This chapter discusses special operations firefighters may encounter, including hazardous materials incidents, terrorism events, clandestine drug labs, and natural disasters. It emphasizes the importance of initial responders taking appropriate action prior to the arrival of specialized personnel. Size-up factors, strategic goals, tactical priorities, and incident management considerations are provided for each scenario to help responders address potential problems and minimize risks to civilians and firefighters. The chapter aims to give firefighters a basic understanding of these complex situations so their initial actions do not complicate the response and can help mitigate minor incidents when specialist assistance may be delayed.