3. Herophilus of Chalcedon (334-280 B.C.) First
anatomical description of liver
Johann Vesling (1647) First to report
bifurcation of human portal vein
Thomas Starzl: Performed first
successful human orthotopic liver
transplant in 1968
HISTORICAL BACKGROUND
4. Hugo Rex 1888 :Described right and left
lobes as being equal in size. Showed the
plane of division is through bed of GB &
notch of IVC ; not through falciform
ligament
J. Cantlie 1897 Confirmed Rex's findings. Rex's
lobular plane of division later named Cantlie's
line.
Henri Bismuth: Performed first heterotopic
liver transplant in humans in 1980
5. FEW FACTS : LIVER
Second largest organ of body after skin
Average weight : 1.5kg ( 2 % of total body weight)
Largest gland
Position – b/w 5th ICS & costal margin
Blood flow : 1500 ml/min (25% of CO)
Blood supply : 1/3rd hepatic artery , 2/3rd portal vein
6. Embryology
3rd &4th week
ventral outgrowth from
distal end
of foregut
Cranial Bud - Liver
Caudal Bud -GB,extrahepatic
Biliary Tree
Early 5th wk--liver bud stalk
9th wk– rapid growth
7. Embryology cont.
• 7th week – biliary
lumen recanalise
• 12th week– liver
begine to secrete
bile
13. Histology
• classic hepatic
Lobules- roughly
hexagonal structure
•At each corner of a
lobule is portal triad
•Between the
hepatocytes are the
liver sinusoids
29. Rise and Demise of Segment IX
• For several years Couinaud and his colleagues, as
well as several other investigators, referred to an
area of the dorsal sector of the liver close to the
IVC as "segment IX." But the existence of this
segment was short-lived when, in 2002, Couinaud
and his associates104 published the following
conclusion:
• Because no separate veins, arteries, or ducts can be
defined for the right paracaval portion of the
posterior liver and because pedicles cross the
proposed division between the right and left
caudate, the concept of segment IX is abandoned.
43. GB & BILIARY TREE
• Kune (1964) Described surgical anatomy
of common bile duct
• Mouret (1987 )Generally credited with
first human laparoscopic cholecystectomy
• Petelim (1991) Performed laparoscopic
choledocholithotomy