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Squamous Cell
Carcinoma
Squamous Cell Carcinoma:
 Affects squamous epithelial tissue
 Squamous cells are large and flattened and
cover linings such as: lung, mouth,
oesophagus and
Signs and Symptoms:
 Often asymptomatic
 Ulcer or reddish plaque that grows slowly
 Presents as ulcerated lesion with hard raised
edges with thickening skin, surrounding
erythema – hard nodules ulcerate
 Intermittent bleeding from tumour
SCC…….
 SCC’s tend to arise in pre-malignant areas
 Areas of chronic inflammation – solar keratosis,
burns, chronic ulcers, leucoplakia and Bowen’s
disorder
 Affects ear, lip, oral cavity, tongue, genitalia,
oesophagus, bladder and lungs
 Associated with HPV
Bowen’s Disease:
 SCC-in-situ. Slow-growing red brown scaly
plaque.
 Full thickness dysplasia which may progress
to SCC
 Rx = Cryotherapy, topical 5-fluorouracil or
photodynamic therapy
Risk Factors:
 Sunlight exposure
 Immunosupression
 GORD
 Tobacco
 Alcohol
 Betel nut
Management:
 Surgical excision = best  >4cm surgical
margin
 Photodynamic therapy: Application of
photosensitisers to target area – becomes
toxic when activated
 Topical chemotherapeutic agents – 5-
fluorouracil
 Radiotherapy
 Cutterage and electrodessication
86467621 squamous-cell-carcinoma
86467621 squamous-cell-carcinoma
86467621 squamous-cell-carcinoma

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86467621 squamous-cell-carcinoma

  • 2. Squamous Cell Carcinoma:  Affects squamous epithelial tissue  Squamous cells are large and flattened and cover linings such as: lung, mouth, oesophagus and
  • 3. Signs and Symptoms:  Often asymptomatic  Ulcer or reddish plaque that grows slowly  Presents as ulcerated lesion with hard raised edges with thickening skin, surrounding erythema – hard nodules ulcerate  Intermittent bleeding from tumour
  • 4. SCC…….  SCC’s tend to arise in pre-malignant areas  Areas of chronic inflammation – solar keratosis, burns, chronic ulcers, leucoplakia and Bowen’s disorder  Affects ear, lip, oral cavity, tongue, genitalia, oesophagus, bladder and lungs  Associated with HPV
  • 5. Bowen’s Disease:  SCC-in-situ. Slow-growing red brown scaly plaque.  Full thickness dysplasia which may progress to SCC  Rx = Cryotherapy, topical 5-fluorouracil or photodynamic therapy
  • 6. Risk Factors:  Sunlight exposure  Immunosupression  GORD  Tobacco  Alcohol  Betel nut
  • 7. Management:  Surgical excision = best  >4cm surgical margin  Photodynamic therapy: Application of photosensitisers to target area – becomes toxic when activated  Topical chemotherapeutic agents – 5- fluorouracil  Radiotherapy  Cutterage and electrodessication