1. This study aims to identify genomic and proteomic risk factors and protective factors associated with coronary heart disease by analyzing gene and protein expression profiles in blood cells from patients with and without heart disease. 2. The study will recruit patients aged 18-80 categorized into five groups based on having heart disease and traditional risk factors. Gene expression in monocytes and neutrophils will be analyzed using microarray technology and real-time PCR. 3. Differentially expressed genes will be identified by comparing expression profiles between patient groups to uncover new diagnostic markers and therapeutic targets for coronary heart disease.