This document discusses the influenza virus and different flu outbreaks throughout history. It provides statistics on deaths from the 1918 Spanish flu, 1957 flu, and 1968 flu pandemics as well as the 2009 H1N1 outbreak. It also summarizes the structure and transmission of influenza viruses, symptoms in birds, and methods of vaccination including inactivated, attenuated, and recombinant DNA vaccines.

1. The Flu – circa 2009 BIOL161 – SPECIAL LECTURE

2. A family is a unit composed not only of children but of men, women, an occasional animal, and the common cold.

3. – Ogden Nash

4. http://www.cdc.gov/flu http://www.who.int

5. http://www.pandemicflu.gov/ Or, http://flu.gov !!

6. Avian and Swine Flu!

7. 1918 Spanish Flu Epidemic

8. International co-circulation of 2009 H1N1 and seasonal influenza (As of November 6, 2009)

10. Doctors Visits

11. Human infections 1918 deaths 675,000 (USA)

12. 50 Million (World) 1957 deaths 70,000 deaths

13. 1-2 Million (World) 1968 deaths 34,000 (USA)

14. 700,000 (World) 2005 34,000 deaths (USA)

15. 114,000 hospitalized 2009 (Aug. 30 to Oct. 31) 672 deaths (H1N1 only)

16. 17,838 hospitalized (H1N1 only)

17. Influenza A Virion Approx. 100 nm d. Contained in a lipid bilayer (derived from the plasma membrane of its host) ~500 molecules of hemagglutinin

18. ~100 molecules of neuraminidase

19. 8 pieces of RNA

20. many copies of a nucleoprotein