Tay-Sachs disease is caused by a mutation (abnormal change) in the gene that codes for Hex-A, and it is a recessive trait. This means that people will have the disease if they have two copies of the defective gene, but they will not have the disease if they have at least one unaffected copy. People with one normal copy and one defective copy are called carriers, because they can pass the disease on to their children. Seizures are sudden altacks of disease, often referring to some type of violent spasms. Just about anyone can be a carrier of the gene for Tay-Sachs disease. In the general population, about 1 in 250 people carries the gene. People inherit Tay-Sachs disease when they inherit a defective gene from both parents, resulting in two defective genes that make the body unable to produce Hex-A correctly. People who have only one defective gene are called carriers. Carriers do not have the disease, because they have inherited one healthy gene to code for Hex-A, but they may pass the defective gene on to their children. If both parents are carriers, each child born to them has a 1 in 4 liklihood of having the disease. However, some populations of people include more carriers than others. For example, 1 in 27 people of eastern European Jewish (Ashkenazi) descent in the United States is a carrier. People of French-Canadian ancestry from one part of Quebec and the Cajunpopulation in Louisiana also have a higher than usual risk of carrying the Tay-Sachs gene. Solution Tay-Sachs disease is caused by a mutation (abnormal change) in the gene that codes for Hex-A, and it is a recessive trait. This means that people will have the disease if they have two copies of the defective gene, but they will not have the disease if they have at least one unaffected copy. People with one normal copy and one defective copy are called carriers, because they can pass the disease on to their children. Seizures are sudden altacks of disease, often referring to some type of violent spasms. Just about anyone can be a carrier of the gene for Tay-Sachs disease. In the general population, about 1 in 250 people carries the gene. People inherit Tay-Sachs disease when they inherit a defective gene from both parents, resulting in two defective genes that make the body unable to produce Hex-A correctly. People who have only one defective gene are called carriers. Carriers do not have the disease, because they have inherited one healthy gene to code for Hex-A, but they may pass the defective gene on to their children. If both parents are carriers, each child born to them has a 1 in 4 liklihood of having the disease. However, some populations of people include more carriers than others. For example, 1 in 27 people of eastern European Jewish (Ashkenazi) descent in the United States is a carrier. People of French-Canadian ancestry from one part of Quebec and the Cajunpopulation in Louisiana also have a higher than usual risk of carrying the Tay-Sachs gene..