R1- شرح مفصل عن عشبة الناردين كمستحضرات صيدلية من مدونتي https://cognosy4all.blogspot.com/2021/06/valerian.html R1- شرح مفصل عن عشبة الناردين كمستحضرات صيدلية من مدونتي https://cognosy4all.blogspot.com/2021/06/valerian.html

1. HERBAL MEDICINE
VALERIAN
DR. MOSTAFA MAHMOUD HEGAZY PH.D

2. Herbal medicine Dr. Mostafa Hegazy
‫الهر‬ ‫حشيشة‬ ‫عشبة‬ ‫أو‬ ،‫الناردين‬ ‫عشبة‬ ‫أو‬ ،‫الفاليريان‬ ‫جذور‬
Valerian (Valeriana officinalis)
 Part used: Whole underground parts, including the
rhizome surrounded by the roots and stolons.
 Constituents:
 1- Volatile oils 0.5–2%: NLT 0. 5% of volatile oil, and NLT 0
. 1 7 % of total valerenic acids, calculated on the dried basis.
 2- Iridoids (valepotriates): Valtrates, didrovaltrates and
isovaltrates groups. The valepotriates are unstable and
decompose on storage or processing.
 Note: valerian is preferably to be administered as a herb
tea or well-preserved pharmaceutical products.

3. Herbal medicine Dr. Mostafa Hegazy
 3- Alkaloids (Pyridine type) e.g. valerianine and valerine.
 4- Other constituents: Amino acids (e.g. arginine, γ-
aminobutyric acid (GABA) which argued if small or
substantial amount can pass BBB (R3)), caffeic and
chlorogenic acids (polyphenolic).
 Active Constituents:
The sedative activity attributed to both the volatile oil and
iridoid valepotriate (highly unstable) and GABA, also the
other unknown compounds may contribute the activity
(R2).

4. Herbal medicine Dr. Mostafa Hegazy
 Actions and Uses
 Main Actions
The traditional use of valerian as a mild sedative and
hypnotic is supported by evidence from preclinical and
some clinical studies. Some studies suggest that valerian
may have a more favorable tolerability profile than
certain benzodiazepines, particularly in view of its
apparent lack of ’hangover’ effects, although this requires
further investigation (R2).
 Other actions
Valerian is stated to possess mild analgesic, antispasmodic,
carminative, and hypotensive properties (R2).

5. Herbal medicine Dr. Mostafa Hegazy
Uses based on scientific research in management and
treatment of diseases.
 1-Insomnia: support of mental relaxation and to aid
natural sleep; well-established use, for the relief of
mild nervous tension and difficulty in falling asleep.
 2- Nervous agitation
 3- Nervous heart complaints
 4- Functional stomach disorders
 5- Irritable bowel syndrome
 6- As an analgesic and for improving of circulation in
teething gel and inflamed gum as adjuvant ingredient
at 5%.

6. Herbal medicine Dr. Mostafa Hegazy
Traditional uses: used for hysterical states, insomnia,
hypochondriasis, migraine, cramp, intestinal colic,
rheumatic pains, dysmenorrhea, and specifically for
conditions presenting nervous excitability.
Hypochondriasis ‫التوهم‬
‫المرضي‬
Mechanism of action
As sedative and hypnotic
1-Increasing availability of GABA (inhibitory
neurotransmitter) by Decreasing its removal or metabolism.
2- GABA receptors agonist.
For intestinal colic and hypertension (smooth muscle
relaxant and vasodilator): Valepotriates are proven to be
calcium channel blocker (R4)

7. Herbal medicine Dr. Mostafa Hegazy
Dose generally and for each use (if any) and Preparation
method
Dosages for oral administration (adults) for traditional uses
recommended in standard herbal reference texts are given
below.
Dried rhizome/root: as an infusion or decoction 1–3 g/ up to
three times/ daily.
Extracts: 400 mg/day.
Herb (single and blend) prescription
The effects of valerian can be enhanced by combining it with
other medicinal plants such as Melissa for nervous agitation
and/or Hops for nervous sleep disorders.

8. Herbal medicine Dr. Mostafa Hegazy
Egyptian pharmaceutical products
Dormival capsule (insomnia), Sedaneurin tab. (anxiolytic),
Calm tab, Songha night tab (insomnia), Dentibaby teething
gel 25 ml and Dologel gingival teething gel 25 ml.
Interactions (if any) with other drugs or herbs or food
Valerian interferes with medicines of similar such as
barbiturates and other sedatives or opposing effects (R2).

9. Herbal medicine Dr. Mostafa Hegazy
Precautions
1- Intake of valerian preparations immediately (up to two
hours) before driving or operating machinery is not
recommended.
2- Excessive consumption of alcohol should be avoided.
3- Patients should seek medical advice if symptoms worsen
beyond two weeks’ continuous treatment with valerian.
4- Post-marketing surveillance-type studies are required to
establish the safety of valerian preparations, particularly with
long-term use (R2).
Contraindications
sensitivity to valerian
Its use should be avoided in Pregnancy and lactation.

10. Herbal medicine Dr. Mostafa Hegazy
References
R1- ‫مدونتي‬ ‫من‬ ‫صيدلية‬ ‫كمستحضرات‬ ‫الناردين‬ ‫عشبة‬ ‫عن‬ ‫مفصل‬ ‫شرح‬
https://cognosy4all.blogspot.com/2021/06/valerian.html
R2- Barnes, J., and L. A. Anderson. "Phillipson JD Herbal Medicines." (2007). (No. Ed. 3).
pharmaceutical press.
R3- Hepsomali, P., Groeger, J. A., Nishihira, J., & Scholey, A. (2020). Effects of oral gamma-
aminobutyric acid (GABA) administration on stress and sleep in humans: A systematic review.
Frontiers in Neuroscience, 14.
https://www.frontiersin.org/articles/10.3389/fnins.2020.00923/full
R4- Dong, F. W., Jiang, H. H., Yang, L., Gong, Y., Zi, C. T., Yang, D., ... & Hu, J. M. (2018).
Valepotriates from the roots and rhizomes of Valeriana jatamansi Jones as novel N-type calcium
channel antagonists. Frontiers in pharmacology, 9, 885.
https://www.frontiersin.org/articles/10.3389/fphar.2018.00885/full

11. Herbal medicine Dr. Mostafa Hegazy