Most human genetic disorders are due to autosomal recessive inheritance. Describe how an individual can acquire these conditions from parents that do not display symptoms. A man has an X-linked recessive form of pattern baldness. From which parent did he inherit this condition. Explain your answer. Sickle cell disease in an inherited human condition of the blood cells. Those who receive the allele from both parents (homozygous) has a fill blown sickle cell disease. A person who only has one copy of the allele (heterozygous) may experiences stickling of their blood cells under certain, stressful conditions. Give a simple explanation for the heterozygous individual having a mild form of the disease. Why do individuals who inherit an A type allele and a B type allele have blood type AB while a person who inherits an A type allele and an O type allele have blood type A? How are pedigrees useful in counseling couples regarding the likelihood they can pass a genetic disorder on to their offspring? A female child has the autosomal dominant condition of polydactyl. The mother has the normal number of fingers and toes while the father has six fingers on each hand. The couple has a second child, a boy, who has the normal number of fingers and toes. Give the genotype of each parent and each child. Draw a pedigree demonstrating polydactyl in the above family. What is the likely hood that if they have a third child they will be born with polydactyl? Solution Ques-1: Autosomal recessive trait is defined as a pattern of inheritance of an allele that is recessive over an autosome as well as two copies of this allele is essential for an expression of phenotype. In autosomal recessive inheritance, both the sons and daughters have a chance to be affected. Most human genetic disorders are due to autosomal recessive inheritance. An individual can acquire these conditions from parents that do not display symptoms because most of the parents carry mutated alleles so that they act as \"carriers\" for the mutated gene resulting in autosomal recessive disorder in the offspring For example, Tay-Sachs disease is a rare autosomal recessive genetic disorder cuased by mutations potentially affects nervous system in humans. Tay-Sachs disease is an autosomal recessive genetic disease, which results in progressive degeneration of nerve cells that causes physical and mental growth retardation eventually followed by death by the age of four. The disease occurs due to the deficiency of hexosaminidase A (HEXA) enzyme, which is needed for the breakdown of ganglioside GM2 (fatty acid). Tay-Sachs disease occurs due to the mutations in the hexosaminidase A (HEXA) enzyme, which causes degeneration of nerve cells..