The document discusses the autonomic nervous system (ANS), which is divided into the sympathetic and parasympathetic nervous systems. The sympathetic division is responsible for the "fight or flight" response and increases heart rate and metabolism, while the parasympathetic division elicits "rest and digest" responses like decreasing heart rate and increasing gastrointestinal function. The ANS helps regulate many involuntary body functions and maintains homeostasis. It transmits signals via the preganglionic and postganglionic neurons with acetylcholine or norepinephrine as neurotransmitters depending on the division. The ANS acts antagonistically on certain organs like the heart or complementarily like on salivary glands and integrates input from the central nervous system to control
Autonomic nervous system: divisions
General organization of ANS Neurons of ANS
Physiological anatomy of sympathetic nervous system& parasympathetic nervous System
Autonomic neurotransmitters and receptors
Functions of ANS: effects of autonomic nerve impulses on effector organs
Differences between sympathetic and parasympathetic systems
APPLIED ASPECTS- Autonomic drugs, Autonomic failure, Autonomic function tests
Autonomic nervous system: divisions
General organization of ANS Neurons of ANS
Physiological anatomy of sympathetic nervous system& parasympathetic nervous System
Autonomic neurotransmitters and receptors
Functions of ANS: effects of autonomic nerve impulses on effector organs
Differences between sympathetic and parasympathetic systems
APPLIED ASPECTS- Autonomic drugs, Autonomic failure, Autonomic function tests
Pharmacology Lecture Slides on Autonomic Nervous System Introduction by Sanjaya Mani Dixit Assistant Professor of Pharmacology at Kathmandu Medical College
introduction to Autonomic Nervous System consisting of Cholinergic, adrenergic and enteric Nervous system with focus on location of neurotransmitters and broad functions of parasympathetic and sympathetic nervous system.
The Autonomic nervous system divided into two parts i.e sympathetic nervous system and parasympathetic nervous system.
ANS also consists cranial nerve and spinal nerve.
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Pharmacology Lecture Slides on Autonomic Nervous System Introduction by Sanjaya Mani Dixit Assistant Professor of Pharmacology at Kathmandu Medical College
introduction to Autonomic Nervous System consisting of Cholinergic, adrenergic and enteric Nervous system with focus on location of neurotransmitters and broad functions of parasympathetic and sympathetic nervous system.
The Autonomic nervous system divided into two parts i.e sympathetic nervous system and parasympathetic nervous system.
ANS also consists cranial nerve and spinal nerve.
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Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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3. Learning Objectives
• List the divisions of nervous system
• List the structural differences between
autonomic and somatic nervous system
• Describe the organisation of autonomic
nervous system
• Describe the origin and course of sympathetic
and parasympathetic fibres
6. Autonomic = Free will
• Cardiovascular system
• Respiratory system
• Endocrine system
• Reproductive system
• Gastrointestinal system
• Renal system
• Musculoskeletal system
Autonomic Nervous System
Somatic Nervous System
7. ANS
• Homeostasis
• Coordinates responses to external stimuli
• Survival possible without ANS
• But ability to combat stress difficult
8. DIVISIONS OF ANS
1. Motor system – sympathetic & parasympathetic
2. Enteric nervous system of GIT
3. Visceral afferent pathways sensory
4. Descending pathways from forebrain, brainstem
30. The Adrenal Medulla
Similarities between adrenal medulla and
postganglionic sympathetic neurons
1. Both are excited by preganglionic
sympathetic fibres
2. Both respond to ACh
3. Both release catecholamines in response to
stimulation
47. Postganglionic sympathetic neurons - Adrenergic
Norepinephrine is the
predominant
neurotransmitter
released by the
Postganglionic
sympathetic neurons
Exceptions – sweat
glands, blood vessels of
skeletal muscles ,
piloerector muscles –
Ach
50. Termination of ACh action
• Acetylcholinesterase – split ACh into acetate
and choline
• Choline is taken up by the nerve terminal for
resynthesis of ACh.
51. Synthesis of epinephrine & norepinephrine
• Synthesis of epinephrine & norepinephrine
begins in the axoplasm and is completed
inside the vesicle
52. Termination of adrenergic action
1. Reuptake into nerve endings
2. Diffusion into blood
3. Degraded by enzymes Mono Amine
Oxidase(MAO), Catechol-O-Methyl
transferase(COMT).
53. • Cholinergic – pertaining to Acetylcholine
• Adrenergic – pertaining to adrenaline &
noradrenaline
54. Cholinergic neurons in the ANS
1. All preganglionic neurons
2. All parasympathetic postganglionic neurons
3. Sympathetic postganglionic neurons that innervate
sweat glands
4. Sympathetic cholinergic fibres – sympathetic
postganglionic neurons that end on blood vessels in
some skeletal muscles and produce vasodilation when
stimulated (sympathetic vasodilator nerves)
59. Sympathetic & parasympathetic tone
The normal basal firing of sympathetic and
parasympathetic neurons is called the
‘sympathetic & parasympathetic tone’
eg: Blood vessels – sympathetic tone
GI tract – parasympathetic
Heart
60. Postganglionic sympathetic and
parasympathetic neurons have muscarinic
as well as nicotinic receptors
• Nicotinic receptor – Ionotropic (ligand gated)
• Muscarinic receptor – Metabotropic (GPCR)
74. ENTERIC NERVOUS SYSTEM
• 3rd division of ANS
1. Myentric plexus – b/w longitudinal & circular M
control motility
2. Meissner’s plexus – b/w circular M & mucosa
control blood flow to GIT & secretions
76. ENTERIC NERVOUS SYSTEM
• MINIBRAIN
• Sensory N , interN, motor N
• Regulated by sympathetic and parasympathetic
nervous system
• But can also function autonomously
80. Horner’s Syndrome
Consists of a triad of signs,
• 1.Miosis
• 2.Anhydrosis (loss of sweating) of half the face
• 3.Ptosis (Drooping of eyelid)
Damage to the sympathetic supply to the face.
Causes:
• 1.Lesion in the brainstem
• 2.Lesion in the sympathetic ganglion
• 3.Damage to the nerves