European exploration of the Americas began in the late 15th century, inspired by Marco Polo's accounts of wealth in Asia. Christopher Columbus led an expedition for Spain in 1492 hoping to find a western route to Asia, instead discovering islands in the Caribbean. Subsequent European powers including Spain, England, France, and the Netherlands established colonies in North America through the 17th century, with goals of conquest, trade, religion, and settlement. Colonists' interactions with indigenous peoples led to devastating disease outbreaks for Native Americans and the rise of African slavery to replace the local workforce.