HBase is a distributed, column-oriented database built on top of HDFS that can handle large datasets across a cluster. It uses a map-reduce model where data is stored as multidimensional sorted maps across nodes. Data is first written to a write-ahead log and memory, then flushed to disk files and compacted for efficiency. Client applications access HBase programmatically through APIs rather than SQL. Map-reduce jobs on HBase use input, mapper, reducer, and output classes to process table data in parallel across regions.