Knobbe Martens' Partner Brenden Gingrich presented "Patenting the Unpatentable - Claim Drafting After Prometheus" at the IP Impact 2012 seminar in McLean, Virginia on Wednesday, May 30, 2012. The seminar was designed for corporate counsel, C-Level executives, venture capitalists, entrepreneurs, IP managers and licensing executives.
In view of the U.S. approval process for biosimilars, companies are gearing up to either produce their own biosimilar products, or to defend against their entry onto the market. While the Biologics Price Competition and Innovation Act (BPCIA) spells out many of the requirements, the pathway for approval is complicated. Our panel of experts discuss the features of the BPCIA and how it operates for both approved biologics as well as biosimilar entrants. They also make some predictions on its impact for life science companies.
The webinar is 60 minutes, complete with Q&A.
The document discusses key issues for patent attorneys regarding biosimilar applications under the Biologics Price Competition and Innovation Act. It outlines the process for demonstrating biosimilarity and interchangeability to the FDA. It also summarizes the patent exchange process that is triggered by biosimilar applications, noting the short timeframes involved. The document advises patent holders to carefully review their portfolios and licensing agreements in preparation for biosimilar litigation given the tight deadlines of the patent exchange process.
The document summarizes a presentation on medical device patents and litigation. It discusses recent statistics on medical device patent applications, grants, and owners. It also reviews recent non-practicing entity (NPE) litigation involving medical device patents, the outcome of inter partes reviews (IPRs) of medical device patents, and notable litigation such as Edwards v. Medtronic over transcatheter heart valves and Masimo v. Philips over pulse oximetry technology. The document concludes with an overview of recent decisions regarding permanent injunctions in medical device patent cases.
At a recent Forresters And Knobbe Martens Seminar, Charlotte Teall (Forresters) and Dan Altman (Knobbe Martens) presented "Latest Developments in European Patent Law: How to Apply Them in Both the United States and Europe."
The second breakout session was directed to attendees in the information technology (IT) and biotechnology sectors, with discussion about the recent Alice v. CLS Bank Supreme Court decision.
Knobbe Martens' Partner Brenden Gingrich presented "Patenting the Unpatentable - Claim Drafting After Prometheus" at the IP Impact 2012 seminar in McLean, Virginia on Wednesday, May 30, 2012. The seminar was designed for corporate counsel, C-Level executives, venture capitalists, entrepreneurs, IP managers and licensing executives.
In view of the U.S. approval process for biosimilars, companies are gearing up to either produce their own biosimilar products, or to defend against their entry onto the market. While the Biologics Price Competition and Innovation Act (BPCIA) spells out many of the requirements, the pathway for approval is complicated. Our panel of experts discuss the features of the BPCIA and how it operates for both approved biologics as well as biosimilar entrants. They also make some predictions on its impact for life science companies.
The webinar is 60 minutes, complete with Q&A.
The document discusses key issues for patent attorneys regarding biosimilar applications under the Biologics Price Competition and Innovation Act. It outlines the process for demonstrating biosimilarity and interchangeability to the FDA. It also summarizes the patent exchange process that is triggered by biosimilar applications, noting the short timeframes involved. The document advises patent holders to carefully review their portfolios and licensing agreements in preparation for biosimilar litigation given the tight deadlines of the patent exchange process.
The document summarizes a presentation on medical device patents and litigation. It discusses recent statistics on medical device patent applications, grants, and owners. It also reviews recent non-practicing entity (NPE) litigation involving medical device patents, the outcome of inter partes reviews (IPRs) of medical device patents, and notable litigation such as Edwards v. Medtronic over transcatheter heart valves and Masimo v. Philips over pulse oximetry technology. The document concludes with an overview of recent decisions regarding permanent injunctions in medical device patent cases.
At a recent Forresters And Knobbe Martens Seminar, Charlotte Teall (Forresters) and Dan Altman (Knobbe Martens) presented "Latest Developments in European Patent Law: How to Apply Them in Both the United States and Europe."
The second breakout session was directed to attendees in the information technology (IT) and biotechnology sectors, with discussion about the recent Alice v. CLS Bank Supreme Court decision.
Knobbe Martens hosted a Pre-Conference Workshop on Monday, October 15, 2012, at the IN3 Medical Device Summit in San Francisco. Knobbe Partners Paul Conover, Curtis Huffmire, and Karen Vogel Weil presented a “Patent Update for Medical Device Companies.” This forum took place in the hub of device investment and innovation in the San Francisco Bay Area, and brought together a diverse group of medtech’s key thought leaders to candidly discuss the critical issues that will define the future of all players in the evolving device space.
Our panel of Knobbe Martens partners hosted this complimentary and informative webinar to discuss the state of software and hardware IP protection and enforcement.
Challenges to obtaining broad software and hardware IP protection are coming from every side. The Supreme Court may decide this year whether certain software even qualifies as patentable subject matter. The USPTO is also examining certain types of software applications with higher scrutiny.
Many recent decisions at the Federal Circuit have made it harder to enforce the IP that you do obtain. In addition to those difficulties, pending patent reform legislation may force a “loser pays” approach in court, where a company may have to pay millions of dollars in legal fees if they don’t win their litigation.
Our panel explained these issues, and provided real-world strategies to help maximize the protection and enforcement of your intellectual property.
On Saturday, May 4, 2013, the Sino-American Biomedical & Pharmaceutical Professionals Association (SABPA) held its 8th Annual Biomedical Forum. The forum focused on career development, entrepreneurship and the latest innovations in pharma/biotech and medical devices industries. The biomedical forum strives to provide an attractive platform for entrepreneurs, scientists, engineers, investors, executives, and policy makers to promote life sciences, biotech, medical device and alliances across the biomedical industry in Southern California and Asian countries. Knobbe Martens Partner Terry Tullis presented on “Commercialization and Patent Infringement.”
On March 30 and 31, 2017, Knobbe Martens attorneys presented written and oral educational material at an IP Seminar Series “Overseas Intellectual Property Rights Protection for Chinese Enterprises” sponsored by CHOFN, a Chinese IP law firm in Guangzhou and Shenzhen, China.
This document summarizes several recent Federal Circuit cases involving issues of patent validity and infringement. The first case summary discusses the Federal Circuit affirming a district court decision upholding patent claims covering the drug Abilify as non-obvious and not invalid for double patenting. The second case discusses the Federal Circuit vacating and remanding a rejection of reissue claims for failure to properly apply the recapture rule. The third case discusses the Federal Circuit affirming a rejection of claims as inherently anticipated by a prior art clinical trial protocol.
Partner Agnes Juang, Ph.D. presented "Navigating the Patent Minefield" at SABPA's 9th Annual Biomedical Forum on Saturday, April 26, at the Crowne Plaza Hotel in Costa Mesa.
The event showcased a number of experts across the pharmaceutical, medical device, and diagnostics industries.
Partner Michael Guiliana presented on "Best Practices for Employee, Contractor and Consulting Agreements" at the Association of Corporate Counsel - Southern California Chapter "DoubleHeader" event.
Knobbe Martens Partner Joseph Re presented at the Washington State Patent Law Association (WSPLA) event "Patent Prosecution Through the Eyes of a Patent Litigator" on Wednesday, September 19, from 12:00 p.m. to 1:30 p.m. View these slides for an in-depth view of patent prosecution and how recent court decisions have impacted IP law.
This document provides an overview of patent systems in Europe and considerations for patent filing and litigation. It discusses the Patent Cooperation Treaty (PCT) system and European Patent Office (EPO) process. Key points include differences from the US system regarding publication grace periods, patentable subject matter, and claim drafting. The document cautions against simply filing foreign counterparts of US applications and recommends tailoring claims and disclosure to individual countries. It also notes risks around amendments and oppositions in the EPO system. Litigation processes in Germany and the UK are briefly outlined.
Knobbe Martens’ patent attorneys Russell Jeide and Scott Cromar hosted a seminar series on intellectual property basics for Temecula’s business community. Entrepreneurs, investors, startups, inventors and anyone interested in learning how intellectual property and patents can help their business will benefit from this presentation.
On October 23, 2013, Knobbe Martens Partners Andrew Douglas and Sabing Lee presented on "Preparing Your Medical Device NewCo for IP Due Diligence" at the OCTANe Medical Device and Investor Forum.
The Federal Circuit Review is a monthly newsletter featuring the latest case summaries handed down from the U.S. Court of Appeals for the Federal Circuit.
In this issue:
Licensing to Foreign Manufacturers Satisfies Domestic Industry
Appeal Found to Be Moot in Light of “Side Bet”
Mere Design Choice Leads to Obviousness Finding
Design Patent Infringement Complaint Survives Dismissal
Knobbe Martens' attorneys Brenden Gingrich and Kathleen Mekjian conducted a workshop on Sunday, May 5, 2012 at the 99th Annual Meeting of The American Association of Immunologists (AAI), entitled "Monetizing Your Intellectual Property: Protecting Ideas that Generate Income." This presentation explores the types of research innovations that are protectable and provides practical tips for protecting innovations while avoiding some common pitfalls, which can compromise intellectual property.
The document summarizes key takeaways from a presentation on post-grant proceedings and recent Supreme Court patent cases. It discusses statistics on inter partes review outcomes, reasons for denying petitions and claims surviving review. It also analyzes the impact of recent Supreme Court cases that lowered standards for fee shifting in patent cases and required a single actor for direct infringement. The document advises patent drafters and litigators on strategies in view of these legal developments.
Diffusion of Innovations Slides Ch.1 & 2David Onoue
The document summarizes key concepts from Everett Rogers' book Diffusion of Innovations. It discusses four main elements of diffusion: the innovation, communication channels, time, and the social system. It describes how innovations diffuse through a social system via communication channels over time. Individuals make innovation decisions through a process from awareness to adoption or rejection. Innovativeness varies among members of a social system in adopting innovations.
This document summarizes Everett Rogers' theory of the diffusion of innovations. It defines innovation as the development or adoption of new ideas or technologies. Rogers proposed that the diffusion of innovations follows an S-shaped adoption curve as ideas spread from innovators to early adopters and the early and late majorities over time through communication channels. The diffusion process focuses on how innovations are communicated through social systems and the stages of the innovation-decision process by which individuals adopt or reject new ideas.
Knobbe Martens hosted a Pre-Conference Workshop on Monday, October 15, 2012, at the IN3 Medical Device Summit in San Francisco. Knobbe Partners Paul Conover, Curtis Huffmire, and Karen Vogel Weil presented a “Patent Update for Medical Device Companies.” This forum took place in the hub of device investment and innovation in the San Francisco Bay Area, and brought together a diverse group of medtech’s key thought leaders to candidly discuss the critical issues that will define the future of all players in the evolving device space.
Our panel of Knobbe Martens partners hosted this complimentary and informative webinar to discuss the state of software and hardware IP protection and enforcement.
Challenges to obtaining broad software and hardware IP protection are coming from every side. The Supreme Court may decide this year whether certain software even qualifies as patentable subject matter. The USPTO is also examining certain types of software applications with higher scrutiny.
Many recent decisions at the Federal Circuit have made it harder to enforce the IP that you do obtain. In addition to those difficulties, pending patent reform legislation may force a “loser pays” approach in court, where a company may have to pay millions of dollars in legal fees if they don’t win their litigation.
Our panel explained these issues, and provided real-world strategies to help maximize the protection and enforcement of your intellectual property.
On Saturday, May 4, 2013, the Sino-American Biomedical & Pharmaceutical Professionals Association (SABPA) held its 8th Annual Biomedical Forum. The forum focused on career development, entrepreneurship and the latest innovations in pharma/biotech and medical devices industries. The biomedical forum strives to provide an attractive platform for entrepreneurs, scientists, engineers, investors, executives, and policy makers to promote life sciences, biotech, medical device and alliances across the biomedical industry in Southern California and Asian countries. Knobbe Martens Partner Terry Tullis presented on “Commercialization and Patent Infringement.”
On March 30 and 31, 2017, Knobbe Martens attorneys presented written and oral educational material at an IP Seminar Series “Overseas Intellectual Property Rights Protection for Chinese Enterprises” sponsored by CHOFN, a Chinese IP law firm in Guangzhou and Shenzhen, China.
This document summarizes several recent Federal Circuit cases involving issues of patent validity and infringement. The first case summary discusses the Federal Circuit affirming a district court decision upholding patent claims covering the drug Abilify as non-obvious and not invalid for double patenting. The second case discusses the Federal Circuit vacating and remanding a rejection of reissue claims for failure to properly apply the recapture rule. The third case discusses the Federal Circuit affirming a rejection of claims as inherently anticipated by a prior art clinical trial protocol.
Partner Agnes Juang, Ph.D. presented "Navigating the Patent Minefield" at SABPA's 9th Annual Biomedical Forum on Saturday, April 26, at the Crowne Plaza Hotel in Costa Mesa.
The event showcased a number of experts across the pharmaceutical, medical device, and diagnostics industries.
Partner Michael Guiliana presented on "Best Practices for Employee, Contractor and Consulting Agreements" at the Association of Corporate Counsel - Southern California Chapter "DoubleHeader" event.
Knobbe Martens Partner Joseph Re presented at the Washington State Patent Law Association (WSPLA) event "Patent Prosecution Through the Eyes of a Patent Litigator" on Wednesday, September 19, from 12:00 p.m. to 1:30 p.m. View these slides for an in-depth view of patent prosecution and how recent court decisions have impacted IP law.
This document provides an overview of patent systems in Europe and considerations for patent filing and litigation. It discusses the Patent Cooperation Treaty (PCT) system and European Patent Office (EPO) process. Key points include differences from the US system regarding publication grace periods, patentable subject matter, and claim drafting. The document cautions against simply filing foreign counterparts of US applications and recommends tailoring claims and disclosure to individual countries. It also notes risks around amendments and oppositions in the EPO system. Litigation processes in Germany and the UK are briefly outlined.
Knobbe Martens’ patent attorneys Russell Jeide and Scott Cromar hosted a seminar series on intellectual property basics for Temecula’s business community. Entrepreneurs, investors, startups, inventors and anyone interested in learning how intellectual property and patents can help their business will benefit from this presentation.
On October 23, 2013, Knobbe Martens Partners Andrew Douglas and Sabing Lee presented on "Preparing Your Medical Device NewCo for IP Due Diligence" at the OCTANe Medical Device and Investor Forum.
The Federal Circuit Review is a monthly newsletter featuring the latest case summaries handed down from the U.S. Court of Appeals for the Federal Circuit.
In this issue:
Licensing to Foreign Manufacturers Satisfies Domestic Industry
Appeal Found to Be Moot in Light of “Side Bet”
Mere Design Choice Leads to Obviousness Finding
Design Patent Infringement Complaint Survives Dismissal
Knobbe Martens' attorneys Brenden Gingrich and Kathleen Mekjian conducted a workshop on Sunday, May 5, 2012 at the 99th Annual Meeting of The American Association of Immunologists (AAI), entitled "Monetizing Your Intellectual Property: Protecting Ideas that Generate Income." This presentation explores the types of research innovations that are protectable and provides practical tips for protecting innovations while avoiding some common pitfalls, which can compromise intellectual property.
The document summarizes key takeaways from a presentation on post-grant proceedings and recent Supreme Court patent cases. It discusses statistics on inter partes review outcomes, reasons for denying petitions and claims surviving review. It also analyzes the impact of recent Supreme Court cases that lowered standards for fee shifting in patent cases and required a single actor for direct infringement. The document advises patent drafters and litigators on strategies in view of these legal developments.
Diffusion of Innovations Slides Ch.1 & 2David Onoue
The document summarizes key concepts from Everett Rogers' book Diffusion of Innovations. It discusses four main elements of diffusion: the innovation, communication channels, time, and the social system. It describes how innovations diffuse through a social system via communication channels over time. Individuals make innovation decisions through a process from awareness to adoption or rejection. Innovativeness varies among members of a social system in adopting innovations.
This document summarizes Everett Rogers' theory of the diffusion of innovations. It defines innovation as the development or adoption of new ideas or technologies. Rogers proposed that the diffusion of innovations follows an S-shaped adoption curve as ideas spread from innovators to early adopters and the early and late majorities over time through communication channels. The diffusion process focuses on how innovations are communicated through social systems and the stages of the innovation-decision process by which individuals adopt or reject new ideas.
Diffusion of Innovation (Development Communication) -ZKZareen Khan
This document discusses key concepts around communication, development communication, diffusion of innovations, and Everett Rogers' diffusion of innovations theory. It covers the main elements that influence the spread of new ideas through communication channels over time within a social system. The document also discusses the innovation-decision process, adopter categories, the rate of adoption, consequences of innovation, and the role of opinion leaders and change agents in diffusion.
Rogers' Diffusion of Innovations model outlines five factors that influence the adoption of new ideas: (1) attributes of the innovation such as its relative advantage and complexity, (2) the type of decision (individual or collective), (3) communication channels (mass media or interpersonal), (4) the social system including norms and opinion leaders, and (5) the degree of promotion by change agents. The rate of adoption depends on how an innovation is perceived along these factors within a social system over time.
This document discusses the diffusion of innovation, including definitions of key concepts like new products, diffusion, adoption, and the innovation adoption process. It outlines the 5 stages of the adoption process: awareness, interest, evaluation, trial, and adoption/rejection. It also describes the characteristics that influence the diffusion of innovations like relative advantage, compatibility, complexity, trialability, and observability. Finally, it provides a profile of consumer innovators and compares their characteristics to non-innovators.
This document provides an overview of the diffusion of innovation theory and consumer adoption processes. It discusses key concepts like the stages of innovation adoption (innovators, early adopters, etc.), characteristics that influence diffusion, and the awareness-interest-evaluation-trial-adoption consumer decision process. It also profiles different types of early adopters like opinion leaders, market mavens, change leaders, and technophiles who influence wider adoption. The document concludes by noting applications for marketing research, new product development, and product reviews.
Diffusion of Innovation theory examines how, why, and the rate at which new ideas and technologies spread through cultures over time. The key aspects of the theory include the innovation, communication channels, time, and the social system. Adoption of innovations follows an S-curve as they are first adopted by innovators, early adopters, early majority, late majority, and laggards. Factors like relative advantage, compatibility, complexity, trialability, and observability influence adoption rates.
Rogers' diffusion of innovations theory proposes that an innovation is communicated through certain channels over time among the members of a social system. The key elements are the innovation itself, communication channels, time, and the social system. Innovations that are perceived as having greater relative advantage, compatibility, trialability, observability, and less complexity will be adopted more rapidly. Early diffusion research studies investigated the spread of hybrid corn and new drugs. Subsequent studies examined opinion leadership, communication channels, and the five stages of the innovation-decision process: knowledge, persuasion, decision, implementation, and confirmation. Criticisms of diffusion research include a pro-innovation bias and issues of equality in diffusion.
New Barriers to Patent Enforcement Affect Personalized MedicineClaire Laporte
The Supreme Court and the Federal Circuit have imposed new challenges for companies in diagnostics and personalized medicine. This presentation suggests the kinds of claims that may survive these new rulings.
Obtaining patentable claims after Prometheus and MyriadMaryBreenSmith
The Supreme Court cases significantly changed what is patentable subject-matter in the U.S. But how broadly has the scope of patentable subject matter been narrowed by these decisions? Presentation analyzes major claim types in diagnostics and gene-type patents and whether they remain patentable under this new case law.
Partners Dan Altman, David Schmidt, Ph.D. and Jessica Achtsam gave an informative presentation on strategic considerations for claim drafting life sciences inventions. The partners provided insights related to effective and efficient patent prosecution for life sciences-related inventions.
Repositioning Old Drugs For New Indications Using Computational ApproachesYannick Pouliot
Topiramate was identified as a potential drug candidate for inflammatory bowel disease (IBD) using a computational approach. Gene expression profiles of drugs and disease states were analyzed to find drugs that induced the reciprocal signature of IBD tissues compared to normal tissues. Topiramate decreased diarrhea in a rat model of IBD and counter-expressed genes observed in microarray data. This provides proof that drugs affecting gene expression anti-correlated to disease patterns may treat symptoms.
Partners Dan Altman and David Schmidt, Ph.D., gave an informative presentation focused on strategic considerations for drafting and prosecuting patent claims directed to life sciences-related inventions, before the United States Patent and Trademark Office. The presentation was summarized in Japanese by IP Strategist, Kenny Masaki.
Fortifying Life Science Patents: Eligibility and EnablementAurora Consulting
The life sciences are currently facing at least two major plagues in our patent world. The first is that many life science innovations have been deemed ineligible in terms of patentable subject matter. In other words, the courts and the patent office believe that the patent laws are not meant to protect these innovations. The second plague is that the courts believe that many life sciences patents are not enabled. In other words, they are not described in sufficient detail to enable one of skill in the art to make and use the invention.
These subject matter eligibility and enablement plagues manifest in dreaded Section 101 and 112 rejections. In this month’s episode, Dr. Ashley Sloat, President and Director of Patent Strategy at Aurora, leads a discussion, along with our all star patent panel, delving deeply into these rejections and, in the interest of avoiding a podcast 101 rejection, provides some very practical application tips that will help to fortify your life science patent applications.
Blog post: https://www.aurorapatents.com/blog/fortifying-life-science-patents
Podcast Episode: https://patentlystrategic.buzzsprout.com
Access to Research
Date 11-08-2018
Venue Conference HAll NIAS IISc campus
Conference and workshops for clinical practitioners to introduce them to modern tools and an alternative approach to modern scientific research.
Purpose
1. Build a network of physicians across the country
2 Train physicians to analyse clinical data and restructure it to make it compatible with research standards
3. Introduce modern tools to understand the mechanism of actions of medicine
4. Introduce artificial intelligence and machine learning to clinical practitioners to support decision-making processes
Access to Science
Clinical experience and traditional knowledge are important sources of data that affect decision making processes in modern healthcare systems. This data should be made accessible for scientific evaluation and validation to improve healthcare worldwide. The Open Source Pharma Foundation believes that clinical practitioners from various disciplines should have the right to access research so that they can help identify problems, contribute their scientific knowledge, and support the discovery ecosystem.
Background
The majority of medical practitioners working on the ground level with patients do not take part in open clinical research worldwide. However, the data collected and owned by them plays an important role in establishing better discovery pathways. Through this workshop, we seek to open opportunities to enhance health care systems around the world and to overcome the following challenges faced by medical practitioners.
1. Regulatory limitations
2. Academic limitations
3. Time constraints
4. Lack of access to modern tools
Drug repurposing involves finding new uses for existing drugs to treat different diseases. It provides a more efficient and lower cost alternative to traditional drug development. Computational approaches like network-based, text mining, and semantic methods are used to discover novel drug-disease relationships for drug repurposing. These include identifying modules in biological networks, propagating information across networks, extracting relationships from literature, and constructing semantic networks to predict new associations. Drug repurposing reduces costs and risks compared to de novo drug development.
Patent Year In Review 2011 60 Minutes Slidesemanzo7672
The document summarizes several key patent law developments from 2011, including developments in patent eligibility under Section 101, proving infringement, and defenses. Specifically, it discusses the Research Corp., Prometheus, Myriad, CyberSource, Classen, Ultramercial, Global-Tech, i4i, Therasense, and August v. Camtek cases. It also summarizes the America Invents Act passed by Congress.
Gene Express Jaima Presentation September 04, 2008 ChibaDavid Lester
This document discusses the challenges and opportunities of molecular diagnostics and personalized medicine. It defines personalized medicine as using a patient's genetic information to tailor their medical care. The two key components are pharmaceuticals and molecular diagnostics. Existing business models for pharma focus on high volume and high margins, while molecular diagnostics focuses on high volume and low margins. Standardization of molecular diagnostic assays is challenging under the current system. Reimbursement is also a major challenge for widespread adoption of molecular diagnostics. The document suggests government reforms are needed to address reimbursement issues and help realize the potential of personalized medicine.
Natural products are an important source for drug discovery. The drug discovery process involves several steps including target identification, validation, lead identification and optimization through screening compounds for activity against the target. Promising lead compounds then undergo preclinical testing in labs and animal models before progressing to human clinical trials. Computational tools also play an important role in drug design, such as identifying binding sites on target proteins and modeling molecular interactions to optimize lead compounds. Natural products, especially toxins from venom, continue to provide templates for rational drug design.
PRINCIPLES OF DRUG DISCOVERY & DEVELOPMENT.pptxDharaMehta45
The document provides an overview of the principles of drug discovery and development. It discusses the various phases including target identification and validation, hit identification and validation, lead selection and profiling, and pre-clinical and clinical development. The target identification process involves techniques like molecular biology, genetics, and data mining to identify potential biological targets. High-throughput screening is used to test large libraries of compounds to identify initial hits which are then optimized into drug candidates or leads through techniques such as medicinal chemistry and structure-activity relationships. The overall process takes 13-15 years and over $2 billion from initial drug discovery to regulatory approval and market launch.
Computer aided drug design (CADD) uses computer modeling to help design and discover new drug molecules. It involves designing molecules that are complementary in shape and charge to bind to a biomolecular target like a protein. This can help drugs activate or inhibit the target to produce therapeutic effects. CADD is not a direct route to new drugs but provides information to guide and coordinate drug discovery experiments in a more efficient manner. It is hoped CADD can help save time and money in the drug development process.
We can aid decision making from the pre-clinical to the clinical setting, supporting line of sight to the clinic, by identifying and translating crucial biomarker approaches into the real world.
This document summarizes meetings and interviews conducted by HaRo Pharmaceutical regarding development of a new drug to treat high-risk neuroblastoma. It discusses key activities like lead optimization, animal modeling, and clinical trials. Experts noted the importance of disease-relevant models and primary cell-based assays to generate convincing data. Clinical partners could support an IND application and initial trials. While the drug may have multiple indications, neuroblastoma requires more institutional support and approval from key opinion leaders. The document outlines HaRo's potential development path and identifies resources and partners needed at each stage.
Oncoceutics leerink global healthcare 2015oncoceutics
- Oncoceutics has discovered a novel class of compounds called ONC201 that shows compelling efficacy against aggressive and refractory tumors in preclinical studies.
- Phase I/II clinical trials are underway at leading cancer centers to evaluate ONC201's safety and efficacy in hematological malignancies and solid tumors.
- ONC201 engages multiple critical cancer pathways without toxicity, demonstrating potential as a first-in-class therapeutic for treatment-resistant cancers.
A biomarker strategy aims to answer key clinical questions to support drug development through identifying and testing biomarkers. Developing a robust biomarker strategy can mitigate risks and inform clinical study design by generating testable hypotheses to bridge pre-clinical and clinical research. Effective biomarker strategies consider assay suitability, study design, and sample availability to reliably detect biomarkers and provide statistically meaningful results. Emerging technologies allow deeper interrogation of drugs and disease through multiplexed readouts to enhance biomarker discovery and clinical development.
This document discusses extrapolating data from in vitro studies to preclinical and human trials. It defines extrapolation as estimating conclusions based on known facts. Two main methods of extrapolation are described: linear scaling and allometric scaling. When estimating a first human dose, the no-observed adverse effect level from animal studies is determined and converted to a human equivalent dose using body surface area. A safety factor is then applied to determine the maximum recommended starting dose. The document also discusses other approaches like using the minimum anticipated biological effect level.
Clinical trials play an important role in drug discovery and development. They involve several phases to test drug safety and effectiveness in humans starting with healthy volunteers and progressing to larger studies. Positive results from clinical trials provide evidence for regulatory approval and allow drugs to help patients if their benefits outweigh the risks. The goal is to develop new treatments and demonstrate they are safe and effective for their intended uses.
Similar to Patentable Subject Matter in Biotechnology (20)
Partner Ben Anger discusses the latest developments and advanced strategies for PTAB practice, specifically focused on the petitioner side. Ben covers issues related to selecting the prior art, anticipation versus single-reference obviousness, motivation to combine, post-institution practice, and more.
Partners Susan Natland and Jessica Sganga discussed potential trademark and copyright issues in the emerging metaverse, including the surge in popularity of NFTs (non-fungible tokens) and how they may affect intellectual property protections. Get up-to-speed on the “hot” cases in this evolving area and get practical tips on how best to protect your intellectual property from infringement in this virtual space.
Speakers: Susan Natland, Jessica Sganga
Knobbe partners Jeff Van Hoosear (OC) Jason Jardine (SD) and associate Julia Hanson (SD) recently gave a presentation at San Diego Fashion week on intellectual property for designers and artists. The presentation explored what IP is, why it is important to designers, top 5 misconceptions, how to get a copyright, how to get a trademark and how to get a design patent.
Partner Mauricio Uribe continued the two-part, comprehensive discussion on responding to IP threats and assertions. The presentation focused on a more detailed exploration of the topic and strategic implications for various scenarios.
Speakers: Mauricio Uribe
This document discusses strategic considerations for intellectual property risk mitigation and responding to patent infringement threats and assertions. It provides an overview of types of patent infringement, including literal infringement which occurs when each element of a patented claim is identical in an allegedly infringing device or process. It also discusses doctrine of equivalents, contributory infringement, and induced infringement. The document outlines appropriate and limited defenses to patent infringement and notes statutes related to willfulness and enhanced damages. Factors courts consider for determining willfulness are also provided.
Partner Mauricio Uribe continued the two-part, comprehensive discussion on open-source software and third-party vendors. The presentation focused on a more detailed exploration of the topic and strategic implications for various scenarios.
Speakers: Mauricio Uribe
Partner Jason Gersting, Ph.D. moderated a panel of his peers in a discussion about learning how to identify the waves in current written description and enablement law and tips for smoothly riding them to expand, enhance and protect life sciences intellectual property rights. Panelists included Knobbe Martens partners Jessica Achtsam, Eric Furman, Ph.D., and Dan Altman.
Partner Mauricio Uribe kicked off a two-part, comprehensive discussion on open-source software and third-party vendors. The presentation served as an introduction to the topic and provided more general information.
Speakers: Mauricio Uribe
Partner Mauricio Uribe continued the two-part, comprehensive discussion on data privacy. The presentation focused on a more detailed exploration of the topic and strategic implications for various scenarios .
Speakers: Mauricio Uribe
Partner Mauricio Uribe kicked off a two-part, comprehensive discussion on data privacy. The presentation served as an introduction to the topic and provided more general information.
Speakers: Mauricio Uribe
Partners Mauricio Uribe and Vlad Lozan gave an informative presentation on design patent law in the United States. The partners provided best practices for filing and prosecuting design patents in the U.S. and techniques and strategies for including multiple design embodiments in design patent applications. They also discussed how to identify and protect visual elements in computer-related technologies and how to integrate design patents into a holistic intellectual property strategy.
Speakers: Mauricio Uribe, Vlad Lozan
Partners Melanie Seelig and Mauricio Uribe continued the two-part, comprehensive discussion on trade secrets. The presentation focused on a more detailed exploration of the topic and strategic implications for various scenarios .
Speakers: Melanie Seelig and Mauricio Uribe
Partners Melanie Seelig and Mauricio Uribe kicked off a two-part, comprehensive discussion on trade secrets. The presentation served as an introduction to the topic and provided more general information.
Speakers: Melanie Seelig and Mauricio Uribe
Partners Mauricio Uribe and Paul Stellman continued the two-part, comprehensive discussion of strategic planning for capturing and protecting intellectual property. The presentation focused on a more detailed exploration of the topic, diving into the best intellectual property portfolios and cost deferrable strategies to maximize intellectual property spend.
Speakers: Mauricio Uribe and Paul Stellmann
Partners Mauricio Uribe and Vlad Teplitskiy gave an informative presentation on strategic considerations for claim drafting electrical and telecommunications Inventions. The partners provided illustrative claim drafting examples and best practices for defining claim scope, as well as claim drafting strategies for avoiding or minimizing unintentional functional claiming.
Speakers: Mauricio Uribe, Vlad Teplitskiy
Partners Maria Stout and Paul Stellman kicked off a two-part, comprehensive discussion of strategic planning for capturing and protecting intellectual property. The presentation served as an introduction to the topic and provided more general information.
Speakers: Maria Stout and Paul Stellmann
Partners Melanie Seelig and Mauricio Uribe continued the two-part, comprehensive discussion of strategic considerations regarding employment and vendor agreements. The presentation focused on a more detailed exploration of managing employment and vendor agreements, follow-on agreements, and sample language and practical examples.
Speakers: Melanie Seelig and Mauricio Uribe
The webinar covered strategic considerations for key terms in employee and vendor agreements regarding intellectual property and restrictive covenants. It discussed defining the scope of work and assignments of ownership for intellectual property created. Restrictive covenants like non-compete clauses, non-solicitation, anti-poaching, and confidentiality were also covered. The presentation addressed terms regarding the duration of the agreements and obligations after termination.
This document discusses advanced claiming strategies for artificial intelligence and machine learning inventions. It provides an overview of machine learning and the minimal requirements for an algorithm to be considered machine learning. It also discusses best practices for drafting patent claims for machine learning inventions, including providing detailed descriptions of the technical underpinnings of the AI technology and step-by-step algorithms. The document gives examples of potential patentable subject matter for machine learning inventions, such as collecting or forming a data set, modifications to algorithms, and using machine learning processed data. It provides sample patent claims related to training a neural network, predicting device failures using state and configuration data, and characterizing user inputs using machine learning.
More from Knobbe Martens - Intellectual Property Law (20)
A Visual Guide to 1 Samuel | A Tale of Two HeartsSteve Thomason
These slides walk through the story of 1 Samuel. Samuel is the last judge of Israel. The people reject God and want a king. Saul is anointed as the first king, but he is not a good king. David, the shepherd boy is anointed and Saul is envious of him. David shows honor while Saul continues to self destruct.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
This presentation was provided by Racquel Jemison, Ph.D., Christina MacLaughlin, Ph.D., and Paulomi Majumder. Ph.D., all of the American Chemical Society, for the second session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session Two: 'Expanding Pathways to Publishing Careers,' was held June 13, 2024.
This presentation was provided by Rebecca Benner, Ph.D., of the American Society of Anesthesiologists, for the second session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session Two: 'Expanding Pathways to Publishing Careers,' was held June 13, 2024.
Philippine Edukasyong Pantahanan at Pangkabuhayan (EPP) CurriculumMJDuyan
(𝐓𝐋𝐄 𝟏𝟎𝟎) (𝐋𝐞𝐬𝐬𝐨𝐧 𝟏)-𝐏𝐫𝐞𝐥𝐢𝐦𝐬
𝐃𝐢𝐬𝐜𝐮𝐬𝐬 𝐭𝐡𝐞 𝐄𝐏𝐏 𝐂𝐮𝐫𝐫𝐢𝐜𝐮𝐥𝐮𝐦 𝐢𝐧 𝐭𝐡𝐞 𝐏𝐡𝐢𝐥𝐢𝐩𝐩𝐢𝐧𝐞𝐬:
- Understand the goals and objectives of the Edukasyong Pantahanan at Pangkabuhayan (EPP) curriculum, recognizing its importance in fostering practical life skills and values among students. Students will also be able to identify the key components and subjects covered, such as agriculture, home economics, industrial arts, and information and communication technology.
𝐄𝐱𝐩𝐥𝐚𝐢𝐧 𝐭𝐡𝐞 𝐍𝐚𝐭𝐮𝐫𝐞 𝐚𝐧𝐝 𝐒𝐜𝐨𝐩𝐞 𝐨𝐟 𝐚𝐧 𝐄𝐧𝐭𝐫𝐞𝐩𝐫𝐞𝐧𝐞𝐮𝐫:
-Define entrepreneurship, distinguishing it from general business activities by emphasizing its focus on innovation, risk-taking, and value creation. Students will describe the characteristics and traits of successful entrepreneurs, including their roles and responsibilities, and discuss the broader economic and social impacts of entrepreneurial activities on both local and global scales.