This document summarizes the current status of transboundary animal diseases in Taiwan. It discusses the prevention and control of foot-and-mouth disease (FMD) and highly pathogenic avian influenza (HPAI). For FMD, vaccination rates for cloven-hoofed animals are over 90% and herd protection levels are over 80%. For HPAI, novel strains were introduced in 2015 through migratory birds and spread among poultry farms, leading to the culling of over 5 million birds. Through control measures, HPAI cases decreased from 1,054 in 2015 to 43 in 2016. Effective biosecurity and surveillance are needed to minimize threats from FMD and HPAI.