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Candidate gene prioritization 
>NSA2_HUMAN Ribosome biogenesis 
>APOB_HUMAN Apolipoprotein B-100 
>CD99_HUMAN CD99 antigen 
>MAVS_HUMAN Mitochondrial antiviral 
>CA031_HUMAN Uncharacterized protein 
>CA043_HUMAN Uncharacterized protein 
>CA049_HUMAN Uncharacterized protein 
… 
Large-scale 
experiments 
A number of target 
candidates 
Stop development 
1. Lack of annotations for individual genes 
2. Difficulties in combining available 
information from different data sources 
This work by Kenji Mizuguchi is licensed under a Creative Commons Attribution 4.0 International License.
Gene 1 
Gene 2 
Gene 3 
Gene 4 
Gene 5 
…. 
…. 
…. 
Gene 200 
Gene 4 
Gene 17 
Gene 45 
Gene 87 
Integrated knowledge 
discovery 
INPUT OUTPUT 
Many 
candidates 
Selected 
targets 
This work by Kenji Mizuguchi is licensed under a Creative Commons Attribution 4.0 International License.

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Test slide for the lab - Target prioritization

  • 1. Candidate gene prioritization >NSA2_HUMAN Ribosome biogenesis >APOB_HUMAN Apolipoprotein B-100 >CD99_HUMAN CD99 antigen >MAVS_HUMAN Mitochondrial antiviral >CA031_HUMAN Uncharacterized protein >CA043_HUMAN Uncharacterized protein >CA049_HUMAN Uncharacterized protein … Large-scale experiments A number of target candidates Stop development 1. Lack of annotations for individual genes 2. Difficulties in combining available information from different data sources This work by Kenji Mizuguchi is licensed under a Creative Commons Attribution 4.0 International License.
  • 2. Gene 1 Gene 2 Gene 3 Gene 4 Gene 5 …. …. …. Gene 200 Gene 4 Gene 17 Gene 45 Gene 87 Integrated knowledge discovery INPUT OUTPUT Many candidates Selected targets This work by Kenji Mizuguchi is licensed under a Creative Commons Attribution 4.0 International License.