Costus igneus, also known as the insulin plant, has leaves that are used as a dietary supplement to treat type 2 diabetes. The leaves contain corosolic acid, which helps regulate blood sugar levels by promoting insulin production and the transport of glucose into cells. Several studies on animal models of diabetes found that extracts of C. igneus leaves reduced blood glucose and increased insulin levels. While conventional diabetes medications have side effects, C. igneus appears to be a safer alternative based on traditional use and preliminary research. Further clinical trials are still needed to fully validate its anti-diabetic effects.

1. Magic Cure For Diabetes type 2

2. Presented by:
Saheli Chakraborty
Sem : 6th Year : 3rd
University Roll no: 20101916032
Registration no: 162010210037 of 2016-2017
Guidance by :
Mrs.Priyanka Chakraborty
Assistant Professor
B.C.D.A. College Of Pharmacy & Technology

3. DIABETES MELLITUS
It is a chronic disease associated with abnormally high levels of the sugar
glucose in the blood.
It is caused by inherited and/or acquired deficiency in production of
insulin by the pancreas.
It is of three types:
 Type 1 DM: insulin-dependent
 Type 2 DM : non-insulin-dependent
 Gestational DM: hyper glycemic with blood glucose occurring
during pregnancy

4. Diabetes in India
According to the Indian Council of Medical Research-Indian Diabetes
study (ICMR-INDIAB), a national diabetes study, India currently has 63
million people with diabetes.
India represents the world’s second largest diabetes population after
China.
This is set to increase to over 100 million by 2030.
The majority of people with diabetes (>90%) have Type 2 diabetes
(T2DM)

5. Type 2 diabetes mellitus
Non insulin dependent
Results from the body’s ineffective
use of insulin
Symptoms:
 Constant hunger
 Weight gain
 Weakness and fatigue
 Slow healing of cuts

6. Treatment of type 2 diabetes
Diet and exercise Conventional medicine
• Improve insulin availability
 exogens insulin
 sulfonylureas
 meglitinide analogues
• Overcome insulin resistance
 bigunanides
 thiazolidinediones
 glucsidase inhibitors

7. Side effects of conventional medicine
• Hypoglycemia
• Non specific side effects like
 nausea
 vomiting
 flatulance
 headache
 weight gain
• Hypersensitivity

8. Introduction On Plant
Costus igneus a medicinal plant is a Magic Cure for type 2
Diabetes mellitus.
It is also known as insulin plant
Its leaves are used as a dietary supplement in the treatment of
diabetes mellitus type 2

9. Synonyms
Spiral nag
Fiery Costus
Chamaecostus cuspidatus
 Piasal.

10. Biological Source
It consist of dried as well as fresh leaves of the plant Costus igneus
Family: Costaceae

11. Taxonomy
Costus igneus
Eukaryota
Plantae
Tracheophyta
Liliopsid
Zingiberales
Costaceae
Costus
Igneus

12. Geographical Source
Costus igneus is native to Southeast Asia, especially on the Greater
Sunda Islands in Indonesia.
It is also found in India including west bengal
In southren India the plant already are used as a dietary
supplement for the treatment of diabetics.

13. Description
• It is a perennial, upright, spreading plant about two feet tall.
LEAVES
• simple,
alternate,
entire,
oblong,
evergreen,
4-8 inches
in length.
FLOWRS
• 1.5 inch ,
orange in
colour,
appearing
on cone like
heads at the
tip of the
branches.
FRUITS
•
• Inconspi-
cuous, not
showy, less
than 0.5 inch,
and green-
colored.

14. Microscopic character
microscopic characters of leaves include
• epidermis with anomocytic stomata,
• mesophyll cells with calcium oxalate crystals
• fibres associated with parenchyma cells.

15. Chemical constituents
• The leaves mainly contained :
Corosolic acid Ascorbic acid
• Other components :
α-tocopherol β-carotene Flavonoids

16. Pharmacological Activity
Anti-diabetic activity
Hypolipidemic activity
Anti-cancer effect
Anti-microbial activity
Antioxidant activity

17. Anti-diabetic Activity
Costus igneus is helpful to treat Type-2 diabetes
The leaf of insulin plant contain corosolic acid that effect on blood sugar level.
Corosolic acid work in metabolism of insulin from pancreas that reduces blood
sugar level by transporting glucose into cell and out of the blood stream.

18. Researches
AUTHOR,YEAR MODEL NAME EXTRACT UESD RESULTS
SP Dhanabal, 2007 Normoglycemic rats
and Hyperglycemic
rats
200, 400 mg/kg b.w
of ethanolic leaf
extract
Normoglycemic
rats: both dose not
reduce glucose
levels
Hyperglycemic rat:
400 mg/kg reduce
glucose level
Nandhakumar
jothivel, 2007
Alloxan induced in
male wister albino
rats
120 mg/kg b.w of
methanolic leaf
extract p.o. single
dose/day for 21
days
Decreased serum
glucose level
Increase plasma
insulin level

19. Marketed
Products

20. Conclusion
This review supports :
The few conventional therapies available are either expensive or often
related with adverse effects.
Although medicinal plants provide better alternatives as they are
generally less-toxic and affordable.
So medicinal plant is better to use in the treatment than conventional
medicine.
The anti-diabetic effect of its leaves is currently been tested in diabetic
patients.

21. References
• Jose B, Reddy LJ. Analysis of the essential oils of the stems, leaves and rhizomes of the
medicinal plant Costus pictus from southern India. Int J Pharmacy Pharm
Sci. 2010;2(Suppl 2):100–1
• Saraswathi R, Upadhyay L, Venkatakrishnan R, Meera R, Devi P. Isolation and biological
evaluation of steroid from stem of Costus igneus. J Chem Pharm Res. 2010;2:444–8.
• Essentials Medical Pharmacology, fifth edition, KD Tripathi (235- 253)
• Pharmacology second edition , Salil K Bhattachrya, Parantpa Sen , Arunabha Ray,
editor: Prasun K Das , (351- 372)
• Ahmed, s.., Hasan, M.M.& Mahmood, Z.A.2016. Antiurolithiatic plants:
multidimensional pharmacology. Journal of pharmacognosy and phytochemistry, 5,04-
24
• Saydah SH, Miret M, Sung J, Varas C, Gause D, Brancati FL (August 2001).
"Postchallenge hyperglycemia and mortality in a national sample of U.S.
adults". Diabetes Care. 24 (8): 1397–402.