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1. DOSEN PENGAMPU :
Apt. RATNA SARI DEWI, M.Farm
FARMAKOTERAPI II
INFEKSI DISEBABKAN JAMUR (MIKOSIS)
OLEH KELOMPOK 10 SI-VIA :
1. Atriwida Sastrawati 1501059
2. Desi Linda Sari 1801124
3. Nurul faridah 1701031
4. Viona lischa nurfahira 1701042
)

2. DEFENISI
01
JENISNYA ( BERDASARKAN
JENIS JAMUR PENYEBAB)02
GEJALA
03
PENGOBATAN SECARA
UMUM04
Sub
bahasan

3. DEFENISI
MIKOSIS merupakakn infeksi jamur yang dapat
menjangkit permukaan kulit hingga organ tubuh
manusia. (Charisma, 2019)
Mikosis didefinisikan sebagai infeksi jamur yang
disebabkan organisme eumycotic yang
oportunistik dan patogenik, seperti:
Dermatophytes spp., Candida spp., Aspergillus
spp., Feomycetes spp., Cryptococcus, dan
beberapa spesies fungi lainnya (Kazemi, 2013).

4. JENISNYA ( BERDASARKAN JENIS JAMUR PENYEBAB)
1
2
3
4
Mikosis superfisial
Mikosis sistemik
( profunda )
Menurut Graham, 2010, jenis – jenis mikosis yaitu :
Mikosis subkutan
Mikosis oportunistik

5. meskipun penyakit ini umumnya lebih parah atau
menyebar pada inang dengan gangguan imun.
Mikosis disebabkan oleh jamur oportunis seperti C.
Albicans, spesies Aspergillus, Trichosporon,
Torulopsis (Candida) glabrata, Fusarium, Alternaria,
dan Mucor umumnya ditemukan hanya pada inang
dengan gangguan imun. Sebagian besar infeksi
jamur diperoleh sebagai hasil dari kejadian inhalasi
udara. Contohnya, Histoplasma capsulatum
ditemukan pada tanah yang terkontaminasi oleh
kotoran kelelawar, ayam, dan burung jajak, dan C.
Neoformans berkaitan dengan tetesan burung
merpati
Faktor inang dan patogen memiliki peran yang saling
mempengaruhi pada penerimaan dan perkembangan
infeksi jamur. Kulit utuh atau permukaan mukosa menjadi
barier utama pada infeksi. Flora bakteri kulit dan membran
mukus bersaing dengan jamur untuk pertumbuhannya.
Perubahan pada keseimbangan flora normal disebabkan
oleh penggunaan antibiotik atau perubahan pada status
nutrisi yang dapat menyebabkan proliferasi jamur seperti
Candida, meningkatkan kemungkinan invasi sistemik dan
Pertumbuhan jamur dalam jaringan tertahan oleh
sejumlah mekanisme. Sebagai contoh, serum memiliki
aktivitas fungistatik melawan Candida sebagian karena
transferin, protein pengikat besi manusia yang
menghilangkan mikroba dari besi yang diperlukan untuk
sintesis enzim pernapasan. Serum juga mengandung
globulin, yang menyebabkan penggumpalan
nonimmunologis Candida, memfasilitasi eliminasi mereka
dengan inflamasi sel.
Reaksi jaringan dengan adanya jamur bervariasi
ergantung dengan spesies jamur, sisi proliferasi, dan
durasi infeksi. Fagositosis oleh neutrofil dan makrofag
merupakan mekanisme paling awal yang mencegah
pembentukan jamur. Akibatnya, pasien dengan penurunan
umlah neutrofil atau penurunan fungsi neutrofil memiliki

6. Penyebab Mikosis
Secara umum Mikosis disebabkan oleh jenis
jamur yang berbeda-beda. Berikut adalah
penyebab mikosis berdasarkan jenisnya
secara umum :
- Tinggal di lingkungan yang lembap
- Mengeluarkan keringat berlebih
(hiperhidrosis)
- Sering memakai pakaian yang ketat
- Memiliki sistem imun lemah

7. Secara umum gejala mikosis
tergantung dari tempat jamur itu
tumbuh dalam dipermukaan kulit
sehingga terjadi infeksi, yaitu bercak
berwarna putih atau kemerahan
dengan ciri khas adanya central
healing seperti jaringan kulit yang
tidak terinfeksi pada bagian tengah
bercak.
Gejala
Charisma, 2010

8. Mikosis dapat ditangani dengan obat antijamur. Jenis obat
antijamur yang digunakan berbeda-beda, tergantung dari
jenis mikosisnya.
Kebanyakan mikosis luar cukup ditangani dengan obat
antijamur topikal berbentuk krim, lotion, bubuk, cairan,
semprot, atau larutan tetes. Namun, ada beberapa
mikosis jenis ini yang juga memerlukan obat-obatan
antijamur yang diminum. Untuk mikosis organ dalam,
pengobatan yang digunakan berupa obat-obatan
antijamur yang diminum atau disuntikan.
Pengobatantan mikosis

9. Menurut indikasi klinis obat
obat antijamur dapat dibagi atas 2 golongan, yaitu:
1. Antijamur untuk infeksi sistemik,
termasuk : amfoterisin B, flusitosin, imidazol
(ketokonazol, flukonazol, mikonazol),
dan hidroksistilbamidin.
2. Antijamur untuk infeksi dermatofit dan mukokutan,
termasuk griseofulfin, golongan
Imidazol (mikonazol, klotrimazol, ekonazol, isokonazol,
tiokonazol, dan bifonazol), nistatin, tolnaftat,
dan antijamur topikal lainnya (kandisidin, asam
undesilenat, dan natamisin) (UNSRI, 2004

10. Diagnosis Mikosis
Pemeriksaan yang dilakukan dokter untuk mendiagnosis
mikosis dibedakan berdasarkan lokasi infeksi yang terjadi.
Berikut penjelasannya:
1. Mikosis luar
Pada mikosis luar, pemeriksaan diawali dengan
menanyakan gejala yang muncul dan melakukan
pemeriksaan fisik. Pada banyak kasus, infeksi jamur pada
kulit menimbulkan gejala yang khas dan dapat didiagnosis
tanpa memerlukan pemeriksaan penunjang
2. Mikosis organ dalam
Gejala mikosis organ dalam terkadang tidak khas
sehingga pemeriksaan jamur di laboratorium perlu
dilakukan guna memastikan jenis jamur dan infeksinya,
serta mengetahui pengobatan yang diperlukan.
Pemeriksaan tersebut akan mengambil sampel cairan
tubuh, seperti darah, urine, dahak, serta cairan otak, atau
sampel jaringan organ yang terdampak.

11. Komplikasi Mikosis
Mikosis dapat menyebabkan komplikasi yang berbeda-
beda, tergantung jenis dan lokasinya. Mikosis organ dalam
dapat menyebar ke aliran darah dan memburuk seiring
waktu. Jika tidak ditangani, infeksi jamur tersebut dapat
menyebabkan kegagalan fungsi berbagai organ.

12. Pencegahan Mikosis
Untuk mencegah terjadinya infeksi jamur, cara yang
paling tepat adalah dengan memastikan bahwa tubuh dan
lingkungan tempat tinggal terbebas dari pertumbuhan
jamur. Oleh karena itu beberapa langkah di bawah ini
dapat mencegah mikosis akibat tubuh yang lembab, di
antaranya:
- Hindari menggunakan pakaian yang ketat
- Hindari penggunaan pakaian secara berulang,
termasuk pakaian dalam.
- Saat pakaian sudah basah akibat keringat, segera
ganti dengan pakaian yang kering.
- Selalu gunakan kaus kaki yang kering dan bersih.

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and appeal to your Presentations.
You can simply impress your audience and add a unique zing
and appeal to your Presentations.
You can simply impress your audience and add a unique zing
and appeal to your Presentations.
You can simply impress your audience and add a unique zing
and appeal to your Presentations.

47. Column Infographic
You can simply impress your audience and add a unique zing and appeal to your Presentations. Easy to change colors, photos and Text.
Get a modern PowerPoint Presentation that is beautifully designed. I hope and I believe that this Template will your Time, Money and
Reputation. Easy to change colors, photos and Text. I hope and I believe that this Template will your Time, Money and Reputation. You can
simply impress your audience and add a unique zing and appeal to your Presentations. Easy to change colors, photos and Text.
Get a modern PowerPoint Presentation that is beautifully designed. I hope and I believe that this Template will your Time, Money and
Reputation.
Easy to change colors, photos and Text. You can simply impress your audience and add a unique zing and appeal to your Presentations.
Easy to change colors, photos and Text.
I hope and I believe that this Template will your Time, Money and Reputation. You can simply impress your audience and add a unique zing
and appeal to your Presentations. You can simply impress your audience and add a unique zing and appeal to your Presentations. Easy to
change colors, photos and Text.
Modern PowerPoint Presentation

48. Column
Infographic
PowerPoint Presentation Templates
Get a modern PowerPoint Presentation that
is beautifully designed. I hope and I believe
that this Template will your Time, Money and
Reputation. Easy to change colors, photos
and Text. You can simply impress your
audience and add a unique zing and appeal
to your Reports and Presentations with our
Templates. Get a modern PowerPoint
Presentation that is beautifully designed. I
hope and I believe that this Template will your
Time, Money and Reputation. Easy to change
colors, photos and Text. You can simply
impress your audience and add a unique zing
and appeal to your Reports and
Presentations with our Templates. Easy to
change colors, photos and Text.
You can simply impress your audience and
add a unique zing and appeal to your Reports
and Presentations with our Templates..
Easy to change colors,
photos and Text.01
PowerPoint Presentation Templates
Get a modern PowerPoint Presentation that
is beautifully designed. I hope and I believe
that this Template will your Time, Money and
Reputation. Easy to change colors, photos
and Text. You can simply impress your
audience and add a unique zing and appeal
to your Reports and Presentations with our
Templates. Get a modern PowerPoint
Presentation that is beautifully designed. I
hope and I believe that this Template will your
Time, Money and Reputation. Easy to change
colors, photos and Text. You can simply
impress your audience and add a unique zing
and appeal to your Reports and
Presentations with our Templates. Easy to
change colors, photos and Text.
You can simply impress your audience and
add a unique zing and appeal to your Reports
and Presentations with our Templates..
Easy to change colors,
photos and Text.02

49. THANK YOUInsert the SubTitle of Your Presentation

50. Fully Editable Shapes

51. Fully Editable Shapes

52. You can Resize without
losing quality
You can Change Fill
Color &
Line Color
www.allppt.com
FREE
PPT
TEMPLATES
Fully Editable Icon Sets: A

53. You can Resize without
losing quality
You can Change Fill
Color &
Line Color
www.allppt.com
FREE
PPT
TEMPLATES
Fully Editable Icon Sets: B

54. You can Resize without
losing quality
You can Change Fill
Color &
Line Color
www.allppt.com
FREE
PPT
TEMPLATES
Fully Editable Icon Sets: C