Antacids (Pharmaceutical Inorganic Chemistry)Dr. Alex Martin
B.Pharm and D.Pharm PCI Syllabus, Acidity, complications of acidity, symptoms of acidity, causes of acidity, antacids, systemic antacids, non-systemic antacids, types of non-systemic antacids,calcium-containing antacids,magnesium-containing antacids, aluminum-containing antacids, combination antacids, ideal characteristics of an antacid, why combination antacids are preferred, simethicone, popular brands of antacids, sodium bicarbonate, assay of sodium bicarbonate, medicinal uses of sodium bicarbonate, aluminum hydroxide, medicinal uses of aluminum hydroxide, magnesium hydroxide mixture, milk of magnesia, medicinal uses of magnesium hydroxide.
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Morphine is used to relieve moderate to severe pain. Morphine extended-release tablets and capsules are only used to relieve severe (around-the-clock) pain that cannot be controlled by the use of other pain medications.
Important questions Of Pharmaceutics According to PCI SyllabusPayaamvohra1
This ppt gives an idea about frequently asked questions of Pharmaceutics tips tricks concepts for learning pharmacy .Do checkout the other ppt for mnemonics of other subjects
I. OBJECTIVES OF PRESERVATION
In this guideline, we are mainly concerned with the taxonomic reasons for preservation. The scientific description of an animal species requires the detailed examination and description of a representative type specimen and a series of specimens which are subsequently deposited, catalogued and maintained in a museum or zoological collection. This remains a reference for other workers to consult in future.
Specimens from any field collection should be deposited in a reference collection in an institutional for the long-term maintenance and access for the future. The animals should therefore be preserved in the best possible condition and where possible, ensure that the natural colour is retained, their external appendages (e.g. fins) are erected and stomach contents intact.
Care should be taken to ensure that specimens are undamaged. Features important in the taxonomic study of fish, for example, are easily damaged with contact even after preservation. Live crabs before preservation should be kept individually as some species will damage each other and other animals, especially fish even when they are being directly preserved.
Antacids (Pharmaceutical Inorganic Chemistry)Dr. Alex Martin
B.Pharm and D.Pharm PCI Syllabus, Acidity, complications of acidity, symptoms of acidity, causes of acidity, antacids, systemic antacids, non-systemic antacids, types of non-systemic antacids,calcium-containing antacids,magnesium-containing antacids, aluminum-containing antacids, combination antacids, ideal characteristics of an antacid, why combination antacids are preferred, simethicone, popular brands of antacids, sodium bicarbonate, assay of sodium bicarbonate, medicinal uses of sodium bicarbonate, aluminum hydroxide, medicinal uses of aluminum hydroxide, magnesium hydroxide mixture, milk of magnesia, medicinal uses of magnesium hydroxide.
LET'S FIGHT COVID BY STAYING AT OUR HOME. USE THIS LINK TO GET YOUR MEDICINES DELIVERED AT YOUR HOME:
http://medlifeinternational.go2cloud.org/aff_c?offer_id=60&aff_id=15560
Coupon Code: MLFIRST
18% off on medicines + 50% Paypal cashback
Paypal max cashback up to Rs.500 on 1st transaction
Free Delivery
Morphine is used to relieve moderate to severe pain. Morphine extended-release tablets and capsules are only used to relieve severe (around-the-clock) pain that cannot be controlled by the use of other pain medications.
Important questions Of Pharmaceutics According to PCI SyllabusPayaamvohra1
This ppt gives an idea about frequently asked questions of Pharmaceutics tips tricks concepts for learning pharmacy .Do checkout the other ppt for mnemonics of other subjects
I. OBJECTIVES OF PRESERVATION
In this guideline, we are mainly concerned with the taxonomic reasons for preservation. The scientific description of an animal species requires the detailed examination and description of a representative type specimen and a series of specimens which are subsequently deposited, catalogued and maintained in a museum or zoological collection. This remains a reference for other workers to consult in future.
Specimens from any field collection should be deposited in a reference collection in an institutional for the long-term maintenance and access for the future. The animals should therefore be preserved in the best possible condition and where possible, ensure that the natural colour is retained, their external appendages (e.g. fins) are erected and stomach contents intact.
Care should be taken to ensure that specimens are undamaged. Features important in the taxonomic study of fish, for example, are easily damaged with contact even after preservation. Live crabs before preservation should be kept individually as some species will damage each other and other animals, especially fish even when they are being directly preserved.
B. Pharm. (Honours) Part-III Practical, Medicinal Chemistry,ManikImran Nur Manik
Synthesis of drug & drug intermediates: Paracetamol b) Benzocaine c) Aspirin d) Phenacetin e) PABA (Para amino-benzoic acid f) Meta Nitro-benzaldehyde g) Ethyl para hydroxy-benzoate h) Para Amino phenol i) Methyl salicylate.
CHEM 2423 Recrystallization of Benzoic Acid Dr. Pahlavan
1
EXPERIMENT 4 - Purification - Recrystallization of Benzoic acid
Purpose:
a) To purify samples of organic compounds that are solids at room temperature
b) To dissociate the impure sample in the minimum amount of an appropriate hot solvent
Equipment / Materials:
hot plate 125-mL Erlenmeyer flask ice stirring rod spatula
Büchner funnel impure benzoic acid weighing paper digital scales
rubber tubing (hose) benzoic acid boiling stones (chips) filter paper
25 mL graguated cylinder 50 mL beaker Mel-temp apparatus
Discussion:
The products of chemical reactions can be impure. Purification of your products must be performed to remove
by-products and impurities. Liquids are customarily purified by distillation, while solids are purified by
recrystallization (sometimes called simply "crystallization").
Recrystallization is a method of purifying a solid. There are two types of impurities: those more soluble in a
given solvent than the main component and those less soluble. (If there are any impurities that have the same
solubility as the main component, then a different solvent needs to be chosen.)
When organic substances are synthesized in the laboratory or isolated from plants, they will obviously contain
impurities. Several techniques for purifying these compounds have been developed. The most basic of these
techniques for the purification of organic solids is recrystallization, which relies on the different solubilities of
solutes in a solvent. Compounds, which are less soluble, will crystallize first. The crystallization process itself
helps in the purification because as the crystals form, they select the correct molecules, which fit into the crystal
lattice and ignore the wrong molecules. This is of course not a perfect process, but it does increase the purity of
the final product.
The solubility of the compound in the solvent used for recrystallization is important. In the ideal case, the
solvent would completely dissolve the compound to be purified at high temperature, usually the boiling point of
the solvent, and the compound would be completely insoluble in that solvent at room temperature or at zero oC.
In addition the impurity either would be completely insoluble in the particular solvent at the high temperature,
or would be very soluble in the solvent at low temperature. In the former case, the impurity could be filtered off
at high temperature, while in the latter case the impurity would completely stay in solution upon cooling. In the
real ...
CHEM 2423 Recrystallization of Benzoic Acid .docxbissacr
CHEM 2423 Recrystallization of Benzoic Acid Dr. Pahlavan
1
EXPERIMENT 4 - Purification - Recrystallization of Benzoic acid
Purpose:
a) To purify samples of organic compounds that are solids at room temperature
b) To dissociate the impure sample in the minimum amount of an appropriate hot solvent
Equipment / Materials:
hot plate 125-mL Erlenmeyer flask ice stirring rod spatula
Büchner funnel impure benzoic acid weighing paper digital scales
rubber tubing (hose) benzoic acid boiling stones (chips) filter paper
25 mL graguated cylinder 50 mL beaker Mel-temp apparatus
Discussion:
The products of chemical reactions can be impure. Purification of your products must be performed to remove
by-products and impurities. Liquids are customarily purified by distillation, while solids are purified by
recrystallization (sometimes called simply "crystallization").
Recrystallization is a method of purifying a solid. There are two types of impurities: those more soluble in a
given solvent than the main component and those less soluble. (If there are any impurities that have the same
solubility as the main component, then a different solvent needs to be chosen.)
When organic substances are synthesized in the laboratory or isolated from plants, they will obviously contain
impurities. Several techniques for purifying these compounds have been developed. The most basic of these
techniques for the purification of organic solids is recrystallization, which relies on the different solubilities of
solutes in a solvent. Compounds, which are less soluble, will crystallize first. The crystallization process itself
helps in the purification because as the crystals form, they select the correct molecules, which fit into the crystal
lattice and ignore the wrong molecules. This is of course not a perfect process, but it does increase the purity of
the final product.
The solubility of the compound in the solvent used for recrystallization is important. In the ideal case, the
solvent would completely dissolve the compound to be purified at high temperature, usually the boiling point of
the solvent, and the compound would be completely insoluble in that solvent at room temperature or at zero oC.
In addition the impurity either would be completely insoluble in the particular solvent at the high temperature,
or would be very soluble in the solvent at low temperature. In the former case, the impurity could be filtered off
at high temperature, while in the latter case the impurity would completely stay in solution upon cooling. In the
real.
PREPARING CHEMICAL SOLUTIONS – MEASURING AND HANDLING SOLID CHEMICALS - MEASU...Dhanuja Kumar
Lab experiments and types of research often require preparation of chemical solutions. Preparations of these chemical solutions are done by weight (w/v) and by volume (v/v).
Estimation of reducing and nonreducing sugarsJasmineJuliet
Reducing suar, non reducing sugar introduction, examples, extraction from plant sample, estimation of reducing sugar, estimation of total sugar, detected value applied in formulas, result.
Estimation of reducing and non reducing sugarJasmineJuliet
Reducing sugar definition and example, non-reducing sugar definition and example, Estimation of reducing sugar by DNSA method, Estimation of total sugars by anthrone metod, Estimation of non-reducing sugar from amount of total sugars and reducing sugar, formula for estimation of non-reduci
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
1. Methcathinone
Preparing the ephedrine/pseudoephedrine solution:
Method A:
Add enough water to completely dissolve pure ephedrine or
pseudoephedrine.
Method B:
Wash sudaphed tablets in cold water until most (it's impossible
to get all of it) of the red coating is gone. Put the tablets
in hot water, heat them to boiling, and stir until the tablets
have completely dissolved. Filter off the liquid.
The amount of water the (pseudo-)ephedrine [I'll call it
ephedrine from now on for simplicity] is dissolved in is not too
important - it should be as little as possible, but at least as
much as the amount of sulfuric acid that is added later (to
insure to that the potassium dichromate dissolves).
To this aqueous mixture add 0.62 grams of potassium dichromate
for every gram of ephedrine in the solution. If you used
sudaphed tablets, figure by the theoretical amount in
solution (number of tablets X content of each tablet). Slowly
add 3ml Sulfuric for each gram ephedrine, stirring as you add
it.
Let react for 30-60 minutes. The color should go from a bright
red/orange to a dark color (a mixture of green and orange from
the two ionization states of the chromium).
Basify the solution with concentrated sodium hydroxide solution
until you see the solution become a bright green (green with a
white precipitate - the methcathinone). This happens above pH
8. Try not to add too much hydroxide (if you do the solution
becomes black and there is probably some decomposition of the
methcathinone).
Extract 3-4 times with naptha (add the naptha, shake it up,
pour off as much naptha as you can - but DON'T get ANY reaction
mixture in the extracts!). Use as much naptha as would equal
about 50-100 percent of the reaction mixture.
Quickly add the extracts to 25ml of hydrochloric acid, diluted
1 part 36% HCl to 4-5 parts water. Shake the mixture, extract
off the aqueous (lower) portion. This is an acid solution of
the methcathinone. [you may want to extract a second time with
HCl to get a slightly higher yield, a 3rd time adds nothing.]
Evaporate the mixture under low to medium heat (preferably
under a vacuum) until it becomes thick. Add acetone and stir
it a little. if the mixture doesn't become white (crystalline)
right away, it hasn't been evaporated enough. Continue
evaporating and adding acetone until it does. Be careful not
to burn the thick mixture (adding acetone helps keep the
temperature down).
After getting crystals/precipitate, cover the mixture tightly
and put in a freezer for 15 minutes. Remove from the freezer,
filter the crystals off and wash with a small amount of cold
2. acetone.
[If the crystals are less than white, you may want to purify
them by boiling and stirring them in acetone again, cooling
the mixture and refiltering as described above.]
The white crystals/powder is methcathinone HCL. I wouldn't
take more than 20mg for a first dose, and I wouldn't take it if
I had a history of heart disease or stroke in the family, or if
I had high blood pressure. Really, really habit forming. Very,
very pleasurable. BE CAREFUL. Don't introduce this stuff to
kids or sell it or I will personally hunt you down.
NOTES:
This synthesis is very forgiving. Substitutions of potassium
hydroxide for sodium hydroxide, sodium dichromate for potassium
dichromate and similar subsitution will not have an impact. I
wouldn't substitute anything for the sulfuric acid, however.
HCl is used to make the drug salt because it is so easy to
evaporate the excess off. Any method of making drug salts you
are familiar with should be satisfactory.
Ether works a little better than naptha, but it's more
dangerous. I stay away from it.
-------------------------------------------------------------------
--Cooper
=============================================================================
Message-ID: <051314Z09071994@anon.penet.fi>
Newsgroups: alt.drugs
From: an42976@anon.penet.fi
Date: Sat, 9 Jul 1994 05:11:24 UTC
Subject: Tips for CAT synthesis
Through experience I have compiled the following tips for ppl wanting
to do the CAT synthesis. It isn't hard, but the posted synthesis cannot
lead to good results becuase of certain ommisions. I don't know if these
were omitted deliberately as to stop non-chemists from completing it or
whether the author of the original article just forgot. In any case, here
are some things you should be aware of.
1) When dissolving the ephedrine don't use 'as little amount of water as
possible' as the instructions say. This will lead to a very thick reaction
mixture. When extracting with naphta this thickness will prevent separation
of layers. The naphta will stay in suspension and the naphta that does
separate will not contain high amounts of CAT. This leads to unacceptably
low yields. Use about 10 ml. of water per gram of dissolved ephedrine. Do
not use tap-water, get de-mineralised water. Trace amounts of minerals will
inhibit the reaction.
2) Add the sulphuric acid *very slowly*. If you don't, local concentrations
will get too high, causing the ephedrine to break down. Stir well while
adding the H2SO4.
3) This is the most important omission: The whole reaction mixture has to
be cooled while basifying it with Sodium hydroxyde. The heat developed
during this stage will cause practicaly all the CAT to break down if you
don't. The best way to cool it is as follows: Place the reaction mixture
3. in an ice-bath 10 minutes before adding the NaOH. Then, just before adding
the NaOH, chuck a handfull of salt over the ice (NOT in the reaction
mixture!) This will cause the temperature to drop another couple of
degrees, ensuring a good cooling.
4) Use a magnetic stirring device troughout the whole procedure.
5) When extracting the CAT from the naphta with the HCl use a 20%
solution in stead of the mentioned 10% (approx.)
6) When evaporating the excess amounts of water (preferably under vacuum)
do not let the temperature exceed 70 degrees C. (approx 150 F.) Again, the
high temperature would cause the CAT to disintegrate. :-(
If you follow these additional comments, you should be able to have success!
The anonymous chemist.
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_____________________________________________________________________________
MAKING CAT (METHCATHINONE)
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
For a more complete description of how cat is made read quot;Secrets of Meth-
amphetamine Manufacturequot; (Third Edition), available from Loompanics Unlimited,
PO Box 1197 Port Townsend, WA 98368 USA. Eye protection is needed and this is
done in a well-ventilated area. AT LEAST a year of college chemistry lab
experience is needed to realize the dangers involved here. This article is for
information purposes only.
Cat (METHCATHINONE) is made by oxidizing EPHEDRINE, while METHAMPHETAMINE is
made by reducing EPHEDRINE. Cat is best made by using CHROME in the +6
oxidation state as the oxidizer. Any of the common hexavalent CHROME salts
can be used as the oxidizer in this reaction. Some of these are CHROME
TRIOXIDE (CrO3), SODIUM or POTASSIUM CHROMATE (Na2CrO4), and SODIUM or
POTASSIUM DICHROMATE (Na2Cr2O7). All of these chemicals are very common.
CHROME TRIOXIDE is used in chrome plating.
First the chemist dissolves EPHEDRINE pills containing a total of 25 grams
of EPHEDRINE HYDROCHLORIDE or EPHEDRINE SULFATE in distilled water. EPHEDRINE
pills usually contain 25mg each of EPHEDRINE so 1000 pills would be needed.
Grinding them up isn't necessary. Let them sit overnight or shake the
solution hard for a while. When they're dissolved bring the solution to a
gentle boil while constantly stirring so none of it burns. As soon as it
starts boiling remove it from the heat and pour through 3 coffee filters
layered together to filter out the unwanted filler crap. Usually it is
necessary to hold the filters like a bag with the liquid that didn't go
through and gently squeeze to get the liquid to go through. The result is an
almost totally clear liquid which is the EPHEDRINE extract in water. Throw the
mush left in the filter away.
The EPHEDRINE extract is poured into any convenient glass container. Next,
75 grams of any of the above mentioned CHROMIUM compounds is added. They
dissolve easily to form a reddish or orange colored solution. Finally,
CONCENTRATED SULFURIC ACID (it usually comes as 96-98%) is carefully added.
4. If CrO3 is being used, 21 ml is enough. If one of the CHROMATES is being used,
42 ml is needed. These chemicals are thoroughly mixed together and allowed
to sit for several hours with occasional stirring.
After several hours LYE solution (1 part water, 1 part LYE) is very slowly
and carefully added dropwise with strong stirring until the solution is
strongly basic (pH 11 or more). This strong stirring is to make sure the cat
is converted to the free base.
Next, TOLUENE is used to extract the cat. Usually this is done with a sep
funnel (separatory funnel, which is a flask with a funnel-shaped bottom and
a stopcock (valve) on the very bottom. Sep funnels are used for separating
liquids by opening the valve on the bottom and letting the bottom-most layer
of liquid drain out.) but a regular glass bottle should be fine but using a
plastic cap wouldn't be good. For safety, the bottle would need to be quot;burpedquot;
often anyway to make sure no gasses build up in it. A large eyedropper-type
tool could be used to efficiently remove the cat layer. A couple hundred ml's
of TOLUENE is added and the container is strongly shaken to make sure the all
of the cat free base gets into the TOLUENE layer. Shake until it resembles
milk (fine suspended globules of TOLUENE within the water layer). Shake really
hard, then allow it to separate. Insufficent shaking will result in poor yield
with some undissolved cat base remaining in the spent sludge layer. The
TOLUENE layer should be clear to pale yellow in color. The water layer should
be orange mixed with green. The green may settle out as a heavy sludge. The
water layer is thrown away and the TOLUENE layer is washed once with water and
then poured into another container. (quot;Washedquot; here means that water is added
and the mixture shaken again and separated. The cat free base stays in the
TOLUENE layer because it doesn't dissolve in water. Any remaining
water-soluble impurities are dissolved into the water layer and not the
TOLUENE layer and thus they're quot;washedquot; out.)
The cat free base now must be converted to cat salt (METHCATHINONE HCL).
Here are 2 methods for doing this.
METHOD 1
~~~~~~~~
Dry HCL gas is made and bubbled through the TOLUENE solution to turn the cat
free base into cat salt (METHCATHINONE HCL). A bottle is selected for holding
the gas-producing mixture and a 1-hole stopper will be put in the top of the
bottle. One end of a J-shaped glass tube (about 1/4 inch diameter) is pushed
into the stopper. This glass tube will reach from the top of the gas-producing
bottle down into the bottle holding the TOLUENE-cat mixture. It should reach
the bottom of the mixture. Usually a sep funnel is used to add SULFURIC ACID
to the gas-producing mixture through a second hole in the stopper to keep gas
flowing. If one doesn't have access to a sep funnel it should be possible to
take the stopper out of the gas-producing bottle just long enough to add a
little SULFURIC ACID when it's needed to keep gas flowing. Place 200 grams of
TABLE SALT into the gas-producing bottle. 35% CONCENTRATED HYDROCHLORIC ACID
(reagent grade) is added and they are mixed into a paste. The surface of the
paste should be rough with lots of holes poked into it for good gas
production. About 1 ml of CONCENTRATED (96-98%) SULFURIC ACID is added to the
paste. This dehydrates the HYDROCHLORIC ACID and produces HYDROGEN CHLORIDE
GAS (** DO NOT BREATHE THIS GAS! **). This gas goes out of the gas-producing
bottle through the glass tube and bubbles through the TOLUENE-cat solution
turning cat free base into cat salt. The cat salt should appear as crystals
and after a while the solution should be thick with them. The crystals are
recovered by pouring through a filter. The crystals are then dried by
evaporating the TOLUENE with gentle heat or under a vacuum. Voila. Pure
METHCATHINONE-HCL.
5. METHOD 2
~~~~~~~~
That was the quot;idealquot; method. The practical method is to dump the base/solvent
solution into a container, add an amount of DILUTE HCl, shake, shake, shake,
measure pH, if it is greater than 7 (pH above 7 is basic), add more acid,
shake, shake, shake, and check pH again. Keep it up until the pH is low,
staying well below 7 (pH below 7 is acidic), then remove the solvent layer and
keep for reuse. Add BAKING SODA to the water layer a little at a time until it
stops bubbling when more is added. Check the pH, make sure it is 7 (neutral)
or higher. The water is now evaporated away on non-plastic plates or pans and
the dried METHCATHINONE HCL can be scraped off with a razor blade. The
METHCATHINONE HCl has a trace of SODIUM CHLORIDE (TABLE SALT) and an even
smaller trace of SODIUM BICARBONATE (BAKING SODA). The BAKING SODA combines
with the excess HCl to become TABLE SALT. This practical method avoids the
mess of producing HCl gas. HCl is a white gas that burns your eyes and nose
really badly should you breathe it. It converts upon contact with water into
HYDROCHLORIC ACID, so if you don't want HYDROCHLORIC ACID in your eyes, nose,
lungs, don't breathe it!
Small amounts of TABLE SALT and BAKING SODA in the cat will go unnoticed. The
ideal method can be used if a source of compressed HCl GAS is found. It is
sold in lab cylinders by chem supply houses and is not watched by the DEA.
Just stick on a regulator, affix the rubber hose with a glass extension for
submersion in the solvent, and open the valve to expel the gas through the
solvent to produce PURE cat HCl.
_____________________________________________________________________________
SUMMARY
~~~~~~~
Ephedrine is oxidized to produce methcathinone. The methcathinone is then
converted to the free base for separation from the rest of the unwanted crap
mixed with it. The free base dissolves in toluene and not in water whereas the
unwanted crap dissolves in water and not in toluene. Since water and toluene
separate into 2 layers the toluene layer containing the cat free base is saved
and the water layer thrown out. The toluene could probably be evaporated
leaving crystals of cat free base which could probably be smoked but I haven't
heard of anyone smoking it nor have I heard of its effects on the human body.
The cat free base is converted to cat salt using dilute hydrochloric acid or
anhydrous HCL gas. Cat salt is soluble in water and not in toluene, just the
opposite of the free base. Using HCL gas the salt produced has no water layer
to dissolve in so it crystalizes out. Using dilute HCL the salt leaves the
toluene layer as before but has a water layer (the water diluting the HCL) to
dissolve in. This water layer is saved and the water evaporated, leaving
methcathinone-HCL.
_____________________________________________________________________________
Sources of items:
~~~~~~~~~~~~~~~~
TOLUENE- Available at most hardware stores. One brand is called quot;Toluolquot; from
Parks. TOLUENE is also called METHYLBENZENE.
LYE- Available at most hardware stores. Even Safeway has it. One brand is
quot;Red Devil Lyequot; which is used to unclog grease clogs in drains.
CONCENTRATED HCL and CONCENTRATED SULFURIC ACID are pretty cheap. When bought
in 2-liter bottles (reagent grade) they're about $20 each. HCl, also called
6. MURIATIC ACID, is available as a concrete cleaner in most lumber yards. Also
used to adjust pH in swimming pools. H2SO4, aka Battery Electrolyte,
obtainable in quart to 5-gallon size containers from automotive supply
houses. This is a dilute acid which must be concentrated by pouring into
large pyrex containers and boiling the water off for many minutes. It has
reached the point of 98% concentration when the liquid stops boiling and
starts fuming off with the release of white clouds of gas (SO3, SULFUR
TRIOXIDE). Bottle while still hot as conc. H2SO4 is hygroscopic (it sucks
water out of the air and becomes dilute again). DO NOT BREATHE SO3 GAS! It
eats out your lungs, just as HCl GAS does.
CHROMIUM TRIOXIDE (CHROMIC OXIDE) (CrO3)- Very common oxidizer. Comes in
powder form. Less than $20 for 100 grams. Since it can be recycled, someone
would never have to purchase large quantities of it. Enough to use as a
reagent and a supply to supplement the losses incured during use would be
enough.
Glass tubing- About $2 per tube (1/4 inch) at chemistry supply outlets. Bent
into different forms slowly and carefully while heating with blow torch.
Glass tubing also used in salt water aquariums. Also for neon signs. Many
sources for glass tubing from veterinary to dairy, from industrial to hobby.
Easy to find if you know how to look.
_____________________________________________________________________________
CREDITS
~~~~~~~
quot;Secrets of Methamphetamine Manufacturequot; by Uncle Fester was used as a
reference. Information about it is in the beginning of this article.
Technical assistance was provided by Steve J. Quest.
_____________________________________________________________________________
=============================================================================
Message-ID: <124353Z31051995@anon.penet.fi>
Newsgroups: alt.drugs
From: an267556@anon.penet.fi
Date: Wed, 31 May 1995 12:37:03 UTC
Subject: CAT synth help
I'm looking for some help with the cat synth posted on hyperreal.
I followed the cat procedure on hyperreal and when I bubbled hcl through
the mix the first time I got white paste that on further drying on a glass plate
turned to a yellow orange oil. Still works great but not as pretty. I think it is
the heat. The second and third attempt at bubbling hcl
through the mix all I got was a milky naptha(I'm using naptha instead of
acetone)
Precipitating the cat has been more succesful for me but the mix never gets
cloudy. I just continue washing out with naptha until I dry it.
Im no chemist but I follow direction well. However besides the above My yeild is
way down.
The first few times I used 1000 30mg
pseudoephedrine HCL pills and only ended up with about 3.5 grams of cat.
Yeild has gotten worse with each attempt.
Anyone who has tried this care to critique my methods
7. 1. 1000 pseudoephedrine HCL pills (30mg) disolved in 300ml water. Bring to a
boil,and let settle. Filter off some of the water leaving paste behind.
2. Add more water and repeat step 1. Filter off top and add to already
filtered material until the paste has no bitter taste to it..
I end up with about 800ml of water. I don't let the temp pass 50c so I don't
really
boil the mix.
2.Add 20 grams potassium dichromate. stirring constantly.
This was hard to come by and unless I mail order it looks like I won't be able to
get
any more of this. Someone mentioned photo supply but several calls in the
bostonarea left me wondering if it is used for photography at all. None of the
people
I talked to had it on thier list.
3.Slowly add concentrated sulfuric acid.
One method calls for 3ml per gram pseudoephedrine HCL (90ml)
another method says 42ml
I have tried both.
I add this slow enough to keep the mix temp below 50C.
4.leave this for several hours constantly stirring. It gets very hot from
the reaction.
5.Put container in ice bath and while stirring slowly add lye until strongly
basic (ph 11) stir this for 1 hour.
6.add naptha to the mixture in the sep funnel
and shake until my arms hurt ~2 minutes. Let settle and syphon off naptha.
repeat 4 times.
7.Put naptha in a sep funnel with 200 ml water and shake. Let settle
and pour off water.
8. bubble hcl gas through the naptha and filter crystals.
I make my own gas.
00g salt +30%hcl in a wide bottom flask. Slowly drip sulfuric acid into mix.
If i use muriatic acid for this I get many bubbles in the mix that
would eventually bubble into naptha/cat mix if not careful.
reagent grade hcl (harder to get) doesn't do this?
The first time I did the naptha clouded up and then crystals began to appear
Quite beautiful to watch. I used my vacuum settup to separate crystals and then
set crystals on glass plate to dry. They changed from white paste to
yellow/amber in color and seemed to evaporate to less than half a gram.
My second and third attempt was even less encouraging. All I got was milky
colored naptha with no precipate. That was another reason I thought heat was
destroying the cat but last night keeping the to 50c or below all I got was
a cloudy mix and after several minutes of bubbling hcl gas through it
there was no precipitate. Very frustrating.
Early attempts at this step I put the naptha/cat mix in a sep funnel,
added 30%hcl and shook till my arms hurt. Pour off the water/hcl and
evaporate under low heat.The instructions said to wait until it got milky,
put in freezer for 15 minutes, then filter off crystals and wash with naptha.
8. This was very difficult and time consuming. The mix never got milky and after
eventualy evaporating all the liquid I ended up with a dark colored paste
that would stay hard under heat but as soon as I removed it it became a
sticky paste again. From what I have read, (I have noone to discuss this
with) sulfuric acid will absorb the moisture in the air so I thought
prehaps there was still hcl in the mix and it was absorbing moisture
from the air. I'm only guessing. I would have thought the hcl would have
evaporated with the water/naptha mix leaving only the cat.
I have talked to two other people on the net but neither do more than ask
questions or agree with my methods. I must be missing something as my
yeild is so low and my results have been poor.
Also the cat high is really great. I don't know how much I do.
two small lines every so often until I start to buzz. When I do hit it though
it is a nice buzz. The cat did not give me a rush. I felt powerful, strong,
euphoric
over the beauty of life. My mind could focus very well and seemed to be
able to connect abstract thought into coherent patterns. I am learning the
guitar in my spare time and under the influence of the cat I wrote several
songs. Sitting playing my guitar a melody would just leap from my fingers
and the words would pour out as if I were reading it from a script. Nothing
profound but enjoyable emotional music pouring out of me faster than
I could write it down... or was that the mushrooms Im growing...
Too much and my heart hits the hyway at well over 100bpm. Not to pleasant.
So the million dollar questions is what am I doing wrong?
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Newsgroups: alt.drugs
From: ralph@inter.NL.net (Ralph Moonen)
Subject: Re: CAT synth help
Message-ID: <D9G3D3.1Hy@inter.NL.net>
Date: Wed, 31 May 1995 13:41:26 GMT
an267556@anon.penet.fi writes:
>1. 1000 pseudoephedrine HCL pills (30mg) disolved in 300ml water. Bring to a
>boil,and let settle. Filter off some of the water leaving paste behind.
Boiling will decompose some of the ephedrine. Don't let it boil.
It will dissolve just fine, it just takes alittle longer.
>3.Slowly add concentrated sulfuric acid.
> One method calls for 3ml per gram pseudoephedrine HCL (90ml)
> another method says 42ml
42 ml is WAY OVER THERE!!! stick to 3, if it's concentrated. Else add
more. It's not critical, except you should go below Ph 3. (approx.)
Too acidic an environment will decompose your ephedrine and cat.
9. >5.Put container in ice bath and while stirring slowly add lye until strongly
>basic (ph 11) stir this for 1 hour.
Nope. Add lye untill mixture turns brright grrreen. This happens at around
Ph = 8. Adding more lye will do nothing, except make the next step more
difficult.
--Ralph
From: nobody@REPLAY.COM (Anonymous)
Date: 2 Feb 1998 23:14:37 +0100
Newsgroups: alt.drugs.chemistry
Subject: Potential Problems with CAT FAQ, my v.2
I happened to be with a friend over the weekend who was doing a CAT synthesis
just like in the CAT FAQ. Now he had done it successfully before, but in this
case I was around to take a look at the technique and add my two cents. I saw
several potential problems:
1. The synthesis is imprecise on the subject of whether the solution becomes
basic as the oxidation progresses. From my calculations, some but not all of
the HCl from the ephedrine salt is used up in the end as KCl is crystalized
out. KOH is a much stronger base than CAT, so it follows that the Cl- goes to
the K in preference to the CAT. Thus there is always some un-neutralized CAT
in the mixture. Thus the need to add extra HCl at the end. Unneutralized CAT
is very problematic as it is very unstable towards cyclization which is
irreversible.
I told my friend to add an equimolar amount (to pot permanganate used) of HCl
to the mixture towards the end. This worked out well, as we got a nice dry CAT
HCl and KCl mixture at crystalization. However, I would want to be careful
even about the addition of HCl to permanganate and manganese dioxide as both
liberate chlorine from it. Free chlorine will split up ephedrine or CAT.
Perhaps H2SO4 is a better choice.