Mr. Namdeo Shinde
SATARA COLLEG OF PHARMACY, SATARA (Maharashtra) India-415004.
Half lifecycle of Plasmodia is completed in body
of mosquito and remaining half in human liver
In RBCs produces
Symptoms of malaria
Pain in joints
If malaria not treated early complicates into anaemia
Drugs which kills P. Vivax and P. falciparum and used
for prophylaxis and treatment of malaria are called
Mechanism of antimalarials
Chloroquine concentrates in RBCs and kills secondary
schizontes by increasing basicity of plasmodial cell
Artemisinin derivatives release highly reactive peroxide
radicals which destroy plasmodial cell.
Sporonticides inhibit plasmodial dihydrofolate