Prof. Bob de Graaff sprak op de VOGIN-IP-lezing op 26 maart 2015, over de veranderingen in de wereld van de inlichtingendiensten; door ontwikkelingen op internet kan nu iedereen zijn eigen inlichtingendienst zijn
Prof. Bob de Graaff sprak op de VOGIN-IP-lezing op 26 maart 2015, over de veranderingen in de wereld van de inlichtingendiensten; door ontwikkelingen op internet kan nu iedereen zijn eigen inlichtingendienst zijn
This is the presentation material used for the VOGIN-IP lezing 28 februari 2013 by Marina Noordegraaf. If you want to hear more about the context and meaning of the images, you know whom you might ask ;-) For the version WITH animations go to http://dl.dropbox.com/u/18649633/VOGINIP280213Slideshare.pptx
De spelregels van de publieke informatieruimte worden opnieuw geschreven. In deze presentatie nemen Frank Huysmans en Marina Noordegraaf je mee in de digitale wereld, waarin toegang tot informatie niet vanzelfsprekend is en soms wordt verzameld zonder dat je het weet.
De presentatie spoort kenniswerkers aan om positie te nemen en hun gebruikers de weg te wijzen naar hun rechten in een gedigitaliseerde maatschappij.
Voginip lezing 2015: Classificeren zonder voorbeeldentmensink
Traditionele beeld-classificatiesystemen zijn getraind op basis van handmatig gelabelde voorbeelden. Per concept is een groot aantal voorbeelden gelabeld, en dan wordt met behulp van machine-learning technieken een classificatiesysteem aangeleerd. Maar wat als het concept waarin je geïnteresseerd bent, niet tussen die voorbeelden staat? In deze voordracht bespreek ik machine-learning methoden die ook zonder expliciete voorbeelden beelden kunnen classificeren voor een specifiek concept.
Traditional visual classification systems are trained based on manually labeled examples. For each concept a large number of images are annotated, on which a classifier is trained. But what if your desired class or label is not in the vocabulary? In this presentation I discuss techniques used to classify without any examples. My results and methods are based on computer vision applications, but the underlying ideas can be used in other domains as well.
Presentation of NewsReader as keynote for VOGIN-IP 2015. Can we handle the news? How computers reads millions of news articles to extract what, when, where and who is involved over longer periods of time. News reading technology is developed for 4 languages (English, Dutch Spanish and Italian), creating RDF from text.
Sinds de publicatie van het “Altmetrics manifesto” door Jason Priem en de zijnen heeft dit onderwerp een grote vlucht genomen. In het huidige bibliometrics landschap krijgt het onderzoek naar andere mogelijkheden om impact van publicaties en onderzoek te meten een prominente plaats. Tegenwoordig willen onderzoekers niet alleen maar beoordeeld worden op basis van Impact Factoren en versterken zij de roep om alternatieve methoden om impact te beoordelen. In het kader van onderzoeksondersteuning kunnen bibliotheken in dit domein een nieuwe en belangrijke rol spelen. In deze sessie worden de ontwikkelingen tegen het licht gehouden en sterke en zwakke punten blootgelegd. Tijdens de workshop wordt ingegaan op de verschillende indicatoren voor het bepalen van de impact van tijdschriften, artikelen, onderzoeksgroepen en onderzoekers. Tools, methoden en het laatste onderzoek komen aan bod.
This is the presentation material used for the VOGIN-IP lezing 28 februari 2013 by Marina Noordegraaf. If you want to hear more about the context and meaning of the images, you know whom you might ask ;-) For the version WITH animations go to http://dl.dropbox.com/u/18649633/VOGINIP280213Slideshare.pptx
De spelregels van de publieke informatieruimte worden opnieuw geschreven. In deze presentatie nemen Frank Huysmans en Marina Noordegraaf je mee in de digitale wereld, waarin toegang tot informatie niet vanzelfsprekend is en soms wordt verzameld zonder dat je het weet.
De presentatie spoort kenniswerkers aan om positie te nemen en hun gebruikers de weg te wijzen naar hun rechten in een gedigitaliseerde maatschappij.
Voginip lezing 2015: Classificeren zonder voorbeeldentmensink
Traditionele beeld-classificatiesystemen zijn getraind op basis van handmatig gelabelde voorbeelden. Per concept is een groot aantal voorbeelden gelabeld, en dan wordt met behulp van machine-learning technieken een classificatiesysteem aangeleerd. Maar wat als het concept waarin je geïnteresseerd bent, niet tussen die voorbeelden staat? In deze voordracht bespreek ik machine-learning methoden die ook zonder expliciete voorbeelden beelden kunnen classificeren voor een specifiek concept.
Traditional visual classification systems are trained based on manually labeled examples. For each concept a large number of images are annotated, on which a classifier is trained. But what if your desired class or label is not in the vocabulary? In this presentation I discuss techniques used to classify without any examples. My results and methods are based on computer vision applications, but the underlying ideas can be used in other domains as well.
Presentation of NewsReader as keynote for VOGIN-IP 2015. Can we handle the news? How computers reads millions of news articles to extract what, when, where and who is involved over longer periods of time. News reading technology is developed for 4 languages (English, Dutch Spanish and Italian), creating RDF from text.
Sinds de publicatie van het “Altmetrics manifesto” door Jason Priem en de zijnen heeft dit onderwerp een grote vlucht genomen. In het huidige bibliometrics landschap krijgt het onderzoek naar andere mogelijkheden om impact van publicaties en onderzoek te meten een prominente plaats. Tegenwoordig willen onderzoekers niet alleen maar beoordeeld worden op basis van Impact Factoren en versterken zij de roep om alternatieve methoden om impact te beoordelen. In het kader van onderzoeksondersteuning kunnen bibliotheken in dit domein een nieuwe en belangrijke rol spelen. In deze sessie worden de ontwikkelingen tegen het licht gehouden en sterke en zwakke punten blootgelegd. Tijdens de workshop wordt ingegaan op de verschillende indicatoren voor het bepalen van de impact van tijdschriften, artikelen, onderzoeksgroepen en onderzoekers. Tools, methoden en het laatste onderzoek komen aan bod.
Keynote presentation at the Lita Forum, Albuquerque. Research and learning practices are enacted in technology rich environments. New tools support digital workflows and the volume and variety of research and learning outputs are growing. Libraries are working to support these new environments and to connect their services to them.
Supporting the Interpretation of Enriched Audiovisual Sources through Tempora...TimelessFuture
This presentation at DH Benelux 2019, receiving one of the two best paper awards, includes findings of the ReVI project. This was a pilot looking at enhancing the Resource Viewer of the CLARIAH Media Suite, where audiovisual materials can be played. Specifically, the ReVI project looked at optimal ways "to support the exploration of different types of content metadata of audiovisual sources, such as segment information or automatic transcripts." During the project, various design thinking sessions were conducted, and a prototype including temporal content visualizations of audiovisual materials was created and evaluated in a user study. The findings of the user study showed a clear value of temporal visualizations and advanced annotation features for research purposes, as well as the continued importance of a data and tool criticism approach. New content exploration tools can benefit scholars doing research with audiovisual sources, for instance in media studies, oral history, film studies, and other disciplines which are increasingly using audiovisual media. The findings documented in the DH Benelux 2019 paper may serve as an inspiration for improving AV-media-based research tools. Concretely, it will also inform the further enhancement of the Resource Viewer of the CLARIAH Media Suite.
Slides from guest presentation at Aron Lindberg's Computational-Qualitative Field Research seminar: http://aronlindberg.github.io/computational_field_research/ Needed readings at https://www.dropbox.com/sh/1gx9s2zlnxvumbz/AAAV9uSAJHsiPeJhSsNnnM9Pa?dl=0
The Liber 2009 presentation repeated for a Dutch audience IN Dutch but with the english slides (just the first one is in Dutch :-)
Samenwerking Hogeschool bibliotheken SHB, 5 november 2009
Outline of the UCSF approach to Research Networking, which focuses on rapid iterations of adding new data sources and features to see what works, and abandon what doesn't work.
Ethnography in Software Design - An Anthropologist's PerspectiveKelly Moran
Ethnography claims its roots from the field of anthropology. How can a technique used for such a seemingly exotic purpose be useful in the modern world of software design? Revealing and most importantly understanding user needs requires sensitivity, empathy, and a disciplined approach – all of which can be found within ethnography. This talk outlines the basic components of an ethnographic perspective, explores a case study from a recent engagement between projekt202 and an enterprise software company, and highlights how the impact of this research ripples through the software development process.
A talk I gave for the SOLAR research group. It covers issues in open scholarship, alt metrics & online identity. It was a bit of a catch-all talk, which I'll probably refine over the next few months.
Small steps-big-opportunities-brussels-open-access-week-2015-kramer-bosman sl...Bianca Kramer
Presentation on 'Innovations in scholarly communication' for Open Access 2015 meeting, Brussels, October 21, 2015. Slides in pdf format.
See also http://101innovations.wordpress.com
Scholarly social media applications platforms for knowledge sharing and net...tullemich
This short presentation deals with some of the current publishing workflows to platforms for scholarly knowledge sharing and SoMe networking. It is touched upon what kind of implications emerge from operating in these open and networked virtual research environments (VRE) e.g. publishing open access.
AI en IP (Artificieele Intelligentie en Intellectueel Eigendom)voginip
Lezing door Fulco Blokhuis over de juridische aspecten die optreden bij generatieve AI, zoals ChatGPT, Dall-e e.d.
VOGIN-IP-lezing 28 april 2024 Amsterdam
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
3. “Can we dispense with traditional peer-
review in the future? I think we might. We
are probably in a transitional phase right
now. Community-based evaluation is where
we are heading..” Rolf Zwaan 2013
“Two minutes is a reasonable
time-frame…” for sharing your
data if someone asks for it.
Daniël Lakens 2015
[demonstratie van
eiwitsequenties]
An Ghysels 2014
analysis outreach publication
4. A simple cyclic model of the research workflow
preparation
analysis
writingpublication
outreach
assessment discovery
5. Activities in the research workflow stages
→discovery analysis writing publication outreach assessment→ → → →
- search
- get access
- reference
management
- read/view
- annotate
- experiment/
collect data
- analyze
- share
workflows,
protocols
- visualize
- write
- cite
- archive/share
publications
- archive/share
data/code
- select journal
to publish in
- publish
- archive/share
presentation /
posters
- public
outreach
- researcher
profiling
- comment
- peer review
(pre-pub &
post-pub)
- measure
impact
10. Most important developments
in scholarly communication (survey)
Discovery Analysis Writing Publication Outreach Assessment
Data sharing Open Access Altmetrics
Usefulness of
data
New review
policies
Research data
management
New business
models
Open Educational Resources / Tools for mobile / Social media / Sharing information