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Kidney Control

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Kidney Control

  1. 1. The Kidney Control of urine volume and concentration
  2. 2. Region of nephron Activity Bowman’s capsule
  3. 3. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood
  4. 4. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule
  5. 5. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule reabsorbtion of water by osmosis
  6. 6. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule reabsorbtion of water by osmosis Reabsorbtion of solutes such as Na + , K + , Cl - , HCO3 - , aa and glucose by a mixture of active and passive processes
  7. 7. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule reabsorbtion of water by osmosis Reabsorbtion of solutes such as Na + , K + , Cl - , HCO3 - , aa and glucose by a mixture of active and passive processes Loop of Henle
  8. 8. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule reabsorbtion of water by osmosis Reabsorbtion of solutes such as Na + , K + , Cl - , HCO3 - , aa and glucose by a mixture of active and passive processes Loop of Henle Active secretion of chloride ions from ultrafiltrate inascending limb
  9. 9. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule reabsorbtion of water by osmosis Reabsorbtion of solutes such as Na + , K + , Cl - , HCO3 - , aa and glucose by a mixture of active and passive processes Loop of Henle Active secretion of chloride ions from ultrafiltrate inascending limb Second convoluted tubule
  10. 10. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule reabsorbtion of water by osmosis Reabsorbtion of solutes such as Na + , K + , Cl - , HCO3 - , aa and glucose by a mixture of active and passive processes Loop of Henle Active secretion of chloride ions from ultrafiltrate inascending limb Second convoluted tubule Reabsorption of Na +
  11. 11. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule reabsorbtion of water by osmosis Reabsorbtion of solutes such as Na + , K + , Cl - , HCO3 - , aa and glucose by a mixture of active and passive processes Loop of Henle Active secretion of chloride ions from ultrafiltrate inascending limb Second convoluted tubule Reabsorption of Na +
  12. 12. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule reabsorbtion of water by osmosis Reabsorbtion of solutes such as Na + , K + , Cl - , HCO3 - , aa and glucose by a mixture of active and passive processes Loop of Henle Active secretion of chloride ions from ultrafiltrate inascending limb Second convoluted tubule Reabsorption of Na + Faculative reabsorbtion of water under control of ADH
  13. 13. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule reabsorbtion of water by osmosis Reabsorbtion of solutes such as Na + , K + , Cl - , HCO3 - , aa and glucose by a mixture of active and passive processes Loop of Henle Active secretion of chloride ions from ultrafiltrate inascending limb Second convoluted tubule Reabsorption of Na + Faculative reabsorbtion of water under control of ADH Secretion of H + , NH4 + , urea,creatinine and some drugs
  14. 14. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule reabsorbtion of water by osmosis Reabsorbtion of solutes such as Na + , K + , Cl - , HCO3 - , aa and glucose by a mixture of active and passive processes Loop of Henle Active secretion of chloride ions from ultrafiltrate inascending limb Second convoluted tubule Reabsorption of Na + Faculative reabsorbtion of water under control of ADH Secretion of H + , NH4 + , urea,creatinine and some drugs Collecting duct
  15. 15. Region of nephron Activity Bowman’s capsule Ultrafiltration of blood in the glomerulus under hydrostatic pressure produces an ultrfiltrate free of plama proteins and cellular elements of the blood First convoluted tubule reabsorbtion of water by osmosis Reabsorbtion of solutes such as Na + , K + , Cl - , HCO3 - , aa and glucose by a mixture of active and passive processes Loop of Henle Active secretion of chloride ions from ultrafiltrate inascending limb Second convoluted tubule Reabsorption of Na + Faculative reabsorbtion of water under control of ADH Secretion of H + , NH4 + , urea,creatinine and some drugs Collecting duct Faculative reabsorbtion of water under control of ADH
  16. 16. Control of water reabsorbtion by ADH <ul><li>The permeability of the walls of the second convoluted tubule and collecting duct is increased by antidiuretic hormone (ADH) </li></ul><ul><li>ADH is produced by the hypothalamus but secreted by the pituitary. </li></ul><ul><li>A rise in blood concentration (i.e. its water potential becomes more negative) is detected by osmoreceptors in the hypothalamus </li></ul>
  17. 17. normal water potential of blood
  18. 18. normal water potential of blood receptors in hypothalamus becomes less negative
  19. 19. normal water potential of blood receptors in hypothalamus second convoluted tubule and collecting ducts becomes less negative less ADH produced
  20. 20. normal water potential of blood receptors in hypothalamus second convoluted tubule and collecting ducts less water reabsorbed becomes less negative less ADH produced
  21. 21. normal water potential of blood receptors in hypothalamus second convoluted tubule and collecting ducts less water reabsorbed becomes less negative less ADH produced
  22. 22. normal water potential of blood receptors in hypothalamus second convoluted tubule and collecting ducts less water reabsorbed blood water potential becomes more negative becomes less negative less ADH produced
  23. 23. normal water potential of blood receptors in hypothalamus second convoluted tubule and collecting ducts less water reabsorbed blood water potential becomes more negative becomes less negative less ADH produced becomes more negative
  24. 24. normal water potential of blood receptors in hypothalamus second convoluted tubule and collecting ducts less water reabsorbed blood water potential becomes more negative becomes less negative less ADH produced becomes more negative more ADH released
  25. 25. normal water potential of blood receptors in hypothalamus second convoluted tubule and collecting ducts less water reabsorbed blood water potential becomes more negative becomes less negative less ADH produced becomes more negative more ADH released more water reabsorbed
  26. 26. normal water potential of blood receptors in hypothalamus second convoluted tubule and collecting ducts less water reabsorbed blood water potential becomes more negative becomes less negative less ADH produced becomes more negative more ADH released more water reabsorbed blood water potential becomes less negative
  27. 27. Control of water reabsorbtion by ADH <ul><li>When ADH is produced more water is reabsorbed </li></ul><ul><li>A more concentrated (hypertonic) urine is produced </li></ul>
  28. 28. Control of water reabsorbtion by ADH <ul><li>A fall in blood concentration inhibits the release of ADH – the walls of the second convoluted tubule and collecting duct become impermeable to water </li></ul><ul><li>Less water is reabsorbed and a hypotonic urine is produced </li></ul>
  29. 29. Control of water reabsorbtion by ADH <ul><li>Another example of negative feedback! </li></ul>

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