREASHOULD BE ATLEAST
2/5TH OF TOTAL FLOOR AREA.
68. OVERCROWDING
Area (in sq. metre) No. of persons
11 or more 2 persons
9 to 10 1.5 persons
7 to 9 1 person
5 to 7 0.5 person
Under 5 Nil
•The WHO accepted standards for floor space are as follows. A baby under 12 months
is not counted, and children between 1 to 10 years are counted as half a unit.
69. ANC
• Generally check up is done at interval of 4 week for 28
weeks at interval of 2 week for 36weeks.
• But according to WHO 4 visit in developing countries can
be sufficient in pregnancy
70. Classification
of malnutrition by IAP
Weight for age Grade of malnutrition
>80% Normal
71-80% Grade 1
61-70% Grade 2
51-60% Grade 3
<50% Grade 4
71. Weight for height Nutritional status
>90% Normal
85-90% Borderline
75-80% Moderate
<75% Severe
72. Head circumference to age
Age Circumference (in cms)
1 month 32-35.5
6month 40-43.5
1year 43.5-46.5
2year 45.5-49.5
3year 46.8-5
4year 47.5-50.5
5year 48.1-51.5
73. Hyperemesis gravidarum
• It is a severe type of vomiting of pregnancy which has
got deleterious effect on the health of the mother and/or
incapacities her in day to day activities.
Low carbohydrate reserve
Hyperemesis gravidarum