This document outlines considerations for establishing a basic pharmacovigilance system in Africa to monitor adverse drug reactions (ADRs), especially for HIV/AIDS treatments. It describes special challenges including limited health infrastructure and resources. The proposed system would have peripheral health facilities report ADRs to district evaluation teams. Tertiary facilities would investigate serious ADRs. It emphasizes communication and appropriate responses to identified safety issues. Key factors for success include training, clear responsibilities, public awareness, and open communication between stakeholders.