DRUG NUTRIENT INTERACTION CAPSULES TYPES OF DOSAGE FORMS SOLID DOSAGE FORMS CAPSULES

1. Drug Nutrient
Interaction
Capsules

2. Table of
contents
• Introduction
• Classification
• Vegetarian
• Gelatin

3. Introduction
Capsule - Latin word "capsula" meaning
a box or a container
• Solid oral dosage of medication -
drug is encapsulated in a hard or soft
shell
• The capsule by itself is tasteless abd
odorless - tolerable to consume

4. Classification of Capsules
BASED ON THE INGR EDIENTS

5. A solid pharmaceutical dosage form that contains a
medicinal agent within either a hard or soft soluble
container or shell, usually used for the oral
administration of medicine.

6. Type A Type B
Gelatin Capsules
Sourced from animal
protein, which is
extracted from collagen
of animal bones or skin
Prepared from Pork Skin Prepared from bones of
different animals

8. Hard Gelatin Capsule

9. Easy to transport
1
Tasteless, masks unpleasant odour of medication
2
Flexible formulation
4
Prevents oxidation of active ingredients
3
Readily soluble in biological fluids at body
temperature
5
Advantages

10. Not suitable for extremely soluble substance such as potassium chloride,
potassium bromide and ammonia chloride
1
Efflorescent materials causes the capsule to soften
2
Filling process is laborious and time-consuming
Disadvantages
3
Deliquescent materials may dry the capsule shell to excessive brittleness
4

11. Soft Gelatin Capsule

12. Low chances of oxidation - sealed capsule
1
May contain an opaque layer - UV sensitive medication
2
Suitable for medication like oils, liquids
4
Prevents oxidation of active ingredients
3
Increases the bioavailabilty of the active ingredients
5
Advantages

13. Expensive manufacturing process & lack of equipment
1
Water soluble substance cannot be used
2
Disadvantages

14. • Plant based capsule - cellulose and water
• Chemically and thermally stable
• Lower moisture content compared to
gelatin based capsules
• Fast dissolution and soluble in water
• Manufacture cost of HMPC are expensive
Hydroxypropyl methyl
cellulose- HPMC

15. Plant based capsule derived from corn starch which
is fermented by bacteria
Low water content compared to gelatin capsules
Provides best oxygen barrier- protects sensitive
medication keeping it potent
Masks the odour of the medication
Sensitive to low moisture - shell- brittle
Pullulan Capsule