ANTIMALARIAL DRUGS

3. 
ANTIMALARIAL DRUGS :
MALARIA
Malaria is a protozoan infection .
It is caused by 4 species:

4. 
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Plasmodium vivax
Plasmodium ovale
Plasmodium falciparum
Plasmodium malaria.
benign
malignant
Benign
tertian.

5. 
BITE OF FEMALE ANOPHELES MOSQUITO

SHARING NEEDLES

BLOOD TRANSFUSION

13. 
It is a 4- aminoquinoline

It is a rapidly acting erythrocytic schzonticide
against all species of plasmodium.

Controls most clinical attacks in 1-2 days with
disappearance of parasites from peripheral
blood in 1-3 days.

14. 
It is a basic drug, which is taken by acidic food
vacuoles of susceptible plasmodia and inhibits
conversion of haeme to haemozoin.

16. chloroquine

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concentrated in acidic vacuole of parasite

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complex

membrane
binds to haeme
drug haeme
damages plasmodia

17. 
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Oral absorption is excellent .absorption after i.m inj is also
good
About 50% is bound to plasma
High affinity for melanin and nuclear chromatin : gets
tightly bound to these tissue constituents and is
concentrated in liver ,spleen,kidney,lungs,skin,leucocytes
and some other tissues.
Its selective accumulation in retina is responsible for ocular
toxicity seen with prolonged usage.
+

18. 

Partly metabolised in liver and excreted in
urine.
Early plasma half life is 3-10 days.because of
tight tissue binding, small amounts persist in
body with a terminal half life of 1-2 months.