Colorectal cancer is the third most common cancer in India and develops from the colon or rectum. Risk factors include increasing age, family history of colon cancer, smoking, and a history of gastrectomy. Symptoms can include changes in bowel habits, rectal bleeding, abdominal pain, unintended weight loss, and rectal lesions. Diagnostic tests include abdominal and rectal exams, sigmoidoscopy, and virtual colonoscopy. Treatment may involve radiation therapy, chemotherapy with drugs like 5-flurouracil or capecitabine, and surgery. Prevention strategies aim to reduce risk through lifestyle changes.