This document discusses three abnormalities of lens shape: 1) Lenticonus, which is an axial bulge of the posterior or anterior lens that can be unilateral and sporadic or bilateral and familial/associated with Lowe syndrome. 2) Coloboma, which is a defect in the iris, choroid, or retina that can be associated with giant retinal tears. 3) A small lens, which can be microphakia with a small diameter or microspherophakia with a small spherical diameter, and may be familial or associated with Lowe or Weill-Marchesani syndrome.

1. ABNORMALITIES OF LENS SHAPE
2. Lenticonus
1. Coloboma
3. Small
lens

2. Coloboma
Coloboma of iris Coloboma of choroid Giant retinal tear
Ocular associations

3. Lenticonus
Posterior
• Posterior axial bulge
• Unilateral - usually sporadic
• Bilateral - familial or in Lowe
syndrome
Anterior
• Anterior axial bulge
• Associated with Alport syndrome

4. Small lens
• Small diameter • Small diameter and spherical
• May be familial (dominant)
Microphakia Microspherophaki
a
• Systemic association
- Lowe syndrome
• Systemic association
- Weill-Marchesani syndrome