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Krebs Cycle

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Krebs Cycle

  1. 1. Also known as: Tricarboxylic acid cycle TCA cycle Kreb’s Cycle
  2. 4. The Krebs Cycle is the Third Stage of Aerobic Respiration
  3. 5. The Krebs Cycle is the Third Stage of Aerobic Respiration
  4. 6. The Krebs Cycle is the Third Stage of Aerobic Respiration Takes place in the matrix of the mitochondria.
  5. 7. The Krebs Cycle is the Third Stage of Aerobic Respiration Takes place in the matrix of the mitochondria. It happens once for every pyruvate molecule in glycolysis….
  6. 8. The Krebs Cycle is the Third Stage of Aerobic Respiration Takes place in the matrix of the mitochondria. It happens once for every pyruvate molecule in glycolysis…. ..and so it goes round twice for every glucose molecule that enters the respiration pathway.
  7. 9. Sir Hans Krebs – on his bike!
  8. 11. AcetylCoA (2C) from the link reaction combines with oxaloacetate (4C) to form citrate (6C). CoA is released back to the link reaction to be reused
  9. 12. The 6-carbon citrate is decarboxylated – loses CO 2 – to give a 5-carbon molecule
  10. 13. Both the citrate and the 5-carbon molecule formed from it are dehydrogenated (lose hydrogen ) in the cycle to reduce the coenzymes NAD and FAD
  11. 14. Overall, 3 reduced NAD + and 1 reduced FAD are produced. These coenzymes not carry the hydrogen to the electron transport chain (etc)
  12. 15. The 5-carbon compound is decarboxylated bringing you back to 4-carbon oxaloacetate . ATP and CO 2 are released.
  13. 18. Products of the Krebs Cycle enter the Final Stage of Aerobic Respiration
  14. 19. Products of the Krebs Cycle enter the Final Stage of Aerobic Respiration Some products are reused,
  15. 20. Products of the Krebs Cycle enter the Final Stage of Aerobic Respiration Some products are reused, some are released
  16. 21. Products of the Krebs Cycle enter the Final Stage of Aerobic Respiration Some products are reused, some are released and others are used in the final stage, oxidative phosphorylation
  17. 22. This is the one to blame!
  18. 23. <ul><li>One CoA is reused in the next link reaction. </li></ul>
  19. 24. <ul><li>One CoA is reused in the next link reaction. </li></ul><ul><li>Oxaloacetate is regenerated so it can be reused in the next Krebs cycle . </li></ul>
  20. 25. <ul><li>One CoA is reused in the next link reaction. </li></ul><ul><li>Oxaloacetate is regenerated so it can be reused in the next Krebs cycle . </li></ul><ul><li>Two carbon dioxide molecules are released as a waste product of respiration. </li></ul>
  21. 26. <ul><li>One CoA is reused in the next link reaction. </li></ul><ul><li>Oxaloacetate is regenerated so it can be reused in the next Krebs cycle . </li></ul><ul><li>Two carbon dioxide molecules are released as a waste product of respiration. </li></ul><ul><li>One molecule of ATP is made per turn of the cycle – by substrate level phosphorlyation. </li></ul>
  22. 27. <ul><li>One CoA is reused in the next link reaction. </li></ul><ul><li>Oxaloacetate is regenerated so it can be reused in the next Krebs cycle . </li></ul><ul><li>Two carbon dioxide molecules are released as a waste product of respiration. </li></ul><ul><li>One molecule of ATP is made per turn of the cycle – by substrate level phosphorlyation. </li></ul><ul><li>Three reduced NAD and one reduced FAD coenzymes are made and enter the e.t.c. </li></ul>
  23. 28. Oxidative Phosphorylation happens via the Electron Transport Chain.

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