BUCCAL DRUG DELIVERY
Under the guidance of
Department of pharmaceutics
Roll no :12H61S0320
• Buccal drug delivary
• Physiology of buccal environment
• Bio adhesion
• Buccal drug delivery systems
Adhesion : is the bond produced by interaction between an adhesive and a
Bioadhesion : is the state of bond formation in which either adhesive or surface is
of biological origin.
Mucoadhesion : is the interaction of the mucin layer with a polymer .
Buccal Drug Delivery
The buccal mucosa lines the inner cheek, and buccal
formulations are placed in the mouth between the upper gingivae
(gums) and cheek to treat local and systemic conditions.
The buccal route provides one of the potential route for typically
large, hydrophilic and unstable proteins, oligonucleotides and
polysaccharides, as well as conventional small drug molecules.
The oral cavity has been used as a site for local and systemic
Drugs with large dose are difficult to be administered
Eating and drinking may be restricted
Possibility of the patient to swallow the tablet
This route cannot administer drugs,which are unstable at buccal pH.
This route cannot administer drugs,which irritate,bitter or unpleasant taste
Small surface area is available for absorption
Buccal drug delivery and mucoadhesivity: :
The term ‘mucoadhesive’ is commonly used for materials that bind to the mucin
layer of a biological membrane.
Mucoadhesive polymers have been utilized in many different dosage forms in
efforts to achieve systemic delivery of drugs through the different mucosae.
These dosage forms include
Tablets, patches, tapes, films, semisolids and powders
Mechanisms of bioadhesion
FORMULATION OF BDDS
The basic components of buccal drug delivery system
Non toxic, non irritable, free from leachable impurities.
Polymer pH should be biocompatible.
Quick adherence, and suffice mechanical strength.
Bioadhesive in both dry and liquid state.
Acceptable shelf life.
Optimum molecular weight.
1 st generation polymers : PAA, NaCMC , HPMC, Carbapol , Chitosan ,
Xanthan gum, PVA etc.
2 nd generation polymers : Lectins , Multifunctional polymers, Thiolated
Backing membrane plays a major role in the attachment of bioadhesive devices to the
The materials used as backing membrane should be inert, and impermeable to the
drug and penetration enhancer.
Such impermeable membrane on buccalbioadhesive patches prevents the drug loss and
offers better patient compliance.
The commonly used materials in backing membrane include carbopol, magnesium
Stearate, HPMC, HPC, CMC, polycarbophil etc
Substances that help to promote drug permeation through the buccal epithelium are
referred to as penetration enhancers, permeation promoters or absorption enhancers.
Most of the compounds used as buccal mucosal penetration enhancers are the ones
generally used to compromise barrier function.
sodium lauryl sulfate,
Sodium glycodeoxycholate, sodium glycocholate, sodium taurodeoxycholate, sodium
Types of buccal
1) Buccal Tablets
2) Buccal Patches and Films
3) Buccal Semisolids (ointments and gels)
4) Buccal Powders
Evaluation of buccal
Swelling rate and bioadhesion studies
Surface pH studies
Drug release studies
Drug release studies
Stability studies in human saliva
Transmucosal permeation studied.
Possible designs of buccal drug
Types of Buccal Dosage
Matrix type :
Drug, Adhesive, Additives are mixed together. Bidirectional patches. i.e.
release drug both in Mucosa, and Mouth.
Reservoir type :
Contains a cavity for drug, and additives separate from drug adhesive. Has an
impermeable backing. For regulating direction of drug flow. Also prevents
patch deformation, disintegration in mouth. Prevents drug loss.
Commercially available bioadhesive
buccal delivery systems
• Buccal mucosal delivery of Proclorperazine: Buccastem
• Buccal mucosal delivery of nicotine: Nicorette
Reported buccoadhesive drug delivery system
The buccal mucosa offers several advantages over controlled drug delivery for
extended periods of time.
First pass metabolism in the liver and presystemic elimination in the
gastrointestinal tract are avoided.
With the right dosage form design and formulation, the permeability and the
local environment of the mucosa can be controlled and manipulated in order to
accommodate drug permeation.
Buccal drug delivery is a promising area for continued research with the aim of
systemic delivery of orally inefficient drugs as well as a feasible and attractive
alternative for non-invasive delivery of potent peptide and protein drug
molecules. However, the need for safe and effective buccal permeation absorption
enhancers is a crucial component for a prospective future in the area of buccal
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S.P Vyas,Roop K.Khar.controlled drug delivery,concepts and
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delivery system,International journal of pharmacy and life
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