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Analytic Comparison Between X-Ray 
Fluorescence CT and K-Edge CT 
X-ray fluorescence computed tomography (XFCT) and K-edge computed tomography (CT) 
are two important modalities to quantify a distribution of gold nanoparticles (GNPs) in a 
small animal for preclinical studies. It is valuable to determine which modality is more 
efficient for a given application. In this paper, we report a theoretical analysis in terms of 
signal-to-noise ratio (SNR) for the two modalities, showing that there is a threshold of GNPs 
concentration such that XFCT has a better SNR than K-edge CT when GNPs concentration 
is less than this threshold, vice versa. Numerical tests are performed for XFCT and K-edge 
CT on two kinds of phantoms with multiple concentration levels and structural features. 
Experimental results illustrate that XFCT is superior to K-edge CT when contrast 
concentration is lower than 0.4% which coincides with the theoretical analysis.

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Analytic comparison between x ray fluorescence ct and k-edge ct

  • 1. Analytic Comparison Between X-Ray Fluorescence CT and K-Edge CT X-ray fluorescence computed tomography (XFCT) and K-edge computed tomography (CT) are two important modalities to quantify a distribution of gold nanoparticles (GNPs) in a small animal for preclinical studies. It is valuable to determine which modality is more efficient for a given application. In this paper, we report a theoretical analysis in terms of signal-to-noise ratio (SNR) for the two modalities, showing that there is a threshold of GNPs concentration such that XFCT has a better SNR than K-edge CT when GNPs concentration is less than this threshold, vice versa. Numerical tests are performed for XFCT and K-edge CT on two kinds of phantoms with multiple concentration levels and structural features. Experimental results illustrate that XFCT is superior to K-edge CT when contrast concentration is lower than 0.4% which coincides with the theoretical analysis.