This document summarizes news from the healthcare IT industry in December 1987:
- Kodak was a major vendor of photographic film but struggled after digital cameras were introduced. A device from Kodak allowed displaying a PC screen on an overhead projector.
- Sentry Data was a major player in the 1980s with their Tandem "non-stop" healthcare IT system. A modern startup reused the name "Sentry."
- In 1987, CEOs of four leading lab vendors made predictions about 1992 - two predictions were premature but others proved accurate about adoption of EHRs and integrated healthcare IT systems.
- The document provides other insights into the early healthcare IT industry including vendors like Medite
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Interesting Ad
• Hard to remember that Kodak was
the giant vendor for photographic
film back then – they almost died
after the introduction of digital
cameras… Anyone remember what
film is? 35mm versus 128mm??
• Kodak was selling a device that
displayed your PC screen on an
overhead projector – from both
IBM PCs and Apple II PCs. No
mention of Windows or Macs…
• Reminds me of how hard it was to
get a projector for my
presentation of HIS-tory at HIMMS
a few years back – and finding a
printer to make the overhead
foils! Today, you plug your PC into
any projector and off you go…
3. Sentry in this Century
• The people section mentioned Rick
Mager, an HIS pioneer who cut his
teeth at TDS and then helped make
Sentry Data Inc. a major player in the
80s with their Tandem “non-stop” HIS.
• Amazingly, just last month one of the
few remaining print magazines in HIS
featured this story about a new
business analytics vendor named,
guess what? Who’d a thunk it!
• Makes one wonder what future start-
up vendors might try to re-use names
like “Healthland” or “Eclipsys?”
• Branding is all the rage on Wall Street
these days – it’s not the product or
services that counts, but the name…
4. 5-Year Predictions From LIS CEOs
• This fascinating article featured predictions by CEOs from four leading Lab
vendors at the time – amazing that two of these vendors still run today:
5. Were Any Predictions Right?
• In case you couldn’t read the fine print, here’s what the CEOs
predicted and how right or wrong they were by 1992 vs today:
• Scott (Lab Force): “By 1992 there will
be an all-digital, including voice and
image, medical record.” A little
premature for 1992, but so true today
with our near-total adoption of EHRs!
• Eggart (3M): “Also in five years, we will
see more fully-integrated HIS vendors
and technology advances in Artificial
Intelligence (AI) or Expert Systems will
be most beneficial.” Again, a little
premature for 1992, but very true by
today regarding fully integrated HIS
vendors (Epic, Cerner, Meditech, et al)
• Patterson (Cerner): The most prescient comment considering how his firm
transitioned from LIS to HIS in the mid-90s: “By 1992 I see most labs being
computerized and what we will see emerging is a ‘replacement market.’”
• Goldblatt (Sunquest): “Within five
years, almost all labs will be
computerized, and most will have
integrated systems with HIS and other
peer systems; networking and
interfacing standards will come to
pass; and by 1992, we will be
approaching a time when HIS will be a
subspecialty in…medicine.” Right on!
Sid was the Pathologist at Conemaugh
Health System in Johnstown, PA,
founded Sunquest in 1979, and sold it
to Misys in 2001 for $400M.
6. Remember These?
• When is the last time you
saw a pay phone in a
hospital, or anywhere else?
• Back in the 80s, the “Ma
Bell” telephone monopoly
had been broken up into
smaller regional players, and
New York/New England gave
their pay phones for free!
• When did you get your first
cell phone? I remember
getting a call from Shelly
Dorenfest on his first in the
mid-80s – very hard to hear
him but what a gutsy guy!
7. Vendor Profile
• Featured vendor was a small start-
up from Mass. that was starting to
make waves in the small hospital
mini-computer system market:
Medical Information Technology.
• Meditech claimed three operating principles in this profile article:
1. “To develop its own product using its own technology.” – So
true: to this day they have built almost every app themselves.
2. “To Provide the most product for the money” – Also true to
this day: they charge 1% per month, 12% per year for software
maintenance; most other vendors charge 2 to 3 times more!!
3. “To emphasize flexibility in product design and marketing
philosophy.” – Bit of a fudge: they only sold Magic in the 80s,
Client/Server in the 90s, and Release 6 in the 2000s. The first
two were pretty much “model” systems – take it or leave it…
8. Big Blue Roots
• Another vendor profiled in
the December 1987 issue of
Bill Child’s HCC was Sunquest
• Hard to read the fine print,
but founder Sid Goldblatt
describes how he developed
his LIS in 1965 (I was a still a
Junior in college!): “It was an
IBM card-based system…”
• Sid then wrote to every
computer manufacturer
about his new system but
only DEC responded, so they
wrote the pioneering CliniLab
LIS in PDP-12 for DEC minis.
9. That Reminds Me…
• I’ll never forget seeing this odd-
looking building at Cedars with
these strange-looking windows
scattered all over the façade as if
they were arbitrarily placed on
different locations on each floor.
• What could the architect have been
thinking for such a strange design?
• Way back in the early 1980s, I
was in working in marketing at
McAuto and we made a sales
call on Cedars Hospital in
Miami, FL. I don’t remember
the exact year or month, but
I’m sure it was winter time…
10. Recognize It?
• Ironically, just this month we were at a gig in Miami and passed by
the same building. My aging memory cells flashed and I asked my
partner Elise Ames to take those pictures – she’s much younger
than I am and did not immediately recognize the meaning of the
odd-shaped windows – do any of you HIS-talk readers?
• Flash back to Sid’s “IBM card-based” system and you get the
answer! Seems back in the 60s, the architect designed this building
to reflect the iconic 5081 keypunch cards first used in the US
census at the turn of the 19th century, and the Hollerith code input
for IBM and BUNCH-group mainframe computers back then.
• I’ve got a small stack if anyone
wants one - very low price…
• Wonder what the picture
“holes” on the Cedars building
spell? Any DP gurus know??
11. Next Month/Year
• Some interesting news & articles from January 1988:
– CliniCom – remember the bedside system revolution?
Pioneer CliniCom completed its funding in January, 1988.
– SMS – this pioneer in shared systems officially formed a
separate division for its DEC-based turnkey mini systems.
– McAuto – SMS’ primary competitor, took over management
of NEIC, a pioneering claims processing (EDI) vendor.
– FDA – Dr. Ralph Korpman, founder of Health Data Sciences,
weighs in on proposed FDA regulations of HIS systems.
Hope you enjoy jumping back to these early days of HIS-tory –
glad to hear any of your memories or negative feedback:
Vince Ciotti HIS Professionals, LLC
505.466.4958 vciotti@hispros.com