1) The document discusses genetic markers that may be associated with vulnerability of plaques and risk of myocardial infarction (MI). It summarizes various studies examining gene expression and polymorphisms in patients with MI. 2) One study identified polymorphisms in 19 genes in men and 18 genes in women that were associated with increased risk of MI. The strongest associations were found with connexin 37 and PAI-1 genes. 3) Determining genotypes of connexin 37, PAI-1, and stromelysin-1 genes may help predict genetic risk of MI. However, MI is a complex disease that could be influenced by more than 1,000 genetic polymorphisms, each with small effect.