Buccal bioadhesive drug delivery system G1ppt

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Buccal bioadhesive drug delivery system G1ppt

  1. 1. BUCCAL DRUG DELIVERY SYSTEMS Under the guidance of Dr.B.Vasudha M.pharm,Ph.D Professor Department of pharmaceutics Presented by P.Jeevan reddy M.Pharm 1styear Pharmaceutics Roll no :12H61S0320
  2. 2. CONTENTS • Introduction • Buccal drug delivary • Physiology of buccal environment • Types • Bio adhesion • Mechanism • Buccal drug delivery systems • Evaluation • Conclusion • References
  3. 3. INTRODUCTION Adhesion : is the bond produced by interaction between an adhesive and a surface. Bioadhesion : is the state of bond formation in which either adhesive or surface is of biological origin.  Mucoadhesion : is the interaction of the mucin layer with a polymer .
  4. 4. Buccal Drug Delivery  The buccal mucosa lines the inner cheek, and buccal formulations are placed in the mouth between the upper gingivae (gums) and cheek to treat local and systemic conditions.  The buccal route provides one of the potential route for typically large, hydrophilic and unstable proteins, oligonucleotides and polysaccharides, as well as conventional small drug molecules.  The oral cavity has been used as a site for local and systemic drug delivery.
  5. 5. Structure Of Oral Mucosa
  6. 6. Anatomy of oral mucosa  Structure of oral mucosa 1) Epithelium - stratum distendum - stratum filamentosum - stratum suprabasale - stratum basale 2) Basal lamina 3) Connective tissue - lamina propria - submucosa
  7. 7. ADVANTAGES
  8. 8. LIMITATIONS Drugs with large dose are difficult to be administered  Eating and drinking may be restricted  Possibility of the patient to swallow the tablet  This route cannot administer drugs,which are unstable at buccal pH.  This route cannot administer drugs,which irritate,bitter or unpleasant taste  Small surface area is available for absorption
  9. 9. Buccal drug delivery and mucoadhesivity: : The term ‘mucoadhesive’ is commonly used for materials that bind to the mucin layer of a biological membrane. Mucoadhesive polymers have been utilized in many different dosage forms in efforts to achieve systemic delivery of drugs through the different mucosae. These dosage forms include Tablets, patches, tapes, films, semisolids and powders
  10. 10. Mechanisms of bioadhesion  Wetting theory  Diffusion theory  Electronic theory  Adsorption theory  Fracture theory
  11. 11. FORMULATION OF BDDS The basic components of buccal drug delivery system Drug substance Bioadhesive polymers Backing membrane Permeation enhancers
  12. 12. Bioadhesive polymers IDEAL CHARACTERISTICS:  Non toxic, non irritable, free from leachable impurities. Polymer pH should be biocompatible. Quick adherence, and suffice mechanical strength.  Bioadhesive in both dry and liquid state. Acceptable shelf life. Optimum molecular weight. TYPES: 1 st generation polymers : PAA, NaCMC , HPMC, Carbapol , Chitosan , Xanthan gum, PVA etc. 2 nd generation polymers : Lectins , Multifunctional polymers, Thiolated polymers etc.
  13. 13. Backing membrane Backing membrane plays a major role in the attachment of bioadhesive devices to the mucus membrane. The materials used as backing membrane should be inert, and impermeable to the drug and penetration enhancer. Such impermeable membrane on buccalbioadhesive patches prevents the drug loss and offers better patient compliance. The commonly used materials in backing membrane include carbopol, magnesium Stearate, HPMC, HPC, CMC, polycarbophil etc
  14. 14. Permeation enhancers Substances that help to promote drug permeation through the buccal epithelium are referred to as penetration enhancers, permeation promoters or absorption enhancers.  Most of the compounds used as buccal mucosal penetration enhancers are the ones generally used to compromise barrier function. sodium lauryl sulfate, sodiumlaurate Bile salts: Sodium glycodeoxycholate, sodium glycocholate, sodium taurodeoxycholate, sodium taurocholate
  15. 15. Types of buccal formulation 1) Buccal Tablets 2) Buccal Patches and Films 3) Buccal Semisolids (ointments and gels) 4) Buccal Powders
  16. 16. Evaluation of buccal tablets In vitro  Swelling rate and bioadhesion studies Surface pH studies  Drug release studies  Permeation studies Mucoadhesion strength  Residence time In vivo Drug release studies Stability studies in human saliva Ex vivo Mucoadhesion time Mucoadhesion force  Transmucosal permeation studied.
  17. 17. Possible designs of buccal drug delivery systems
  18. 18. Drugs given as buccal tablets • Propranalol • Metoprolol • Metoclopromide • Insulin • Nitroglycerine • Codeine • Morphine • Diltiazem • Chlorpheniramine maleate
  19. 19. Types of Buccal Dosage forms Matrix type : Drug, Adhesive, Additives are mixed together. Bidirectional patches. i.e. release drug both in Mucosa, and Mouth. Reservoir type : Contains a cavity for drug, and additives separate from drug adhesive. Has an impermeable backing. For regulating direction of drug flow. Also prevents patch deformation, disintegration in mouth. Prevents drug loss.
  20. 20. Patch designs
  21. 21. Commercially available bioadhesive buccal delivery systems • Buccal mucosal delivery of Proclorperazine: Buccastem • Buccal mucosal delivery of nicotine: Nicorette
  22. 22. Reported buccoadhesive drug delivery system Drug Dosage Action polymer Benzydamine Patch Local Pectin, PAA Benzocaine Bioadhesive gel Local HPMC Carvedilol Buccal patch Systemic HPMC Clotrimazole liposome gel Local Carbopol Captopril Tablet Systemic Carbopol, chitosan Clotrimazole Diltiazem HCL Disk local Carbopol, HPMC
  23. 23. Conclusion The buccal mucosa offers several advantages over controlled drug delivery for extended periods of time. First pass metabolism in the liver and presystemic elimination in the gastrointestinal tract are avoided. With the right dosage form design and formulation, the permeability and the local environment of the mucosa can be controlled and manipulated in order to accommodate drug permeation. Buccal drug delivery is a promising area for continued research with the aim of systemic delivery of orally inefficient drugs as well as a feasible and attractive alternative for non-invasive delivery of potent peptide and protein drug molecules. However, the need for safe and effective buccal permeation absorption enhancers is a crucial component for a prospective future in the area of buccal drug delivery
  24. 24. References  Edith mathiowitz. Encyclopedia of controlled drug delivery.In: mucosal drug delivery, buccal.A wiley-interscience publication.P.555-557  Yie W.Chien.Novel drug delivery systems.In: buccal drug delivery.2 nd ed.CBS publishers & distributors.New Delhi.P.210-215  S.P Vyas,Roop K.Khar.controlled drug delivery,concepts and advances.vallabh prakashan.P.291-299  Anay R.patel,Dhagash v. patel,sharad v. choudry.Mucoadhesive drug delivery system,International journal of pharmacy and life sciences.2(6).2011.848-856
  25. 25. • Kumar V, Aggarwal G,Zakir F,Choudry A.Buccal bioadhesive drug delivery-A novel technique.International journal of pharmacy and biological sciences.1(3).2011.89-102

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