1. Dr Harshal Rajekar MS MRCS DNB
Consultant hepatobiliary and transplant
surgeon, Pune
2. Prometheus enraged the Gods after climbing
the Mount Olympus and stealing the torch in
order to give fire to the humans.
He was punished by Zeus and chained to a
rock in the Kaukasus Mountains. Every
couple of days, an eagle came and ate part of
his liver.
As the liver regenerated every time, the eagle
returned again and again to eat the liver and
thereby torture poor Prometheus.
3. Glisson performed extensive investigations
of the vascular anatomy in 1654.
It was more than two centuries before his
work was rediscovered and further clarified
by Rex (1888) in Germany and Cantlie
(1897) in England.
These contributions led to the division of
the liver into the present left and right lobe
as we know them.
4. Langenbuch was the first to perform a
successful elective liver resection in 1887 and
Wendel did the first hemihepatectomy in
1911.
The principles of liver haemostasis and
regeneration were determined in the period
1880-1900.
The knowledge of the principle of inflow and
outflow of the liver and vascular control was
one of the major advancements.
Before that, wedge resections and mattress
sutures were mostly used.
5. This insight of inflow and outflow reduction
was marked by the publication of James
Hogart Pringle of Glasgow, Scotland.
He described the idea of digital control of
the hilar ligament to reduce liver
haemorrhage.
6. In the beginning, however, blood loss and
mortality were considerable.
A multicentre analysis in 1977 of more
than 600 hepatic resections for various
indications showed an operative mortality
of 13%, which rose to 20% for major
resections
7. The first hepatectomy for cancer was
reported by Ichio Honjo (Kyoto University)
in 1949, and
Jean-Louis Lortat-Jacob in 1952, the
patient being a 58-year-old woman
diagnosed with colorectal cancer which
had metastasized to the liver.
8. Longmire, called it a "hostile" organ
because it welcomes malignant cells and
sepsis so warmly, bleeds so copiously, and
is often the 1st organ to be injured in blunt
abdominal trauma.
Yet, the liver is able to to regenerate after
massive loss of substance, and is able, in
many ways, to forgive insult.