Christopher Columbus sailed west from Spain in 1492 hoping to find a trade route to Asia but instead landed in the Caribbean islands, claiming the region for Spain and beginning European exploration and colonization of the Americas. Subsequent explorers like Vasco da Gama and Amerigo Vespucci further mapped the globe while conquistadors like Hernán Cortés and Francisco Pizarro conquered powerful civilizations in Mexico and Peru, extracting gold and silver that enriched Spain. European diseases also devastated the indigenous populations who had no immunity, making conquest easier.