The autonomic nervous system consists of the sympathetic and parasympathetic divisions. The sympathetic division uses norepinephrine as its neurotransmitter and is active during stress responses, while the parasympathetic division uses acetylcholine and is active at rest. Together they control functions like heart rate, digestion, and gland secretion through complementary actions on target organs like the heart and intestines. Pharmacological agents can either mimic or block the neurotransmitters of each division to modulate autonomic functions.
Classification of nerve fibers, Nervous System PhysiologyShaista Jabeen
https://www.youtube.com/channel/UCrrAABI7QDRCJ1yMrQCip_w/videos
https://www.facebook.com/ShaistaJabeeen/
https://www.facebook.com/Human-Physiology-Lectures-100702741804409/
Classification of nerve fibers
Nervous System Physiology
BASIS OF CLASSIFICATION
DEPENDING UPON STRUCTURE
DEPENDING UPON DISTRIBUTION
DEPENDING UPON ORIGIN
DEPENDING UPON FUNCTION
DEPENDING UPON SECRETION OF NEUROTRANSMITTER
DEPENDING UPON DIAMETER AND CONDUCTION OF IMPULSE
Short Notes
pdf ppt
Classification of nerve fibers, Nervous System PhysiologyShaista Jabeen
https://www.youtube.com/channel/UCrrAABI7QDRCJ1yMrQCip_w/videos
https://www.facebook.com/ShaistaJabeeen/
https://www.facebook.com/Human-Physiology-Lectures-100702741804409/
Classification of nerve fibers
Nervous System Physiology
BASIS OF CLASSIFICATION
DEPENDING UPON STRUCTURE
DEPENDING UPON DISTRIBUTION
DEPENDING UPON ORIGIN
DEPENDING UPON FUNCTION
DEPENDING UPON SECRETION OF NEUROTRANSMITTER
DEPENDING UPON DIAMETER AND CONDUCTION OF IMPULSE
Short Notes
pdf ppt
Peripheral Nervous System, Audumbar MaliAudumbar Mali
Peripheral Nervous System,
Types of PNS,
Spinal nerves,
Types of neuron (3 basic types),
Plexus,
Cranial nerves,
Autonomic nervous system,
Structure of Neuron,
Human Anatomy and Physiology-I,
Syllabus As per PCI,
B. Pharm-I
the ddep structure of brain, diencephalon, third ventricle, thalamus, hypothalamus, epithalamus, meta thalamus, boudaries of diencephalon, extent of diencephalon, boundaries of thalamus, boundaries of hypothalamus, functions of meta thalamus, functions of sub thalamus.components of epithalamus, functions of epithalamus, fornix, third ventricle, optic chiasma,
understanding spinal cord, its bransches, lesions, functions and anatomy.
hope to give you better knowledge of spinal cord by the end of it.
plese review ans comment for my future updates and corrections that iw ill be needing in this.
Peripheral Nervous System, Audumbar MaliAudumbar Mali
Peripheral Nervous System,
Types of PNS,
Spinal nerves,
Types of neuron (3 basic types),
Plexus,
Cranial nerves,
Autonomic nervous system,
Structure of Neuron,
Human Anatomy and Physiology-I,
Syllabus As per PCI,
B. Pharm-I
the ddep structure of brain, diencephalon, third ventricle, thalamus, hypothalamus, epithalamus, meta thalamus, boudaries of diencephalon, extent of diencephalon, boundaries of thalamus, boundaries of hypothalamus, functions of meta thalamus, functions of sub thalamus.components of epithalamus, functions of epithalamus, fornix, third ventricle, optic chiasma,
understanding spinal cord, its bransches, lesions, functions and anatomy.
hope to give you better knowledge of spinal cord by the end of it.
plese review ans comment for my future updates and corrections that iw ill be needing in this.
introduction to Autonomic Nervous System consisting of Cholinergic, adrenergic and enteric Nervous system with focus on location of neurotransmitters and broad functions of parasympathetic and sympathetic nervous system.
Autonomic nervous system: divisions
General organization of ANS Neurons of ANS
Physiological anatomy of sympathetic nervous system& parasympathetic nervous System
Autonomic neurotransmitters and receptors
Functions of ANS: effects of autonomic nerve impulses on effector organs
Differences between sympathetic and parasympathetic systems
APPLIED ASPECTS- Autonomic drugs, Autonomic failure, Autonomic function tests
REPORT | Zoology/ Anaphy- Summary of Parasympathetic and Sympathetic Division of PNS
PHARMA 1Y2-4 | Our Lady of Fatima University
Presentation Templates | Slides Carnival <3
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
3. 3
Sympathetic and Parasympathetic
Divisions of the ANS
• How they are similar:
– Both divisions are part of
the ANS
– Both have effects on
smooth muscle, cardiac
muscle and glands
• How they differ:
– Stimulation of effectors by
each system vary from one
body system to another.
Effects may be stimulatory
or inhibitory.
– Location
– Length of pre and
postganglionic fiber
– Neurotransmitters used
4. 4
Comparison of ANS and Somatic Motor
Pathways
• Somatics
– Single neuron from spinal
cord to effector
– One neuron innervates the
effector cell
– NTS is acetylcholine (ACh)
• Autonomics
– Two neurons relay
(ganglion) to effector
– Dual innervation of
effectors
– NTS at ganglia (ACh); NTS
at effector can be ACh or
norepinephrine
5. Location and neurotransmitters
used by Sympathetic/Parasymp
sympathetic
parasympathetic
preganglionic neuron
postganglionic neuron
nicotinic receptors muscarinic receptors
adrenergic receptors
6. Characteristics of Sympathetic and
Parasympathetic Function
• Post-ganglionic sympathetic nerves release
norepinephrine at their nerve endings
– these nerves are called adrenergic nerves
• Pre and post-ganglionic parasympathetic
nerves release acetylcholine at their nerve
endings (Nitric oxide- corpora cavernosa)
– these nerves are called cholinergic nerves
• EXCEPTION FOR SYMPATHETIC:
– Cholinergic: mACH; used in body wall.
– Vasodilation of vessels in brain and
skeletal muscle
– Piloerector muscles
– Sweat glands
– Nitric oxide: vasodilation of vessels in
brain, skeletal muscle
7. 7
Sympathetic
Nervous System
“Thoracolumbar”
Figure 60-1;
Guyton & Hall
When active?
Length of pre and
postganglionic
nerve?
Location of cell
bodies of
preganglionic nerve?
Location of cell
bodies of
postganglionic
nerve?
Neurotransmitters
released?
Adrenal medulla
8. 8
Lipolysis and thermogenesisAdipose tissue
β 3
Inhibitory, relaxation of resp. tract to
get dilation
Respiratory tract, GI,
glands, hepatocytes
β 2
Increased heart rate and inotropyHEART, kidney,
adipocytes
β 1
Presynaptic control/ release of NTVascular endothelium
α 2c
Increase vasoconstriction (increased
MI mortality w/polymorphism)
Vascular endothelium
α 2b
Lipid metabolismVascular endothelium
and adipocytes
α 2a
Increased BP, vasoconstrictionArteries, heart
α 1B
Increased inotropy, closure of GI
sphincters, vasoconstriction, pupil
dilation
Iris, intestine, heart and
arteries
α 1a
ActionsWhere found?Receptor
9. 9
Parasympathetic
Nervous System
“cranio-sacral”
Parasympathetic nerves originate
from cranial nerves III, VII, IX, and X
and the sacral spinal cord.
occulomotor nerve - fibers to
the pupillary sphincters and
ciliary muscle
facial nerve - fibers to lacrimal
and submandibular gland
glossopharyngeal nerve - fibers
to parotid gland
vagus nerve - motor inputs to
visceral organs
sacral segments - fibers to
descending colon, rectum,
bladder and genitalia
Figure 60-3;
Guyton & Hall
10. Effects of the ANS on the Organs
• eye
– sympathetic --pupillary dilation
(alpha 1 receptor)
– parasympathetic--pupillary
constriction and
accommodation (focusing) of
the lens (mACh receptor)
• glands of the body
– parasympathetic stimulate the
nasal, lacrimal, salivary, and
G.I. glands (mACh receptor)
– sympathetic stimulates the
sweat glands (mACh receptor)
11. Effect of the Autonomic Nervous
System on the Organs
• G.I. tract
– parasympathetic stimulates overall
activity including G.I. smooth muscle
– sympathetic has very little effect
• heart
– sympathetic increases the rate and
contractility
– parasympathetic decreases heart rate
• blood vessels
– sympathetic causes vasoconstriction.
Reduced sympathetic response accounts
for most vasodilation.
– parasympathetic causes some
vasodilation (e.g., penis)
12. Sympathetic and Parasympathetic
“Tone”
• the basal rate of activity
of each system
• this background activity
allows for an increase or
decrease in activity by a
single system
– sympathetic tone
normally causes about a
50 % vasoconstriction
• increasing or decreasing
“tone” can change vessel
diameter
– parasympathetic tone
provides background
G.I. activity
13. adrenergic or sympathomimetic
drugs act like norepinephrine
• these drugs have an effect which is much more prolonged
than that of either norepinephrine
– phenylephrine stimulates alpha receptors
– isoproterenol stimulates both beta1 and beta2 receptors
– albuterol stimulates only beta2 receptors
• some drugs act indirectly by increasing the release of
norepi from its storage terminals
– ephedrine, amphetamine, pseudoephedrine,
14. Pharmacology of the Sympathetic
Nervous System
• drugs that block the
effect of
norepinephrine
• alpha blockers
– phentolamine
– Cheap Viagra!
• beta blockers
– beta1 and 2 -
propranolol
15. Pharmacology of the
Parasympathetic Nervous System
• parasympathomimetic drugs
– muscarine
– pilocarpine
• activates muscarinic
receptors, cause profuse
sweating (why if sweat
glands are controlled by
sympathetic system?)
• cholinesterase inhibitors
– neostigmine, potentiates the
effect of acetylcholine
• antimuscarinic drugs
– atropine blocks the effect of
acetylcholine on effector cells