5- Use the following pedigree to determine the probability that IV-1 (.docx

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5. Use the following pedigree to determine the probability that IV-1 (child yet to be born) will have albinism. = has cystic fibrosis = = consanguineous marriage (cousins) 6. Using the following pedigrees, mark the genotype of each member and determine the mode of inheritance: B) C) I II III IV 1 2 0. Achondroplasia is an autosomal dominant form of dwarfism. People with achondroplasia are heterozygotes because carrying two copies of the dominant, mutant allele is fatal during embryogenesis. Two people with achondroplasia decide to start a family. A) Fill out a Punnett square for this couple. A) What is the probability that their first child born will be of average stature? B) What is the probability that this couple has two daughters with achondroplasia and one son of average stature in that order? C) What is the probability that this couple has two children with achondroplasia and one of average stature in any order? .

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Please give an explaination fir those quesions! 2 3 4 5 1. Aman with red.geen colour blindness is marned to a girl with normal colwir vision. What is the probaliliny that his childron will be coluur blind? 2. A boy has Dachenne muscular dyatrophy. His malemal uncle had died of museular dystrophy at the age of 21 years. What is the prohatility that this chilfs sibs will be affected? Assignments \#3 rocosive or S -kinked dominant and X -linked recesive inheritance. (Nole that a potigrte may be coempable with muve thas ane type of inheritance.) Assignnents \#4 Examine the pedieree frum a funily with a ernetic disease and anvv the questiens below: a. Does this pedigree isdicate autosonal deuninant, teoessive of set-link type of inheritance? Give reasons for your choice. b. Assuaning that B and b are the normal and mataut alleies respectively what would be the enenotypes of the individuals :II.1, 11 2 and III .3? c. Individual II. 3 requested genctic counselling. What is the probubility that her child woald be affected. Fxplain why. Assignments \#5 Susan's grandfather was deaf, and passed down a hercditary form of deafhess within Susan's family as shown in Figure. A. Is this mutation most likely to be dominant of recessive?? B. Is it carried on an autosome of a sex cluomosome? Why? C. A complete SNP analysis has been done for all of the 11 grandchildren (4 affected, and 7 unaffected) In comparing these 11 SNP result, how long a haplotype block would you expect to find around the critical \#ene? How might you deleet it? Assignments \#1 Distinguish between the following genetic terms: A. Gene and allele. B. Homozygous and heterozygous. C. Genotype and phenotype. D. Dominant and recessive. 1. A man with red-green colour blindness is married to a girl with normal colour vision. What is the probability that his children will be colour blind? 2. A boy has Duchenne muscular dystrophy. His maternal uncle had died of muscular dystrophy at the age of 21 years. What is the probability that this child's sibs will be affected? Explain, giving reasons, whether the following pedigrees are compatible with autosomal dominant, autosomal recessive or X -linked dominant and X -linked recessive inheritance. (Note that a pedigree may be compatible with more than one type of inheritance.) a. b. c. a. b. c. Assignments \#4 Examine the pedigree from a family with a genetic disease and ansv the questions below: a. Does this pedigree indicate autosomal dominant, recessive or sex-link type of inheritance? Give reasons for your choice. b. Assuming that B and b are the normal and mutant alleles respectively what would be the genotypes of the individuals: II.I, II.2 and III.3 ? c. Individual II. 3 requested genetic counselling. What is the probability that her child would be affected. Explain why. Susan's grandfather was deaf, and passed down a hereditary form of deafness within Susan's family as shown in Figure. A. Is this mutation most likely to be dominant or recessive? B. I.

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2. Cross a heterozygous tall and round seed pea plant with another heterozygous tall, round seed plant. 3. Cross a pea plant that is heterozygous for purple flowers and homozygous dominant for yellow seeds with a plant that is heterozygous for purple flowers and homozygous recessive for green seeds. Cross a plant that is heterozygous for round seeds and homozygous recessive for white flowers with a plant that is homozygous recessive for wrinkled seeds and heterozygous for purple flowers. Blood Type 5. What are the possible genotypes for each blood type? Phenotype Genotype Type A Type B Type AB Type O Juan has blood type A (I A I A ), his wife Lucia has blood type B (I B i). What are the possible genotypes of their children? Answer: A child has genotype of ii. If the child’s mother has a genotype of I A i, which blood types COULD represent the father? Dad Mom Baby ____ ____ ____ _____ ____ ____ Dad’s possible Genotypes Dad’s possible Phenotypes If a man with blood type O marries a woman with Type A, what would be the possible phenotypes of the offspring? 9. What are the possible genotypes of children born to a man that has the genotype I A i and a woman that has the genotype I A I B ? 10. What blood types can donate blood to (list all): a. A person with type A blood? b. A person with type O blood? c. A person with type AB blood? SEX LINKED TRAITS: 11. Rickets is a condition in which the bones become soft. Children with rickets develop bone deformities. A lack of vitamin D, calcium, and phosphorus in the diet usually cause this condition. One form of rickets, called vitamin D-resistant rickets, is caused by the recessive trait on the X chromosome . A mother who is heterozygous for rickets marries a man who HAS rickets. Normal= Rickets= Mom= Dad= a. What chance do they have of having a daughter with rickets ? b. What chance do they have of having a daughter that is a carrier of rickets ? c. What chance do they have of having a son who isnormal ? d. What chance do they have of having a child with rickets ? Baldness is a sex-linked trait. Sam wanted to know if he would be bald when he grew up. Therefore, Sam decided to find out how much of a chance he had of becoming bald. Through research, he found out that his mother is a carrier for the baldness trait and that his father has a normal gene for hair. a. What chance does Sam have of being bald when he gets older? b. What chance would of having a daughter who will be bald ? c. What chance would of having a daughter who is a carrier of the baldness trait ? In humans colorblindness is a sex-linked, recessive gene. Having normal vision is dominant. A woman who is heterozygous for colorblindness marries a man who is normal . .

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Blaine Kitchenware – Case Assignment MBA – Corporate Finance You have been hired as a consultant to Victor Dubinski, the CEO of Blaine Kitchenware. You are charged with putting together a written report with supporting numerical analysis that addresses the following items: 1. Is the current capital structure and payout policy for Blaine optimal? Explain and justify your conclusion. Use numbers whenever possible. 2. Should Blaine recommend a large share repurchase to the Board of Directors? What are the advantages and disadvantages of this action? Again, explain and justify your conclusions. Use numbers whenever possible. 3. Consider two specific share repurchase proposals: a. First Proposal i. Blaine will issue $50 million in new debt at an interest rate of 6.75% ii. Blaine will use $209 million of cash from its balance sheet iii. Blaine will use these two sources of cash to repurchase 14 million shares at $18.50/share. b. Second Proposal i. Blaine will issue $95 million in new debt at an interest of 6.875% ii. Blaine will use $209 million of cash from its balance sheet iii. Blaine will use the two sources of cash to repurchase 16 million shares at $19.00/share. c. Third Proposal i. Blaine will issue $156 million in new debt at 7.125% ii. Blaine will use $209 million of cash from its balance sheet iii. Blaine will use the two sources of cash to repurchase 18.5 million shares. d. How does a share repurchase affect Blaine? Consider the impact on items including (but not limited to) Blaine’s EPS, ROE, interest coverage, debt ratio, debt rating, the family’s ownership interest (proportion of shares outstanding) and the company’s cost of capital (WACC). e. What is your recommendation for the good of the company based on your analysis of the share repurchase options? Should they stay with the status quo, or go with one of the recapitalization options? BSC1005 Biology General Chapter 10 Patterns of Inheritance 1 Chapter 10: Patterns of Inheritance, Mendel Laws Multiple-Choice Questions 2) Which of the following statements best represents the theory of pangenesis developed by Hippocrates? A) Pregnancy is a spontaneous event, and the characteristics of the offspring are determined by the gods. B) Particles called pangenes, which originate in each part of an organism's body, collect in the sperm or eggs and are passed on to the next generation. C) Offspring inherit the traits of either the mother or the father, but not both. D) Fertilization of plants is dependent on an animal. E) Heritable traits are influenced by the environment and the behaviors of the parents. 3) Which of the following statements regarding hypotheses about inheritance is false? A) The theory of pangenesis incorrectly suggests that reproductive cells receive particles from somatic cells. B) Contrary to the theory of pangenesis, somatic cells do not influence eggs or sperm. C) The blending hypothesis does not explain how trait ...

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1. In a given plant, the yellow seed color allele (Y) is dominant to green seed color (y). Give the genotypic and phenotypic ratios for the following crosses? a. homozygous yellow x green b. heterozygous yellow x green c. heterozygous yellow x heterozygous yellow d. green x green 2. If two animals heterozygous for a single pair of genes are mated and have 276 offspring, how many would be expected to have the dominant genotype? 3. Two long-winged fies are mated. The offspring included 90 with long wings and 32 with short wings. Which phenotype is recessive? 4. A blood test reveals that a couple both have the sickle-cell trat. What is the probability of their producing a child with sickle-cell anemia? 5. A blood type A woman has a type B child. She accuses a type O man of being the father. Knowing genetics you are asked to give an opinion; do so. 6. Assume that human eye color is controlled by a single pair of alleles. A blue-eyed man, both of whose parents were bom brown-eyed, marries a brown-eyed woman whose father was blue-eyed and whose mother was brown-eyed. They have a blue-eyed child. Which are the genotypes of all individuals mentioned? 7. A red fruit, tall tomato plant RrTt, is crossed with a yellow-fruited dwarf plant ritt. What genotypes and phenotypes would be expected in the offispring? 8. What genotype and phenotype would be expected in the offspring if the cross in the previous problem had been RrTt x RrTt ?.

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A wild-type chromosome has the following segments: A B C middot D E F G H I An individual is heterozygous for the following chromosome mutation: A B C middot D H I How would the mutated and wild-type chromosomes pair in prophase I of meiosis? D E F G H of the wild-type chromosome will form a deletion loop. E F G of the wild-type chromosome will form a deletion loop. D E F G H of the wild-type chromosome will form an Inversion loop. E F G of the wild- type chromosome will form an inversion loop. Red-green color blindness is a human x-linked recessive disorder. A young man with a 47, XXY karyotype (Klinefelter syndrome) is color Wind. His 46, XY brother also is color blind. Both parents have normal color vision. Where did the no disjunction that gave rise to the young man with Klinefelter syndrome take place? Assume that no crossing over took place In prophase I of meiosis. Mother - meiosis I Mother - meiosis II Father - meiosis I Father - meiosis II Both parents Functional epidermal lies bull nose (JEB) Is a severe skin disorder that results in blisters over the entire body. The disorder is caused by autosomal recessive mutations at any one of three loci that help to encode lamina 5, a major component In the dermal-epidermal basement membrane. Leena Pulicine and colleagues described a male newborn who was born with JEB and died at 2 months of age (L. Pulkkinen et al. 1997. American Journal of Human Genetics 61:611-619); the child had healthy unrelated parents. Chromosome analysis revealed that the infant had 46 normal-appearing chromosomes. Analysis of DNA showed that his mother was heterozygous for a JEB-causing allele at the LAMB3 locus, which is on chromosome 1. The father had two normal alleles at this locus. DNA fingerprinting demonstrated that the male assumed to be the father had, In fact, conceived the child. Assuming that no new mutations occurred in this family, what might best explain the presence of an autosomal recessive disease in the child when the mother is heterozygous and the father Is homozygous normal? The infant inherited both copies of chromosome 1 from the mother, which is an example of unit parental disomic. The infant is monatomic for chromosome 1, which he received from his mother but did not receive a chromosome 1 from his father. Epitasis masked the disease phenotype in the father, but complementation of the parental alleles gave rise to a child with functional epidermal lies bull nose. The infant has tiresome 1, where he inherited two recessive alleles from his mother. A translocation between chromosome 1 and chromosome 22 generated a recessive phenotype. Plasmid DNA, like bacterial DNA: is circular. is single stranded. comes in homologous pairs. All of the above. None of the above. Solution 10. Answer is B. EFG of the wild type will form a deletion loop. Because EFG in one chromosome has no matching pair in other chromosome. So EFG loop will be formed and it will be removed. 13. Answer is A. Plasmid DNA like bacte.

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