Europeans sought to gain direct access to Asian goods by exploring new trade routes, bypassing Middle Eastern merchants. Portugal led the way in the 1400s by exploring along the western coast of Africa under Prince Henry. In 1497, Vasco da Gama reached India, acquiring spices at huge profits. This opened the sea route to Asia and led Portugal to seize key ports in the Indian Ocean. Christopher Columbus mistakenly reached the Americas in 1492 while seeking a western route to Asia, leading to European discovery of the new continents.