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Supply of oxygen to tissues mainly involves two systems i.e. respiratory system and the cardiovascular system. Supply of oxygen to tissues depends upon Adequate PO2 in atmospheric air Adequate pulmonary ventilation Adequate gaseous exchange in the lungs Adequate uptake of oxygen by the blood Adequate blood flow to the tissues Adequate ability of the tissues to utilize oxygen Oxygen diffuses from the alveoli into the pulmonary capillary blood because the oxygen partial pressure (Po2) in the alveoli is greater than the Po2 in the pulmonary capillary blood. In the other tissues of the body, a higher Po2 in the capillary blood than in the tissues causes oxygen to diffuse into the surrounding cells. The Po2 of the gaseous oxygen in the alveolus averages 104 mm Hg, whereas the Po2 of the venous blood entering the pulmonary capillary at its arterial end averages only 40 mm Hg Therefore, the initial pressure difference that causes oxygen to diffuse into the pulmonary capillary is 104 – 40, or 64 mm Hg. About 98 percent of the blood that enters the left atrium from the lungs has just passed through the alveolar capillaries and has become oxygenated up to a Po2 of about 104 mm Hg. Another 2 per cent of the blood which supplies mainly the deep tissues of the lungs and is not exposed to lung air. This blood flow is called “shunt flow,” meaning that blood is shunted past the gas exchange areas One gram of Hb can bind 1.34 ml of Oxygen Normal level of Hb is 15 grams/dL Thus 15 grams of hemoglobin in 100 milliliters of blood can combine with a total of almost exactly 20 milliliters of oxygen if the hemoglobin is 100 per cent saturated This is usually expressed as 20 volumes per cent Hemoglobin is a conjugated protein consisting of heme and globin. The ferrous form can bind oxygen. Hemoglobin molecule consists of four subunits each consists of one heme and one polypeptide chain Each subunit can bind one molecule of Oxygen Oxygenation is a very rapid and reversible process and it can occur in 0.01 seconds When PO2 is high, oxygen binds with Hb to form Oxyhemoglbin When PO2 is low oxygen leaves Hb to form Deoxy Hb. Factors that shift the oxygen hemoglobin dissociation curve
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Once the oxygen diffuses across the alveoli, it enters the bloodstream and is transported to the tissues where it is unloaded, and carbon dioxide diffuses out of the blood and into the alveoli to be expelled from the body. Although gas exchange is a continuous process, the oxygen and carbon dioxide are transported by different mechanisms. What You’ll Learn to Do Describe how oxygen is bound to hemoglobin and transported to body tissues Explain how carbon dioxide is transported from body tissues to the lungs
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Supply of oxygen to tissues mainly involves two systems i.e. respiratory system and the cardiovascular system. Supply of oxygen to tissues depends upon Adequate PO2 in atmospheric air Adequate pulmonary ventilation Adequate gaseous exchange in the lungs Adequate uptake of oxygen by the blood Adequate blood flow to the tissues Adequate ability of the tissues to utilize oxygen Oxygen diffuses from the alveoli into the pulmonary capillary blood because the oxygen partial pressure (Po2) in the alveoli is greater than the Po2 in the pulmonary capillary blood. In the other tissues of the body, a higher Po2 in the capillary blood than in the tissues causes oxygen to diffuse into the surrounding cells. The Po2 of the gaseous oxygen in the alveolus averages 104 mm Hg, whereas the Po2 of the venous blood entering the pulmonary capillary at its arterial end averages only 40 mm Hg Therefore, the initial pressure difference that causes oxygen to diffuse into the pulmonary capillary is 104 – 40, or 64 mm Hg. About 98 percent of the blood that enters the left atrium from the lungs has just passed through the alveolar capillaries and has become oxygenated up to a Po2 of about 104 mm Hg. Another 2 per cent of the blood which supplies mainly the deep tissues of the lungs and is not exposed to lung air. This blood flow is called “shunt flow,” meaning that blood is shunted past the gas exchange areas One gram of Hb can bind 1.34 ml of Oxygen Normal level of Hb is 15 grams/dL Thus 15 grams of hemoglobin in 100 milliliters of blood can combine with a total of almost exactly 20 milliliters of oxygen if the hemoglobin is 100 per cent saturated This is usually expressed as 20 volumes per cent Hemoglobin is a conjugated protein consisting of heme and globin. The ferrous form can bind oxygen. Hemoglobin molecule consists of four subunits each consists of one heme and one polypeptide chain Each subunit can bind one molecule of Oxygen Oxygenation is a very rapid and reversible process and it can occur in 0.01 seconds When PO2 is high, oxygen binds with Hb to form Oxyhemoglbin When PO2 is low oxygen leaves Hb to form Deoxy Hb. Factors that shift the oxygen hemoglobin dissociation curve
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Neural control of respiration (like neural control of many other physiological functions, micturition, for example) is highly complex and not fully elucidated. Research is still going on to determine the centers in the brain and their complex interactions. There may be variations of opinion between different researchers depending on newer findings. Every effort has been made to keep this information as current and authoritative as possible, yet in a simple enough form for the student to understand and digest the information. Dr Sanjoy Sanyal, Professor and Course Director of Neuroscience and FCM-III Neurology in Caribbean created this PPTX after studying this complex topic for a very long time. Tags: Respiration, Breathing, Respiratory Centers, Brainstem, Apneustic Breathing, Biots Breathing, Cheyne-Stokes, Ataxic, Agonal, Kussmaul, Brainstem Reticular Nuclei, NTS, Locus Ceruleus, Fastigial, Raphe nucleus, Vagus, RTN nucleus, pFRG nucleus, Kolliker-Fuse, PBC nucleus, RVL nucleus "Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use." Educational Value: A very complex and poorly understood topic has been rendered in as simple a format and style as possible, so as to make it easily digestible to any Basic Science medical student and Medical Resident
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The control of respiration seems to be based on the following factors: a) An intrinsic rhythm of the respiratory neurones of the medulla oblongata. This rhythm is dependent upon oxygen supply to the neurones involved. It is regulated by both reflex and chemical mechanisms. b) The chemical regulation of respiration concerns the hydrogen ion content of the respiratory neurones which in turn is dependent upon the carbon dioxide tension of the blood and the rate of flow of blood through the medulla. Variations in blood oxygen tension under normal conditions are not thought to be concerned with direct regulating effects on the respiratory neurones. The control of respiration seems to be based on the following factors: a) An intrinsic rhythm of the respiratory neurones of the medulla oblongata. This rhythm is dependent upon oxygen supply to the neurones involved. It is regulated by both reflex and chemical mechanisms. b) The chemical regulation of respiration concerns the hydrogen ion content of the respiratory neurones which in turn is dependent upon the carbon dioxide tension of the blood and the rate of flow of blood through the medulla. Variations in blood oxygen tension under normal conditions are not thought to be concerned with direct regulating effects on the respiratory neurones. The Chemical Control of Respiration As already pointed out the role of anoxemia is concerned with a direct depressing influence of oxygen lack on the respiratory cells of the medulla, and an opposing excitatory effect upon chemoreceptors in the carotid body whose stimulation results in reflex augmentation of respiration. The respiratory neurones of the medulla, however, are extremely sensitive to variations in the CO2 tension of the blood and somewhat less so to any other acids. In both cases the stimulatory effect concerns
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If you are a Domino Administrator in any size company you already have a range of skills that make you an expert administrator across many platforms and technologies. In this session Gab explains how to apply those skills and that knowledge to take your career wherever you want to go.
A Domino Admins Adventures (Engage 2024)
A Domino Admins Adventures (Engage 2024)
Gabriella Davis
How to get Oracle DBA Job as fresher.
Strategies for Landing an Oracle DBA Job as a Fresher
Strategies for Landing an Oracle DBA Job as a Fresher
Remote DBA Services
Presented by Sergio Licea and John Hendershot
How to Troubleshoot Apps for the Modern Connected Worker
How to Troubleshoot Apps for the Modern Connected Worker
ThousandEyes
Details
Histor y of HAM Radio presentation slide
Histor y of HAM Radio presentation slide
vu2urc
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08448380779 Call Girls In Greater Kailash - I Women Seeking Men
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Explore the leading Large Language Models (LLMs) and their capabilities with a comprehensive evaluation. Dive into their performance, architecture, and applications to gain insights into the state-of-the-art in natural language processing. Discover which LLM best suits your needs and stay ahead in the world of AI-driven language understanding.
Evaluating the top large language models.pdf
Evaluating the top large language models.pdf
ChristopherTHyatt
Presentation on how to chat with PDF using ChatGPT code interpreter
Presentation on how to chat with PDF using ChatGPT code interpreter
Presentation on how to chat with PDF using ChatGPT code interpreter
naman860154
Axa Assurance Maroc - Insurer Innovation Award 2024
Axa Assurance Maroc - Insurer Innovation Award 2024
Axa Assurance Maroc - Insurer Innovation Award 2024
The Digital Insurer
The Raspberry Pi 5 was announced on October 2023. This new version of the popular embedded device comes with a new iteration of Broadcom’s VideoCore GPU platform, and was released with a fully open source driver stack, developed by Igalia. The presentation will discuss some of the major changes required to support this new Video Core iteration, the challenges we faced in the process and the solutions we provided in order to deliver conformant OpenGL ES and Vulkan drivers. The talk will also cover the next steps for the open source Raspberry Pi 5 graphics stack. (c) Embedded Open Source Summit 2024 April 16-18, 2024 Seattle, Washington (US) https://events.linuxfoundation.org/embedded-open-source-summit/ https://eoss24.sched.com/event/1aBEx
Raspberry Pi 5: Challenges and Solutions in Bringing up an OpenGL/Vulkan Driv...
Raspberry Pi 5: Challenges and Solutions in Bringing up an OpenGL/Vulkan Driv...
Igalia
Breathing New Life into MySQL Apps With Advanced Postgres Capabilities
🐬 The future of MySQL is Postgres 🐘
🐬 The future of MySQL is Postgres 🐘
RTylerCroy
Read about the journey the Adobe Experience Manager team has gone through in order to become and scale API-first throughout the organisation.
Scaling API-first – The story of a global engineering organization
Scaling API-first – The story of a global engineering organization
Radu Cotescu
Slides from the presentation on Machine Learning for the Arts & Humanities seminar at the University of Bologna (Digital Humanities and Digital Knowledge program)
Handwritten Text Recognition for manuscripts and early printed texts
Handwritten Text Recognition for manuscripts and early printed texts
Maria Levchenko
As privacy and data protection regulations evolve rapidly, organizations operating in multiple jurisdictions face mounting challenges to ensure compliance and safeguard customer data. With state-specific privacy laws coming up in multiple states this year, it is essential to understand what their unique data protection regulations will require clearly. How will data privacy evolve in the US in 2024? How to stay compliant? Our panellists will guide you through the intricacies of these states' specific data privacy laws, clarifying complex legal frameworks and compliance requirements. This webinar will review: - The essential aspects of each state's privacy landscape and the latest updates - Common compliance challenges faced by organizations operating in multiple states and best practices to achieve regulatory adherence - Valuable insights into potential changes to existing regulations and prepare your organization for the evolving landscape
TrustArc Webinar - Stay Ahead of US State Data Privacy Law Developments
TrustArc Webinar - Stay Ahead of US State Data Privacy Law Developments
TrustArc
Building Digital Trust in a Digital Economy Veronica Tan, Director - Cyber Security Agency of Singapore Apidays Singapore 2024: Connecting Customers, Business and Technology (April 17 & 18, 2024) ------ Check out our conferences at https://www.apidays.global/ Do you want to sponsor or talk at one of our conferences? https://apidays.typeform.com/to/ILJeAaV8 Learn more on APIscene, the global media made by the community for the community: https://www.apiscene.io Explore the API ecosystem with the API Landscape: https://apilandscape.apiscene.io/
Apidays Singapore 2024 - Building Digital Trust in a Digital Economy by Veron...
Apidays Singapore 2024 - Building Digital Trust in a Digital Economy by Veron...
apidays
Sara Mae O’Brien Scott and Tatiana Baquero Cakici, Senior Consultants at Enterprise Knowledge (EK), presented “AI Fast Track to Search-Focused AI Solutions” at the Information Architecture Conference (IAC24) that took place on April 11, 2024 in Seattle, WA. In their presentation, O’Brien-Scott and Cakici focused on what Enterprise AI is, why it is important, and what it takes to empower organizations to get started on a search-based AI journey and stay on track. The presentation explored the complexities of enterprise search challenges and how IA principles can be leveraged to provide AI solutions through the use of a semantic layer. O’Brien-Scott and Cakici showcased a case study where a taxonomy, an ontology, and a knowledge graph were used to structure content at a healthcare workforce solutions organization, providing personalized content recommendations and increasing content findability. In this session, participants gained insights about the following: Most common types of AI categories and use cases; Recommended steps to design and implement taxonomies and ontologies, ensuring they evolve effectively and support the organization’s search objectives; Taxonomy and ontology design considerations and best practices; Real-world AI applications that illustrated the value of taxonomies, ontologies, and knowledge graphs; and Tools, roles, and skills to design and implement AI-powered search solutions.
IAC 2024 - IA Fast Track to Search Focused AI Solutions
IAC 2024 - IA Fast Track to Search Focused AI Solutions
Enterprise Knowledge
I've been in the field of "Cyber Security" in its many incarnations for about 25 years. In that time I've learned some lessons, some the hard way. Here are my slides presented at BSides New Orleans in April 2024.
The 7 Things I Know About Cyber Security After 25 Years | April 2024
The 7 Things I Know About Cyber Security After 25 Years | April 2024
Rafal Los
This presentations targets students or working professionals. You may know Google for search, YouTube, Android, Chrome, and Gmail, but did you know Google has many developer tools, platforms & APIs? This comprehensive yet still high-level overview outlines the most impactful tools for where to run your code, store & analyze your data. It will also inspire you as to what's possible. This talk is 50 minutes in length.
Powerful Google developer tools for immediate impact! (2023-24 C)
Powerful Google developer tools for immediate impact! (2023-24 C)
wesley chun
Digital Global Overview Report 2024 Slides presentation for Event presented in 2024 after compilation of data around last year.
[2024]Digital Global Overview Report 2024 Meltwater.pdf
[2024]Digital Global Overview Report 2024 Meltwater.pdf
hans926745
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Tech Trends Report 2024 Future Today Institute.pdf
Tech Trends Report 2024 Future Today Institute.pdf
Workshop - Best of Both Worlds_ Combine KG and Vector search for enhanced R...
Workshop - Best of Both Worlds_ Combine KG and Vector search for enhanced R...
A Domino Admins Adventures (Engage 2024)
A Domino Admins Adventures (Engage 2024)
Strategies for Landing an Oracle DBA Job as a Fresher
Strategies for Landing an Oracle DBA Job as a Fresher
How to Troubleshoot Apps for the Modern Connected Worker
How to Troubleshoot Apps for the Modern Connected Worker
Histor y of HAM Radio presentation slide
Histor y of HAM Radio presentation slide
08448380779 Call Girls In Greater Kailash - I Women Seeking Men
08448380779 Call Girls In Greater Kailash - I Women Seeking Men
Evaluating the top large language models.pdf
Evaluating the top large language models.pdf
Presentation on how to chat with PDF using ChatGPT code interpreter
Presentation on how to chat with PDF using ChatGPT code interpreter
Axa Assurance Maroc - Insurer Innovation Award 2024
Axa Assurance Maroc - Insurer Innovation Award 2024
Raspberry Pi 5: Challenges and Solutions in Bringing up an OpenGL/Vulkan Driv...
Raspberry Pi 5: Challenges and Solutions in Bringing up an OpenGL/Vulkan Driv...
🐬 The future of MySQL is Postgres 🐘
🐬 The future of MySQL is Postgres 🐘
Scaling API-first – The story of a global engineering organization
Scaling API-first – The story of a global engineering organization
Handwritten Text Recognition for manuscripts and early printed texts
Handwritten Text Recognition for manuscripts and early printed texts
TrustArc Webinar - Stay Ahead of US State Data Privacy Law Developments
TrustArc Webinar - Stay Ahead of US State Data Privacy Law Developments
Apidays Singapore 2024 - Building Digital Trust in a Digital Economy by Veron...
Apidays Singapore 2024 - Building Digital Trust in a Digital Economy by Veron...
IAC 2024 - IA Fast Track to Search Focused AI Solutions
IAC 2024 - IA Fast Track to Search Focused AI Solutions
The 7 Things I Know About Cyber Security After 25 Years | April 2024
The 7 Things I Know About Cyber Security After 25 Years | April 2024
Powerful Google developer tools for immediate impact! (2023-24 C)
Powerful Google developer tools for immediate impact! (2023-24 C)
[2024]Digital Global Overview Report 2024 Meltwater.pdf
[2024]Digital Global Overview Report 2024 Meltwater.pdf
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