This document discusses effective strategies for searching for evidence in databases. It outlines the basic principles, including carefully defining a clinical question using PICO elements, choosing appropriate search terms, broadening searches using synonyms and truncation if needed, and using Boolean operators. The document provides guidance on elaborating the search steps and using index terms and MeSH headings to search PubMed and other databases. The overall goal is for students to understand how to effectively search PubMed and other resources to find evidence.