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Science 7 
Module 
Cell Structure and Function 
Smiling Grass Cell 
Philippine Normal University 
Taft Ave., Manila 
College of Education 
Department of field Study and Student Teaching 
Certificate of Teaching Program 
(CTP)
About the Cover 
(Photo not mine, credits to the owner) 
A cross section of the leaf of marram grass 
Ammophila arenaria, a species of dune grass that’s 
primarily responsible for trapping wind­blown 
sand 
and building the dune systems around our coast. 
Marram grass survives by rolling up its leaves during 
long periods of drought, minimizing water loss. This 
cross section of a partially rolled leaf has been 
stained with fluorescent dyes to light up different cell 
types within the leaf, with the outside surface of the leaf at the bottom of the picture 
(smooth, curved surface) and the inner convoluted surface at the top. 
(http://beyondthehumaneye.blogspot.com/2009/06/dune­builder. 
html) 
Copyright Page 
Science 7 
Module 
Cell Structure and Function 
by 
John Daniel P. Gumban 
to 
Dr. Lenard A. Tabaranza 
October 2013
Module 
Cell Structure and Function 
What this module is about 
This module will help you gain knowledge about cell: the basic unit of all living 
matter. It is the unit of structure and function of which all plants and animals are 
composed. The cell is the smallest unit in the living organism that is capable of integrating the 
essential life processes. The cell is the key to biology because it is at this level that life truly 
springs. As you read this, you will learn more about the activities of the cell, the structures and 
the material of life that fills them. Later on, you will discover what a living matter is made of. 
This module has the following lessons: 
● Lesson 1 ­Cell 
Theory 
● Lesson 2 ­Cell: 
The Basis of Life 
● Lesson 3 ­Cell 
Types 
What are you expected to learn 
After going this module, you are expected to: 
● Identify the different parts of the cell; 
● Differentiate plant cells from animal cell; 
● Differentiate unicellular organisms from multicellular organisms; 
● Differentiate prokaryotic from eukaryotic cells; 
● Appreciate cell as a highly organized structure. 
How to learn from this module 
I know you want to start to learn about cells. So you must follow these steps 
and instructions to be able to achieve the objectives of this module. 
● Read and follow the instructions carefully. 
● Answer the pretest before you start the lesson. 
● Take note and record point for clarification. 
● Try to achieve at least 75% level of proficiency in the tests. 
● Work diligently and honestly. 
● Answer the protest.
What to do before (Pretest) 
To start off, you have to answer the pre­test 
for you to measure how much 
you know about the topic. You can start now. 
There are 20 questions. Each question has ONLY ONE CORRECT 
ANSWER. Choose the one you believe to be best. Each question is worth 2 
points. Read each question fully and carefully. Take your time. GOOD LUCK! 
1. A cell is observed to contain a nucleus, mitochondria and chloroplasts. From this 
information you can conclude that the cell is: 
a. a plant cell c. a bacteria cell 
b. an animal cell d. a prokaryotic cell 
2. A cell that lacks a nucleus and membrane bound organelles is known as a (an) 
______________ cell. 
a. plant c. eukaryote 
b. animal d. prokaryote 
3. A cell with relatively few energy needs will probably have a relatively small 
number of ________________. 
a. ribosomes c. mitochondria 
b. lysosomes d. chromosomes 
4. Digestive enzymes or hydrolytic enzymes are terms associated with _________. 
a. ribosomes c. golgi apparatus 
b. lysosomes d. smooth endoplasmic reticulum 
5. In which of the following items would you expect to find cells? 
a. strawberry c. silver dollar 
b. eyeglasses d. plastic flower 
6. Organisms whose cells do not have a nucleus are called _______________. 
a. plants c. eukaryotes 
b. organelles d. prokaryotes 
7. Plant cells often have a box­like 
shape because of the ________________. 
a. nucleus c. cytoplasm 
b. cell wall d. cell membrane 
8. The site of ATP production and the site of photosynthesis are the 
_______________ and _________________. 
a. ribosomes and vacuoles c. mitochondria and chloroplast 
b. chloroplasts and lysosome d. Golgi complex and chloroplast
9. What is the outermost boundary of an animal cell? 
a. the cell wall c. the cell membrane 
b. the cytoplasm d. the nuclear envelope 
10. What site regulates what goes in and out of the cell? 
a. cell wall c. cell membrane 
b. vacuole d. nuclear membrane 
11. What type of cell has these characteristics: contains DNA but no nucleus, 
contains flagella, ribosomes, cytoplasm, and a cell membrane. 
a. plant c. animal 
b. fungi d. bacteria 
12. Where is the site of protein synthesis? 
a. nucleus c. ribosome 
b. lysosome d. mitochondria 
13. Which is the “brain” of the cell? 
a. nucleus c. golgi bodies 
b. chloroplast d. mitochondria 
14. Which of the following forms of life is not eukaryotic? 
a. a bacteria cell c. a plant cell like gumamela 
b. protist such as amoeba d. a human cell such as Red Blood Cell 
15. Which of the following is found in the nucleus? 
a. vacuoles c. mitochondria 
b. chloroplasts d. chromosomes 
c. 
16. Which of the following is not true of chloroplasts? 
a. They synthesize sugar c. They are only found in plants. 
b. They contain pigments d. They appear green because of chlorophyll 
17. Which of the following organelles transports materials inside the cell? 
a. lysosome c. mitochondria 
b. chloroplast d. endoplasmic reticulum 
18. Which of the following statements is always true? 
a. All cells have a cell wall. c. All cells contain chloroplast. 
b. All cells contain nucleus. d. All cells have cell membrane. 
19. Which of the following structures are common to both eukaryotic and prokaryotic cells? 
a. nucleus c. both b and c 
b. ribosomes d. cell membrane 
20. Which organelle has no membrane? 
a. vacuole c. ribosome 
b. lysosome d. chloroplast
Lesson 1. Cell Theory 
The cell theory, or cell doctrine, states that all organisms are composed of 
similar units of organization, called cells. The concept was formally articulated in 
1839 by Schleiden and Schwann and has remained as the foundation of modern 
biology. The idea predates other great paradigms of biology including Darwin’s 
theory of evolution (1859), Mendel’s laws of inheritance (1865), and the 
establishment of comparative biochemistry (1940). 
Fact File 
The average human being is composed of around 100 Trillion individual 
cells. It would take as many as 50 cells to cover the area of a dot on 
the letter “i”. 
First Cells Seen in Cork 
“I took a good clear piece of Cork and with a Pen­knife 
sharpen’d as keen as a razor … 
cut off … an exceeding thin piece of it, and placing it on a balck object Plate … and casting the 
light on it with a deep planoconvex Glass, I could exceedingly plainly perceive it to be all 
perforated and porous … these pores, or cells, were not very deep, but consisted of a great 
many little Boxes, separated out of one continued long pore by certain Diaphragms … Nor is 
this kind of texture peculiar to Cork only; for upon examination with my Microscope, I have found 
that the pith of an Elder, or almost any other Tree, the inner pul or pith of the Cany hollow stalks 
of several other Vegetables: as of Fennel, Carrets, Daucus, Bur­docks, 
Teasels, Fearn … & c. 
have so much kind of Schematisme, as I have lately shown that of Cork.” 
­Robert 
Hooke (first report on the existence of cell, 1665) from Microphagia 
While the invention of the telescope made the Cosmos 
accessible to human observation, the microscope opened up smaller 
worlds, showing what living forms were composed of. The cell was 
first discovered and named by Robert Hooke in 1665. He remarked 
that it looked strangely similar to cellula or small rooms which monks 
inhabited, thus deriving the name. However what Hooke actually saw 
was the dead cell walls of plant cells (cork) as it appeared under the 
microscope. Hooke’s description of these cells was published in 
Micrographia. The cell walls observed by Hooke gave no indication of 
the nucleus and other organelles found in most living cells. 
Figure 1.1 The cells 
observed by Hook in the 
honeycomb structure of 
a cork tissue
Using handcrafted microscopes, Anton van Leeuwenhoek was the first person to 
observe and describe single celled organisms, which he originally referred to as animalcules 
(which we now refer to as microorganisms). He was also the first to record and observe muscle 
fibres, bacteria, spermatozoa and blood flow in capillaries (small blood vessels). 
Fact File 
In 1681, Anton van Leeuwenhoek examined his own stool samples 
during times of diarrhea. In his runny stool, he found little animals. 
Leeuwenhoek described Giardia being a slow moving animal, but able 
to make quick motions with their “paws.” Today, we know this is a 
helical motion that is caused by flagella. 
Formulation of Cell Theory 
In 1838, Theodor Schwann and Matthias Schleiden were enjoying after­dinner 
coffee and 
talking about their studies on cells. It has been suggested that when Schwann heard Schleiden 
describe plant cells with nuclei, he was struck by the similarity of these plant cells to cells he had 
observed in animal tissues. The two scientists went immediately to Schwann’s lab to look at his 
slides. Schwann published his book on animal and plant cells (Schwann 1839) the next year, a 
treatise devoid of acknowledgments of anyone else’s contribution, including that of Schleiden 
(1838). 
These discoveries of Schleiden and Schwann introduced the cell theory. This theory 
states that: 
1. All living things are made up of one or more cells. 
2. The cell is the fundamental, structural and functional unit of all living organisms. 
In 1855, third statement on the cell theory was added by Rudolf Virchow. It states that: 
3. All living cells come from pre­existing 
cells, by division. 
This ability of cells to divide and form new cells is the reason for the reproduction and 
growth of all organisms. 
The modern principles of the Cell Theory include the following: 
1. All living things are made up of one or more cells. 
2. The cell is the fundamental, structural and functional unit of all living organisms. 
3. All living cells come from pre­existing 
cells, by division. 
4. The activity of an organism is the total activity of the independent cells of the organism. 
5. All energy flow of life occurs within the cell. 
6. The cells contain hereditary information and is passed from one to another during cell 
division. 
7. The chemical composition of cell are basically the same in organisms of similar species.
Table 1.1 Landmarks in the Study of Cell Biology 
1595 Hans and Zacharias Jansen credited with 1st compound microscope. 
1626 Francesco Redi postulated that living things do not arise from spontaneous generation. 
1655 Robert Hooke described ‘cells’ in cork. 
1674 Anton Van Leeuwenhoek discovered protozoa. He saw bacteria some 9 years later. 
1833 Robert Brown described the cell nucleus in cells of the orchid. 
1840 Albrecht von Roelliker realized that sperm cells and egg cell are also cells. 
1856 Nathanael Pringsheim observed how a sperm cell penetrated an egg cell. 
1858 Rudolf Virchow (physician, pathologist and anthropologist) expounds his famous 
conclusion: “omnis cellula e cellula”, that is “cells develop only from existing cells” 
(cells come from pre­existing 
cells) 
1857 Albert von Kölliker described mitochondria. 
1869 Johannes Friedrich Miescher isolated DNA for the first time. 
1879 Walther Flemming described chromosome behavior during mitosis. 
1833 Germ cell are haploid, chromosome theory of heredity. 
1898 Golgi described the golgi apparatus. 
1926 Theodor Svedberg developed the first analytical ultracentrifuge. 
1938 Peter Behrens used differential centrifugation to separate nuclei from cytoplasm. 
1939 Siemens produced the first commercial transmission electron microscope, 
1941 Albert Coons used fluorescent labeled antibodies to detect cellular antigens. 
1952 George Otto Gey and co­workers 
established a continuous human cell line. 
1953 Francis Crick, Maurice Wilkins and James Watson proposed structure of DNA 
double­helix. 
1955 Harry Eagle systematically defined the nutritional needs of animal cells in culture. 
1957 Matthew Meselson, Franklin Stahl and Jerome Vinograd developed density gradient 
centrifugation in cesium chloride solutions for separating nucleic acids. 
1965 RG Ham introduced a defined serum­free 
medium. Cambridge Instruments produced 
the first commercial scanning electron microscope.
1976 Rizzino Sato and colleagues publish papers showing that different cell lines require 
different mixtures of hormones and growth factors in serum­free 
media. 
1981 Transgenic mice and fruit flies are produced. Mouse embryonic stem cell line 
established. 
1987 First knockout mouse created. 
1998 Mice are cloned from somatic cells. 
2000 Human genome DNA sequence draft. 
2001 Cell cycle regulation (cyclins). 
2002 Mouse genome sequenced. 
2004 Rat genome sequenced. 
2006 Andrew Fire and Craig Mello described method of RNA interference (RNAi) with 
single­stranded 
RNA. 
Prior to 1931 when the first electron microscope was developed, magnification of 
microscopes was limited to about 2000 times. The small cell structures did not show up well or 
remained invisible. The electron microscope not only showed more detail of previously known 
parts of the cell but also revealed new parts. Cells and cell structures can now be examined at 
magnifications of up to 500 000 times and more. 
Fact File 
The shape and appearance of a cell depends on what job it does. Cells 
consist of jelly­like 
cytoplasm, surrounded by a membrane. Nutrients 
pass through this membrane and substances produced by the cell 
leave.
What you will do 
Activity 1.1 
The Street Sweepers 
The air we breathe is filled with dust, smoke, and even small bacteria. 
How come all these materials do not accumulate in the lungs and clog their 
passageways? 
What you will do 
Self Test 1.1 
Answer the following questions briefly. 
1. What contributions did van Leeuwenhoek, Hook, Schleiden, Schwann, and Virchow make 
to the development of the cell theory? 
2. What role did the invention of the microscope play in the development of the cell theory?
Lesson 2. Cell: The Basis of Life 
Have you tried check leaves and observe its surface? Have you tried to exam the wings 
of insects? Have you ever observed the skin of the onion? Such curiosity led early scientist to 
examine living things in the hope of getting a better view of their structure. Little by little, they 
discovered that all living things are made of cells. Cell is the fundamental, structural and 
functional unit of all living organisms such as the birds you watch, the cork trees and so on are 
made of living cells. 
Figure 2.1 All living organisms are composed of one or more cells. 
http://www.deshow.net/animal/bing­animal­wallpaper­846. 
html 
Fact File 
Cells need food, oxygen and a watery environment in order to survive. 
Food and water are supplied by the blood and other body fluids, which 
also carry away wastes. Blood also contains all of the food substances 
and chemicals needed by the cell. 
THE STRUCTURE OF THE CELL 
Cells have three major parts: 
1. Nucleus serves as the control center of the cell; 
2. Cytoplasm is the material between the nucleus and the outer boundary where 
organelles are found; 
3. Cell Membrane serves as the outer boundary of the cell and organelles the 
passage of materials to and from the cell.
Cell Membrane 
The cell membrane is a thin semi­permeable 
membrane that surrounds the cytoplasm of a cell, 
enclosing its contents. Its function is to protect the 
integrity of the interior of the cell by allowing certain 
substances into the cell, while keeping other substances 
out. It also serves as a base of attachment for the 
cytoskeleton in some organisms and the cell wall in 
others. Thus the cell membrane also serves to help 
support the cell and help maintain its shape. 
Figure 2.2 
Cell Membrane 
Find Out 
Break a chicken egg into a dish, and look at the yolk. How large do you think is it? 
Estimate its width. Then use a metric ruler to measure the width of your chicken 
yolk cell. With a hand lens, observe the yolk closely. Other cells that can be seen 
easily are large fish eggs. 
Feedback: Most cells are too small to be seen without the help of a microscope. Luckily, there 
are a few cells that can be seen with your naked eyes. 
Fact File 
The largest cell in human body is the egg cell or ovum, which may be 
fertilized by a sperm cell and grow into a baby. 
Cytoplasm Structures 
The cytoplasm consists of all of the contents outside of the nucleus and enclosed within 
the cell membrane of a cell. This includes mitochondria, endoplasmic reticulum, ribosome, golgi 
bodies, lysosomes, and vacuole.
Mitochondria are commonly called the “power houses” of the 
cell. They trap the energy that results when food is broken down. Just 
as a power plant supplies energy to a business, mitochondria provide 
energy for the cell. Some types of cells are more active than others, 
that’s why they can have more mitochondria. 
Figure 2.3 
Mitochondria 
Analyze This 
Why might a muscle cell have more mitochondria than other cells? 
Feedback: Muscle cells are always undergoing some type of movement. Muscles are also the 
ones exposed to strenuous activities like doing some household chores, running, walking, etc. 
Endoplasmic reticulum are network of canals extends from the nucleus to the cell 
membrane and takes up quite a lot of space in some cells. It moves material from one place to 
another place inside the cell. 
There are two regions of the 
endoplasmic reticulum that 
differ in both structure and 
function. One region is called 
Rough Endoplasmic Reticulum 
because it has ribosomes 
attached to the cytoplasmic 
side of the membrane. The 
other region is called Smooth 
Endoplasmic Reticulum 
because it lacks attached 
ribosomes. Typically, the 
smooth endoplasmic reticulum 
is a tubule network and the 
rough endoplasmic reticulum 
is a series of flattened sacs. 
Figure 2.4 
Endoplasmic Reticulum
Ribosomes are the tiny dots you see 
on the edges of some of the endoplasmic 
reticulum. Some cells may contain millions 
of ribosomes. Ribosomes are cell organelles 
that consist of RNA and proteins. They are 
responsible for assembling the proteins of 
the cell. Depending on the protein production 
level of a particular cell, ribosomes may 
number in the millions. 
Figure 2.5 
Ribosome 
Fact File 
Cells contain thousands of ribosomes. Ribosomes are organelles that 
produce amino acids and proteins in the cells. They do this by reading 
RNA (ribonucleic acid), which is a process called translation. Every 
second, ribosomes can add 3+ amino acids to a new protein. 
In a manufacturing business, products are made, packaged, 
and moved to loading centers to be carried away. Structures called 
golgi bodies are responsible for manufacturing, warehousing, and 
shipping certain cellular products, particularly those from the 
endoplasmic reticulum (ER). Depending on the type of cell, there can 
be just a few complexes or there can be hundreds. Cells that 
specialize in secreting various substances typically have a high 
number of Golgi bodies. are the packaging and releasing structures 
of the cell. When something is released, it is given off by the cell. 
Figure 2.6 
Golgi Bodies 
Applying a Concept 
An animal cell contains about 10 to 20 golgi bodies, while a plant cell contains 
several hundreds. Why do you think there is such a difference in the number of these 
structures in each cell type? 
Feedback: The fact that plants produce so many materials (food, oils, resins, etc.), they will be in 
need of more golgi bodies to store the said materials.
Do you know that cells also produce wastes? In the cytoplasm, structures called 
lysosomes. Lysosomes are membranous sacs of enzymes. They are made by the endoplasmic 
reticulum and Golgi bodies. Lysosomes contain various 
hydrolytic enzymes that are capable of digesting nucleic acid, 
polysaccharides, fats, and proteins.They are active in recycling 
the cell's organic material and in the intracellular digestion of 
macromolecules. In addition, in many organisms, lysosomes 
are involved in programmed cell death. On the other hand, 
lysosomes contain chemicals that digest wastes and 
worn­out/ 
damaged cell parts. When a cell dies, chemicals in 
the lysosomes act to quickly break down the cell. In a healthy 
cell, the membrane around the lysosome keeps it from 
breaking down the cell itself. Plant cells do not have lysosomes. Figure 2.7 
Lysosome 
Fact File 
There are two ways that a cell can die: necrosis and apoptosis. 
Necrosis occurs when a cell is damaged by an external force, such as 
poison, a bodily injury, an infection or getting cut off from the blood 
supply. Apoptosis, it's when a cell commits suicide. It's sometimes 
referred to as programmed cell death, and indeed, the process of 
apoptosis follows a controlled, predictable routine. 
Many businesses have warehouses for storing products 
until they are sold. Vacuoles are storage areas in cells. A 
membrane­bound 
vesicle found in the cytoplasm of a cell 
whose function includes intracellular secretion, excretion, 
storage, and digestion. It can be found in animal and plant 
cells, and it can be especially conspicuous in plant cells. 
Figure 2.8 
Vacuole
Analyze This 
In plant cells, vacuoles are big. In animal cells, vacuoles are small. Why do you 
think so? 
Feedback: Plants are said to be the producers of food in the environment. They may produce 
sugar, oil, nectar, etc. They are in need of bigger vacuoles to store such materials. 
The Nucleus 
The nucleus is a membrane bound structure and act as the “control center” of the cell. The 
nucleus contains the cell's hereditary information and controls the cell's growth and 
reproduction. The nucleus is bounded by a double membrane called the nuclear envelope 
(nuclear membrane). This membrane separates the contents of the nucleus from the 
cytoplasm. The envelope helps to maintain the shape of the nucleus and assists in regulating the 
flow of molecules into and out of the nucleus through nuclear pores. The nucleus contains coded 
instructions for all of the cell’s activities. These coded instructions are stored on special 
structure called the chromosomes. When a cell is 
"resting" i.e. not dividing, the chromosomes are 
organized into long entangled structures called 
chromatin and not into individual chromosomes as we 
typically think of them. The nucleus also contains the 
nucleolus which helps to synthesize ribosomes. The 
nucleolus contains nucleolar organizers which are parts 
of chromosomes with the genes for ribosome synthesis 
on them. Copious amounts of RNA and proteins can be 
found in the nucleolus as well. The nucleus controls the 
synthesis of proteins in the cytoplasm through the use of 
messenger RNA. Messenger RNA is produced in the 
nucleolus of the cell and travels to the cytoplasm through 
the pores of the nuclear envelope. 
Figure 2.9 
Parts of Nucleus 
Fact File 
A typical DNA molecule is so long and thin that if it were the thickness of spaghetti, it 
would be 5 miles (8km) long.
Figure 2.10 
Animal Cell 
You have just looked at the inner workings of an animal cell. Imagine now that you are 
taking a microscopic tour through 
the green plant cell on the side. 
You will find that some structures 
in this cell are quite different from 
the structures in an animal cell. 
Take note of them. The outer 
covering of the plant cell is not soft 
and thin. Instead, it is surrounded 
by a rigid/tough structure called the 
cell wall that supports and protects 
the plant cell. Once you pass 
through the cell wall, you see the 
same structures you saw in the 
animal cell. The dark green bodies 
you see around you are 
chloroplasts. Substances inside 
the chloroplast help a green plant 
cell trap the sun’s energy and then 
produce food. 
Figure 2.11 
Plant Cell
Imagine you could take a trip into a tiny bacterial cell. Bacteria and blue­bacteria 
are quite 
different from other cells. They have fewer structures than plant or animal cells. However, they 
carry out all of the life processes that other cells carry out. You can see that a bacterium has a 
cell wall, a cell membrane, and cytoplasm. The chromosome material (nucleoid), which directs 
the cell’s activities, floats freely through the cytoplasm. The other structures are lacking. 
Figure 2.12 
Bacterial Cell 
Fact File 
Bacteria are tiny, single­celled 
organisms. They can measure as little as 
0.001 mm across and they can only be seen under a microscope. There 
are many different sorts of bacteria, and most of them are harmless.
What you will do 
Activity 2.1 
Challenge 
Make your own model of a cell at home. Prepare a small package of gulaman and pour it into 
dish. Put common foods in the gelatin to represent cell structures. You could use lettuce or 
shredded carrots for endoplasmic reticulum and raisins for mitochondria. Be creative! Unmold 
your “cell”. And serve it to your family for salad or dessert. 
What you will do 
Self­test 
2.1 
Let us see how well you can make a summary of what you know about 
the cell. Below is a table that lists the names of the cell structure(s). Now, 
compare animal, plant and bacterial cells by putting a (/) if the structure is present 
and an (x) if the structure is absent under each column. 
Structures Animal Cell Plant Cell Bacterial Cell 
1. Cell wall 
2. Cell membrane 
3. Cytoplasm 
4. Mitochondria 
5. Ribosomes 
6.Endoplasmic Reticulum 
7. Golgi bodies 
8. Lysosomes 
9. Vacuoles 
10. Chloroplasts 
11. Nucleus 
12. Chromosomes
What you will do 
Self Test 2.2 
A Tale of a Tail 
Mr. Gumban’s' class studied the parts of plant and 
animal cells. The class captured tiny tadpoles in a local 
stream. Mr. Gumban showed the students how to care for the 
tadpoles in the classroom. Gradually, as the animals grew, the 
bodies were changing in shape. Back and front legs grew out. 
The mouth expanded from a small hole to a large opening 
capable of swallowing large insects. In addition, the tails started 
to disappear. Mr. Gumban told the whole class that there would 
be a bonus question about the tadpoles in the test on animals. 
For a study clue, she told them to review their notes on cells. 
What do changes in the body parts of the tadpoles have to do 
with cells? Figure 2.13 
Tadpole 
Think critically: 
Answer the bonus question: 
What cell part makes the tadpole tails disappear? How?
Lesson 3. Cell Types 
PROKARYOTES AND EUKARYOTES 
Not all organelles described in the previous section are present in all cells. Cells can be 
grouped into two large categories: prokaryotes (cell without a true nucleus) and eukaryotes (cell 
with a true nucleus). 
Prokaryotes 
Prokaryotes are single­celled 
organisms that are the earliest and most primitive forms of 
life on earth. As organized in the Three Domain System, prokaryotes include bacteria and 
archaeans. Prokaryotes are able to live and thrive in various types of environments including 
extreme habitats such as hydrothermal vents, hot springs, swamps, wetlands, and the guts of 
animals. 
Fact File 
The first recorded observation were of the bacteria found in the dental plaque of two old men 
who never cleaned their teeth. 
Prokaryotic Cell Structure 
Prokaryotic cells are not as complex as eukaryotic cells. They have no true nucleus as the DNA 
is not contained within a membrane or separated from the rest of the cell, but is coiled up in a 
region of the cytoplasm called the nucleoid. Prokaryotes do not have membrane­bound 
organelles like mitochondria and endoplasmic reticulum. They do not possess lysosomes, 
vacuoles, and Golgi bodies. Their ribosomes are small. Chlorophyll, when present, is not 
contained in chloroplasts. 
Figure 3.1 Examples of Prokaryotes. From left to right: lactobacillus, E. coli and salmonella.
Eukaryotes 
Eukaryotes include animals, plants, fungi and protists. Typically, eukaryotic cells are more 
complex and much larger than prokaryotic cells. On average, prokaryotic cells are about 10 
times smaller in diameter than eukaryotic cells. Eukaryotes have well­defined 
nuclear membrane 
and distinct nucleolus. Membrane­bound 
organelles are found in eukaryotes, such as Golgi 
bodies and mitochondria. 
Plant and Animal Cells 
The second cell grouping is Plants versus Animal cells. Both of these cell types are 
eukaryotes. This means they have a lot of organelles in common. One organelle they don’t have 
in common is chloroplasts, which only plants have. Another organelle difference is the vacuoles. 
In animal cells the vacuoles are small and plenty. In the plant cells, there is a large central 
vacuole that occupies over 50% of the plant cell’s volume. This vacuole is filled with water and 
nutrients under pressure. The pressure helps maintain the plant cell’s rigid shape. The rigid 
shape results in plant cells looking rectangular as compared to the round like animal cells. While 
both cell types have cell membranes, the plant cell’s rigidity is further maintained by an additional 
cell wall outside the membrane. 
Figure 3.2 Eukaryotic Organisms 
Fact File 
DNA strands look like a twisted ladder. Sections of DNA are called 
genes. All the instructions for growing a new human being are coded 
into the DNA molecule.
Table 3.1 Comparison of prokaryotic and Eukaryotic Cells. 
Cell Structure Prokaryotic Cell Eukaryotic Cell 
Cell membrane present present 
Nuclear membrane absent present 
Membrane­bound 
organelles absent present 
Ribosomes small large 
Chlorophyll when present are not found in 
chloroplasts 
found in chloroplasts 
Mitochondria absent present 
Chromosomes single loop of circular DNA multiple double­helix 
Fact File 
Chromosomes are tiny threads that are present in all cells apart from red 
blood cells. They contain all the information for an entire person to 
develop. There are 46 chromosomes in each cell. They come in 22 pairs, 
plus another special pair that determine the person’s sex. 
What you will do 
Self Test 3.1 
Answer the following questions: 
1. Chloroplasts are found in which type of cell? 
2. What do you call the broad group of cells that lack membrane bounded organelles? 
3. What type of cell (prokaryote or eukaryote) has DNA that floats freely in the cell? 
4. Mushroom is a unicellular organism. (True or false) 
5. Human is a multicellular organism. (True or false)
Let’s Summarize 
1. Cells are amazing, variable, beautiful, and functionally superb. A concept of genius, they 
work alone or in groups with equal ease. 
2. Cells are the basic units of life. All living things are made up of one or more cells. 
Organisms that exist as single cells are called unicellular and organisms that are made 
up of groups of cells working together are called multicellular. 
3. Because all living things are made up of cells, and because we desire to understand 
ourselves and the other living things around us it makes sense to learn something about 
cells. 
4. All living things are divided into two major groups depending on how their cells are set up. 
These two groups are the Prokaryotes and the Eukaryotes. 
5. The basic structure of plant and animal cell is almost the same except for certain 
differences. The basic structure of a cell is composed of the following components. 
a. Cell Membrane 
b. Cytoplasm 
c. Nucleus 
However in plants, a rigid "Cell wall" is present outside the cell membrane or 
plasma membrane. 
6. Cell Theory: All living things are composed of cells. Cells are the basic units of structure 
and function in living things. All cells come from preexisting cells 
Whew! At last! You have finished studying the module. But, before you completely exit from this 
module, let us find out how much you learned from this material.
Post-Test 
Multiple Choice. Choose the letter of the best answer. Write the chosen letter on 
a separate sheet of paper. 
1. A cell is observed to contain a nucleus, mitochondria and chloroplasts. From this 
information you can conclude that the cell is: 
a. a plant cell c. a bacterial cell 
b. a animal cell d. a prokaryotic cell 
2. A cell that lacks a nucleus and membrane bound organelles is known as a(an) 
______________ cell. 
a. plant c.eukaryote 
b. animal d. prokaryote 
3. A cell with relatively few energy needs will probably have a relatively small number of 
a. ribosomes c. mitochondria 
b. lysosomes d. chromosomes 
4. Digestive enzymes or hydrolytic enzymes are terms associated with 
a. ribosomes c. golgi apparatus 
b. lysosomes d. smooth endoplasmic reticulum 
5. In which of the following items would you expect to find cells? 
a. strawberry c. silver dollar 
b. eyeglasses d. plastic flower 
6. Organisms whose cells do not have a nucleus are called 
a. plants c. eukaryotes 
b. organelles d. prokaryotes 
7. Plant cells often have a box­like 
shape because of the 
a. nucleus c. cytoplasms 
b. cell wall d. cell membrane 
8. The site of ATP production and the site of photosynthesis are the _______________ and 
_________________. 
a. ribosomes and vacuoles c. mitochondria and chloroplasts 
b. chloroplasts and lysosomes d. Golgi complex and chloroplast 
9. What is the outermost boundary of an animal cell? 
a. the cell wall c. the nuclear membrane 
b. the cytoplasm d. the nuclear envelope
10. What site regulates what goes in and out of the cell? 
a. cell wall c. cell membrane 
b. vacuole d. nuclear membrane 
11. What type of cell has these characteristics: contains DNA but no nucleus, contains 
flagella, ribosomes, cytoplasm, and a cell membrane. 
a. plant c. animal 
b. fungi d. bacteria 
12. Where is the site of protein synthesis? 
a. nucleus c. ribosome 
b. lysosomes d. mitochondria 
13. Which is the “brain” of the cell? 
a. nucleus c. golgi bodies 
b. chlorop[lats d. mitochondria 
14. Which of the following forms of life is NOT eukaryotic? 
a. a bacterial cell c. a plant cell like gumamela 
b. protist such as amoeba d. a human cell such as red blood cell 
15. Which of the following is found in the nucleus? 
a. vacuole c. mitochondria 
b. chloroplasts d. chromosomes 
16. Which of the following is NOT true of chloroplasts? 
a. They synthesize sugar 
b. They contain pigments 
c. They are only found in planta 
d. They appear green because of chlorophyll 
17. Which of the following organelles transports materials inside the cell 
a. lysosome c. mitochondria 
b. chloroplasts d. endoplasmic reticulum 
18. Which of the following statements is always true? 
a. All cells have a cell wall c. All cells contain chloroplast. 
b. All cells contain nucleus. d. All cells have a cell membrane. 
19. Which of the following structures are common to both eukaryotic and prokaryotic cells? 
a. nucleus c. both b and c 
b. ribosomes d. cell membrane 
20. Which organelle has no membrane? 
a. vacuole c. ribosome 
b. lysosome d. chloroplast
Key to Answers 
Pretest 
1. c 6. d 11. d 16. c 
2. d 7. b 12. a 17. a 
3. d 8. a 13. d 18. d 
4. c 9. b 14. b 19. c 
5. a 10. c 15. c 20. c 
LESSON 1 
Activity 1.1 
The Street Sweepers 
Lining the passageways are special cells that release a mixture of water, carbohydrates, and 
salts, called mucus. The particles of dust and dirt that are inhaled are trapped in this sticky 
mucus. Underneath this layer of mucus is another group of specialized cells that have cilia. As 
the cilia move, they create a sweeping action. This action keeps the most vital passageways in 
the body clean and open for business. 
Self­Test 
1.1 
1. Leeuwenhoek: discovered protozoa 
Hooke: described “cells” in cork 
Schleiden & Schwann: proposed cell theory 
Virchow: concluded that cells come from preexisting cells 
2. The microscope opened up the world of the very small to biologists. It enabled scientists 
to discover that all living things are made up of cells. 
LESSON 2 
Self­Test 
2.1 
Structures Animal Cell Plant Cell Bacterial Cell 
1. Cell wall X / / 
2. Cell membrane / / / 
3. Cytoplasm / / / 
4. Mitochondria / / x
5. Ribosomes / / / 
6.Endoplasmic Reticulum / / x 
7. Golgi bodies / / x 
8. Lysosomes / x x 
9. Vacuoles / / x 
10. Chloroplasts x / x 
11. Nucleus / / x 
12. Chromosomes / / / 
Self­Test 
2.2 
The body parts of the tadpoles change in response to the activity of the cells which is cell 
division. When cells divide, their number increases. Growth results when cells increase in 
number. 
The tails of the tadpole disappear due to the lysosomal activity. The lysosome, if you will recall, 
contains powerful chemicals which are used to digest or break down materials 
LESSON 3 
Activity 3.1 
Feedback: One­celled 
organisms may have fewer or different structures from plant or animal 
cells. However, they carry out all of the life processes (reproduction, digestion, excretion, 
respiration, etc.) that other cells carry out. 
Self­Test 
3.1 
1. plant 
2. prokaryote 
3. prokaryote 
4. false 
5. true 
Post­Test 
1. c 6. b 11. b 16. c 
2. d 7. a 12. a 17. a 
3. d 8. c 13. d 18. d 
4. b 9. c 14. b 19. c 
5. c 10. d 15. a 20. c
References 
Books: 
Ahuja M.; (2006). Life Sciences. Gyan Publishing House. pp. 105­109 
Chancellor Press (Bounty Books); (2001). Tell Me What?. WS Pacific Publications Inc., Manila, 
Philippines. pp. 38­71 
Chancellor Press (Bounty Books); (2001). Tell Me Where?. WS Pacific Publications Inc., Manila, 
Philippines. pp. 140­173 
Chancellor Press (Bounty Books); (2001). Tell me When?. WS Pacific Publications Inc., Manila, 
Philippines. pp. 38­71 
Lozano, L.; Sandico, P.M.; (2003). Science and Technology for the Future II. Diwa Scholastic 
Press Inc. pp. 92­104 
Module: 
Project EASE (Effective Alternative Secondary Education). Biology Module 2. Cell structure and 
Function. Bureau of Secondary Education, Department of Education, Pasig City. 
Electronic Sources: 
Retrieved October 15, 2013 from 
http://depedmati.wikispaces.com/file/view/K+TO+12+BEC+COMPETENCIES+AND+LEARNING 
+RESOURCES+FOR+GRADE+7.pdf 
Retrieved October 15, 2013 from http://goo.gl/fLMSSo 
Retrieved October 15, 2013 from 
http://science.howstuffworks.com/life/cellular­microscopic/ 
cell­info. 
htm 
Retrieved October 15, 2013 from 
http://beyondthehumaneye.blogspot.com/2009/06/dune­builder. 
html 
Retrieved October 15, 2013 from 
http://www.infoplease.com/encyclopedia/science/cell­biology. 
html 
Retrieved October 15, 2013 from http://bitesizebio.com/articles/history­of­cell­biology/ 
Retrieved October 15, 2013 from 
http://commons.wikimedia.org/wiki/File:Cork_Micrographia_Hooke.png 
Retrieved October 15, 2013 from http://biology.tutorvista.com/cell/cell­theory. 
html 
Retrieved October 15, 2013 from fig.cox.Miami.edu/~cmallery/150/unity/cell.text.htm
Retrieved October 15, 2013 from http://goo.gl/SbqIZp 
Retrieved October 15, 2013 from http://cellbiology.med.unsw.edu.au/units/science/timeline.htm 
Retrieved October 15, 2013 from 
http://www.history­of­the­microscope. 
org/hans­and­zacharias­jansen­microscope­history. 
php 
Retrieved October 15, 2013 from http://www.deshow.net/animal/bing­animal­wallpaper­846. 
html 
Retrieved October 15, 2013 from http://goo.gl/12giJo 
Retrieved October 15, 2013 from 
http://www.history­of­the­microscope. 
org/anton­van­leeuwenhoek­microscope­history. 
php 
Retrieved October 16, 2013 from 
http://www.answersingenesis.org/articles/aid/v7/n1/antony­van­leeuwenhoek­creation­magnified­microscopes 
Retrieved October 16, 2013 from http://biology.about.com/od/cellanatomy/p/nucleus.htm 
Retrieved October 16, 2013 from 
http://biology.about.com/od/biologydictionary/g/cell­membrane. 
htm 
Retrieved October 16, 2013 from 
http://biology.about.com/od/cellanatomy/ss/endoplasmic­reticulum. 
htm 
Retrieved October 16, 2013 from http://biology.about.com/od/cellanatomy/p/ribosomes.htm 
Retrieved October 16, 2013 from http://www.ask.com/question/interesting­facts­about­ribosome 
Retrieved October 17, 2013 from http://biology.about.com/b/2008/11/07/what­are­lysosomes. 
htm 
Retrieved October 17, 2013 from 
http://science.howstuffworks.com/life/cellular­microscopic/ 
apoptosis.htm 
Retrieved October 17, 2013 from http://www.biology­online. 
org/dictionary/Vacuole 
Retrieved October 17, 2013 from http://biology.about.com/od/cellanatomy/ss/prokaryotes.htm 
Retrieved October 17, 2013 from http://www.ask.com/question/examples­of­prokaryotic­organisms 
Retrieved October 17, 2013 from http://goo.gl/pPKiaU 
Retrieved October 17, 2013 from http://biology.about.com/od/cellanatomy/a/eukaryprokarycells.htm 
Retrieved October 17, 2013 from http://hyperphysics.phy­astr. 
gsu.edu/hbase/biology/golgi.html

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Module cell structure and function

  • 1. Science 7 Module Cell Structure and Function Smiling Grass Cell Philippine Normal University Taft Ave., Manila College of Education Department of field Study and Student Teaching Certificate of Teaching Program (CTP)
  • 2. About the Cover (Photo not mine, credits to the owner) A cross section of the leaf of marram grass Ammophila arenaria, a species of dune grass that’s primarily responsible for trapping wind­blown sand and building the dune systems around our coast. Marram grass survives by rolling up its leaves during long periods of drought, minimizing water loss. This cross section of a partially rolled leaf has been stained with fluorescent dyes to light up different cell types within the leaf, with the outside surface of the leaf at the bottom of the picture (smooth, curved surface) and the inner convoluted surface at the top. (http://beyondthehumaneye.blogspot.com/2009/06/dune­builder. html) Copyright Page Science 7 Module Cell Structure and Function by John Daniel P. Gumban to Dr. Lenard A. Tabaranza October 2013
  • 3. Module Cell Structure and Function What this module is about This module will help you gain knowledge about cell: the basic unit of all living matter. It is the unit of structure and function of which all plants and animals are composed. The cell is the smallest unit in the living organism that is capable of integrating the essential life processes. The cell is the key to biology because it is at this level that life truly springs. As you read this, you will learn more about the activities of the cell, the structures and the material of life that fills them. Later on, you will discover what a living matter is made of. This module has the following lessons: ● Lesson 1 ­Cell Theory ● Lesson 2 ­Cell: The Basis of Life ● Lesson 3 ­Cell Types What are you expected to learn After going this module, you are expected to: ● Identify the different parts of the cell; ● Differentiate plant cells from animal cell; ● Differentiate unicellular organisms from multicellular organisms; ● Differentiate prokaryotic from eukaryotic cells; ● Appreciate cell as a highly organized structure. How to learn from this module I know you want to start to learn about cells. So you must follow these steps and instructions to be able to achieve the objectives of this module. ● Read and follow the instructions carefully. ● Answer the pretest before you start the lesson. ● Take note and record point for clarification. ● Try to achieve at least 75% level of proficiency in the tests. ● Work diligently and honestly. ● Answer the protest.
  • 4. What to do before (Pretest) To start off, you have to answer the pre­test for you to measure how much you know about the topic. You can start now. There are 20 questions. Each question has ONLY ONE CORRECT ANSWER. Choose the one you believe to be best. Each question is worth 2 points. Read each question fully and carefully. Take your time. GOOD LUCK! 1. A cell is observed to contain a nucleus, mitochondria and chloroplasts. From this information you can conclude that the cell is: a. a plant cell c. a bacteria cell b. an animal cell d. a prokaryotic cell 2. A cell that lacks a nucleus and membrane bound organelles is known as a (an) ______________ cell. a. plant c. eukaryote b. animal d. prokaryote 3. A cell with relatively few energy needs will probably have a relatively small number of ________________. a. ribosomes c. mitochondria b. lysosomes d. chromosomes 4. Digestive enzymes or hydrolytic enzymes are terms associated with _________. a. ribosomes c. golgi apparatus b. lysosomes d. smooth endoplasmic reticulum 5. In which of the following items would you expect to find cells? a. strawberry c. silver dollar b. eyeglasses d. plastic flower 6. Organisms whose cells do not have a nucleus are called _______________. a. plants c. eukaryotes b. organelles d. prokaryotes 7. Plant cells often have a box­like shape because of the ________________. a. nucleus c. cytoplasm b. cell wall d. cell membrane 8. The site of ATP production and the site of photosynthesis are the _______________ and _________________. a. ribosomes and vacuoles c. mitochondria and chloroplast b. chloroplasts and lysosome d. Golgi complex and chloroplast
  • 5. 9. What is the outermost boundary of an animal cell? a. the cell wall c. the cell membrane b. the cytoplasm d. the nuclear envelope 10. What site regulates what goes in and out of the cell? a. cell wall c. cell membrane b. vacuole d. nuclear membrane 11. What type of cell has these characteristics: contains DNA but no nucleus, contains flagella, ribosomes, cytoplasm, and a cell membrane. a. plant c. animal b. fungi d. bacteria 12. Where is the site of protein synthesis? a. nucleus c. ribosome b. lysosome d. mitochondria 13. Which is the “brain” of the cell? a. nucleus c. golgi bodies b. chloroplast d. mitochondria 14. Which of the following forms of life is not eukaryotic? a. a bacteria cell c. a plant cell like gumamela b. protist such as amoeba d. a human cell such as Red Blood Cell 15. Which of the following is found in the nucleus? a. vacuoles c. mitochondria b. chloroplasts d. chromosomes c. 16. Which of the following is not true of chloroplasts? a. They synthesize sugar c. They are only found in plants. b. They contain pigments d. They appear green because of chlorophyll 17. Which of the following organelles transports materials inside the cell? a. lysosome c. mitochondria b. chloroplast d. endoplasmic reticulum 18. Which of the following statements is always true? a. All cells have a cell wall. c. All cells contain chloroplast. b. All cells contain nucleus. d. All cells have cell membrane. 19. Which of the following structures are common to both eukaryotic and prokaryotic cells? a. nucleus c. both b and c b. ribosomes d. cell membrane 20. Which organelle has no membrane? a. vacuole c. ribosome b. lysosome d. chloroplast
  • 6. Lesson 1. Cell Theory The cell theory, or cell doctrine, states that all organisms are composed of similar units of organization, called cells. The concept was formally articulated in 1839 by Schleiden and Schwann and has remained as the foundation of modern biology. The idea predates other great paradigms of biology including Darwin’s theory of evolution (1859), Mendel’s laws of inheritance (1865), and the establishment of comparative biochemistry (1940). Fact File The average human being is composed of around 100 Trillion individual cells. It would take as many as 50 cells to cover the area of a dot on the letter “i”. First Cells Seen in Cork “I took a good clear piece of Cork and with a Pen­knife sharpen’d as keen as a razor … cut off … an exceeding thin piece of it, and placing it on a balck object Plate … and casting the light on it with a deep planoconvex Glass, I could exceedingly plainly perceive it to be all perforated and porous … these pores, or cells, were not very deep, but consisted of a great many little Boxes, separated out of one continued long pore by certain Diaphragms … Nor is this kind of texture peculiar to Cork only; for upon examination with my Microscope, I have found that the pith of an Elder, or almost any other Tree, the inner pul or pith of the Cany hollow stalks of several other Vegetables: as of Fennel, Carrets, Daucus, Bur­docks, Teasels, Fearn … & c. have so much kind of Schematisme, as I have lately shown that of Cork.” ­Robert Hooke (first report on the existence of cell, 1665) from Microphagia While the invention of the telescope made the Cosmos accessible to human observation, the microscope opened up smaller worlds, showing what living forms were composed of. The cell was first discovered and named by Robert Hooke in 1665. He remarked that it looked strangely similar to cellula or small rooms which monks inhabited, thus deriving the name. However what Hooke actually saw was the dead cell walls of plant cells (cork) as it appeared under the microscope. Hooke’s description of these cells was published in Micrographia. The cell walls observed by Hooke gave no indication of the nucleus and other organelles found in most living cells. Figure 1.1 The cells observed by Hook in the honeycomb structure of a cork tissue
  • 7. Using handcrafted microscopes, Anton van Leeuwenhoek was the first person to observe and describe single celled organisms, which he originally referred to as animalcules (which we now refer to as microorganisms). He was also the first to record and observe muscle fibres, bacteria, spermatozoa and blood flow in capillaries (small blood vessels). Fact File In 1681, Anton van Leeuwenhoek examined his own stool samples during times of diarrhea. In his runny stool, he found little animals. Leeuwenhoek described Giardia being a slow moving animal, but able to make quick motions with their “paws.” Today, we know this is a helical motion that is caused by flagella. Formulation of Cell Theory In 1838, Theodor Schwann and Matthias Schleiden were enjoying after­dinner coffee and talking about their studies on cells. It has been suggested that when Schwann heard Schleiden describe plant cells with nuclei, he was struck by the similarity of these plant cells to cells he had observed in animal tissues. The two scientists went immediately to Schwann’s lab to look at his slides. Schwann published his book on animal and plant cells (Schwann 1839) the next year, a treatise devoid of acknowledgments of anyone else’s contribution, including that of Schleiden (1838). These discoveries of Schleiden and Schwann introduced the cell theory. This theory states that: 1. All living things are made up of one or more cells. 2. The cell is the fundamental, structural and functional unit of all living organisms. In 1855, third statement on the cell theory was added by Rudolf Virchow. It states that: 3. All living cells come from pre­existing cells, by division. This ability of cells to divide and form new cells is the reason for the reproduction and growth of all organisms. The modern principles of the Cell Theory include the following: 1. All living things are made up of one or more cells. 2. The cell is the fundamental, structural and functional unit of all living organisms. 3. All living cells come from pre­existing cells, by division. 4. The activity of an organism is the total activity of the independent cells of the organism. 5. All energy flow of life occurs within the cell. 6. The cells contain hereditary information and is passed from one to another during cell division. 7. The chemical composition of cell are basically the same in organisms of similar species.
  • 8. Table 1.1 Landmarks in the Study of Cell Biology 1595 Hans and Zacharias Jansen credited with 1st compound microscope. 1626 Francesco Redi postulated that living things do not arise from spontaneous generation. 1655 Robert Hooke described ‘cells’ in cork. 1674 Anton Van Leeuwenhoek discovered protozoa. He saw bacteria some 9 years later. 1833 Robert Brown described the cell nucleus in cells of the orchid. 1840 Albrecht von Roelliker realized that sperm cells and egg cell are also cells. 1856 Nathanael Pringsheim observed how a sperm cell penetrated an egg cell. 1858 Rudolf Virchow (physician, pathologist and anthropologist) expounds his famous conclusion: “omnis cellula e cellula”, that is “cells develop only from existing cells” (cells come from pre­existing cells) 1857 Albert von Kölliker described mitochondria. 1869 Johannes Friedrich Miescher isolated DNA for the first time. 1879 Walther Flemming described chromosome behavior during mitosis. 1833 Germ cell are haploid, chromosome theory of heredity. 1898 Golgi described the golgi apparatus. 1926 Theodor Svedberg developed the first analytical ultracentrifuge. 1938 Peter Behrens used differential centrifugation to separate nuclei from cytoplasm. 1939 Siemens produced the first commercial transmission electron microscope, 1941 Albert Coons used fluorescent labeled antibodies to detect cellular antigens. 1952 George Otto Gey and co­workers established a continuous human cell line. 1953 Francis Crick, Maurice Wilkins and James Watson proposed structure of DNA double­helix. 1955 Harry Eagle systematically defined the nutritional needs of animal cells in culture. 1957 Matthew Meselson, Franklin Stahl and Jerome Vinograd developed density gradient centrifugation in cesium chloride solutions for separating nucleic acids. 1965 RG Ham introduced a defined serum­free medium. Cambridge Instruments produced the first commercial scanning electron microscope.
  • 9. 1976 Rizzino Sato and colleagues publish papers showing that different cell lines require different mixtures of hormones and growth factors in serum­free media. 1981 Transgenic mice and fruit flies are produced. Mouse embryonic stem cell line established. 1987 First knockout mouse created. 1998 Mice are cloned from somatic cells. 2000 Human genome DNA sequence draft. 2001 Cell cycle regulation (cyclins). 2002 Mouse genome sequenced. 2004 Rat genome sequenced. 2006 Andrew Fire and Craig Mello described method of RNA interference (RNAi) with single­stranded RNA. Prior to 1931 when the first electron microscope was developed, magnification of microscopes was limited to about 2000 times. The small cell structures did not show up well or remained invisible. The electron microscope not only showed more detail of previously known parts of the cell but also revealed new parts. Cells and cell structures can now be examined at magnifications of up to 500 000 times and more. Fact File The shape and appearance of a cell depends on what job it does. Cells consist of jelly­like cytoplasm, surrounded by a membrane. Nutrients pass through this membrane and substances produced by the cell leave.
  • 10. What you will do Activity 1.1 The Street Sweepers The air we breathe is filled with dust, smoke, and even small bacteria. How come all these materials do not accumulate in the lungs and clog their passageways? What you will do Self Test 1.1 Answer the following questions briefly. 1. What contributions did van Leeuwenhoek, Hook, Schleiden, Schwann, and Virchow make to the development of the cell theory? 2. What role did the invention of the microscope play in the development of the cell theory?
  • 11. Lesson 2. Cell: The Basis of Life Have you tried check leaves and observe its surface? Have you tried to exam the wings of insects? Have you ever observed the skin of the onion? Such curiosity led early scientist to examine living things in the hope of getting a better view of their structure. Little by little, they discovered that all living things are made of cells. Cell is the fundamental, structural and functional unit of all living organisms such as the birds you watch, the cork trees and so on are made of living cells. Figure 2.1 All living organisms are composed of one or more cells. http://www.deshow.net/animal/bing­animal­wallpaper­846. html Fact File Cells need food, oxygen and a watery environment in order to survive. Food and water are supplied by the blood and other body fluids, which also carry away wastes. Blood also contains all of the food substances and chemicals needed by the cell. THE STRUCTURE OF THE CELL Cells have three major parts: 1. Nucleus serves as the control center of the cell; 2. Cytoplasm is the material between the nucleus and the outer boundary where organelles are found; 3. Cell Membrane serves as the outer boundary of the cell and organelles the passage of materials to and from the cell.
  • 12. Cell Membrane The cell membrane is a thin semi­permeable membrane that surrounds the cytoplasm of a cell, enclosing its contents. Its function is to protect the integrity of the interior of the cell by allowing certain substances into the cell, while keeping other substances out. It also serves as a base of attachment for the cytoskeleton in some organisms and the cell wall in others. Thus the cell membrane also serves to help support the cell and help maintain its shape. Figure 2.2 Cell Membrane Find Out Break a chicken egg into a dish, and look at the yolk. How large do you think is it? Estimate its width. Then use a metric ruler to measure the width of your chicken yolk cell. With a hand lens, observe the yolk closely. Other cells that can be seen easily are large fish eggs. Feedback: Most cells are too small to be seen without the help of a microscope. Luckily, there are a few cells that can be seen with your naked eyes. Fact File The largest cell in human body is the egg cell or ovum, which may be fertilized by a sperm cell and grow into a baby. Cytoplasm Structures The cytoplasm consists of all of the contents outside of the nucleus and enclosed within the cell membrane of a cell. This includes mitochondria, endoplasmic reticulum, ribosome, golgi bodies, lysosomes, and vacuole.
  • 13. Mitochondria are commonly called the “power houses” of the cell. They trap the energy that results when food is broken down. Just as a power plant supplies energy to a business, mitochondria provide energy for the cell. Some types of cells are more active than others, that’s why they can have more mitochondria. Figure 2.3 Mitochondria Analyze This Why might a muscle cell have more mitochondria than other cells? Feedback: Muscle cells are always undergoing some type of movement. Muscles are also the ones exposed to strenuous activities like doing some household chores, running, walking, etc. Endoplasmic reticulum are network of canals extends from the nucleus to the cell membrane and takes up quite a lot of space in some cells. It moves material from one place to another place inside the cell. There are two regions of the endoplasmic reticulum that differ in both structure and function. One region is called Rough Endoplasmic Reticulum because it has ribosomes attached to the cytoplasmic side of the membrane. The other region is called Smooth Endoplasmic Reticulum because it lacks attached ribosomes. Typically, the smooth endoplasmic reticulum is a tubule network and the rough endoplasmic reticulum is a series of flattened sacs. Figure 2.4 Endoplasmic Reticulum
  • 14. Ribosomes are the tiny dots you see on the edges of some of the endoplasmic reticulum. Some cells may contain millions of ribosomes. Ribosomes are cell organelles that consist of RNA and proteins. They are responsible for assembling the proteins of the cell. Depending on the protein production level of a particular cell, ribosomes may number in the millions. Figure 2.5 Ribosome Fact File Cells contain thousands of ribosomes. Ribosomes are organelles that produce amino acids and proteins in the cells. They do this by reading RNA (ribonucleic acid), which is a process called translation. Every second, ribosomes can add 3+ amino acids to a new protein. In a manufacturing business, products are made, packaged, and moved to loading centers to be carried away. Structures called golgi bodies are responsible for manufacturing, warehousing, and shipping certain cellular products, particularly those from the endoplasmic reticulum (ER). Depending on the type of cell, there can be just a few complexes or there can be hundreds. Cells that specialize in secreting various substances typically have a high number of Golgi bodies. are the packaging and releasing structures of the cell. When something is released, it is given off by the cell. Figure 2.6 Golgi Bodies Applying a Concept An animal cell contains about 10 to 20 golgi bodies, while a plant cell contains several hundreds. Why do you think there is such a difference in the number of these structures in each cell type? Feedback: The fact that plants produce so many materials (food, oils, resins, etc.), they will be in need of more golgi bodies to store the said materials.
  • 15. Do you know that cells also produce wastes? In the cytoplasm, structures called lysosomes. Lysosomes are membranous sacs of enzymes. They are made by the endoplasmic reticulum and Golgi bodies. Lysosomes contain various hydrolytic enzymes that are capable of digesting nucleic acid, polysaccharides, fats, and proteins.They are active in recycling the cell's organic material and in the intracellular digestion of macromolecules. In addition, in many organisms, lysosomes are involved in programmed cell death. On the other hand, lysosomes contain chemicals that digest wastes and worn­out/ damaged cell parts. When a cell dies, chemicals in the lysosomes act to quickly break down the cell. In a healthy cell, the membrane around the lysosome keeps it from breaking down the cell itself. Plant cells do not have lysosomes. Figure 2.7 Lysosome Fact File There are two ways that a cell can die: necrosis and apoptosis. Necrosis occurs when a cell is damaged by an external force, such as poison, a bodily injury, an infection or getting cut off from the blood supply. Apoptosis, it's when a cell commits suicide. It's sometimes referred to as programmed cell death, and indeed, the process of apoptosis follows a controlled, predictable routine. Many businesses have warehouses for storing products until they are sold. Vacuoles are storage areas in cells. A membrane­bound vesicle found in the cytoplasm of a cell whose function includes intracellular secretion, excretion, storage, and digestion. It can be found in animal and plant cells, and it can be especially conspicuous in plant cells. Figure 2.8 Vacuole
  • 16. Analyze This In plant cells, vacuoles are big. In animal cells, vacuoles are small. Why do you think so? Feedback: Plants are said to be the producers of food in the environment. They may produce sugar, oil, nectar, etc. They are in need of bigger vacuoles to store such materials. The Nucleus The nucleus is a membrane bound structure and act as the “control center” of the cell. The nucleus contains the cell's hereditary information and controls the cell's growth and reproduction. The nucleus is bounded by a double membrane called the nuclear envelope (nuclear membrane). This membrane separates the contents of the nucleus from the cytoplasm. The envelope helps to maintain the shape of the nucleus and assists in regulating the flow of molecules into and out of the nucleus through nuclear pores. The nucleus contains coded instructions for all of the cell’s activities. These coded instructions are stored on special structure called the chromosomes. When a cell is "resting" i.e. not dividing, the chromosomes are organized into long entangled structures called chromatin and not into individual chromosomes as we typically think of them. The nucleus also contains the nucleolus which helps to synthesize ribosomes. The nucleolus contains nucleolar organizers which are parts of chromosomes with the genes for ribosome synthesis on them. Copious amounts of RNA and proteins can be found in the nucleolus as well. The nucleus controls the synthesis of proteins in the cytoplasm through the use of messenger RNA. Messenger RNA is produced in the nucleolus of the cell and travels to the cytoplasm through the pores of the nuclear envelope. Figure 2.9 Parts of Nucleus Fact File A typical DNA molecule is so long and thin that if it were the thickness of spaghetti, it would be 5 miles (8km) long.
  • 17. Figure 2.10 Animal Cell You have just looked at the inner workings of an animal cell. Imagine now that you are taking a microscopic tour through the green plant cell on the side. You will find that some structures in this cell are quite different from the structures in an animal cell. Take note of them. The outer covering of the plant cell is not soft and thin. Instead, it is surrounded by a rigid/tough structure called the cell wall that supports and protects the plant cell. Once you pass through the cell wall, you see the same structures you saw in the animal cell. The dark green bodies you see around you are chloroplasts. Substances inside the chloroplast help a green plant cell trap the sun’s energy and then produce food. Figure 2.11 Plant Cell
  • 18. Imagine you could take a trip into a tiny bacterial cell. Bacteria and blue­bacteria are quite different from other cells. They have fewer structures than plant or animal cells. However, they carry out all of the life processes that other cells carry out. You can see that a bacterium has a cell wall, a cell membrane, and cytoplasm. The chromosome material (nucleoid), which directs the cell’s activities, floats freely through the cytoplasm. The other structures are lacking. Figure 2.12 Bacterial Cell Fact File Bacteria are tiny, single­celled organisms. They can measure as little as 0.001 mm across and they can only be seen under a microscope. There are many different sorts of bacteria, and most of them are harmless.
  • 19. What you will do Activity 2.1 Challenge Make your own model of a cell at home. Prepare a small package of gulaman and pour it into dish. Put common foods in the gelatin to represent cell structures. You could use lettuce or shredded carrots for endoplasmic reticulum and raisins for mitochondria. Be creative! Unmold your “cell”. And serve it to your family for salad or dessert. What you will do Self­test 2.1 Let us see how well you can make a summary of what you know about the cell. Below is a table that lists the names of the cell structure(s). Now, compare animal, plant and bacterial cells by putting a (/) if the structure is present and an (x) if the structure is absent under each column. Structures Animal Cell Plant Cell Bacterial Cell 1. Cell wall 2. Cell membrane 3. Cytoplasm 4. Mitochondria 5. Ribosomes 6.Endoplasmic Reticulum 7. Golgi bodies 8. Lysosomes 9. Vacuoles 10. Chloroplasts 11. Nucleus 12. Chromosomes
  • 20. What you will do Self Test 2.2 A Tale of a Tail Mr. Gumban’s' class studied the parts of plant and animal cells. The class captured tiny tadpoles in a local stream. Mr. Gumban showed the students how to care for the tadpoles in the classroom. Gradually, as the animals grew, the bodies were changing in shape. Back and front legs grew out. The mouth expanded from a small hole to a large opening capable of swallowing large insects. In addition, the tails started to disappear. Mr. Gumban told the whole class that there would be a bonus question about the tadpoles in the test on animals. For a study clue, she told them to review their notes on cells. What do changes in the body parts of the tadpoles have to do with cells? Figure 2.13 Tadpole Think critically: Answer the bonus question: What cell part makes the tadpole tails disappear? How?
  • 21. Lesson 3. Cell Types PROKARYOTES AND EUKARYOTES Not all organelles described in the previous section are present in all cells. Cells can be grouped into two large categories: prokaryotes (cell without a true nucleus) and eukaryotes (cell with a true nucleus). Prokaryotes Prokaryotes are single­celled organisms that are the earliest and most primitive forms of life on earth. As organized in the Three Domain System, prokaryotes include bacteria and archaeans. Prokaryotes are able to live and thrive in various types of environments including extreme habitats such as hydrothermal vents, hot springs, swamps, wetlands, and the guts of animals. Fact File The first recorded observation were of the bacteria found in the dental plaque of two old men who never cleaned their teeth. Prokaryotic Cell Structure Prokaryotic cells are not as complex as eukaryotic cells. They have no true nucleus as the DNA is not contained within a membrane or separated from the rest of the cell, but is coiled up in a region of the cytoplasm called the nucleoid. Prokaryotes do not have membrane­bound organelles like mitochondria and endoplasmic reticulum. They do not possess lysosomes, vacuoles, and Golgi bodies. Their ribosomes are small. Chlorophyll, when present, is not contained in chloroplasts. Figure 3.1 Examples of Prokaryotes. From left to right: lactobacillus, E. coli and salmonella.
  • 22. Eukaryotes Eukaryotes include animals, plants, fungi and protists. Typically, eukaryotic cells are more complex and much larger than prokaryotic cells. On average, prokaryotic cells are about 10 times smaller in diameter than eukaryotic cells. Eukaryotes have well­defined nuclear membrane and distinct nucleolus. Membrane­bound organelles are found in eukaryotes, such as Golgi bodies and mitochondria. Plant and Animal Cells The second cell grouping is Plants versus Animal cells. Both of these cell types are eukaryotes. This means they have a lot of organelles in common. One organelle they don’t have in common is chloroplasts, which only plants have. Another organelle difference is the vacuoles. In animal cells the vacuoles are small and plenty. In the plant cells, there is a large central vacuole that occupies over 50% of the plant cell’s volume. This vacuole is filled with water and nutrients under pressure. The pressure helps maintain the plant cell’s rigid shape. The rigid shape results in plant cells looking rectangular as compared to the round like animal cells. While both cell types have cell membranes, the plant cell’s rigidity is further maintained by an additional cell wall outside the membrane. Figure 3.2 Eukaryotic Organisms Fact File DNA strands look like a twisted ladder. Sections of DNA are called genes. All the instructions for growing a new human being are coded into the DNA molecule.
  • 23. Table 3.1 Comparison of prokaryotic and Eukaryotic Cells. Cell Structure Prokaryotic Cell Eukaryotic Cell Cell membrane present present Nuclear membrane absent present Membrane­bound organelles absent present Ribosomes small large Chlorophyll when present are not found in chloroplasts found in chloroplasts Mitochondria absent present Chromosomes single loop of circular DNA multiple double­helix Fact File Chromosomes are tiny threads that are present in all cells apart from red blood cells. They contain all the information for an entire person to develop. There are 46 chromosomes in each cell. They come in 22 pairs, plus another special pair that determine the person’s sex. What you will do Self Test 3.1 Answer the following questions: 1. Chloroplasts are found in which type of cell? 2. What do you call the broad group of cells that lack membrane bounded organelles? 3. What type of cell (prokaryote or eukaryote) has DNA that floats freely in the cell? 4. Mushroom is a unicellular organism. (True or false) 5. Human is a multicellular organism. (True or false)
  • 24. Let’s Summarize 1. Cells are amazing, variable, beautiful, and functionally superb. A concept of genius, they work alone or in groups with equal ease. 2. Cells are the basic units of life. All living things are made up of one or more cells. Organisms that exist as single cells are called unicellular and organisms that are made up of groups of cells working together are called multicellular. 3. Because all living things are made up of cells, and because we desire to understand ourselves and the other living things around us it makes sense to learn something about cells. 4. All living things are divided into two major groups depending on how their cells are set up. These two groups are the Prokaryotes and the Eukaryotes. 5. The basic structure of plant and animal cell is almost the same except for certain differences. The basic structure of a cell is composed of the following components. a. Cell Membrane b. Cytoplasm c. Nucleus However in plants, a rigid "Cell wall" is present outside the cell membrane or plasma membrane. 6. Cell Theory: All living things are composed of cells. Cells are the basic units of structure and function in living things. All cells come from preexisting cells Whew! At last! You have finished studying the module. But, before you completely exit from this module, let us find out how much you learned from this material.
  • 25. Post-Test Multiple Choice. Choose the letter of the best answer. Write the chosen letter on a separate sheet of paper. 1. A cell is observed to contain a nucleus, mitochondria and chloroplasts. From this information you can conclude that the cell is: a. a plant cell c. a bacterial cell b. a animal cell d. a prokaryotic cell 2. A cell that lacks a nucleus and membrane bound organelles is known as a(an) ______________ cell. a. plant c.eukaryote b. animal d. prokaryote 3. A cell with relatively few energy needs will probably have a relatively small number of a. ribosomes c. mitochondria b. lysosomes d. chromosomes 4. Digestive enzymes or hydrolytic enzymes are terms associated with a. ribosomes c. golgi apparatus b. lysosomes d. smooth endoplasmic reticulum 5. In which of the following items would you expect to find cells? a. strawberry c. silver dollar b. eyeglasses d. plastic flower 6. Organisms whose cells do not have a nucleus are called a. plants c. eukaryotes b. organelles d. prokaryotes 7. Plant cells often have a box­like shape because of the a. nucleus c. cytoplasms b. cell wall d. cell membrane 8. The site of ATP production and the site of photosynthesis are the _______________ and _________________. a. ribosomes and vacuoles c. mitochondria and chloroplasts b. chloroplasts and lysosomes d. Golgi complex and chloroplast 9. What is the outermost boundary of an animal cell? a. the cell wall c. the nuclear membrane b. the cytoplasm d. the nuclear envelope
  • 26. 10. What site regulates what goes in and out of the cell? a. cell wall c. cell membrane b. vacuole d. nuclear membrane 11. What type of cell has these characteristics: contains DNA but no nucleus, contains flagella, ribosomes, cytoplasm, and a cell membrane. a. plant c. animal b. fungi d. bacteria 12. Where is the site of protein synthesis? a. nucleus c. ribosome b. lysosomes d. mitochondria 13. Which is the “brain” of the cell? a. nucleus c. golgi bodies b. chlorop[lats d. mitochondria 14. Which of the following forms of life is NOT eukaryotic? a. a bacterial cell c. a plant cell like gumamela b. protist such as amoeba d. a human cell such as red blood cell 15. Which of the following is found in the nucleus? a. vacuole c. mitochondria b. chloroplasts d. chromosomes 16. Which of the following is NOT true of chloroplasts? a. They synthesize sugar b. They contain pigments c. They are only found in planta d. They appear green because of chlorophyll 17. Which of the following organelles transports materials inside the cell a. lysosome c. mitochondria b. chloroplasts d. endoplasmic reticulum 18. Which of the following statements is always true? a. All cells have a cell wall c. All cells contain chloroplast. b. All cells contain nucleus. d. All cells have a cell membrane. 19. Which of the following structures are common to both eukaryotic and prokaryotic cells? a. nucleus c. both b and c b. ribosomes d. cell membrane 20. Which organelle has no membrane? a. vacuole c. ribosome b. lysosome d. chloroplast
  • 27. Key to Answers Pretest 1. c 6. d 11. d 16. c 2. d 7. b 12. a 17. a 3. d 8. a 13. d 18. d 4. c 9. b 14. b 19. c 5. a 10. c 15. c 20. c LESSON 1 Activity 1.1 The Street Sweepers Lining the passageways are special cells that release a mixture of water, carbohydrates, and salts, called mucus. The particles of dust and dirt that are inhaled are trapped in this sticky mucus. Underneath this layer of mucus is another group of specialized cells that have cilia. As the cilia move, they create a sweeping action. This action keeps the most vital passageways in the body clean and open for business. Self­Test 1.1 1. Leeuwenhoek: discovered protozoa Hooke: described “cells” in cork Schleiden & Schwann: proposed cell theory Virchow: concluded that cells come from preexisting cells 2. The microscope opened up the world of the very small to biologists. It enabled scientists to discover that all living things are made up of cells. LESSON 2 Self­Test 2.1 Structures Animal Cell Plant Cell Bacterial Cell 1. Cell wall X / / 2. Cell membrane / / / 3. Cytoplasm / / / 4. Mitochondria / / x
  • 28. 5. Ribosomes / / / 6.Endoplasmic Reticulum / / x 7. Golgi bodies / / x 8. Lysosomes / x x 9. Vacuoles / / x 10. Chloroplasts x / x 11. Nucleus / / x 12. Chromosomes / / / Self­Test 2.2 The body parts of the tadpoles change in response to the activity of the cells which is cell division. When cells divide, their number increases. Growth results when cells increase in number. The tails of the tadpole disappear due to the lysosomal activity. The lysosome, if you will recall, contains powerful chemicals which are used to digest or break down materials LESSON 3 Activity 3.1 Feedback: One­celled organisms may have fewer or different structures from plant or animal cells. However, they carry out all of the life processes (reproduction, digestion, excretion, respiration, etc.) that other cells carry out. Self­Test 3.1 1. plant 2. prokaryote 3. prokaryote 4. false 5. true Post­Test 1. c 6. b 11. b 16. c 2. d 7. a 12. a 17. a 3. d 8. c 13. d 18. d 4. b 9. c 14. b 19. c 5. c 10. d 15. a 20. c
  • 29. References Books: Ahuja M.; (2006). Life Sciences. Gyan Publishing House. pp. 105­109 Chancellor Press (Bounty Books); (2001). Tell Me What?. WS Pacific Publications Inc., Manila, Philippines. pp. 38­71 Chancellor Press (Bounty Books); (2001). Tell Me Where?. WS Pacific Publications Inc., Manila, Philippines. pp. 140­173 Chancellor Press (Bounty Books); (2001). Tell me When?. WS Pacific Publications Inc., Manila, Philippines. pp. 38­71 Lozano, L.; Sandico, P.M.; (2003). Science and Technology for the Future II. Diwa Scholastic Press Inc. pp. 92­104 Module: Project EASE (Effective Alternative Secondary Education). Biology Module 2. Cell structure and Function. Bureau of Secondary Education, Department of Education, Pasig City. Electronic Sources: Retrieved October 15, 2013 from http://depedmati.wikispaces.com/file/view/K+TO+12+BEC+COMPETENCIES+AND+LEARNING +RESOURCES+FOR+GRADE+7.pdf Retrieved October 15, 2013 from http://goo.gl/fLMSSo Retrieved October 15, 2013 from http://science.howstuffworks.com/life/cellular­microscopic/ cell­info. htm Retrieved October 15, 2013 from http://beyondthehumaneye.blogspot.com/2009/06/dune­builder. html Retrieved October 15, 2013 from http://www.infoplease.com/encyclopedia/science/cell­biology. html Retrieved October 15, 2013 from http://bitesizebio.com/articles/history­of­cell­biology/ Retrieved October 15, 2013 from http://commons.wikimedia.org/wiki/File:Cork_Micrographia_Hooke.png Retrieved October 15, 2013 from http://biology.tutorvista.com/cell/cell­theory. html Retrieved October 15, 2013 from fig.cox.Miami.edu/~cmallery/150/unity/cell.text.htm
  • 30. Retrieved October 15, 2013 from http://goo.gl/SbqIZp Retrieved October 15, 2013 from http://cellbiology.med.unsw.edu.au/units/science/timeline.htm Retrieved October 15, 2013 from http://www.history­of­the­microscope. org/hans­and­zacharias­jansen­microscope­history. php Retrieved October 15, 2013 from http://www.deshow.net/animal/bing­animal­wallpaper­846. html Retrieved October 15, 2013 from http://goo.gl/12giJo Retrieved October 15, 2013 from http://www.history­of­the­microscope. org/anton­van­leeuwenhoek­microscope­history. php Retrieved October 16, 2013 from http://www.answersingenesis.org/articles/aid/v7/n1/antony­van­leeuwenhoek­creation­magnified­microscopes Retrieved October 16, 2013 from http://biology.about.com/od/cellanatomy/p/nucleus.htm Retrieved October 16, 2013 from http://biology.about.com/od/biologydictionary/g/cell­membrane. htm Retrieved October 16, 2013 from http://biology.about.com/od/cellanatomy/ss/endoplasmic­reticulum. htm Retrieved October 16, 2013 from http://biology.about.com/od/cellanatomy/p/ribosomes.htm Retrieved October 16, 2013 from http://www.ask.com/question/interesting­facts­about­ribosome Retrieved October 17, 2013 from http://biology.about.com/b/2008/11/07/what­are­lysosomes. htm Retrieved October 17, 2013 from http://science.howstuffworks.com/life/cellular­microscopic/ apoptosis.htm Retrieved October 17, 2013 from http://www.biology­online. org/dictionary/Vacuole Retrieved October 17, 2013 from http://biology.about.com/od/cellanatomy/ss/prokaryotes.htm Retrieved October 17, 2013 from http://www.ask.com/question/examples­of­prokaryotic­organisms Retrieved October 17, 2013 from http://goo.gl/pPKiaU Retrieved October 17, 2013 from http://biology.about.com/od/cellanatomy/a/eukaryprokarycells.htm Retrieved October 17, 2013 from http://hyperphysics.phy­astr. gsu.edu/hbase/biology/golgi.html